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Cholecystectomy increases the risk of metabolic syndrome in the Korean population:a longitudinal cohort study

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Hepatobiliary Surgery and Nutrition 2023年第4期12卷 523-533,I0023页

作者： Ji Hye Huh Kyong Joo Lee Yun kyung Cho Shinje moon Yoon Jung Kim kyung-Do Han Jun Goo Kang Seong Jin Lee Sung-Hee Ihm Department of Internal Medicine Hallym University College of MedicineChuncheonRepublic of Korea Department of Internal Medicine Asan Medical CenterUniversity of Ulsan College of MedicineSeoulRepublic of Korea Department of Statistics and Actuarial Science Soongsil UniversitySeoulRepublic of Korea

Background:Cholecystectomy is a common surgical procedure to treat symptomatic gallstones;however,the long-term outcomes after cholecystectomy are ***,we aimed to investigate whether incident metabolic syndrome(MetS)is associated with cholecystectomy through a large,population-based,longitudinal ***:Subjects aged≥20 years who underwent cholecystectomy from 2010 to 2014(n=76,485)and controls(n=76,485),matched for age and sex,were identified from the Korean National Health Insurance *** proportional hazards analyses were performed to evaluate the association between cases and incident MetS,and hazard ratios and 95% confidence intervals(CIs)were ***:A total of 152,970 patients were *** age was 52.47±12.76 years,and 50.65% of participants were *** the follow-up period,there were 38,979(25.48%)newly diagnosed MetS cases in the study *** risk of MetS in the cholecystectomy group was approximately 20% higher than that in the control group[adjusted odds ratio(OR),1.20;95%CI:1.17-1.23].In the fully adjusted models,the corresponding ORs for new-onset high waist circumference(WC),low high-density lipoprotein cholesterol(HDL-C)levels,high triglycerides(TG)levels,high blood pressure(BP),and high blood glucose levels were 1.16(1.13-1.19),1.19(1.16-1.22),1.25(1.22-1.28),1.27(1.23-1.31),and 1.21(1.18-1.24),*** was an independent risk factor of incident MetS,after adjusting for potential confounding *** the subgroup analyses,the cholecystectomy group had a higher risk of MetS than the control group in subjects without hypertension or dyslipidemia,***:In this large,population-based study,cholecystectomy was associated with an increased risk of developing MetS,independent of other confounding ***,careful monitoring of metabolic variables and long-term follow-up are required to evaluate MetS risk after cholecystectomy.

关键词： Cholecystectomy metabolic syndrome(MetS) obesity diabetes cardiovascular risk

Current Research and Future Directions in Pattern Identification： Results of an International Symposium

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Chinese Journal of Integrative Medicine 2016年第12期22卷 947-955页

作者： Myeong Soo Lee Ju Ah Lee Terje Alraek 卞兆祥 Stephen Birch Hirozo Goto Jeeyoun Jung 高尚德 Sang-Kwan moon Bongki Park kyung-Mo Park Sooseong You kyung-Jin Yun Chris Zaslawski Korea Institute of Oriental Medicine Daejeon 305-811 Republic of Korea National Research Center in Complementary and Alternative Medicine UiT The Artic University of Norway Troms 9037 Norway University College of Health Sciences Institute of Acupuncture Oslo 0855 Norway School of Chinese Medicine Hong Kong Baptist University Hong Kong SAR China Department of Kampo Medicine Hokusei Hospital Toyama 930-0814 Japan College of Chinese Medicine China Medical University Taiwan China Department of Cardiovascular and Neurologic Disease Hospital of Korean Medicine Kyung Hee University Seoul 130-872 Republic of Korea Department of Biomedical Engineering Kyung Hee University Yongin Republic of Korea College of Traditional Chinese Medicine University of technologysydney(Post Box 1231) Australia

A symposium on pattern identification（PI）was held at the Korea Institute of Oriental Medicine（KIOM）on October 2,2013,in Daejeon,South *** symposium was convened to provide information on the current research in PI as well as suggest future research *** participants discussed the nature of PI,possible research questions,strategies and future international collaborations in pattern *** eight presentations and an extensive panel discussion,the symposium allowed participants to discuss research methods in traditional medicine for *** speaker presented the topic,＇Clinical pattern differentiation and contemporary research in PI.＇Two speakers presented current trends in research on blood stasis while the remaining five other delegates discussed the research methods and future directions of PI *** participants engaged in in-depth discussions regarding the nature of PI,potential research questions,strategies and future international collaborations in pattern research.

