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International Journal of Minerals,Metallurgy and Materials 2015年第8期22卷 811-819页

作者： Cheng-song Liu Shu-feng Yang kyung-ho Kim Jing-she Li Hiroyuki Shibata Shin-ya Kitamura School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Institute of Multidisciplinary Research for Advanced Materials Tohoku University

To clarify the influence of Fe O and sulfur on solid state reaction between an Fe-Mn-Si alloy and Mn O-Si O2-Fe O oxides under the restricted oxygen diffusion flux, two diffusion couples with different sulfur contents in the oxides were produced and investigated after heat treatment at 1473 K. The experimental results were also compared with previous work in which the oxides contained higher Fe O. It was found that although the Fe O content in the oxides decreased from 3wt% to 1wt% which was lower than the content corresponding to the equilibrium with molten steel at 1873 K, excess oxygen still diffused from the oxides to solid steel during heat treatment at 1473 K and formed oxide particles. In addition, increasing the sulfur content in the oxides was observed to suppress the diffusion of oxygen between the alloy and the oxides.

关键词： refining solid state reactions heat treatment incl

Effects of bisphenol compounds on the growth and epithelial mesenchymal transition of MCF-7 CV human breast cancer cells

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The Journal of Biomedical Research 2017年第4期31卷 358-369页

作者： Ji-Youn Kim ho-Gyu Choi Hae-Miru Lee Geum-A Lee kyung-A Hwang kyung-Chul Choi Laboratory of Biochemistry and Immunology Veterinary Medical Center and College of Veterinary Medicine ChungbukNational University Cheongju Chungbuk 28644 Republic of Korea

Bisphenol-A（BPA） has been considered as an endocrine disrupting chemical（EDC） because it can exert estrogenic *** bisphenol-S（BPS） and bisphenol-F（BPF） that are BPA analogs and substitutes,their risk to estrogendependent cancer has been reported rarely compared with the numerous cases of *** this study,we examined whether BPA,BPS,and BPF can lead to the proliferation,migration,and epithelial mesenchymal transition（EMT） of MCF-7 clonal variant（MCF-7 CV） breast cancer cells expressing estrogen receptors（ERs）.In a cell viability assay,BPA,BPS,and BPF significantly increased proliferation of MCF-7 CV cells compared to control（DMSO） as did17β-estradiol（E2）.In Western blotting assay,BPA,BPS,and BPF enhanced the protein expression of cell cycle progression genes such as cyclin D1 and *** addition,MCF-7 CV cells lost cell to cell contacts and acquired fibroblast-like morphology by the treatment of BPA,BPS,or BPF for 24 *** cell migration assay,BPA,BPS,and BPF accelerated the migration capability of MCF-7 CV cells as did *** relation with the EMT process,BPA,BPS,and BPF increased the protein expression of N-cadherin,while they decreased the protein expression of *** BPA,BPS,and BPF were co-treated with ICI 182,780,an ER antagonist,proliferation effects were reversed,the expression of cyclin D1 and cyclin E1 was downregulated,and the altered cell migration and expression of N-cadherin and E-cadherin by BPA,BPS,and BPF were restored to the control ***,these results imply that BPS and BPF also have the risk of breast cancer progression as much as BPA in the induction of proliferation and migration of MCF-7 CV cells by regulating the protein expression of cell cycle-related genes and EMT markers via the ER-dependent pathway.

关键词： human breast cancer cells endocrine disrupting chemicals bisphenol-A bisphenol-S bisphenol-F epithelial-mesenchymal transition migration

Melatonin for the treatment of irritable bowel syndrome

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World Journal of Gastroenterology 2014年第10期20卷 2492-2498页

作者： Kewin Tien ho Siah Reuben Kong Min Wong Khek yu ho Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Singapore 119228Singapore Yong Loo Lin School of Medicine National University of Singapore Singapore 119228 Singapore

