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Upconverting nanoparticle-containing erythrocyte-sized hemoglobin microgels that generate heat,oxygen and reactive oxygen species for suppressing hypoxic tumors

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Bioactive Materials 2023年第4期22卷 112-126页

作者： Hanju Kim Johyun Yoon Hwang kyung Kim Woo Tak lee Nguyen Thi Nguyen Xuan Thien Le Eun-hee lee Eun Seong lee kyung Taek Oh Han-Gon Choi Yu Seok Youn School of Pharmacy Sungkyunkwan University2066 Seobu-roJangan-guSuwonGyeonggi-do16419Republic of Korea College of Pharmacy Korea University2511 Sejong-roSejong30019Republic of Korea Department of Biotechnology and Department of Biomedical-Chemical Engineering the Catholic University of Korea43 Jibong-roBucheon-siGyeonggi-do14662Republic of Korea College of Pharmacy Chung-Ang University84 Heukseok-roDongjak-guSeoul06974Republic of Korea College of Pharmacy Hanyang University55Hanyangdaehak-roSangnok-guAnsan15588Republic of Korea

Inspired by erythrocytes that contain oxygen-carrying hemoglobin(Hb)and that exhibit photo-driven activity,we introduce homogenous-sized erythrocyte-like Hb microgel(μGel)systems(5-6μm)that can(i)emit heat,(ii)supply oxygen,and(iii)generate reactive oxygen species(ROS;1O2)in response to near-infrared(NIR)laser *** μGels consist of Hb,bovine serum albumin(BSA),chlorin e6(Ce6)and erbium@lutetium upconverting nanoparticles(UCNPs;~35 nm)that effectively convert 808 nm NIR light to 660 nm visible *** Hb μGels are capable of releasing oxygen to help generate sufficient reactive oxygen species(^(1)O_(2))from UCNPs/Ce6 under severely hypoxic condition upon NIR stimulation for efficient photodynamic ***,the Hb μGels emit heat and increase surface temperature due to NIR light absorption by heme(iron protoporphyrin IX)and display photothermal *** changing the Hb/UCNP/Ce6 ratio and controlling the amount of NIR laser irradiation,it is possible to formulate bespoke Hb μGels with either photothermal or photodynamic activity or both in the context of combined therapeutic *** Hb μGels effectively suppress highly hypoxic 4T1 cell spheroid growth and xenograft mice tumors in vivo.

关键词： Hemoglobin microgel Upconversion Photothermal therapy Photodynamic therapy Hypoxic tumors Oxygen-generation

New anti-mesenteric delta-shaped stapled anastomosis: Technical report with short-term postoperative outcomes in patients with Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2592-2601页

作者： Jong Lyul lee Yong Sik Yoon Hyun Gu lee Young Il Kim Min Hyun Kim Chan Wook Kim In Ja Park Seok-Byung Lim Chang Sik Yu Division of Colon and Rectal Surgery Department of SurgeryUniversity of Ulsan College of MedicineAsan Medical CenterSeoul 05505South Korea Department of Surgery Gangdong Kyung Hee University HospitalSeoul 05278South Korea

BACKGROUND Medical treatment for Crohn’s disease(CD)has continuously improved,which has led to a decrease in surgical recurrence *** these advancements,25%of patients will undergo repeat intestinal *** of CD com-monly occurs on the mesentery side of the anastomosis *** To compare the new anti-mesenteric side-to-side delta-shaped stapled anasto-mosis(DSA)with the conventional stapled functional end-to-end anastomosis(CSA).METHODS This retrospective study included CD patients who underwent ileo-ileal or ileo-colic anastomosis between January 2020 and December *** DSA technique employed a stapler to maintain the concept of anti-mesentery side-to-side ana-stomosis by performing a 90°vertical closure of the open window compared with the CSA *** the corner where the open window is closed,the DSA avoids forming a pouch and creates an anastomosis resembling a delta shape within the intestinal *** compared demographics,preoperative condition,operative findings,and operative outcomes for the two *** The study included 175 patients,including 92 in the DSA group and 83 in the CSA *** two groups were similar in baseline characteristics,preoperative medical treatment,and operative findings except for the Montreal classification *** 30-days postoperative complication rate was signi-ficantly lower in the DSA group compared with the CSA group(16.3%vs 32.5%,P=0.009).Ileus incidence was significantly lower in the DSA group than in the CSA group(4.3%vs 14.5%,P=0.033),and the hospital stay was shorter in the DSA group than in the CSA group(5.67±1.53 days vs 7.39±3.68 days,P=0.001).CONCLUSION The DSA technique was feasible and showed comparable postoperative outcomes with lower short-term complic-ations compared with the CSA *** studies on CD recurrence and long-term complications are warranted.

