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Effect of W/C ratio and cover thickness on polarization characteristics of embedded steel in mortar

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中国有色金属学会会刊：英文版 2009年第4期19卷 909-912页

作者： kyung-man moon Sung-Yul LEE Myung-Hoon LEE Yun-Hae KIM Department of Mechanical and Material Engineering Korea Maritime University Department of Marine System Engineering Korea Maritime University

The effects of cover thickness and W/C(water-to-cement) ratio on polarization properties of embedded steel bar were investigated with electrochemical *** potentials shift to the noble direction with increasing the cover *** addition,when the cover thickness increasingly becomes thinner and thinner,effect of the W/C ratio on variation of corrosion potential increases as *** value at 100 kHz indicating the resistance of cover thickness increases with the decrement of W/C ratio as well as the increment of cover ***,in the case of W/C ratio at 0.6,impedance at 10 mHz shows the relatively larger value than that at W/C ratio of 0.4 or 0.5 in the range of cover thickness from 4 to 8 cm,which is probably expected that oxide film built up on the surface of steel bar due to strong alkali environment by hydration reaction with increasing W/C ratio is performed as the resistance *** is also observed that liquid junction potential tends to increase with decreasing W/C ratio.

关键词：保护层厚度嵌入式偏振特性钢筋砂浆覆盖厚度极化性能电化学方法

Environmentally friendly hybrid coating prepared by electro-deposition method at various seawater conditions

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中国有色金属学会会刊：英文版 2009年第B09期19卷 110-113页

作者： Myeong-Hoon LEE kyung-man moon Jong-Do KIM Kang JUN Kwang-Ho KIM Division of Marine System Engineering Korea Maritime University Dongsam-Dong Youngdo Busan 606-791 Korea National Core Research Center for Hybrid Materials Solution Pusan National University Busan 609-735 Korea

The formation mechanism of calcareous deposit films in seawater involves an increase in pH at the metal/solution interface due to cathodic reactions, a raised carbonate ion concentration at the interface and precipitation of inorganic deposits such as CaCO3, Mg(OH)2. Environmentally friendly hybrid calcareous deposit films were formed by an electrochemical technique on steel substrates in various solution environments. And the influence of dissolved gas on formation of calcareous deposit films was investigated by scanning electron microscopy(SEM), energy dispersive spectroscopy(EDS) and X-ray diffractometry(XRD). Consequently, these results showed that formation of good overall calcareous deposited films by dissolved gas in seawater environments can be achieved by controlling the material composition and structure through effective use of electrochemical method.

关键词：海水混合环保电沉积扫描电子显微镜涂层制备溶液界面

Effect of process parameters on electrical,optical properties of IZO films produced by inclination opposite target type DC magnetron sputtering

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中国有色金属学会会刊：英文版 2009年第4期19卷 997-1000页

作者： Do-Hoon SHIN Yun-Hae KIM Joong-Won HAN kyung-man moon Ri-Ichi MURAKAMI Korean Air Aerospace Division Department of Mechanical and Material Engineering Korea Maritime University Department of Mechanical Engineering The University of Tokushima

IZO films were deposited onto PET substrate at room temperature with the inclined opposite target type DC magnetron sputtering equipment,in which a sintered oxide IZO target(doped with 10% ZnO,packing density of 99.99%) was *** effects of total sputtering pressure and film thickness on IZO films properties were *** the films produced at room temperature have a amorphous structure,irrespective of the total sputtering pressure and film thickness.A resistivity of the order of 10-4 Ωcm was obtained for IZO films deposited at lower pressure(film thickness of 190 nm).The resistivity of IZO films deposited at room temperature depends on film thickness and shows a minimum at a thickness of 530 nm.

