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SARS-CoV-2 aberrantly elevates mitochondrial bioenergetics to induce robust virus propagation

Signal Transduction and Targeted Therapy 2024年第6期9卷 2702-2715页

作者： Hye Jin Shin Wooseong Lee Keun Bon Ku Gun Young yoon Hyun-Woo Moon Chonsaeng Kim Mi-Hwa Kim yoon-Sun Yi Sangmi jun Bum-Tae Kim Jong-Won Oh Aleem Siddiqui Seong-jun Kim Department of Convergent Research of Emerging Virus Infection Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea Gyeongnam Biohealth Research Center Gyeongnam Branch InstituteKorea Institute of ToxicologyJinju 52834Republic of Korea Center for Research Equipment Korea Basic Science InstituteCheongjuChungcheongbuk-do 28119Republic of Korea Department of Biotechnology Yonsei UniversitySeoul 03722Republic of Korea Division of Infectious Diseases School of MedicineUniversity of CaliforniaSan DiegoLa JollaCA 92093USA Present address:Department of Microbiology Chungnam National University School of MedicineDaejeon 35015Republic of Korea

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is a‘highly transmissible respiratory pathogen,leading to severe multiorgan ***,knowledge regarding SARS-CoV-2-induced cellular alterations is *** this study,we report that SARSCoV-2 aberrantly elevates mitochondrial bioenergetics and activates the EGFR-mediated cell survival signal cascade during the early stage of viral ***-CoV-2 causes an increase in mitochondrial transmembrane potential via the SARS-CoV-2 RNAnucleocapsid cluster,thereby abnormally promoting mitochondrial elongation and the OXPHOS process,followed by enhancing ATP ***,SARS-CoV-2 activates the EGFR signal cascade and subsequently induces mitochondrial EGFR trafficking,contributing to abnormal OXPHOS process and viral *** EGFR inhibitors remarkably reduce SARS-CoV-2 propagation,among which vandetanib exhibits the highest antiviral *** of SARS-CoV-2-infected cells with vandetanib decreases SARS-CoV-2-induced EGFR trafficking to the mitochondria and restores SARS-CoV-2-induced aberrant elevation in OXPHOS process and ATP generation,thereby resulting in the reduction of SARS-CoV-2 ***,oral administration of vandetanib to SARS-CoV-2-infected hACE2 transgenic mice reduces SARS-CoV-2 propagation in lung tissue and mitigates SARS-CoV-2-induced lung *** also exhibits potent antiviral activity against various SARS-CoV-2 variants of concern,including alpha,beta,delta and omicron,in in vitro cell culture *** together,our findings provide novel insight into SARS-CoV-2-induced alterations in mitochondrial dynamics and EGFR trafficking during the early stage of viral infection and their roles in robust SARS-CoV-2 propagation,suggesting that EGFR is an attractive host target for combating COVID-19.

关键词： alterations aberrant thereby

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Mechanisms involved in Korean mistletoe lectin-induced apoptosis of cancer cells

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World Journal of Gastroenterology 2007年第20期13卷 2811-2818页

作者： Lee-Yong Khil Wi Kim Suyun Lyu Won Bong Park Ji-Won yoon Hee-Sook jun Department of Microbiology and Infectious Diseases Faculty of MedicineUniversity of CalgaryCalgaryAlbertaT2N 4N1Canada Immune Modulation Group Boots Science BuildingSchool of PharmacyUniversity of NottinghamUniversity ParkNottinghamNG7 2RDUnited Kingdom College of Natural Science Seoul Women’s UniversitySeoul 139-774Korea Department of Pathology Chicago Medical SchoolNorth ChicagoIL60064United States Sadly Department of Pathology Chicago Medical SchoolNorth ChicagoIL60064United States SadlyDr. Ji-Won Yoon passed away on April 62006

