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Comparison of the efficacy and safety of once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction

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Asian Journal of Andrology 2015年第1期17卷 143-148,I0011,I0012页

作者： Soon Hyun Park Sung Woo Park Bong Yun Cha Ie Byung Park kyung wan min Yeon Ah Sung Tae Hwa Kim Jae min Lee Kang Seo Park Department of Internal Medicine Eulji University School of Medicine Daejeon 302-799 South Korea Department of Endocrinology and Metabolism Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Seou1110-746 South Korea Department of Endocrinology and Metabolism College of Medicine the Catholic University of Korea Seou1137-701 South Korea Department of Internal Medicine Gachon University of Medicine and Science Graduate School of Medicine Incheon 405-760 South Korea Department of Internal Medicine Eulji University School of Medicine Seou1139-872 South Korea Department of Endocrinology Ewha Woman's University School of Medicine Seoul 158-710 South Korea Department of Internal Medicine College of Medicine Hanyang University Seoul 133-792 South Korea.

We compared the efficacy and safety between once-daily dosing and on-demand use of udenafil for type 2 diabetic patients with erectile dysfunction （ED）. A multi-center, randomized, open-label, parallel-group, 12-week study was conducted. 161 patients who improved with on-demand 200 mg of udenafil according to Sexual Encounter Profile （SEP） diary Question 2 and 3 （Q2 and Q3） were randomized into 200 mg on-demand （n = 80） or 50 mg once-daily （n = 81） dosing groups for 8 weeks. The dosing period was followed by a 4-week treatment-free period. The primary efficacy endpoint was the change of the International Index of Erectile Function （IIEF） erectile function domain （EFD） score. The secondary efficacy endpoints included changes to the SEP diary Q2, Q3, IIEF Q3, Q4, other domains of IIEF, Global Assessment Question, and shift to the normal rate （EFD 〉 26）. Vascular endothelial markers were also assessed. The IIEF-EFD score of both groups improved after 8 weeks of treatment （P 〈 0.0001）. There was no statistically significant difference between two groups. Improvement was not maintained after the treatment-free follow-up period. Similar results were observed in the secondary efficacy endpoints. There was also no significant difference in vascular endothelial markers. Daily udenafil was well-tolerated, and there was no significant difference in the adverse drug reactions and adverse events between the two groups. Flushing and headache were the most frequent adverse events. Both regimens improved ED in diabetic patients and were well-tolerated. Further studies are needed to assess the effect of daily udenafil treatment in diabetic patients.

关键词： erectile dysfunction International Index of Erectile Function once-daily dosing ptiosphodiesterase type 5 inhibitor type 2 diabetes mellitus udenafil

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Canonical Foliations of Certain Classes of Almost Contact Metric Structures

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Acta Mathematica Sinica,English Series 2005年第4期21卷 841-846页

作者： Tae wan KIM Hong kyung PAK Department of Mathematics Education Silla UniversityPusan617-736.Korea Department of Computer and Information Security Daegu Haany University

The purpose of this paper is to study the canonical foliations of an almost cosymplectic or almost Kenmotsu manifold M in a unified way. We prove that the canonical foliation F defined by the contact distribution is Riemannian and tangentially almost Kahler of codimension 1 and that F is tangentially Kahler if the manifold M is normal. Furthermore, we show that a semi-invariant submanifold N of such a manifold M admits a canonical foliation FN which is defined by the antiinvariant distribution and a canonical cohomology class c（N） generated by a transversal volume form for FN. In addition, we investigate the conditions when the even-dimensional cohomology classes of N are non-trivial. Finally, we compute the Godbillon Vey class for FN.

关键词： Almost α-cosymplectic manifold Almost cosymplectic manifold Almost Kenmotsu manifold Semi-invariant submanifold

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Modified constitutive models for Inconel 718 considering current density and temperature in electrically assisted forming process

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Chinese Journal of Aeronautics 2024年第2期37卷 524-540页

作者： Xuan CUI Rui ZHAO min wan School of Mechanical Engineering and Automation Beihang UniversityBeijing 100191China Jiangxi Research Institute of Beihang University Jiangxi 330000China

Electrically Assisted Forming(EAF)technology has obvious advantages in material *** develop an effective constitutive model considering electrical effects,room temperature and electrically assisted quasi-static uniaxial tensile tests were conducted using ultrathin nickelbased superalloy plates with a thickness of 0.25 *** research focused on the two most widely recognized effects:the Joule thermal and the electric athermal *** mechanism of current action can be divided into two scenarios:one considering the Joule thermal effect only,and the other considering both effects *** basic constitutive models,namely the Modified-Hollomon model and the Johnson-Cook(J-C)model,were selected to be optimized through the classification of two different situations,and four optimized constitutive models were *** was found that the J-C model with simultaneous consideration of the Joule thermal effect and electric athermal effect had the best prediction effect by comparing the results of these four ***,the accuracy of the optimization model was verified by finite element simulation of the electrically assisted stretching optimization *** results show that the constitutive model can effectively predict the temperature effect caused by the Joule heat effect and the athermal effect of current on the material.