关键词：溅射薄膜工艺参数光学性能磁控直流类型薄膜厚度电力

Photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes to promote PD-L1 multivalent binding for effective immune checkpoint blockade therapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1428-1440页

作者： Youngjoo Lee Sukyung Song Suah Yang Jinseong Kim Yujeong moon Nayeon Shim Hong Yeol Yoon Sehoon Kim man Kyu Shim Kwangmeyung Kim KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea Medicinal Materials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea College of Pharmacy Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoul 03760Republic of Korea Department of Bioengineering Korea UniversitySeoul 02841Republic of Korea

Immune checkpoint blockade(ICB)therapy targeting PD-L1 via monoclonal antibody(m Ab)has shown extensive clinical benefits in the diverse types of advanced ***,most patients are completely refractory to ICB therapy owing to the PD-L1 recycling ***,we propose photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes(immune checkpoint blockade liposomes;ICB-LPs)to promote PD-L1 multivalent binding for inducing lysosomal degradation of PD-L1 in tumor *** ICB-LPs are prepared by formulation of DC_(8,9)PC with photo-polymerized diacetylenic moiety,1,2-dipalmitoylphosphatidylcholine(DPPC)and anti-PD-L1peptide(D-form NYSKPTDRQYHF)-conjugated DSPE-PEG_(2k)(anti-PD-L1-DSPE-PEG_(2k))in a molar ratio of 45:45:10,followed by cross-linking of liposomal bilayer upon UV *** 10 mol% antiPD-L1-DSPE-PEG_(2k)incorporated ICB-LPs have a nano-sized lipid bilayer structure with an average diameter of 137.7±1.04 nm,showing a high stability in serum ***,the ICB-LPs efficiently promote the multivalent binding with PD-L1 on the tumor cell membrane,which are endocytosed with aim to deliver PD-L1 to the lysosomes,wherein the durable PD-L1 degradation is observed for72 h,in contrast to anti PD-L1 m Abs showing the rapid PD-L1 recycling within 9 *** in vitro coculture experiments with CD8^(+)T cells show that ICB-LPs effectively enhance the T cell-mediated antitumor immune responses against tumor cells by blocking the PD-L1/PD-1 *** ICB-LPs are intravenously injected into colon tumor-bearing mice,they efficiently accumulate within the targeted tumor tissues via both passive and active tumor targeting,inducing a potent T cell-mediated antitumor immune response by effective and durable PD-L1 ***,this study demonstrates the superior antitumor efficacy of crosslinked and anti-PD-L1 peptide incorporated liposome formulation that promotes PD-L1 multivalent binding for trafficking of PD-L1 toward

关键词： Cancer immunotherapy Immune checkpoint blockade PEGylated liposome Crosslinked lipid nanoparticles Anti-PD-L1 peptide Tumor-targeting PD-L1 multivalent binding Lysosomal PD-L1 degradation

Trends in colorectal cancer incidence according to an increase in the number of colonoscopy cases in Korea

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World Journal of Gastrointestinal Oncology 2024年第1期16卷 51-60页

作者： Ga Hee Kim Yeong Chan Lee Tae Jun Kim Sung Noh Hong Dong kyung Chang Young-Ho Kim Dong-Hoon Yang Chang Mo moon kyunga Kim Hyun Gun Kim Eun-Ran Kim Division of Gastroenterology Department of Internal MedicineAsan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Digital Health Samsung Advanced Institute for Health Science and TechnologySungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSamsung Medical CenterSungkyunkwan University School of MedicineSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineEwha Womans UniversitySeoul 07985South Korea Biomedical Statistics Center Samsung Medical CenterSeoul 06351South Korea Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of MedicineSeoul 04401South Korea