Irritable bowel syndrome(IBS)is a common disorder characterized by recurrent abdominal pain or discomfort,in combination with disturbed bowel habits in the absence of identifiable organic ***(Nacetyl-5-methoxytryptamine)is a hormone produced by the pineal gland and also large number by enterochromaffin cells of the digestive *** plays an important part in gastrointestinal physiology which includes regulation of gastrointestinal motility,local anti-inflammatory reaction as well as moderation of visceral *** is commonly given *** is categorized by the United States Food and Drug Administration as a dietary *** treatment has an extremely wide margin of safety though it may cause minor adverse effects,such as headache,rash and *** was touted as a potential effective candidate for IBS *** role of melatonin in IBS treatment include analgesic effects,regulator of gastrointestinal motility and sensation to sleep ***-controlled studies in melatonin suffered from heterogeneity in *** studies utilized 3 mg at bedtime as the standard dose of ***,all studies had consistently showed improvement in abdominal pain,some showed improvement in quality of life of IBS *** is a relatively safe drug that possesses potential in treating *** studies should focus on melatonin effect on gut mobility as well as its central nervous system effect to elucidate its role in IBS patients.

关键词： Melatonin Irritable bowel syndrome Pain Sleep Analgesia

Nutraceutical support for respiratory diseases

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Food Science and Human Wellness 2018年第3期7卷 205-208页

作者： yu-Ya Hwang yuan-Soon ho Graduate Institute of Medical Sciences College of MedicineTaipei Medical UniversityTaipei 10031TaiwanChina

Respiratory diseases have been a major health concern for human beings since several *** the irritated nasal passages and airways had been a mutual necessity in multiple ancient *** ancient China,herbs were largely used to help deal with cough and reduce mucus,thereby maintaining respiratory *** India,knowledge of herb-related remedies passed down through *** the human society,freshly prepared herb ointments,including air-dried herbs,and boiled herbal soups have had a long history of combining botanical nutrients with local *** the use of herbs and natural products from plants(NPFPs)has been primarily cited in reviews based on modern respiratory diseases,the concept of soothing and alleviating disease progression or reducing mucus production has been highly ***,only a few herbs could directly disrupt the irreversible fibrotic *** the other hand,natural products from animals(NPFAs)have more potential in disrupting procollagen or extracellular matrix *** to these reasons,NPFAs could be considered as important functional foods for patients with respiratory *** this article,we provide a review of both NPFAs and NPFPs that are adjuvant to respiratory health.

关键词： Respiratory disease NPFP NPFA Nutrition Antioxidants

Electrochemically metal-doped reduced graphene oxide films:Properties and applications

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Journal of Materials Science & Technology 2020年第5期40卷 72-80页

作者： Myung-Sic Chae Tae ho Lee kyung Rock Son Tae hoon Park Kyo Seon Hwang Tae Geun Kim School of Electrical Engineering Korea UniversityAnam-ro 145Seongbuk-guSeoul 02841South Korea Department of Clinical Pharmacology and Therapeutics College of MedicineKyung Hee UniversitySeoul 02447South Korea

The fine control of doping levels in graphene materials such as reduced graphene oxide(RGO)is important to properly manipulate their ambipolar transport characteristics for various device ***,conventional doping methods involve complex chemical reactions,large-scale doping processes,and poor ***,a simple and controllable electrochemical doping treatment(EDT),performed via the conductive channels created at the RGO surface by the application of an electric field,is introduced to tailor the electrical properties of RGO films.X-ray photoelectron spectroscopy and Raman spectroscopy measurements are performed to detect the presence of Ni atoms in RGO films after the EDT(EDT-RGO).Then,EDT-RGO field-effect transistors(FETs)are fabricated with different doping areas(0 to 100%fractional area)on the RGO active channel to investigate the effect and selective-area doping capability of the *** to p-type doping compensation by the intercalated Ni atoms,the electron mobility of the EDT-RGO FET decreases from 1.40 to 0.12 cm2 V-1s-1 compared with that of the undoped RGO-FET,leading to the conversion from ambipolar to unipolar p-type transfer characteristics.

