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Silk-based nerve guidance conduits with macroscopic holes modulate the vascularization of regenerating rat sciatic nerve

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Neural Regeneration Research 2025年第6期20卷 1789-1800页

作者： Carina Hromada Patrick Heimel Markus Kerbl lászlógál Sylvia Nürnberger Barbara Schaedl James Ferguson Nicole Swiadek Xavier Monforte Johannes C.Heinzel Antal Nógrádi Andreas H.Teuschl-Woller David Hercher Department life Science Engineering University of Applied Sciences Technikum WienViennaAustria Austrian Cluster for Tissue Regeneration ViennaAustria ludwig Boltzmann Institute for Traumatology The Research Center in Cooperation with AUVAViennaAustria University Clinic of Dentistry Medical University of ViennaViennaAustria Department of Plastic Reconstructive and Aesthetic SurgeryLandesklinikum Wiener Neustadt2700 Wiener NeustadtAustria Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary Medical University of Vienna Department of Orthopedics and Trauma SurgeryDevision of Trauma SurgeryViennaAustria Department of Hand- PlasticReconstructive and Burn SurgeryBG Unfallklinik TuebingenUniversity of TuebingenTuebingenGermany

Peripheral nerve injuries induce a severe motor and sensory deficit. Since the availability of autologous nerve transplants for nerve repair is very limited, alternative treatment strategies are sought, including the use of tubular nerve guidance conduits(tNgCs). However, the use of tNgCs results in poor functional recovery and central necrosis of the regenerating tissue, which limits their application to short nerve lesion defects(typically shorter than 3 cm). given the importance of vascularization in nerve regeneration, we hypothesized that enabling the growth of blood vessels from the surrounding tissue into the regenerating nerve within the tNgC would help eliminate necrotic processes and lead to improved regeneration. In this study, we reported the application of macroscopic holes into the tubular walls of silk-based tNgCs and compared the various features of these improved silk^(+) tNgCs with the tubes without holes(silk^(–) tNgCs) and autologous nerve transplants in an 8-mm sciatic nerve defect in rats. Using a combination of micro-computed tomography and histological analyses, we were able to prove that the use of silk^(+) tNgCs induced the growth of blood vessels from the adjacent tissue to the intraluminal neovascular formation. A significantly higher number of blood vessels in the silk^(+) group was found compared with autologous nerve transplants and silk^(–), accompanied by improved axon regeneration at the distal coaptation point compared with the silk^(–) tNgCs at 7 weeks postoperatively. In the 15-mm(critical size) sciatic nerve defect model, we again observed a distinct ingrowth of blood vessels through the tubular walls of silk^(+) tNgCs, but without improved functional recovery at 12 weeks postoperatively. Our data proves that macroporous tNgCs increase the vascular supply of regenerating nerves and facilitate improved axonal regeneration in a short-defect model but not in a critical-size defect model. This study suggests that further optimizatio

关键词： axon regeneration blood vessel functional recovery macroporous nerve lesion peripheral nerve repair sciatic nerve silk-based nerve guidance conduit vascularization

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Restoration of Motor Function through Delayed Intraspinal Delivery of Human Il-10-Encoding Nucleoside-Modified mRNA after Spinal Cord Injury

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Research 2023年第4期2023卷 131-144页

作者： lászlógál Tamás Bellák Annamária Marton Zoltán Fekécs Drew Weissman Dénes Török Rachana Biju Csaba Vizler Rebeka Kristóf Mitchell B.Beattie Paulo J.C.lin Norbert Pardi Antal Nógrádi Krisztián Pajer Department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary National Biotechnology laboratory Institute of GeneticsBiological Research CentreSzegedHungary Institute of Biochemistry Biological Research CentreSzegedHungary Department of Medicine University of PennsylvaniaPhiladelphiaPA19104USA Acuitas Therapeutics VancouverBCV6T 1Z3Canada

Efficient in vivo delivery of anti-inflammatory proteins to modulate the microenvironment of an injured spinal cord and promote neuroprotection and functional recovery is a great ***-modified messenger RNA(mRNA)has become a promising new modality that can be utilized for the safe and efficient delivery of therapeutic ***,we used lipid nanoparticle(lNP)-encapsulated human interleukin-10(hIl-10)-encoding nucleoside-modified mRNA to induce neuroprotection and functional recovery following rat spinal cord contusion *** administration of hIl-10 mRNA-lNP to rats led to a remarkable reduction of the microglia/macrophage reaction in the injured spinal segment and induced significant functional recovery compared to ***,hIl-10 mRNA treatment induced increased expression in tissue inhibitor of matrix metalloproteinase 1 and ciliary neurotrophic factor levels in the affected spinal segment indicating a time-delayed secondary effect of Il-105 d after *** results suggest that treatment with nucleoside-modified mRNAs encoding neuroprotective factors is an effective strategy for spinal cord injury repair.