BACKGROUND The incidence of colorectal cancer(CRC)and preinvasive CRC(e.g.,early colon cancer and advanced adenoma)is gradually increasing in several *** To evaluate the trend in incidence of CRC and preinvasive CRC according to the increase in the number of colonoscopies performed in *** This retrospective cohort study enrolled Korean patients from 2002 to 2020 to evaluate the incidence of CRC and preinvasive CRC,and assess the numbers of diagnostic colonoscopies and colonoscopic ***-related complications by age group were also *** The incidence of CRC showed a rapid increase,then decreased after 2012 in the 50-75 year-age *** the study period,the rate of incidence of preinvasive CRC increased at a similar level in patients under 50 and 50-75 years of *** 2009,the increase has been rapid,showing a pattern similar to the increase in *** rate of colonoscopic polypectomy in patients aged under 50 was similar to the rate in patients over 75 years of age after *** rate of complications after colonoscopy and related deaths within 3 mo was high for those over 75 years of *** The diagnosis of preinvasive CRC increased with the increase in the number of colonoscopies *** the risk of colonoscopy-related hospitalization and death is high in the elderly,if early lesions at risk of developing CRC are diagnosed and treated under or at the age of 75,colonoscopy-related complications can be reduced for those aged 76 years or over.

关键词： Colorectal cancer Preinvasive colorectal cancer Colorectal polypectomy Colonoscopy

Meningioma originating from the superior petrosal vein without dural attachment:A case report

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World Journal of Clinical Cases 2024年第17期12卷 3156-3160页

作者： Yeong-Jin Kim Shin Jung Tae-Young Jung kyung-Sub moon In-Young Kim Department of Neurosurgery Chonnam National University Medical SchoolChonnam National University Hwasun HospitalHwasun 58128South Korea

BACKGROUND Meningioma in the cerebellopontine angle(CPA)without dural attachment is extremely *** report a unique case of meningioma derived from the superior petrosal vein without dural *** SUMMARY A 44-year-old right-handed woman presented with a two-month history of headache and *** magnetic resonance imaging showed a well-defined contrast-enhancing lesion in the right CPA without a dural tail *** resection was performed using a right retro sigmoid approach.A dural attachment was not seen at the tentorium or posterior surface of the petrous *** tumor was firmly adherent to the superior petrosal *** origin site was cauterized and resected with the preservation of the superior petrosal vein.A diagnosis of meningothelial meningioma was *** patient’s headache and tinnitus gradually disappeared,and a recurrence was not observed five years after the *** The rare occurrence of meningioma without dural attachment makes it difficult to determine dural attachment before *** absence of dural attachment makes it easy to completely resect such *** related to tumors should be removed carefully,considering the possible presence of tumor stem cells in the microvessels.

关键词： Meningioma Dura mater Superior petrosal vein Tumor stem cell Case report

A pilot clinical study to evaluate feasibility of using single patient classifier as a prognostic test in stage Ⅱ-Ⅲ gastric cancer patients

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Chinese Journal of Cancer Research 2024年第4期36卷 368-378页

作者： Ji Yeong An Sung Eun Oh Soomin Ahn Hyoung-II Kim Yoo Min Kim Minah Cho Keun Won Ryu Hong man Yoon Young Kyu Park In Gyu Kwon Sung Hoon Noh kyung Hee Lee In Cho Myoung Won Son Jong Won Kim Young-Woo Kim Department of Surgery Samsung Medical Center Sungkyunkwan University School of Medicine Department of Pathology and Translational Genomics Samsung Medical Center Sungkyunkwan University School of Medicine Department of Surgery Yonsei University College of Medicine Gastric Cancer Center Yonsei Cancer CenterYonsei University Health System Center for Gastric Cancer National Cancer Center Department of Surgery Chonnam National University Hwasun Hospital Chonnam National University College of Medicine Department of Surgery Gangnam Severance Hospital Yonsei University College of Medicine Department of Hematology-Oncology Yeungnam University Medical Center Department of Surgery Soonchunhyang University College of Medicine Department of Surgery Soonchunhyang University Cheonan Hospital Soonchunhyang University College of Medicine Department of Surgery Chung-Ang University Hospital Chung-Ang University College of Medicine