AIM： To investigate the anti-cancer mechanisms of Korean mistletoe lectin （Viscum album coloratura agglutinin, VCA） using a human colon cancer cell line （COLO）. METHODS： Cytotoxic effects of VCA on COLO cells were determined by 3-（4,5-dimethylthiazol-2-yl）-2,5- diphenyltetrazolium bromide （MTI-） assay in vitro and tumor-killing effects in vivo. To study the mechanisms involved, the expression of various pro-caspases, anti- apoptotic proteins, and death receptors was determined by western blot. To determine which death receptor is involved in VCA-induced apoptosis of COLO cells, cytotoxicity was examined by MTT assay after treatment with agonists or antagonists of death receptors. RESULTS： VCA killed COLO cells in a time- and dosedependent manner and induced complete regression of tumors in nude mice transplanted with COLO cells. Treatment of COLO cells with VCA activated caspase-2, -3, -8, and -9 and decreased expression of anti-apoptotic molecules including receptor interacting protein, nuclear factor-κB, X-linked inhibitor of apoptosis protein, and Akt/protein kinase B. We then examined the involvement of death receptors in VCA-induced apoptosis. Only tumor necrosis factor receptor 1, among the death receptors examined, was involved in apoptosis of COLO cells, evidenced by inhibition of VCA-induced apoptosis and decreased activation of caspases, particularly caspase-8, by tumor necrosis factor receptor 1 antagonizing ***： VCA-induced apoptotic COLO cell death is due to the activation of caspases and inhibition of antiapoptotic proteins, in part through the tumor necrosis factor receptor 1 signaling pathway.

关键词： Viscum album coloratum Lectin Apoptosis Tumor necrosis factor receptor-i Caspase Colon cancer

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Dwindling in the mountains: Description of a critically endangered and microendemic Onychodactylus species(Amphibia, Hynobiidae) from the Korean Peninsula

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Zoological Research 2022年第5期43卷 750-755页

作者： Amael Borzee Yucheol Shin Nikolay APoyarkov Jong yoon Jeon Hae jun Baek Chang Hoon Lee junghwa An yoon Jee Hong Mi-Sook Min Laboratory of Animal Behaviour and Conservation College of Biology and the EnvironmentNanjing Forestry UniversityNanjingJiangsu 210037China Department of Biological Sciences School of Natural ScienceKangwon National UniversityChuncheon 24341Republic of Korea Department of Vertebrate Zoology Biological FacultyM.V.Lomonosov Moscow State UniversityMoscow 119234Russia Research Institute for Veterinary Science College of Veterinary MedicineSeoul National UniversitySeoul 08826Republic of Korea Animal Resources Division National Institute for Biological ResourcesIncheon 22689Republic of Korea

DEAR EDITOR,Species that are not formally described are generally not targets for conservation,regardless of their threatened *** habitat degradation has increased over the past several decades in the Republic of Kore... 详细信息

关键词： habitat endangered mountains

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Interplay between ABA and GA Modulates the Timing of Asymmetric Cell Divisions in the Arabidopsis Root Ground Tissue

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Molecular Plant 2016年第6期9卷 870-884页

作者： Shin Ae Lee Sejeong Jang Eun kyung yoon jung-Ok Heo Kwang Suk Chang Ji Won Choi Souvik Dhar Gyuree Kim Jeong-Eun Choe Jae Bok Heo Chian Kwon Jae-Heung Ko Yong-Sic Hwang jun Lim Department of Systems Biotechnology Konkuk University Seour 05029 Korea Department of Molecular Biotechnology Dong-A University Busan 49201 Korea Department of Molecular Biology Dankook University Yongin 16890 Korea Department of Plant and Environmental New Resources Kyung Hee University Yongin 17104 Korea These authors contributed equally to this article. Present address: The Sainsbury Laboratory University of Cambridge Cambridge CB2 1LR United Kingdom Present address: Department of Life Science Research Institute for Natural Sciences Hanyang University Seoul 04763 Korea

In multicellular organisms, controlling the timing and extent of asymmetric cell divisions （ACDs） is crucial for correct patterning. During post-embryonic root development in Arabidopsis thaliana, ground tissue （GT） maturation involves an additional ACD of the endodermis, which generates two different tissues： the endo- dermis （inner） and the middle cortex （outer）. It has been reported that the abscisic acid （ABA） and gibberellin （GA） pathways are involved in middle cortex （MC） formation. However, the molecular mechanisms under- lying the interaction between ABA and GA during GT maturation remain largely unknown. Through transcriptome analyses, we identified a previously uncharacterized C2H2-type zinc finger gene, whose expression is regulated by GA and ABA, thus named GAZ （GA- AND ABA-RESPONSIVE ZINC FINGER）. Seedlings ectopically overexpressing GAZ （GAZ-OX） were sensitive to ABA and GA during MC formation, whereas GAZ-SRDX and RNAi seedlings displayed opposite phenotypes. In addition, our results indicated that GAZ was involved in the transcriptional regulation of ABA and GA homeostasis. In agreement with pre- vious studies that ABA and GA coordinate to control the timing of MC formation, we also confirmed the unique interplay between ABA and GA and identified factors and regulatory networks bridging the two hor- mone pathways during GT maturation of the Arabidopsis root.

