检索结果-南通市图书馆

Holocene Environmental Climatic Changes Based on Palynofacies and organic Geochemical Analyses from an Inland Pond at Altitude in Southern Brazil

引用

American Journal of Climate Change 2014年第1期3卷 95-117页

作者： Gabrielli Teresa Gadens-Marcon Margot Guerra-Sommer Joao Graciano Mendonca-Filho Joalice de oliveira Mendonca Marcelo de Araújo Carvalho léo afraneo hartmann Unidade litoral Norte Universidade Estadual do Rio Grande do SulOsórioBrasil Instituto de Geociências Universidade Federal do Rio Grande do SulPorto AlegreBrazil Instituto de Geociências Universidade Federal do Rio de JaneiroRio de JaneiroBrazil Museu Nacional Universidade Federal do Rio de JaneiroRio de JaneiroBrazil

This paper focuses on the interpretations in the analyses of palynofacies and organic geochemistry carried out on a sedimentary profile covering 9542 cal yr BP from a pond located at the mining district from Ametista do Sul, southernmost Brazil. The hydrological isolation renders this pond, located on a hilltop, highly sensitive to climatic change because the water entering in the system is subsidized exclusively by the rainfall. The main goal of this study is to establish relationships between the sedimentary organic record and climatic fluctuations in the Holocene, trying to correlate the alterations in the particulate organic matter with regional climatic changes or perhaps even events on a global scale. Fluctuations in water depth are inferred from the frequency of the autochthonous elements (algae), which predominate in the basal intervals, but tend to decrease progressively toward the top, when begining to alternate periods of high and low frequency with the parautochthonous (spores) and allochthonous (pollen grains) elements, due to changes in the patterns of moisture. Pseudoschizaea seems to have a closer relationship with the spores than with all other algae and can serve as a biological marker of transitional intervals or have some role in the successional process of vegetation. The variety of spores of ferns and pollen grains on the topmost interval indicates increased vegetal diversity, and is probably related to the process of successional evolution of the area. An increased rainfall event detected between 8.6 to 7.4 ka yr BP can be responsible for the beginning of the process of water accumulation in the gossan and sedimentation of the pond and can be related with the “Bond Events”. The saturation level of the pond, in turn, remained relatively constant until 6.8 ka yr BP, when changes in the patterns of moisture make the environment drier and resulted in an intermittent pattern of water depth, currently existing on the site.

关键词： organic Matter(oM) Total organic Carbon(ToC) Total Sulfur(TS) Paleoclimatic Change Rainfall Influence

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Blood biomarkers of Alzheimer’s disease:important considerations for use in clinical practice

引用

Neural Regeneration Research 2025年第1期20卷 205-206页

作者： Sarah Fullam Sean o’Dowd Antoinette o’Connor Department of Neurology Tallaght University HospitalDublinIreland Academic Unit of Neurology Trinity College DublinIreland

Introduction:Fluid and positron emission tomography(PET)biomarkers that enable the detection of the hallmark proteins of Alzheimer’s disease(AD)(amyloid and tau)have revolutionized our approach to the diagnosis of *** evolution of AD diagnostic criteria to include biological characterization(Alzheimer’s Association Working Group,2023)provides an appropriate framework to reduce levels of clinico-pathologic mismatch and improve in-vivo diagnostic *** the therapeutic landscape for neurodegenerative disease evolves,it is increasingly incumbent on clinicians to provide timely,and pathologically precise diagnoses for ***,the expensive and invasive nature of these tests limits their scalability.

关键词： Blood Alzheimer diagnosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point spherical source embedded within a fluid-saturated poroelastic formation of infinite extent

引用

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 139-156页

作者： H.HoSSEINI o.BAlIlASHAKI Department of Mechanical Engineering Faculty of EngineeringGolestan University