Objective: Precision medicine approaches emphasize the importance of reliable prognostic tools for guiding individualized therapy decisions. In this study, we evaluated the clinical feasibility of the single patient classifier(SPC) test, a new clinical-grade prognostic assay, in stage Ⅱ-Ⅲ gastric cancer ***: A prospective multicenter study was conducted, involving 237 patients who underwent gastrectomy between September 2019 and August 2020 across nine hospitals. The SPC test was employed to stratify patients into risk groups, and its feasibility and performance were evaluated. The primary endpoint was the proportion of the cases in which the test results were timely delivered before selecting postoperative treatment. Furthermore, 3-year disease-free survivals of risk groups were ***: The SPC test met the primary endpoint criteria. The 99.5% of SPC tests were timely delivered to hospitals before the postoperative treatment started. In a clinical setting, the median time from the specimen transfer to laboratory to the result delivery to hospital was 4 d. Furthermore, 3-year disease-free survivals were significantly different between risk groups classified with SPC ***: This study highlights the SPC test's feasibility in offering crucial information timely delivered for making informed decisions regarding postoperative treatment strategies. It also provides evidence to support the implementation of a future prospective clinical trial aimed at evaluating the clinical utility of the SPC test in guiding personalized treatment decisions for gastric cancer patients.

关键词： Prognostic test adjuvant chemotherapy advanced gastric cancer feasibility gastrectomy

Association between Tropical Convection and Boreal Wintertime Extratropical Circulation in 1982/83 and 1988/89

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Advances in Atmospheric Sciences 2003年第4期20卷 593-603页

作者： Ja-Yeon moon kyung-Ja HA Climate Research Laboratory Meteorological Research InstituteSeoul156-720KoreaDepartment of Atmospheric SciencesPusan National UniversityPusan609-735Korea

Boreal wintertime extratropical circulation is studied in relation to the tropical convection during the 1982/83 El Niño and 1988/89 La Niña. The anomaly structure of 1982/83 and 1988/89 over the extratropics reveals remarkably different features as the longitudinal tropical forcing region changes. The Rossby wave source (Positive) shows the largest maximum over East Asia in both years due to the persistent heating from the western Pacific warm pool area. However, the sink term shows contrasting features over the subtropics and extratropics between the two years. In the El Niño year, enhanced tropical convection over the eastern Pacific produces the Rossby wave sink at 10°N and shifted eastward over the North Pacific, while in the La Niña year, the sink area is shifted westward over the North Pacific. The contrasting features between the two events in mean-eddy interaction appears especially over the downstream area of the East Asian Jet. The extension (retraction) of the meanflow eastward (westward) to the east (west) of the dateline is related with the effect of the westward (eastward) E-vector and the strengthening (weakening) of the negative anomalies of the barotropic growth of kinetic energy. Hence, almost opposite characteristics between the two events can explain the close relationship of tropical convection and the extratropical internal variability.

关键词： tropical convection extratropical circulation rossby wave source mean-eddy interaction

Evaluation of lubrication performance of crank pin bearing in a marine diesel engine

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Friction 2018年第4期6卷 464-471页

作者： Suk man moon Yong Joo CHO Tae Wan KIM School of Mechanical Engineering Pusan National University Department of Mechanical Engineering Pukyong National University

In this study, the lubrication performance of the crank pin bearing in a marine two–stroke diesel engine is evaluated to investigate the adhesional failure on the crank pin bearing. A numerical algorithm for the lubrication analysis considering motion analysis of the crank pin system is developed. The film pressure and thickness for three clearances and three lubricant temperatures are calculated. The results show that the lubricant temperature has a higher effect on film thickness than clearance. In terms of the film parameter, the operating condition that can result in solid–solid contact is investigated. We also suggest the desirable operating conditions of clearance and lubricant temperature to prevent the solid–solid contact.

关键词： crank pin bearing film thickness lubricant film parameter diesel engine