关键词： Joule heating Elastoplasticity Plastic deformation Superalloys Constitutive models

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Pre-compensation of Friction for CNC Machine Tools through Constructing a Nonlinear Model Predictive Scheme

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Chinese Journal of Mechanical Engineering 2023年第5期36卷 62-76页

作者： Qunbao Xiao min wan Xuebin Qin State IJR Center of Aerospace Design and Additive Manufacturing School of Mechanical EngineeringNorthwestern Polytechnical UniversityXi’an 710072China

Nonlinear friction is a dominant factor afecting the control accuracy of CNC machine *** paper proposes a friction pre-compensation method for CNC machine tools through constructing a nonlinear model predictive *** nonlinear friction-induced tracking error is frstly modeled and then utilized to establish the nonlinear model predictive scheme,which is subsequently used to optimize the compensation signal by treating the friction-induced tracking error as the optimization *** the optimization procedure,the derivative of compensation signal is constrained to avoid vibration of machine *** contrast to other existing approaches,the proposed method only needs the parameters of Stribeck friction model and an additional tuning parameter,while fnely identifying the parameters related to the pre-sliding phenomenon is not *** a result,it greatly facilitates the practical *** air cutting and real cutting experiments conducted on an in-house developed open-architecture CNC machine tool prove that the proposed method can reduce the tracking errors by more than 56%,and reduce the contour errors by more than 50%.

关键词： Nonlinear model predictive control Friction compensation P-PI controller Stribeck model

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Densification simulation of compacted Al powders using multi-particle finite element method

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中国有色金属学会会刊：英文版 2009年第B9期19卷 68-75页

作者： kyung-Hun LEE Jung-min LEE Byung-min KIM School of Mechanical Engineering Pu san National University

The powder compaction simulations were performed to demonstrate deformation behavior of particles and estimate the effect of different punch speeds and particle diameters on the relative density of powder by a multi-particle finite element model(MPFEM). Individual particle discretized with a finite element mesh allows for a full description of the contact mechanics. In order to verify the reliability of compaction simulation by MPFEM, the compaction tests of porous aluminum with average particle size of 20 μm and 3 μm were performed at different ram speeds of 5, 15, 30 and 60 mm/min by MTS servo-hydraulic tester. The results show that the slow ram speed is of great advantage for powder densification in low compaction force due to sufficient particle rearrangement and compaction force increases with decrease in average particle size of aluminum.

关键词：粉末压实粉末粒子多孔铝有限元法模拟致密化平均粒径有限元模型

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Forming limit of sheet metals based on mixed hardening model

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Science China(Technological Sciences) 2009年第5期52卷 1202-1211页

作者： HaiBo wang min wan School of Mechanical Engineering and Automation Beihang University Beijing 100191 China

The calculation method of forming limit of sheet metals based on M-K instability theory is proposed,and the method is applicable to different yield criterions and hardening *** forming limit dia-grams of AA5754-O,AA6111-T4 aluminum alloy sheet and DP steel sheet under combined loading paths are obtained based on mixed hardening model with YLD2000-2D yield criterion proposed by Barlat in 2003 and L-C nonlinear kinematic hardening model proposed by Lemaitre and *** results show that the forming limit diagram made up of limit strain(FLD-strain) is evidently influenced by the loading *** forming limit diagram made up of limit stress(FLD-stress) is also influenced by loading path and it is not an only curve,which differs from the conventional *** degree of the influence of loading path on FLD-stress is related with *** larger the pre-strain is,the greater the influence of loading path on FLD-stress will *** change of FLD-stress is small only when pre-strain is *** addition,the hardening behavior of the material will influence the path-dependence of FLD-stress:The larger the proportion of kinematic hardening in the whole hard-ening is,namely the more obvious Bauschinger effect of the material,the greater the influence of loading path on FLD-stress will be.

关键词： plastic forming of sheet metals forming limit hardening model complex loading path

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Design of a tunable mass damper for mitigating vibrations in milling of cylindrical parts

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Chinese Journal of Aeronautics 2019年第3期32卷 748-758页

作者： Heng YUAN min wan Yun YANG School of Mechanical Engineering Northwestern Polytechnical University State IJR Center of Aerospace Design and Additive Manufacturing Northwestern Polytechnical University

Milling the free-end of cylindrical parts, which are vertically fixed on the machine table,often suffers from large chatter vibrations. This kind of phenomenon is harmful to the cutting process. Therefore, it is of great importance to develop means to suppress these undesirable *** paper proposes a new idea for designing a tunable mass damper(TMD) to reduce vibrations in milling of cylindrical parts. Frequency response function(FRF) of the milling system is derived to comprehensively reveal the influence of both the dynamic response of the machine tools and the TMD. Critical axial depth of cut, which is usually used to characterize the process stability, is formulated by considering the FRFs of both the milling system itself and the TMD. Maximization of critical axial depth of cut is taken as objective function, while kernel dynamic parameters of TMD,which are involved in the derived expression of critical axial depth of cut, are extracted as designable variables. Optimization procedure is carried out to adjust the parameters of TMD by using sequential quadratic programming algorithm. A series of experiments with a designed passive TMD validate that the design has a good performance in reducing vibrations and improving stability of milling process.