关键词： Crohn’s disease Surgery Anastomosis Complication Recurrence

Formation of photo-reactive heterostructure from a multicomponent amorphous alloy with atomically random distribution

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Journal of Materials Science & Technology 2022年第14期109卷 245-253页

作者： Hae Jin Park hee Jin lee Tae kyung Kim Sung Hwan Hong Wei-Min Wang Taek Jib Choi Ki Buem Kim Department of Nanotechnology and Advanced Materials Engineering Sejong University209 Neung dong-roGwangjin-guSeoul 05006Republic of Korea Key Laboratory for Liquid-Solid Structural Evolution and Processing of Materials Ministry of EducationShandong UniversityJinan 250061China

In this study,metallic glass is designed tunable for promising functional applications via a facile and stable,one-step *** approach about alloy design and process is based on the unique properties of the Ti-Cu-Ni-Sn metallic glass that are afforded by the varying oxygen affinities of the four constituent *** metallic glass exhibits homogeneous nucleation of oxides and uniform formation of the various metal *** alloy design and hydrothermal synthesis to customize the metallic glasses are the most critical factors that determine the characteristics of the metal oxides and the resulting nanostructures and photoelectrode *** enables the desired element to be selectively grown via a facile single-step *** results provide a promising road map for the application of metallic glasses to photoelectrochemical(PEC)solar water splitting,as well as various other new possibilities.

关键词： Metallic glass Alloy design Hydrothermal synthesis Metal oxide Water splitting

Conditioned secretome of adipose-derived stem cells improves dextran sulfate sodium-induced colitis in mice

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World Journal of Gastroenterology 2021年第23期27卷 3342-3356页

作者： Seunghun lee Jeonghoon Heo Eun-kyung Ahn Jae Hyun Kim Young-Ho Kim hee-kyung Chang Sang-Joon lee Jongsik Kim Seun-Ja Park Department of Colorectal Surgery Kosin University College of MedicineBusan 49267South Korea Department of Molecular Biology and Immunology Kosin University College of MedicineBusan 49267South Korea Department of Gastroenterology Kosin University College of MedicineBusan 49267South Korea Department of Pathology Kosin University College of MedicineBusan 49267South Korea Department of Ophthalmology Kosin University College of MedicineBusan 49267South Korea Department of Anatomy Kosin University College of MedicineBusan 49267South Korea

BACKGROUND Inflammatory bowel diseases(IBD)is related to uncontrolled immune ***,there is no successful treatment for significant improvement in *** cells display their therapeutic effects through their repopulating capacity or secreting *** To investigate the effects of conditioned mouse adipose-derived stem cells(mADSCs)secretome on colitis-induced *** mADSCs were isolated from adipose tissue of C57BL/6 *** mADSCs secrectome was obtained by culturing of mADSCs with lipopolysaccharides(LPS,1μg/mL)for 24 *** colitis was induced by 2%dextran sulfate sodium(DSS)drinking water for 7 d and then normal drinking water for 4 *** mice were treated with normal culture medium(NM group),conditioned mADSCs secretome(CM group)or mADSCs(SC group).The length of colon and histopatholgy of colon tissues were *** mRNA expression levels of inflammatory cytokines in colon tissue and the serum interleukin(IL)-6 levels were *** The isolated mADSCs maintained the mADSCs specific gene expression profiles during *** conditioned mADSCs secretome released by the treatment of mADSCs with LPS contained mainly inflammatory chemokines,colony-stimulating factors and inflammatory *** loss of body weight and reduction in colon length were ameliorated in the CM *** conditioned mADSCs secretome reduced the histological score in colon *** expression of IL-1b and IL-6 mRNAs in colon tissues significantly inhibited in the CM group compared to SC group and NM group,*** elevation of serum IL-6 levels was also ameliorated in the CM *** results indicate that the conditioned mADSCs secretome suppressed the synthesis of inflammatory cytokines in damaged colon tissue and the elevation of serum IL-6 concentration in DSS-induced mice CONCLUSION Conditioned mADSCs secretome might play regenerative roles by the suppression of IL-6 in serum and tissue during acute colitis,and may be

关键词： Adipose-derived stem cells Conditioned secretome Cytokines Interleukin-6 Colitis Regeneration

Thermal performance analysis of borehole size effect on geothermal heat exchanger

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Journal of Central South University 2012年第12期19卷 3524-3529页