关键词： pattern identification international symposium Chinese medicine traditional Korean medicine

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World Journal of Gastroenterology 2008年第27期14卷 4359-4364页

作者： Young Hye Byun Jun Haeng Lee moon kyung Park Ji Hyun Song Byung-Hoon Min Dong kyung Chang Young- Ho Kim Hee Jung Son Poong-Lyul Rhee Jae J Kim Jong Chul Rhee Ji Hye Hwang Dong Il Park Sang Goon Shim In kyung Sung Department of Medicine Sungkyunkwan University School of Medicine Samsung Medical Center Department of Physical Medicine and Rehabilitation Sungkyunkwan University School of Medicine Samsung Medical Center Department of Medicine Sungkyunkwan University School of Medicine Kangbuk Samsung Hospital Department of Medicine Sungkyunkwan University School of Medicine Masan Samsung Hospital Department of Internal Medicine Konkuk University College of Medicine

AIM: To determine the prevalence and risk factors of work-related musculoskeletal disorders in gastrointestinal endoscopists in Korea. METHODS: A survey of musculoskeletal symptoms, using a self-administered questionnaire, was conducted on 55 endoscopists practicing in general hospitals or health promotion centers. RESULTS: Forty-nine (89.1%) endoscopists reported musculoskeletal pain on at least one anatomic location and 37 (67.3%) endoscopists complained of pain at rest. Twenty-six (47.3%) endoscopists had severe musculoskeletal pain defined as a visual analogue score greater than 5.5. Factors related to the development of severe pain were (1) standing position during upper endoscopy, (2) specific posture/ habit during endoscopic procedures, and (3) multiple symptomatic areas. Finger pain was more common in beginners, whereas shoulder pain was more common in experienced endoscopists. Sixteen percent of symptomatic endoscopists have modified their practice or reduced the number of endoscopic examinations. Only a few symptomatic endoscopists had sought professional consultation with related specialists. CONCLUSION: The prevalence of musculoskeletal pain in endoscopists is very high. The location of pain was different between beginners and experienced endoscopists. Measures for the prevention and adequate management of endoscopy-related musculoskeletal symptoms are necessary.

关键词： Endoscopy Endoscopist Musculoskeletal symptom

不同种植方法对即刻负载正畸种植体骨结合的影响

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中华口腔医学杂志 2008年第7期43卷 431-433页

作者：陈岩赵文婷 Hee-moon kyung 内蒙古医学院附属医院口腔科呼和浩特010050 华北煤炭医学院冀唐分院口腔系 700-412 Daegu Department of Orthodontics School of DentistryKyungpook National University

目的通过比较助攻法和自攻法植入的即刻负载正畸种植体的骨结合情况，评价不同种植方法对种植体及周围组织的影响。方法以3只犬的最后一颗前磨牙与第一磨牙根间区、第一磨牙近远中根根分歧的颊侧为植入点，植入24枚正畸种植体；每只犬植... 详细信息

目的通过比较助攻法和自攻法植入的即刻负载正畸种植体的骨结合情况，评价不同种植方法对种植体及周围组织的影响。方法以3只犬的最后一颗前磨牙与第一磨牙根间区、第一磨牙近远中根根分歧的颊侧为植入点，植入24枚正畸种植体；每只犬植入8枚，自攻法（自攻组）植入4枚，助攻法（助攻组）植入4枚。镍钛弹簧即刻提供1．47～1．96N水平力，持续9周。光学显微镜和荧光显微镜评价种植体周围骨组织的变化和骨结合率。结果两组种植体均与骨组织形成骨结合，其间未见结缔组织。自攻组可见较多的陈旧骨，助攻组的骨生长和再生更活跃。自攻组种植体的骨结合率[（41．7±10．7）％]高于助攻组[（25．9±8．0）％]，差异有统计学意义（P〈0．01）。结论即刻负载不影响正畸种植体的骨结合。自攻法对骨组织损伤小，且骨结合率高于助攻组。

关键词：组织学种植体支抗骨结合

基于InSAR、GPS形变场的长白山地区火山岩浆囊参数模拟研究

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地球物理学报 2008年第4期51卷 1085-1092页