关键词： Chatter Milling Mitigation of vibrations Stability Tunable mass damper (TMD)

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Vibration Control of A Flexible Marine Riser System Subject to Input Dead Zone and Extraneous Disturbances

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China Ocean Engineering 2024年第2期38卷 271-284页

作者： ZHOU Li wanG Guo-rong wan min School of Mechatronic Engineering Southwest Petroleum UniversityChengdu 610500China Energy Equipment Institute Southwest Petroleum UniversityChengdu 610500China National Key Laboratory of Oil and Gas Reservoir Geology and Exploitation Southwest Petroleum UniversityChengdu 610500China

An observer-based adaptive backstepping boundary control is proposed for vibration control of flexible offshore riser systems with unknown nonlinear input dead zone and uncertain environmental *** control algorithm can update the control law online through real-time data to make the controller adapt to the environment and improve the control ***,based on the adaptive backstepping framework,virtual control laws and Lyapunov functions are designed for each *** direction interference observers are designed to track the timevarying boundary *** this basis,the inverse of the dead zone and linear state transformation are used to compensate for the original system and eliminate the adverse effects of the dead *** addition,the stability of the closed-loop system is proven by Lyapunov stability *** the system states are bounded,and the vibration offset of the riser converges to a small area of the initial ***,four examples of flexible marine risers are simulated in MATLAB to verify the effectiveness of the proposed controller.

关键词： adaptive backstepping control disturbance observer flexible marine riser input dead zone vibration control

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Characteristics of Solute Transport Continuously Released from Coastal Unconfined Aquifers under the Tidal Action Based on Laboratory Experiment

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Journal of Earth Science 2024年第5期35卷 1738-1748页

作者： min Guo Junwei wan Kun Huang Hubei Key Laboratory of mine Environmental Pollution Control and Remediation Hubei Polytechnic UniversityHuangshi435003China School of Environmental Studies China University of GeosciencesWuhan 430074China

Most studies on solute transport in coastal aquifers affected by tides focus on the transport of instantaneous released solute,and there are few studies on continuously released solute affected by *** this study,the image monitoring method is used to establish the quantitative relationship between the concentration of the colored tracer and the hue value of the image,and the digital image is used to determine the tracer concentration *** image monitoring method laboratory experiments,quantitative analysis of the characteristics of continuously released solute transport in coastal unconfined aquifers under the tidal *** show that the high tide inhibits the increase in the concentration of each point in the *** the influence of tides,the solute plume retreats towards the *** the low tide period,the solute plume migrates toward the sea *** the solute plume will maintain a relatively stable shape after entering the aquifer for a long enough *** the tidal effect seems to have little effect on the estimation of the position of the solute plume,but ignoring the tidal effect has a certain influence on the estimation of the dispersion range of the solute *** matter whether considering the tidal action,the final dispersion range of the solute plume is almost the *** before the solute plume reaches a stable state,ignoring the tidal effect will lead to a smaller dispersion range of the solute plume.

关键词： tidal action coastal unconfined aquifers continuously released solute solute transport image monitoring method marine geology

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15th Anniversary of Journal of Integrative Agriculture(JIA)

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Journal of Integrative Agriculture 2017年第12期16卷 2655-2656页

作者： wan Jian-min JIA Chinese Academy of Agricultural Sciences Chinese Academy of Engineering

The year 2017 marks the 15th anniversary of Joumal of Integrative Agriculture （JIA）, an official journal of the Chinese Academy of Agricultural Sciences （CAAS）. JIA has experi- enced a successful journey during the past 15 years. The 21 st century began with great challenges in global climate change, food safety, resource scarcity, and other key issues which are closely related to the agriculture sciences. Effec- tive solutions for agricultural problems require an internation- al exchange of experience via platforms such as academic journals. To contribute to these forums, the agriculture community in China sought to establish a scholarly journal published in English. In Jan. 2002, an agriculture journal in English was launched by CAAS and the first issue of the journal Agricultural Sciences in China was published. From the start, it has emphasized global concerns in multi-disci- plinary agricultural fields of crop science, horticulture, plant protection, animal science, veterinary medicine, agro-eco- system and environment science, food science and etc. And it is a peer-reviewed international journal published monthly in English. The first Editor-in-Chief was ZHAI Huqu, the president of CAAS at that time.

关键词： 15th Anniversary of Journal of Integrative Agriculture JIA

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