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Combination of Korean Red Ginseng Extract and Hydrogen-Rich Water Improves Spermatogenesis and Sperm Motility in Male Mice

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Chinese Journal of Integrative Medicine 2020年第5期26卷 361-369页

作者： Ja Yoon Ku min Jung park hyun Jun park Nam Cheol park Bo Sun Joo Department of Urology Pusan National University HospitalPusan National University School of MedicineBusan(49241)Republic of Korea Biomedical Research Institute Pusan National University HospitalBusan(49241)Republic of Korea The Korea Institute for Public Sperm Bank Busan(49241)Republic of Korea

Objective: To investigate the effect of hydrogen-rich Korean Red Ginseng(KRG) water(HRGW) mixture on the spermatogenesis and sperm motility of mice of different ages. Methods: Eighty young(3 month-old) and aged(12 month-old) male mice were randomly assigned to 4 groups(n=10 per group) including control group, hydrogen-rich water(HRW) group(10 m L/kg daily), KRG group(50 mg/kg daily) and HRGW group(10 m L/kg HRW and 50 mg/kg KRG daily) by an oral zoned needle for 4 weeks. Sperm count and motility were measured using sperm suspension released from cauda epididymis. Serum follicle stimulating hormone(FSH), luteinizing hormone(LH), testosterone, and reactive oxygen species(ROS) in serum have also been estimated. Tubular changes were examined through histological hematoxylin and eosin staining. Expression of antioxidation(PPx3, PPx4, GSTm5 and GPx4), spermatogenesis(inhibin-α, neptin-2 and CREM), antiaging(SIRT1 and SIRT2), and angiogenesis [visfatin and vascular endothelial growth factor(VEGF)] related genes were examined through realtime polymerase chain reaction. Results: HRW and KRG treatment stimulated spermatogenesis followed by increasing sperm production and sperm motility(P<0.05). These effects were strengthened synergistically by a HRGW mixture(P<0.05 or P<0.01). HRGW greatly increased the expressions of antioxidation, antiaging, spermatogenesis related genes and VEGF especially in aged mice(P<0.05). Serum testosterone and FSH levels also increased, while serum ROS level decreased(all P<0.05). Conclusion: HRGW increases sperm production and motility by enhancing antioxidation and stimulating spermatogenesis and sex hormone production, particularly in aged mice.

关键词： aging ginseng infertlit mineral waters sperm mtility

Computing the User Experience via Big Data Analysis:A Case of Uber Services

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Computers, Materials & Continua 2021年第6期67卷 2819-2829页

作者： Jang hyun Kim Dongyan Nan Yerin Kim hyung park min Department of Interaction Science/Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea Department of Applied Artificial Intelligence/Department of Human-Artificial Intelligence Interaction Sungkyunkwan UniversitySeoul03063Korea

As of 2020,the issue of user satisfaction has generated a significant amount of ***,we employ a big data approach for exploring user satisfaction among Uber *** develop a research model of user satisfaction by expanding the list of user experience(UX)elements(i.e.,pragmatic,expectation confirmation,hedonic,and burden)by including more elements,namely:risk,cost,promotion,anxiety,sadness,and ***,we collect 125,768 comments from online reviews of Uber services and perform a sentiment analysis to extract the UX *** results of a regression analysis reveal the following:hedonic,promotion,and pragmatic significantly and positively affect user satisfaction,while burden,cost,and risk have a substantial negative ***,the influence of expectation confirmation on user satisfaction is not ***,sadness,anxiety,and anger are positively related to the perceived risk of *** with sadness and anxiety,anger has a more important role in increasing the perceived burden of *** on these findings,we also provide some theoretical implications for future UX literature and some core suggestions related to establishing strategies for Uber and similar *** proposed big data approach may be utilized in other UX studies in the future.