作者：陈国浒单新建 Wooil M．moon kyung-Ryul Kim 地震动力学国家重点实验室中国地震局地质研究所北京100029 京市地质研究所北京100011 韩国首尔大学地球环境学院韩国首尔151747

利用差分合成孔径雷达干涉测量技术(D-InSAR)获取长白山地区的形变场.结果显示1995～1998年期间,位于长白山东南侧的间白山火山存在6～12 cm的视线向形变。而长白山天池火山处于平静期,没有明显形变.利用2002～2003年的GPS和水准获取的... 详细信息

利用差分合成孔径雷达干涉测量技术(D-InSAR)获取长白山地区的形变场.结果显示1995～1998年期间,位于长白山东南侧的间白山火山存在6～12 cm的视线向形变。而长白山天池火山处于平静期,没有明显形变.利用2002～2003年的GPS和水准获取的形变数据,分别采用Mogi单源、双源模型反演了长白山地区火山的岩浆囊参数.其中双源模型拟合效果较为理想,两个点源一个位于长白山天池老火山口下方7.9 km处,另一个位于间白山火山下方5.5 km处.对双源模型反演得到的岩浆囊参数进行适当调整,拟合得到与InSAR形变场基本吻合的结果.上述研究结果表明长白山地区火山活动存在时间上的间歇性和空间上的迁移性,为进一步研究长白山地区火山活动机制提供了参考和依据.

关键词： InSAR, 长白山火山, Mogi点源模型,火山岩浆囊参数

Corticotropin-releasing factor stimulates colonic motility via muscarinic receptors in the rat

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World Journal of Gastroenterology 2017年第21期23卷 3825-3831页

作者： kyung-Jo Kim Ki Bae Kim Soon man Yoon Joung-Ho Han Hee Bok Chae Seon Mee Park Sei Jin Youn Department of Gastroenterology University of Ulsan College of Medicine Asan Medical Center Department of Internal Medicine Chungbuk National University College of Medicine

AIM To measure exogenous corticotropin-releasing factor(CRF)-induced motility of the isolated rat colon and to demonstrate the effect of pharmacologic inhibition on CRF-induced motility. METHODS The isolated vascularly-perfused rat colon was used. Luminal pressure was monitored via microtip catheter pressure transducers in the proximal and distal colon. At first, exogenous CRF was administered in a stepwise manner and the concentration of CRF yielding maximal colonic motility was selected. After recording basal colonic motility, hexamethonium, phentolamine, propranolol, atropine and tetrodotoxin were infused into the isolated colon. Initially, only the test drug was infused; then, CRF was added. The motility index was expressed as percentage change over basal level. RESULTS Administration of 1.4, 14.4, 144 and 288 pmol/L CRF progressively increased colonic motility in the proximal and distal colon. Infusion of atropine or tetrodotoxin reduced CRF-induced motility of both the proximal and distal colon, whereas hexamethonium, phentolamine and propranolol had no *** CRF-induced colonic motility appears to be mediated by local cholinergic signaling via muscarinic receptors. Muscarinic receptors are potential targets for counteracting CRF-induced colonic hypermotility.

关键词： Gastrointestinal motility Rats Stress Colon Corticotropin-releasing factor

Assimilating OSTIA SST into regional modeling systems for the Yellow Sea using ensemble methods

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Acta Oceanologica Sinica 2017年第3期36卷 37-51页

作者： JI Xuanliang KWON kyung man CHOI Byoung-Ju LIU Guimei PARK Kwang-Soon WANG Hui BYUN Do-Seong LI Yun JI Qiyan ZHU Xueming National Marine Environmental Forecasting Center State Oceanic AdminstrationBeijing 100081China Key Laboratory of Research on Marine Hazards Forecasting National Marine Environmental Forecasting CenterState Oceanic AdminstrationBeijing 100081China Department of Oceanography Kunsan National UniversityGunsan 54150Republic of Korea Department of Oceanography Chonnam National UniversityGwangju 61186Republic of Korea Korea Institute of Ocean Science and Technology Ansan 15627Republic of Korea Korea Hydrographic and Oceanographic Agency Busan 49111Republic of Korea Marine Acoustics and Remote Sensing Laboratory Zhejiang Ocean UniversityZhoushan 316000China