关键词： protective Restoration utilized

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Revision of the genus Inouenola lászló,Ronkay & Witt,2010(lepidoptera,Noctuoidea,Nolidae,Nolini) with description of 6 new species

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Journal of Forestry Research 2015年第2期26卷 457-467页

作者： gyula M.lászló gábor Ronkay lászló Ronkay Fadrusz u.25 Budapest 1114Hungary Heterocera Press ltd. Szt.István krt.4Budapest 1137Hungary Department of Zoology Hungarian Natural History Museum

This paper contains the revision of the genus Inouenola la′szlo′,Ronkay ＆ Witt,2010 and presents the checklist of the known taxa and their distribution and the description of six new species（Inouenola brunneolinea... 详细信息

关键词： Inouenola Nolini Nolidae Noctuoidea New species New status South East Asia

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Beginning from the end:the presynaptic terminal as a pathomechanism hub in frontotemporal dementia and amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3217-3218页

作者： laura Huggon Emma l.Clayton UK Dementia Research Institute at King’s College london LondonUK Department of Basic and Clinical Neuroscience Institute of Psychiatry Psychology&NeuroscienceKing’s College LondonLondonUK

Frontotemporal dementia and amyotrophic lateral sclerosis:Frontotemporal dementia(F T D)and amyo t rophic lateral sclerosis(AlS)are neurodegenerative diseases with significant overlapping *** these neurodegenerative diseases affect different neuronal populations(with FTD affecting neurons of the frontal and temporal lobes,and AlS affecting upper and lower motor neurons),these two diseases are complexly *** and AlS exist on a disease spectrum,with shared genetic causes,clinical presentations,and pathologies.

关键词： diseases amyotrophic sclerosis

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Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.Smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

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Comparison of layer-stacking and Dempster-Shafer Theory-based Methods Using Sentinel-1 and Sentinel-2 Data Fusion in Urban land Cover Mapping

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geo-Spatial Information Science 2022年第3期25卷 425-438页

作者： Dang Hung Bui lászlóMucsi Department of geoinformatics Physical and Environmental GeographyUniversity of SzegedSzegedHungary Institute for Environmental Science Engineering and ManagementIndustrial University of Ho Chi Minh CityHo Chi Minh CityVietnam

Data fusion has shown potential to improve the accuracy of land cover mapping,and selection of the optimal fusion technique remains a *** study investigated the performance of fusing Sentinel-1(S-1)and Sentinel-2(S-2)data,using layer-stacking method at the pixel level and Dempster-Shafer(D-S)theory-based approach at the decision level,for mapping six land cover classes in Thu Dau Mot City,*** the pixel level,S-1 and S-2 bands and their extracted textures and indices were stacked into the different single-sensor and multi-sensor datasets(*** datasets).The datasets were categorized into two *** group included the datasets containing only spectral and backscattering bands,and the other group included the datasets consisting of these bands and their extracted *** random forest(RF)classifier was then applied to the datasets within each *** the decision level,the RF classification outputs of the single-sensor datasets within each group were fused together based on D-S ***,the accuracy of the mapping results at both levels within each group was *** results showed that fusion at the decision level provided the best mapping accuracy compared to the results from other products within each *** highest overall accuracy(OA)and Kappa coefficient of the map using D-S theory were 92.67%and 0.91,*** decision-level fusion helped increase the OA of the map by 0.75%to 2.07%compared to that of corresponding S-2 products in the ***,the data fusion at the pixel level delivered the mapping results,which yielded an OA of 4.88%to 6.58%lower than that of corresponding S-2 products in the groups.