作者： CHOI Hoon-ki YOO Geun-jong LIM kyung-bin lee Sang-hoon lee Chang-hee Department of Mechanical Design and Manufacturing Engineering Changwon National UniversityChangwon 641-773Korea Department of Mechanical Design Engineering Hanbat National UniversityDaejon 305-719Korea Department of Energy Engineering Jeonju UniversityJeonju 560-759Korea STX Institute of Technology Changwon 642-845Korea

Thermal performance was the most important factor in the development of borehole heat exchanger utilizing geothermal energy. The thermal performance was affected by many different design parameters, such as configuration type and borehole size of geothermal heat exchanger. These eventually determined the operation and cost efficiency of the geothermal heat exchanger system. The main purpose of this work was to assess the thermal performance of geother^nal heat exchanger with variation of borehole sizes and numbers of U-tubes inside a borehole. For this, a thermal response test rig was established with line-source theory. The thermal response test was performed with in-line variable input heat source. Effective thermal conductivity and thermal resistance were obtained from the measured data. From the measurement, the effective thermal conductivity is found to have similar values for two- pair type （4 U-tubes） and three-pair type （6 U-tubes） borehole heat exchanger systems indicating similar heat transfer ability. Meanwhile, the thermal resistance shows lower value for the three-pair type compared to the two-pair type. Measured data based resistance have lower value compared to computed result from design programs. Overall comparison finds better thermal performance for the three-pair type, however, fluctuating temperature variation indicates complex flow behavior inside the borehole and requires further study on flow characteristics.

关键词： large size borehole heat exchanger thermal response test effective thermal conductivity thermal resistance borehole

Characteristic analysis of bleeding effect on standing column well (SCW) type geothermal heat exchanger

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Journal of Central South University 2012年第11期19卷 3202-3207页

作者： CHOI Hoon-ki YOO Geun-jong LIM kyung-bin lee Sang-hoon lee Chang-hee Department of Mechanical Design/Manufacturing Engineering Changwon National UniversityChangwon 641-773Korea Department of Mechanical Design Engineering Hanbat National UniversityDaejon 305-719Korea Department of Energy Engineering Jeonju UniversityJeonju 560-759Korea STX Institute of Technology Gyeongnam 642-845Korea

Thermal performance is the most important factor in the development of a borehole heat exchanger utilizing geothermal *** thermal performance is affected by many different design parameters and different operating conditions such as *** eventually determines the operation and cost efficiency of the borehole heat exchanger *** thermal performance of an open standing column well (SCW) type geothermal heat exchanger was assessed under the influence of *** this,a thermal response test rig was established with line-source *** test rig also had a bleeding function by releasing fluid while taking additional underground water through the heat *** thermal response test was performed with an additional constant input heat *** thermal conductivity and thermal resistance were obtained from the measured *** the measurement,the effective thermal conductivity is found to have 1.47 times higher value when bleeding is *** thermal resistance also increases by 1.58 times compared to a non-bleeding *** trend indicates enhanced heat transfer in the SCW type heat exchanger with a bleeding ***,therefore,could be an effective method of achieving a high heat transfer rate in the SCW type heat exchanger with sufficient underground water supply.

关键词： standing column well type thermal response test effective thermal conductivity thermal resistance bleeding effect

Bidirectional rotating direct-current triboelectric nanogenerator with self-adaptive mechanical switching for harvesting reciprocating motion

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International Journal of Extreme Manufacturing 2024年第4期6卷 324-335页

作者： Donghan lee Joonmin Chae Sumin Cho Jong Woo Kim Awais Ahmad Mohammad Rezaul Karim Moonwoo La Sung Jea Park Dongwhi Choi Department of Mechanical Engineering(Integrated Engineering Program) Kyung Hee University1732 Deogyeong-daeroYonginGyeonggi 17104Republic of Korea Department of Chemistry University of LahoreLahorePakistan Department of Mechanical Engineering College of EngineeringKing Saud UniversityRiyadh 11421Saudi Arabia School of Mechanical Engineering Korea University of Technology and Education1600 Chungjeol-roCheonanChungnam 31253Republic of Korea

Amid the growing interest in triboelectric nanogenerators(TENGs)as novel energy-harvesting devices,several studies have focused on direct current(DC)TENGs to generate a stable DC output for operating electronic ***,owing to the working mechanisms of conventional DC TENGs,generating a stable DC output from reciprocating motion remains a ***,we propose a bidirectional rotating DC TENG(BiR-TENG),which can generate DC outputs,regardless of the direction of rotation,from reciprocating *** distinct design of the BiR-TENG enables the mechanical rectification of the alternating current output into a rotational-direction-dependent DC ***,it allows the conversion of the rotational-direction-dependent DC output into a unidirectional DC output by adapting the configurations depending on the rotational *** to these tailored design strategies and subsequent optimizations,the BiR-TENG could generate an effective unidirectional DC *** of the BiR-TENG for the reciprocating motions of swinging doors and waves were demonstrated by harnessing this *** study demonstrates the potential of the BiR-TENG design strategy as an effective and versatile solution for energy harvesting from reciprocating motions,highlighting the suitability of DC outputs as an energy source for electronic devices.