关键词： Reduced graphene oxide Electrochemical doping treatment Electrical breakdown process Field-effect transistor

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地球宜居性的深部驱动机制

科学通报 2024年第2期69卷 169-183页

作者：徐义刚黄小龙王强王煜李高军刘耘毛河光倪怀玮朱茂炎中国科学院广州地球化学研究所同位素地球化学国家重点实验室广州510640 南京大学地球科学与工程学院南京210023 中国科学院地球化学研究所矿床地球化学国家重点实验室贵阳550081 北京高压科学研究中心北京100094 中国科学技术大学中国科学院壳幔物质与环境重点实验室合肥230026 中国科学院南京地质古生物研究所现代古生物和地层学国家重点实验室南京210080

除与太阳之间的距离和行星的大小有关外,地球之所以宜居的一个重要因素是其拥有动力十足的地球内部.与地球宜居性是地球表生作用结果的传统认识不同,本文认为地球深部驱动着对宜居环境至关重要的外部层圈,并提出地球内外层圈间的联动机... 详细信息

除与太阳之间的距离和行星的大小有关外,地球之所以宜居的一个重要因素是其拥有动力十足的地球内部.与地球宜居性是地球表生作用结果的传统认识不同,本文认为地球深部驱动着对宜居环境至关重要的外部层圈,并提出地球内外层圈间的联动机制是地球系统科学研究的突破口.在调研和评述的基础上,本文建议未来研究需要关注早期地球、地磁场、深地挥发分循环、超级火山、深地新化学反应和地质空调器等方向,围绕地球宜居性的深部驱动机制这一主题,开展地球固体层圈与流体层圈的整合研究,助力我国地球科学研究从单一学科研究向多学科交叉融合研究的转变,推动我国固体地球科学从跟踪前沿向开拓前沿的跨越式发展.

关键词：地球宜居性深部引擎深地过程层圈相互作用地球系统科学

Inhibitory effects of polysaccharides isolated from Phellinus gilvus on benzo(a)pyrene-induced forestomach carcinogenesis in mice

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World Journal of Gastroenterology 2005年第4期11卷 577-579页

作者： Jae-Sung Bae Kwang-ho Jang Hyunee Yim Seung-Chun Park Hee-kyung Jin College of Veterinary Medicine kyungpook National University Daegu 702-701 Republic of Korea Department of Pathology Ajou University School of Medicine Suwon Republic of Korea

AIM: Although polysaccharides from Phellinus mushrooms are a well-known material with anti-tumor properties, there is no information about the effect of polysaccharides from Phellinus gilvus (PG) on tumor. The modulating effect of polysaccharides isolated from PG on the benzo(a)pyrene (BaP)-induced forestomach carcinogenesis in ICR female mice was investigated in this ***: A forestomach carcinogenesis model was established in 40 ICR female mice receiving oral administration of BaP for 4 wk. The mice were randomly assigned to 4 groups (10 each). The mice in each group were treated with sterile water or PG for 4 and 8 wk (SW4,PGW4, SW8, and PGW8 groups). Eight or 12 wk after the first dose of BaP, forestomachs were removed for histopathological and RT-PCR ***: In histopathological changes and RT-PCR analysis, sterile water-treated mice showed significant hyperplasia of the gastric mucosa with a significantly increased expression of mutant p53 mRNA compared to mice treated with PG for 8 ***: Polysaccharides isolated from PG may inhibit BaP-induced forestomach carcinogenesis in mice bydown-regulating mutant p53 expression.

关键词： Forestomach carcinogenesis Phellinus gilvus Polysaccharides p53 Gene

Simple keratectomy and corneal tattooing for limbal dermoids:results of a 3-year study

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International Journal of Ophthalmology(English edition) 2013年第4期6卷 463-466页

作者： Dong Min Cha kyung-hoon Shin Keun ho Kim Ji-Won Kwon Department of Ophthalmology Jeju National University College of Medicine Jeju National University hospital Department of Ophthalmology Myongji HospitalKwandong University College of Medicine

AIM:To evaluate and report the efficacy of combined surgical excision and corneal tattooing in patients with limbal dermoids.·METhoDS:In a retrospective interventional case series,9 eyes of 8 patients were treated with combined surgery of simple keratectomy and corneal tattooing for limbal *** records,including best-corrected visual acuity,anterior segment photography,demographic,clinical data,and follow-up information were reviewed.·RESULTS:The mean follow up period in this study was 50±15(range 36-77) *** was no evidence of infection or recurrent limbal dermoids in any of the eyes during the follow-up *** patients achieved good cosmetic outcomes with no complications.·CONCLUSION:Simple keratectomy and corneal tattooing of limbal dermoids could be an alternative option for surgery,especially when a donor cornea is not available.