关键词： ABA GA GRAS ground tissue root development transcription factor

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Miniaturized multicolor fluorescence imaging system integrated with a PDMS light-guide plate for biomedical investigation

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npj Flexible Electronics 2023年第1期7卷 494-503页

作者： Hyogeun Shin Gun-Wook yoon Woongsun Choi Donghwan Lee Hoyun Choi Deok Su Jo Nakwon Choi jun-Bo yoon Il-Joo Cho Department of Biomedical Sciences College of MedicineKorea UniversitySeoulRepublic of Korea School of Electrical Engineering Korea Advanced Institute of Science and Technology(KAIST)DeajeonRepublic of Korea Center for Brain Technology Brain Science InstituteKorea Institute of Science and Technology(KIST)SeoulRepublic of Korea Biotechnology Research Institute of CHROMACH Co. LtdSuwonRepublic of Korea School of Chemical Engineering Sungkyunkwan University(SKKU)SuwonRepublic of Korea KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoulRepublic of Korea Department of Anatomy College of MedicineKorea UniversitySeoulRepublic of Korea Noul Co. LtdYonginRepublic of Korea

Miniaturized fluorescence imaging systems are promising platforms that overcome the limited use of conventional microscopes in the biomedical ***,there are physical limitations for multicolor fluorescence imaging in existing miniaturized imaging systems because multiple filters have to be integrated into a small ***,we present a miniaturized multicolor fluorescence imaging system integrated with single polydimethylsiloxane(PDMS)light-guide plate(LGP)for multicolor fluorescence *** PDMS LGP allows guiding the transmitted light from the light source only to the fluorescent samples regardless of the wavelength of the light ***,our system is capable of multicolor fluorescence imaging without multiple filters that block the excitation *** demonstrated the usability of our system in the biomedical field by observing green-and red-labeled cells in the *** proposed system can be used in a wide range of applications for studies that require multicolor fluorescence imaging in the biomedical field.

关键词： structure field system

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Electroacupuncture for abdominal pain relief in patients with acute pancreatitis:A three-arm randomized controlled trial

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Journal of Integrative Medicine 2023年第6期21卷 537-542页

作者： Dong Kee Jang jun Kyu Lee Chan Yung jung kyung Ho Kim Ha Ra Kang Yeon Sun Lee Jong Hwa yoon Kwang Ro Joo Min Kyu Chae Yong Hyeon Baek Byung-Kwan Seo Sang Hyub Lee Chiyeon Lim Department of Internal Medicine Seoul Metropolitan Government Boramae Medical CenterSeoul National University College of MedicineSeoul 07061Republic of Korea Department of Internal Medicine Dongguk University Ilsan HospitalDongguk University College of MedicineGoyang 10326Republic of Korea Department of Acupuncture and Moxibustion Dongguk University Ilsan Oriental HospitalCollege of Korean MedicineDongguk UniversityGoyang 10326Republic of Korea Department of Korean Medicine Dongguk UniversityGoyang 10326Republic of Korea Department of Acupuncture and Moxibustion College of Korean MedicineDongguk UniversityGyeongju 38067Republic of Korea Department of Gastroenterology Kyung Hee University Hospital at GangdongSeoul 05278Republic of Korea Department of Acupuncture and Moxibustion Kyung Hee University Korean Medicine Hospital at GangdongSeoul 05278Republic of Korea Department of Internal Medicine and Liver Research Institute Seoul National University HospitalSeoul National University College of MedicineSeoul 03080Republic of Korea Department of Biostatistics College of MedicineDongguk UniversityGoyang 10326Republic of Korea