关键词： User satisfaction user experience big data sentiment analysis Uber

Risk factors of organ failure in cholangitis with bacteriobilia

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World Journal of Gastroenterology 2015年第24期21卷 7506-7513页

作者： Jae min Lee Sang Hyub Lee Kwang hyun Chung Jin Myung park Ban Seok Lee Woo hyun Paik Joo kyung park Ji Kon Ryu Yong-Tae Kim Departments of Internal Medicine and Liver Research Institute Seoul National University College of Medicine Seoul National University Hospital Department of Internal Medicine Gyeongsang National University College of Medicine Gyeongsang National University Hospital Department of Internal Medicine Kangwon National University School of Medicine Kangwon National University Hospital Department of Internal Medicine Inje University Ilsan Paik Hospital Department of Gastroenterology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine

AIM: To identify the risk factors for organ failure(OF) in cholangitis with ***: This study included 182 patients with acute cholangitis who underwent percutaneous transhepatic biliary drainage between January 2005 and April 2013. We conducted a retrospective analysis of comprehensive clinical and laboratory ***: There were 24 cases(13.2%) of OF and five deaths(2.7%). Bile culture was positive for microbial growth in 130 out of 138(94.2%) patients. In multivariate analysis of 130 patients with positivebile cultures, significant predictive factors for OF were the presence of extended-spectrum beta-lactamase(ESBL) organisms in blood cultures, pre-existing renal dysfunction, and choledocholithiasis as an etiology, with odds ratios of 15.376, 6.319, and 3.573, respectively. We developed a scoring system with a regression coefficient of each significant variable. The OF score was calculated using the following equation:(2.7 × ESBL organisms in blood cultures) +(1.8 × pre-existing renal dysfunction) +(1.3 × choledocholithiasis). This scoring system for predicting OF was highly specific(99.1%) and had a positive predictive value of 86.2%.CONCLUSION: ESBL organisms in blood cultures, preexisting renal dysfunction, and choledocholithiasis are risk factors for OF in cholangitis with bacteriobilia. The OF scoring system may aid clinicians to identify a poor prognosis group.

关键词： Acute cholangitis Bacteriobilia Bile culture Organ failure

Priapism secondary to penile metastasis of rectal cancer

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World Journal of Gastroenterology 2009年第33期15卷 4209-4211页

作者： Ji Chan park Wook hyun Lee min Kyu Kang Suk Young park Division of Oncology Department of Internal MedicineThe Catholic University of KoreaDaejeon St. Mary's Hospital

Metastatic penile carcinoma is rare and usually originates from genitourinary tumors. The presenting symptoms or signs have been described as nonspecific except for priapism. Rectal adenocarcinoma is a very unusual source of metastatic penile carcinoma. We report a case of metastatic penile carcinoma that originated from the rectum. Symptomatic improvement occurred with palliative radiotherapy.

关键词： Penile neoplasms Neoplasm metastasis Priapism Rectal cancer

Depolarization mitigated in ferroelectric Hf_(0.5)Zr_(0.5)O_(2)ultrathin films(<5 nm)on Si substrate by interface engineering

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Journal of Advanced Ceramics 2024年第3期13卷 282-292页

作者： Se hyun Kim Younghwan Lee Dong hyun Lee Geun Hyeong park hyun Woo Jeong Kun Yang Yong Hyeon Cho Young Yong Kim min Hyuk park Department of Materials Science and Engineering College of EngineeringSeoul National UniversitySeoul 08826Republic of Korea Research Institute of Advanced Materials College of EngineeringSeoul National UniversitySeoul 08826Republic of Korea Inter-university Semiconductor Research Center College of EngineeringSeoul National UniversitySeoul 08826Republic of Korea Pohang Accelerator Laboratory Pohang University of Science&TechnologyPohang 790784Republic of Korea