The effects of a harmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely within a fluid-saturated poroelastic formation of infinite extent are examined theoretically. It is assumed that the source is located outside the cavity at a specified distance from the borehole axis. The magnitudes of the hoop and radial stresses beside the pore pressures exerted on the interface and inside the porous medium surrounding the borehole are calculated and discussed. Biot's poroelastic modeling along with three types of boundary conditions for the cylindrical interface including the ideal fluid, empty borehole, and rigid inclusion with a hard boundary is employed for the analysis. Utilizing a proper translational addition theorem for expressing the incident spherical wave in terms of cylindrical wave expansions, the proposed boundary conditions at the interface are satisfied. Stresses are formulated by means of wave potential functions in a three-dimensional(3D) manner. The effects of the frequency and the radial distance between the source and borehole on the induced stresses are examined for the first cylindrical modes over frequency spectra. Two permeability conditions for the interface and three types of soils for the porous formation are considered throughout the analysis. To give an overall outline of the study, a numerical example is presented. The results clearly indicate that the distance is a key parameter and has considerable effects on the induced stress values. In addition, the interface permeability condition and soil characteristics play an important role in determining the dynamic response of the borehole. Finally,the obtained results are compared with the relevant analyses existing in the literature for some limit cases, and good agreement is achieved.

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neuroinflammation revisited through the microglial lens

引用

Neural Regeneration Research 2025年第7期20卷 1989-1990页

作者： Renato Socodato João B.Relvas Institute of Research and Innovation in Health(i3S)and Institute for Molecular and Cell Biology(IBMC) University of PortoPortoPortugal Department of Biomedicine Faculty of Medicine of the University of Porto(FMUP)PortoPortugal

Neuroimmunology is emerging as a pivotal field,shedding light on the intricate dialogues between the central nervous system(CNS)and the immune *** exploration is particularly significant in understanding microglia,the CNS’s innate immune cells,beyond the conventional conflation of“neuroinflammation”and“microglial activation.”This conflation has clouded the true complexity of these processes,potentially stalling scientific progress and the development of new *** challenge the long-standing perspectives that have oversimplified these interactions,advocating for a deeper exploration of the dynamic relationship between neuroinflammation and microglial *** dissecting specific molecular pathways,we aim to illuminate their elaborate roles in neuroinflammatory responses,especially in the context of Alzheimer’s disease(AD).Here,neuroinflammation is not merely a passive observer or a direct antagonist but a complex agent in the disease’s *** article calls for a significant paradigm shift towards an integrative,multi-omics approach to *** such a comprehensive framework is crucial for advancing our understanding of neuroinflammatory conditions and paving the way for targeted therapeutic strategies for brain diseases.

关键词： inflammation simplified activation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Polyethylene glycol has immunoprotective effects on sciatic allografts, but behavioral recovery and graft tolerance require neurorrhaphy and axonal fusion

引用

Neural Regeneration Research 2025年第4期20卷 1192-1206页

作者： Tyler A.Smith liwen Zhou Cameron l.Ghergherehchi Michelle Mikesh Cathy Z.Yang Haley o.Tucker JuliAnne Allgood Jared S.Bushman George D.Bittner Department of Molecular Biosciences University of Texas at AustinAustinTXUSA Department of Neuroscience University of Texas at AustinAustinTXUSA Division of Pharmaceutical Sciences University of WyomingLaramieWYUSA

Behavioral recovery using(viable)peripheral nerve allografts to repair ablation-type(segmental-loss)peripheral nerve injuries is delayed or poor due to slow and inaccurate axonal ***,such peripheral nerve allografts undergo immunological rejection by the host immune *** contrast,peripheral nerve injuries repaired by polyethylene glycol fusion of peripheral nerve allografts exhibit excellent behavioral recovery within weeks,reduced immune responses,and many axons do not undergo Wallerian *** relative contribution of neurorrhaphy and polyethylene glycol-fusion of axons versus the effects of polyethylene glycol per se was unknown prior to this *** hypothesized that polyethylene glycol might have some immune-protective effects,but polyethylene glycol-fusion was necessary to prevent Wallerian degeneration and functional/behavioral *** examined how polyethylene glycol solutions per se affect functional and behavioral recovery and peripheral nerve allograft morphological and immunological responses in the absence of polyethylene glycol-induced axonal ***-type sciatic nerve injuries in outbred Sprague–Dawley rats were repaired according to a modified protocol using the same solutions as polyethylene glycol-fused peripheral nerve allografts,but peripheral nerve allografts were loose-sutured(loose-sutured polyethylene glycol)with an intentional gap of 1–2 mm to prevent fusion by polyethylene glycol of peripheral nerve allograft axons with host *** to negative control peripheral nerve allografts not treated by polyethylene glycol and in contrast to polyethylene glycol-fused peripheral nerve allografts,animals with loose-sutured polyethylene glycol peripheral nerve allografts exhibited Wallerian degeneration for all axons and myelin degeneration by 7 days postoperatively and did not recover sciatic-mediated behavioral functions by 42 days *** morphological signs of rejection,such as col