Background: Electroacupuncture(EA) may reduce the severity of acute pancreatitis(AP) and provide additional pain relief in patients with chronic pancreatitis. However, the ability of EA to relieve pain in patients with AP has not been well ***: This study was undertaken to compare the pain-relieving effects of EA and conventional treatment in patients with ***, setting, participants and interventions: This study was conducted using a randomized, controlled,three-arm, parallel-group and multi-center design. Patients diagnosed with AP were randomly and equally assigned to EA1, EA2 or control groups. All participants received conventional standard-of-care therapy for AP. Local EA alone was administered in EA1, and local plus distal EA was given in *** EA included two abdominal acupoints, while distal EA included twelve peripheral acupoints. EA groups underwent one session of EA daily for 4 days(days 1–4), or until pain was resolved or *** outcome measures: The primary outcome measure was the change in the visual analogue scale(VAS;0–100) pain score between baseline and day ***: Eighty-nine participants were randomized into EA1, EA2 and control groups, and 88(EA1, 30;EA2, 29;control, 29) were included in the full-analysis set. VAS score change(median [interquartile range]) on day 5 was(12.3 ± 22.5) in the EA1 group,(10.3 ± 21.5) in the EA2 group, and(8.9 ± 15.2) in the control group. There were not significant differences in the change in VAS score among treatments(P = 0.983). However, time to food intake was significantly shorter in the EA group(EA1 + EA2) than in the control group(median 2.0 days vs 3.0 days), with a hazard ratio of 0.581(P = 0.022;95% CI,0.366–0.924). No significant adverse events ***: EA treatment did not significantly reduce pain after 4 days of treatment in patients with AP-associated abdominal pain but significantly reduced time to first food intake.

关键词： Acute pancreatitis Electroacupuncture Pain management Abdominal pain Randomized controlled trial

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Inhomogeneous lithium-storage reaction triggering the inefficiency of all-solid-state batteries

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Journal of Energy Chemistry 2022年第3期31卷 226-236,I0008页

作者： Jaeyoung Kim Wontae Lee Jangwhan Seok Eunkang Lee Woosung Choi Hyunyoung Park Soyeong Yun Minji Kim jun Lim Won-Sub yoon Department of Energy Science Sungkyunkwan UniversitySuwon 16419South Korea Pohang Accelerator Laboratory Pohang University of Science and TechnologyPohang 37673South Korea

All-solid-state batteries offer an attractive option for developing safe lithium-ion *** the various solid-state electrolyte candidates for their applications,sulfide solid electrolytes are the most suitable owing to their high ionic conductivity and facile ***,their performance is extensively lower compared with those of conventional liquid electrolyte-based batteries mainly because of interfacial reactions between the solid electrolytes and high capacity ***,the kinetic evolution reaction in the composite cathode of all-solid-state lithium batteries has not been actively ***,electrochemical analyses were performed to investigate the differences between the organic liquid electrolyte-based battery and all-solid-state battery *** with electrochemical analyses and synchrotron-based in situ and ex situ X-ray analyses,it was confirmed that inhomogeneous reactions were due to physical *** contacted and/or isolated active material particles account for the inhomogeneously charged regions,which further intensify the inhomogeneous reactions during extended cycles,thereby increasing the polarization of the *** study highlighted the benefits of electrochemo-mechanical integrity for securing a smooth conduction pathway and the development of a reliable homogeneous reaction system for the success of solid-state batteries.

关键词： Liquid electrolyte lithium batteries All-solid-state lithium batteries Ni-rich cathode Synchrotron-based X-ray techniques Inhomogeneous reaction

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Mononeuropathy multiplex associated with systemic vasculitis:A case report

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World Journal of Clinical Cases 2021年第7期9卷 1741-1747页

作者： Hyun jun Chae jung Woo Kim Yae Lim Lee Jeong Hwan Park Sang yoon Lee Department of Rehabilitation Medicine Seoul National University College of MedicineSeoul National University HospitalSeoul 07061South Korea Department of Pathology Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoul 07061South Korea Department of Rehabilitation Medicine Seoul National University College of MedicineSMG-SNU Boramae Medical CenterSeoul 07061South Korea