关键词： direct-current triboelectric nanogenerator mechanical rectification self-adaptive mechanical design harvesting reciprocation motion

Determination of diffusion coefficient by image-based fluorescence recovery after photobleaching and single particle tracking system implemented in a single platform

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Journal of Innovative Optical Health Sciences 2021年第2期4卷 93-101页

作者： Donghee lee Jeonghoon lee Jung kyung Kim Department of Genetics Cell Biology and Anatomy University of Nebraska Medical CenterOmahaNE 68198USA School of Mechanical Engineering KOREA TECH Cheonan 31253Republic of Korea School of Mechanical Engineering and Department of Integrative Biomedical Science and Engineering Graduate School Kookmin University Seoul 02707Republic of Korea

Fluorescence recovery after photobleaching(FRAP)and single particle tracking(SPT)techni-ques determine the diffusion coefficient from average diffusive motion of high-concentration molecules and from trajectories of low-concentration single molecules,*** dif-fusion coefficients measured by FRAP and SPT techniques for the same biomolecule on cell membrane have exhibited inconsistent values across laboratories and platforms with larger dif-fusion coefficient determined by FRAP,but the sources of the inconsistency have not been investigated ***,we designed an image-based FRAP-SPT system and made a direct comparison between FRAP and SPT for diffusion coefficient of submicron particles with known theoretical values derived from Stokes-Einstein equation in aqueous *** combined iFRAP-SPT technique allowed us to measure the diffusion coefficient of the same fluorescent particle by utilizing both techniques in a single platform and to scrutinize inherent errors and artifacts of *** results reveal that diffusion coefficient overestimated by FRAP is caused by inaccurate estimation of the bleaching spot size and can be corrected by simple image *** iFRAP-SPT technique can be potentially used for not only cellular membrane dynamics but also for quantitative analysis of the spatiotemporal distribution of the solutes in small scale analytical devices.

关键词： Diffusion coefficient fluorescence recovery after photobleaching(FRAP) single particle tracking(SPT)

Pembrolizumab-induced psoriatic arthritis treated with disease-modifying anti-rheumatic drugs in a patient with gastric cancer:A case report

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World Journal of Clinical Cases 2023年第1期11卷 218-224页

作者： Sehan Kim Jong hee Sun Hongsik Kim hee kyung Kim Yaewon Yang Jun Su lee In Ah Choi Hye Sook Han Department of Internal Medicine Chungbuk National University HospitalCheongju 28644South Korea Department of Gastroenterology Asan Medical CenterUniversity of Ulsan College of MedicineSeoul 05505South Korea Department of Internal Medicine Chungbuk National University HospitalChungbuk National University College of MedicineCheongju 28644South Korea

BACKGROUND Immune checkpoint inhibitor(ICI)-induced rheumatic immune-related adverse events(ir AEs)have been infrequently reported,and the treatment of severe or refractory arthritis as ir AEs has not been established *** SUMMARY The patient was a 67-year-old man with a history of well-controlled foot psoriasis who presented with *** had received pembrolizumab for metastatic gastric adenocarcinoma 2 mo *** examination revealed erythematous swelling in the distal interphalangeal joints,left shoulder,and both *** had plaque psoriasis with psoriatic nail dystrophy and dactylitis in the distal joints of the fingers and *** markers including C-reactive protein and erythrocyte sedimentation rate were elevated but rheumatoid factor and anticyclic citrullinated peptide antibody were *** patient was diagnosed with psoriatic arthritis(PsA)and started on methylprednisolone 1 mg/kg/day after pembrolizumab ***,despite 1 wk of methylprednisolone treatment,PsA worsened;hence,leflunomide and methotrexate were *** 4 wk of steroid treatment,PsA worsened and improved repeatedly with steroid ***,the therapy was intensified to include etanercept,a tumor necrosis factor inhibitor,which ultimately resulted in adequate PsA *** This is the first report of ICI-induced PsA in a gastric cancer *** rheumatic ir AEs with refractory severe arthritis may require disease-modifying anti-rheumatic drugs and long-term management.

关键词： Pembrolizumab Psoriatic arthritis Disease-modifying anti-rheumatic drugs Gastric cancer Case report