关键词： allograft rejection axotomy macrophage myelin nerve repair polyethylene glycol(PEG) sciatic nerve T cell transplantation Wallerian degeneration

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Contribution of mechanical forces to structural synaptic plasticity:insights from 3D cellular motility mechanisms

引用

Neural Regeneration Research 2025年第7期20卷 1995-1996页

作者： Rita o.Teodoro Mafalda Ribeiro Ramos lara Carvalho iNoVA4Health NOVA Medical School|Faculdade de Ciências MédicasNMS|FCMUniversidade Nova de LisboaLisboaPortugal

Cells,tissues,and organs are constantly subjected to the action of mechanical forces from the extracellular environment-and the nervous system is no ***-intrinsic properties such as membrane lipid composition,abundance of mechanosensors,and cytoskeletal dynamics make cells more or less likely to sense these *** and extrinsic cues are integrated by cells and this combined information determines the rate and dynamics of membrane protrusion growth or retraction(Yamada and Sixt,2019).Cell protrusions are extensions of the plasma membrane that play crucial roles in diverse contexts such as cell migration and neuronal synapse *** the nervous system,neurons are highly dynamic cells that can change the size and number of their pre-and postsynaptic elements(called synaptic boutons and dendritic spines,respectively),in response to changes in the levels of synaptic activity through a process called *** plasticity is a hallmark of the nervous system and is present throughout our lives,being required for functions like memory formation or the learning of new motor skills(Minegishi et al.,2023;Pillai and Franze,2024).

关键词： plasticity structural mechanisms

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Apples to oranges:environmentally derived,dynamic regulation of serotonin neuron subpopulations in adulthood?

引用

Neural Regeneration Research 2025年第9期20卷 2596-2597页

作者： Christopher J.o’Connell Matthew J.Robson Department of Genetics College of MedicineHarvard UniversityBostonMAUSA James l.Winkle College of Pharmacy Division of Pharmaceutical SciencesUniversity of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program College of MedicineUniversity of CincinnatiCincinnatiOHUSA

Traumatic brain injury(TBI)is a public health problem with an undue economic burden that impacts nearly every age,ethnic,and gender group across the globe(Capizzi et al.,2020).TBIs are often sustained during a dynamic range of exposures to energetic environmental forces and as such outcomes are typically heterogeneous regarding severity and pathology(Capizzi et al.,2020).

关键词： sustained orange dynamic

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

引用

Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Proto-Adamastor ocean crust(920 Ma)described in Brasiliano orogen from coetaneous zircon and tourmaline

引用

Geoscience Frontiers 2019年第4期10卷 1623-1633页

作者： léo A.hartmann Mariana Werle Cassiana R.l. Michelin Cristiano lana Gláucia N. Queiroga Marco P. Castro Karine R. Arena Instituto de Geociências Universidade Federal do Rio Grande do SulAvenida Bento Goncalves950091501-970Porto AlegreRio Grande do SulBrazil Departamento de Geologia Escola de MinasUniversidade Federal de Ouro PretoMorro do Cruzeiro35400-000Ouro PretoMinas GeraisBrazil

Proto-Adamastor ocean bathed Rodinia and successor continental fragments from 1.0-0.9 Ga up to0.75 Ga,and evolved into world Adamastor ocean at 0.75-0.60 *** oceanic crust is poorly preserved on continents,only indirect evidence registered in Brasiliano *** report first evidence of ophiolite originated in *** use multi-technique U-Pb-Hf zircon andδ^11B tourmaline isotopic and elemental *** host tourmalinite is enclosed in metaserpentinite,both belonging to the Bossoroca *** is 920 Ma-old,εHf(920 Ma)=+12,HfTDM=1.0 Ga and has’oceanic’composition(e.g.,U/Ybourmaline is dravite withδ^11B=+1.8‰(Tur 1),0‰(Tur 2),-8.5‰(Tur 3).These characteristics are a novel contribution to Rodinia and associated world ocean,because a fragment of proto-Adamastor oceanic crust and mantle evolved at the beginning of the Brasiliano orogen.

关键词： Coeval zircon and tourmaline Bossoroca ophiolite Early Brasiliano orogen Zircon U-Pb-Hf isotopes Zircon trace elements Tourmaline boron isotopes

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Multiple sclerosis is at a checkpoint: advancing the program

引用

Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：