The effects of sea surface temperature（SST） data assimilation in two regional ocean modeling systems were examined for the Yellow Sea（YS）. The SST data from the Operational Sea Surface Temperature and Sea Ice Analysis（OSTIA） were assimilated. The National Marine Environmental Forecasting Center（NMEFC） modeling system uses the ensemble optimal interpolation method for ocean data assimilation and the Kunsan National University（KNU） modeling system uses the ensemble Kalman filter. Without data assimilation, the NMEFC modeling system was better in simulating the subsurface temperature while the KNU modeling system was better in simulating SST. The disparity between both modeling systems might be related to differences in calculating the surface heat flux, horizontal grid spacing, and atmospheric forcing data. The data assimilation reduced the root mean square error（RMSE） of the SST from 1.78°C（1.46°C） to 1.30°C（1.21°C） for the NMEFC（KNU） modeling system when the simulated temperature was compared to Optimum Interpolation Sea Surface Temperature（OISST） SST dataset. A comparison with the buoy SST data indicated a 41%（31%） decrease in the SST error for the NMEFC（KNU） modeling system by the data assimilation. In both data assimilative systems, the RMSE of the temperature was less than 1.5°C in the upper 20 m and approximately 3.1°C in the lower layer in October. In contrast, it was less than 1.0°C throughout the water column in February. This study suggests that assimilations of the observed temperature profiles are necessary in order to correct the lower layer temperature during the stratified season and an ocean modeling system with small grid spacing and optimal data assimilation method is preferable to ensure accurate predictions of the coastal ocean in the YS.

关键词： ensemble optimal interpolation ensemble Kalman filter SST Yellow Sea assimilation

Complications after ileal pouch-anal anastomosis in Korean patients with ulcerative colitis

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World Journal of Gastroenterology 2014年第23期20卷 7488-7496页

作者： Seung-Bum Ryoo Heung-Kwon Oh Eon Chul Han Heon-Kyun Ha Sang Hui moon Eun kyung Choe Kyu Joo Park Division of Colorectal Surgery Department of SurgerySeoul National University College of MedicineSeoul 110-744South Korea Healthcare Research Institute Seoul National University Hospital Healthcare System Gangnam CenterSeoul 135-984South Korea

AIM: To investigate the outcomes of treatments for complications after ileal pouch-anal anastomosis (IPAA) in Korean patients with ulcerative colitis.

关键词： Ulcerative colitis Ileal pouch-anal anastomosis Complications Pouch failure Pouch function

New magnifying endoscopic classification for superficial esophageal squamous cell carcinoma

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World Journal of Gastroenterology 2017年第24期23卷 4416-4421页

作者： Su Jin Kim Gwang Ha Kim moon Won Lee Hye kyung Jeon Dong Hoon Baek Bong Eun Lee Geun Am Song Department of Internal Medicine Pusan National University School of Medicine and Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan Hospital Department of Internal Medicine Pusan National University School of Medicine and Biomedical Research InstitutePusan National University Hospital

To assess the accuracy of a new magnifying endoscopy (ME) classification for predicting depth of invasion of superficial esophageal squamous cell carcinoma (SESCC). METHODSThis study included a total of 70 lesions in 69 patients with SESCC who underwent ME with narrow-band imaging (ME-NBI) before resection from August 2010 to July 2016. Accuracy of ME-NBI for predicting depth of invasion of SESCC was analyzed by using a new ME classification proposed by the Japan Esophageal Society (JES), and interobserver agreement was assessed. RESULTSOverall accuracy of ME-NBI for estimating depth of invasion of SESCC was 78.6%. Sensitivity and specificity of type B1 for tumors limited to the epithelial layer (m1) or invading into the lamina propria (m2) were 71.4% and 100%, respectively. Sensitivity and specificity of type B2 for tumors invading into the muscularis mucosa (m3) or superficial submucosa (≤ 200 μm, sm1) were 94.4% and 73.1%, respectively, while those of type B3 for tumors invading into the deep submucosa (> 200 μm, sm2) were 75.0% and 97.8%, respectively. Interobserver agreement was excellent (κ = 0.86, 95%CI: 0.76-0.95). CONCLUSIONThe recently developed JES ME classification is useful for predicting depth of invasion of SESCC, with reliable interobserver agreement.

关键词： Narrow-band imaging Esophageal cancer Squamous cell carcinoma Magnifying endoscopy