关键词： land cover mapping data fusion random forest Dempster-Shafer theory optical data radar data pixel level decision level

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Early Analogue Modeling Experiments and Related Studies to Today's Problems of geo-electromagnetic Exploration

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Journal of China University of geosciences 2009年第3期20卷 618-625页

作者： lászló Szarka geodetic and geophysical Research Institute of the Hungarian Academy of Sciences University of West-HungaryH-9401 Sopron POB 5 Hungary

As I learned it from extensive geo-electromagnetic analogue modeling experiments, some specific nonconventional interpretation parameters, in certain conditions, give more detailed information about the geometry of subsurface resistivity inhomogeneities than the routinely used parameters. In this article, I show several examples, and I present how these early results influenced our later research. An enhanced geometric sensitivity may be due to special array geometry （as we call it ＂null array＂）, or it may be due to a narrow and very special frequency range （i.e., the so-called ＂keyhole＂ range）. Nonconventional but physically based interpretation parameters （like the Poynting vector） or higher order invariants of resistivity or impedance tensors may also give useful additional information about the shape of subsurface bodies. One should be very careful in their application because a large part of these nontraditional approaches are strongly constrained by measuring errors and geological noise.

关键词： electromagnetic method analogue modeling null component rotational invariant.

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generation of brain vascular heterogeneity:recent advances from the perspective of angiogenesis

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Neural Regeneration Research 2025年第7期20卷 2013-2014页

作者： Nathanael J.lee Ryota l.Matsuoka Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOHUSA

Heterogeneous proper t i es of vascular endothelial cells in the brain:The brain displays large energy dynamics and consumption,and this high level of metabolic demands is fulfilled by a continuous supply of glucose and oxygen through its vascular *** vasculature consists of highly divergent blood vessel branches,giving rise to a dense network of capillaries that supply blood to all cells across the *** elaborated vascular network is thought to develop via angiogenesis,a process in which new blood vessels grow from pre-existing *** capillaries exhibit organotypic features distinct from other tissues and are formed primarily by two major endothelial cell(EC)types:those that form the semi-permeable blood-brain barrier(BBB)and those that develop highly permeable pores known as fenestrae(Matsuoka et al.,2022).The structural and functional differences between BBB and fenestrated vascular ECs represent a fundamental feature of brain vasculature and form the foundation for both brain function and homeostasis.

关键词： angiogenesis homeostasis network

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Prediction of Dynamic and Aerodynamic Characteristics of the Centrifugal Fan with Forward Curved Blades

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Journal of Thermal Science 2013年第6期22卷 517-521页

作者： Jií Polansky lászló Kalmár Roman gápár Univerzitní 8 306 14 PlzeňCzech Republic Miskolc-Egyetemváros MiskolcHungary

The main aim of this paper is determine the centrifugal fan with forward curved blades aerodynamic characteristics based on numerical modeling. Three variants of geometry were investigated. The first, basic "A" variant contains 12 blades. The geometry of second "B" variant contains 12 blades and 12 semi-blades with optimal length[1]. The third, control variant "C" contains 24 blades without semi-blades. Numerical calculations were performed by CFD Ansys. Another aim of this paper is to compare results of the numerical simulation with results of approximate numerical procedure. Applied approximate numerical procedure [2] is designated to determine characteristics of the turbulent flow in the bladed space of a centrifugal-flow fan impeller. This numerical method is an extension of the hydro-dynamical cascade theory for incompressible and inviscid fluid flow. Paper also partially compares results from the numerical simulation and results from the experimental investigation. Acoustic phenomena observed during experiment, during numerical simulation manifested as deterioration of the calculation stability, residuals oscillation and thus also as a flow field oscillation. Pressure pulsations are evaluated by using frequency analysis for each variant and working condition.

关键词： Centrifugal Fan CFD Pressure Coefficient Flow Coefficient

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Phase-field lattice Boltzmann model for dendrites growing and moving in melt flow

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npj Computational Materials 2019年第1期5卷 140-149页

作者： lászlóRátkai Tamás Pusztai lászlógránásy Wigner Research Centre for Physics P.O.Box 49H-1525 BudapestHungary Brunel Centre of Advanced Solidification Technology Brunel UniversityUxbridgeMiddlesex UB83PHUK

The phase-field and lattice Boltzmann methods have been combined to simulate the growth of solid particles moving in melt *** handle mobile particles,an overlapping multigrid scheme was developed,in which each individual particle has its own moving grid,with local fields attached to *** this approach we were able to simulate simultaneous binary solidification,solute diffusion,melt flow,solid motion,the effect of gravity,and collision of the *** method has been applied for describing two possible modes of columnar to equiaxed transition in the Al–Ti system.

关键词： solidification moving lattice

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