(Hf,Zr)O_(2)offers considerable potential for next-generation semiconductor devices owing to its nonvolatile spontaneous polarization at the ***,scaling this material to sub-5 nm thickness poses several challenges,including the formation of an interfacial layer and high trap *** particular,a low-k SiO_(2)interfacial layer is naturally formed when(Hf,Zr)O_(2)films are directly grown on a Si substrate,leading to high depolarization fields and rapid reduction of the remanent *** address these issues,we conducted a study to significantly improve ferroelectricity and switching endurance of(Hf,Zr)O_(2)films with sub-5 nm thicknesses by inserting a TiO_(2)interfacial *** deposition of a Ti film prior to Hf_(0.5)Zr_(0.5)O_(2)film deposition resulted in a high-k TiO_(2)interfacial layer and prevented the direct contact of Hf_(0.5)Zr_(0.5)O_(2)with *** findings show that the high-k TiO_(2)interfacial layer can reduce the SiO_(2)/Si interface trap density and the depolarization field,resulting in a switchable polarization of 60.2μC/cm^(2)for a 5 nm thick Hf_(0.5)Zr_(0.5)O_(2)***,we propose that inserting a high-k TiO_(2)interfacial layer between the Hf_(0.5)Zr_(0.5)O_(2)film and the Si substrate may offer a promising solution to enhancing the ferroelectricity and reliability of(Hf,Zr)O_(2)grown on the Si substrate and can pave the way for next-generation semiconductor devices with improved performance.

关键词： ferroelectric charge trapping hafnia depolarization

Fabrication and characterization of Ag flake hybrid circuits with IPL-sintering

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Journal of Materials Science & Technology 2020年第18期52卷 13-18页

作者： Choong-Jae Lee Kwang-Ho Jung kyung Deuk min Bum-Geun park Seung-Boo Jung School of Advanced Materials Science Engineering Sungkyunkwan University2066 Seobu-roJangan-guSuwon-si16419Republic of Korea Visual Display Business Samsung Electronics Co.Ltd.129Samsung-roYeongtong-guSuwon-si16677Republic of Korea

The study of photonic sintering has gained interest based on the advantages of fast processing at room ***,printed electronics made from photonic sintering with an intensive pulsed light(IPL)energy source exhibit more mechanical instability than those made from conventional thermal sintering *** solve the mechanical instability problems,we fabricated Ag flake hybrid pastes with a variety of concentrations of Ag flake(0,25,50,75,and 100 wt.%).All of the screen-printed hybrid Ag circuits were fabricated on polyimide substrates and were sintered at 3.5 *** porosity was analyzed using the Brunauer-Emmett-Teller *** IPC(Packaging Electronic Circuits)sliding test was performed to analyze the flexibility of the screen-printed Ag flake hybrid *** adhesion strength of the hybrid circuits was evaluated with a roll-type 90°peel *** hybrid Ag printed circuit showed improvements in both the flexibility and adhesion strength with the addition of Ag flake.

关键词： Low-temperature sintering Flexibility Flaky powders Adhesion strength Intensive pulsed light

Zwitterion-assisted transition metal dichalcogenide nanosheets for scalable and biocompatible inkjet printing

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Nano Research 2020年第10期13卷 2726-2734页

作者： Hyeokjung Lee min Koo Chanho park Madhumita Patel Hyowon Han Tae hyun park Pawan Kumar Won-Gun Koh Cheolmin park Department of Materials Science and Engineering Yonsei University Seoul 03722Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul 03722Republic of Korea

Inkjet printing of two-dimensional(2D)transition metal dichalcogenide(TMD)nanosheets fabricated by liquid-phase exfoliation(LPE)allows simple,mass-producible,and low-cost photo-electronic *** LPE processes involve toxic and environmentally hazardous solvents;however,dispersants have restricted the extent of applications of 2D-TMD ***,various 2D-TMD nanosheets,including MoS2,MoSe2,WS2,and WSe2,in addition to few-layered graphene,are inkjet-printed using a LPE process based on zwitterionic dispersants in *** with cationic and anionic species are water-soluble,while alkyl chain moieties associated with two ionic species adhere universally on the surface of TMD nanosheets,resulting in high throughput liquid exfoliation of the *** zwitterion-assisted TMD nanosheets in water are successtully employed as an ink without the need for additives to adjust the viscosity and surface tension of the ink for use in an office inkjet printer;this gives rise to A4 scale,large-area inkjet-printed images on diverse substrates,such as metals,oxides,and polymer substrates patchable onto human *** with conductive graphene nanosheet inks allowed the development of mechanically flexible,biocompatible-printed arrays of photodetectors with pixelated MoSe2 channels on a paper exhibiting a photocurrent ON/OFF ratio of approximately 1038 and photocurrent switching of 500 ms.