关键词： corneal tattooing limbal dermoid simple keratectomy

Defect inspection of indoor components in buildings using deep learning object detection and augmented reality

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Earthquake Engineering and Engineering Vibration 2023年第1期22卷 41-54页

作者： Shun-Hsiang Hsu ho-Tin Hung yu-Qi Lin Chia-Ming Chang Department of Civil and Environmental Engineering University of Illinois at Urbana-ChampaignUSA Department of Civil Engineering Taiwan University(NTU)TaiwanChina

Visual inspection is commonly adopted for building operation,maintenance,and *** durability and defects of components or materials in buildings can be quickly assessed through visual ***,implementations of visual inspection are substantially time-consuming,labor-intensive,and error-prone because useful auxiliary tools that can instantly highlight defects or damage locations from images are not ***,an advanced building inspection framework is developed and implemented with augmented reality(AR)and real-time damage detection in this *** this framework,engineers should walk around and film every corner of the building interior to generate the three-dimensional(3D)environment through ***,a trained YOLOv5 model real-time detects defects during this process,even in a large-scale field,and the defect locations indicating the detected defects are then marked in this 3D *** defects areas can be measured with centimeter-level accuracy with the light detection and ranging(LiDAR)on *** required damage information,including defect positions and sizes,is collected at a time and can be rendered in the 2D and 3D ***,this visual inspection can be efficiently conducted,and the previously generated environment can also be loaded to re-localize existing defect marks for future maintenance and change ***,the proposed framework is also implemented and verified by an underground parking lot in a building to detect and quantify surface defects on concrete *** seen in the results,the conventional building inspection is significantly improved with the aid of the proposed framework in terms of damage localization,damage quantification,and inspection efficiency.

关键词： visual inspection damage detection augmented reality damage quantification deep learning

An Exponential Chaotic Oscillator Design and Its Dynamic Analysis

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IEEE/CAA Journal of Automatica Sinica 2020年第4期7卷 1081-1086页

作者： Xiaoyuan Wang Chenxi Jin Xiaotao Min Dongsheng yu Herbert ho Ching Iu the School of Electronics and Information Hangzhou Dianzi UniversityHangzhou 310018China the School of Electrical and Power Engineering China University of Minning and TechnologyXuzhou 221116China the School of Electrical Electronic and Computer EngineeringThe University of Western AustraliaPerth WA 6009Australia

After years of development, chaotic circuits have possessed many different mathematic forms and multiple realization methods. however, in most of the existing chaotic systems, the nonlinear units are composed of the product terms. In this paper, in order to obtain a chaotic oscillator with higher nonlinearity and complexity to meet the needs of utilization, we discuss a novel chaotic system whose nonlinear term is realized by an exponential term. The new exponential chaotic oscillator is constructed by adding an exponential term to the classical Lüsystem. To further investigate the dynamic characteristics of the oscillator, classical theoretical analyses have been performed, such as phase diagrams, equilibrium points, stabilities of the system,Poincaré mappings, Lyapunov exponent spectrums, and bifurcation diagrams. Then through the National Institute of Standards and Technology(NIST) statistical test, it is proved that the chaotic sequence generated by the exponential chaotic oscillator is more random than that produced by the Lü system. In order to further verify the practicability of this chaotic oscillator, by applying the improved modular design method, the system equivalent circuit has been realized and proved by the Multisim simulation. The theoretical analysis and the Multisim simulation results are in good agreement.

关键词： Chaos exponent multisim nonlinear circuits oscillators simulation