BACKGROUND Vasculitis,a systemic disorder with inflammation of blood vessel walls,can develop broad spectrum of signs and symptoms according to involvement of various organs,and therefore,early diagnosis of vasculitis is *** herein describe a patient who developed a special case of systemic vasculitis with mononeuropathy multiplex,rectal perforation and antiphospholipid syndrome(APS)presented with pulmonary *** SUMMARY A 61-year-old woman visited hospital with complaints of myalgia and occasional *** was initially diagnosed as proctitis and treated with antibiotics,however,there was no *** addition,she also complained right foot drop with hypesthesia,and left 2^(nd) and 3^(rd) finger tingling *** underwent nerve conduction study for evaluation,and it revealed sensorimotor polyneuropathy in the left arm and bilateral *** sural nerve biopsy strongly suggested vasculitic *** on nerve biopsy and clinical manifestation,she was diagnosed with vasculitis and treated with immunosuppressive *** treatment,sudden rectal perforation and pulmonary thromboembolism occurred,and further laboratory study suggested probable concomitant *** Hartmann operation was performed for rectal perforation,and anti-coagulation therapy was started for *** few cycles of immunosuppressive therapy,tingling sensation and weakness in her hand and foot had been partially recovered and vasculitis was considered to be *** Vasculitis can be presented with a variety of signs and symptoms,therefore,clinicians should always consider the possibility of diagnosis.

关键词： Systemic Vasculitis Peripheral nervous system diseases Mononeuropathies Antiphospholipid syndrome Pulmonary embolism Case report

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Prognostic factors in patients with middle and distal bile duct cancers

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World Journal of Gastroenterology 2014年第21期20卷 6658-6665页

作者： Hyung jun Kwon Sang Geol Kim Jae Min Chun Won Kee Lee yoon Jin Hwang Department of Surgery Kyungpook National University Medical CenterDaegu 702-210South Korea Department of Surgery School of MedicineKyungpook National UniversityDaegu 700-422South Korea Department of Preventive Medicine School of Medicine Kyungpook National University Daegu 700-422South Korea

AIM: To identify the influence of the surgery type and prognostic factors in middle and distal bile duct cancers.

关键词： Distal extrahepatic bile duct cancer Lymphovascular invasion Tumor node metastasis Pancreaticoduodenectomy Bile duct resection Prognostic factor

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Features of extrahepatic metastasis after radiofrequency ablation for hepatocellular carcinoma

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World Journal of Gastroenterology 2020年第32期26卷 4833-4845页

作者： Jae H yoon Young J Goo Chae-jun Lim Sung K Choi Sung B Cho Sang S Shin Chung H jun Department of Gastroenterology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Gastroenterology Hwasun Chonnam National University Hospital and Medical SchoolHwasun 58128South Korea Department of Radiology Chonnam National University Hospital and Medical SchoolGwangju 61469South Korea Department of Internal Medicine Mokpo Hankook HospitalMokpo 58643South Korea

BACKGROUND Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)is associated with poor ***,the clinical features and risk factors of EHM of HCC after radiofrequency ablation(RFA)remain *** To elucidate the characteristics and risk factors of EHM after RFA for *** From January 2008 to December 2017,we retrospectively enrolled 661 patients who underwent RFA as first-line treatment for HCC at 2 tertiary *** inclusion criteria were age≥18 years,a diagnosis of HCC,and *** computed tomography(CT)or magnetic resonance imaging(MRI)and alpha-fetoprotein measurements were routinely performed at 1 mo after RFA and followed-up at intervals of 3-6 *** analyses were performed using the chi-squared test or Student’s t-test,and univariate and multivariate analyses were performed via logistic regression,as *** EHM was diagnosed in 44 patients(6.7%)during a median follow-up period of 1204 *** 10-year cumulative rate of HCC recurrence and EHM was 92.7%and 33.7%,*** recurrence was most often intrahepatic,and the rate of extrahepatic recurrence at initial recurrence was only 1.2%.The median time to the diagnosis of EHM was 2.68 years,and 68.2%of patients developed EHM within 2 years of the first recurrence,regardless of recurrence-free survival and 75.0%of patients developed EHM within 5 years after first *** was mostly diagnosed via abdominal CT/MRI in 33(75.0%)and 38 of 44 patients(86.4%)with EHM had either positive abdominal CT scan results or serum AFP level *** multivariate analysis,recurrence-free survival400 IU/mL were associated with a high EHM *** EHM occurs following multiple intrahepatic recurrences after RFA and combined contrast-enhanced abdominal CT and serum AFP were useful for *** especially with high-risk factors require close follow-up for

关键词： Hepatocellular carcinoma Metastasis Radiofrequency ablation Surveillance Risk factor

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