关键词： transition metal dichalcogenide nanosheets zwitterions zwitterion-assisted liquid-phase exfoliation scalable inkjet printing biocompatible

Predictive proteomic biomarkers for inflammatory bowel disease-associated cancer:Where are we now in the era of the next generation proteomics?

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World Journal of Gastroenterology 2014年第37期20卷 13466-13476页

作者： Jong-min park Na Young Han Young-min Han Mi kyung Chung Hoo Keun Lee Kwang hyun Ko Eun-Hee Kim Ki Baik Hahm CHA Cancer Prevention Research Center CHA University Gachon University College of Pharmacy Digestive Disease Center CHA University Bundang Medical Center

Recent advances in genomic medicine have opened up the possibility of tailored medicine that may eventually replace traditional “one-size-fits all” approaches to the treatment of inflammatory bowel disease (IBD). In addition to exploring the interactions between hosts and microbes, referred to as the microbiome, a variety of strategies that can be tailored to an individual in the coming era of personalized medicine in the treatment of IBD are being investigated. These include prompt genomic screening of patients at risk of developing IBD, the utility of molecular discrimination of IBD subtypes among patients diagnosed with IBD, and the discovery of proteome biomarkers to diagnose or predict cancer risks. Host genetic factors influence the etiology of IBD, as do microbial ecosystems in the human bowel, which are not uniform, but instead represent many different microhabitats that can be influenced by diet and might affect processes essential to bowel metabolism. Further advances in basic research regarding intestinal inflammation may reveal new insights into the role of inflammatory mediators, referred to as the inflammasome, and the macromolecular complex of metabolites formed by intestinal bacteria. Collectively, knowledge of the inflammasome and metagenomics will lead to the development of biomarkers for IBD that target specific pathogenic mechanisms involved in the spontaneous progress of IBD. In this review article, our recent results regarding the discovery of potential proteomic biomarkers using a label-free quantification technique are introduced and on-going projects contributing to either the discrimination of IBD subtypes or to the prediction of cancer risks are accompanied by updated information from IBD biomarker research.

关键词： Inflammatory bowel disease Biomarker Proteomics Tailored medicine Colitic cancer

Effect of composite yogurt enriched with acacia fiber and Bifidobacterium lactis

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World Journal of Gastroenterology 2012年第33期18卷 4563-4569页

作者： Yang Won min Sang Un park Yeon Sil Jang Young-Ho Kim Poong-Lyul Rhee Seo hyun Ko Nami Joo Sun Im Kim Cheol-hyun Kim Dong kyung Chang Division of Gastroenterology Department of Medicine Samsung Medical Center Sungkyunkwan University School of Medicine Seoul 135-710 South Korea Department of Food and Nutrition Sookmyung Women's University Seoul 140-742 South Korea Department of Animal Resource and Science Dankook University Cheonan 330-714 South Korea

AIM: To investigate whether composite yogurt with acacia dietary fiber and Bifidobacterium lactis (B. lactis) has additive effects in irritable bowel syndrome (IBS). METHODS: A total of 130 patients were randomly allocated to consume, twice daily for 8 wk, either the composite yogurt or the control product. The composite yogurt contained acacia dietary fiber and high-dose B. lactis together with two classic yogurt starter cultures. Patients were evaluated using the visual analogscale via a structured questionnaire administered at baseline and after treatment. RESULTS: Improvements in bowel habit satisfaction and overall IBS symptoms from baseline were significantly higher in the test group than in the control group (27.16 vs 15.51, P = 0.010, 64.2 ± 17.0 vs 50.4 ± 20.5, P minant IBS, improvement in overall IBS symptoms was significantly higher in the test group than in the control group (72.4 ± 18.4 vs 50.0 ± 21.8, P minant IBS, improvement in bowel habit satisfaction from baseline was significantly higher in the test group than in the control group (32.90 vs 7.81, P = 0.006). CONCLUSION: Our data suggest that composite yogurt enriched with acacia fiber and B. lactis has greater therapeutic effects in patients with IBS than standard yogurt.

关键词： Acacia dietary fiber Bifidobacterium lactis Irritable bowel syndrome Probiotics Yogurt