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Intraoperative radiofrequency ablation with or without tumorectomy for hepatocellular carcinoma in locations difficult for a percutaneous approach

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Hepatobiliary & Pancreatic Diseases International 2009年第6期8卷 591-596页

作者： Hyung Ook kim Seung Kwon kim Byung Ho Son Chang Hak Yoo Hyun Pyo Hong Yong kyun Cho Byung Ik kim Departments of Surgery Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Radiology Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine Division of Interventional Radiology Mallinckrodt Institute of RadiologyWashington University School of Medicine Internal Medicine Kangbuk Samsung Hospital Sungkyunkwan University School of Medicine

BACKGROUND:Although hepatic resection is widely accepted as a proper modality for treating hepatocellular carcinoma(HCC),a majority of patients are unable to undergo surgical resection due to various tumor and patient *** ablation(RFA)has mostly been used as a therapeutic alternative to resection for treating *** objective of this study was to evaluate the results of intraoperative RFA for HCCs in locations difficult for a percutaneous ***:Eight patients(male,seven;age,49-67 years) with 8 HCCs in difficult locations were treated by intraoperative *** of the patients had local tumor progression after initial transarterial chemoembolization or ultrasound(US)guided percutaneous *** locations of the tumors were hepatic dome in six patients,posterior subcapsule in one,and caudate lobe in *** tumor size was 2.0 to 6.4 cm(mean,3.9 cm).Intraoperative RFA was performed at the tumor itself and an anticipated resection line under US guidance with 3 cm monopolar single or clustered internally cooled *** resection was performed in six *** month later,treatment response was assessed by contrast material-enhanced computed tomography(CT).CT studies were performed every 2 or 3 months after ***:RFA was technically successful in all tumors,and the contrast-enhanced CT images acquired one month later showed complete disappearance of tumor *** pneumothorax *** a median follow-up of 18 months(range,6-30 months),no tumors showed local *** the follow-up period,four new recurrent tumors were observed in three *** patients were alive at the time of this report and the other four died of hepatorenal syndrome,liver failure,and progression of new recurrent ***:Intraoperative RFA with tumor resection can be an alterative treatment option for HCC in locations difficult for a percutaneous approach.

关键词： hepatocellular carcinoma radiofrequency ablation intraoperative

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Two-week bismuth-containing quadruple therapy and concomitant therapy are effective first-line treatments for Helicobacter pylori eradication: A prospective open-label randomized trial

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World Journal of Gastroenterology 2019年第46期25卷 6790-6798页

作者： So Jeong kim Jun-Won Chung Hyun Sun Woo Su Young kim Jung Ho kim Yoon Jae kim Kyoung Oh kim Kwang An Kwon Dong kyun Park College of Medicine Gachon University Graduate School of MedicineIncheon 21936South Korea Division of Gastroenterology Department of Internal MedicineGachon University Gil Medical CenterIncheon 21565South Korea Division of Gastroenterology Department of Internal MedicineYonsei University Wonju College of MedicineWonju 26426South Korea

BACKGROUND Increasing levels of antibiotic resistance have reduced the Helicobacter pylori(***)eradication rates afforded by the standard triple ***,2-wk firstline four-drug regimens must be *** To analyze the eradication rates of modified bismuth-containing quadruple therapy(mBCQT)and concomitant therapy(CT),the associated adverse events,and *** Patients infected with *** were prospectively randomized to receive mBCQT or CT for 2 *** featured a proton pump inhibitor(PPI),bismuth,metronidazole,and tetracycline,taken twice *** included a PPI,clarithromycin,metronidazole,and amoxicillin,taken twice *** 13C-urea breath test was performed no earlier than 4 wk after therapy concluded to confirm *** either the histological or rapid urease test was positive,*** infection was *** The demographic characteristics of 68 patients who received mBCQT and 68 who received CT did not differ *** intention-to-treat analysis,the eradication rate was 88.2%(60/68)in the mBCQT group and 79.4%(54/68)in the CT group(P=0.162).By per-protocol analysis,the respective eradication rates were 98.4%(60/61)and 93.1%(54/58)(P=0.199).More CT than mBCQT patients experienced adverse events[33.8%(23/68)mBCQT vs 51.5%(35/58)CT patients,respectively,P=0.037].All patients showed good compliance[85.3%(58/68)mBCQT vs 82.4%(56/68)CT patients,P=0.641].CONCLUSION The *** eradication rates of the 2-wk mBCQT and CT regimens are *** patients show good compliance,and more CT than mBCQT patients experience adverse events.

关键词： Helicobacter pylori Therapy Bismuth-containing quadruple therapy Concomitant therapy

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Chemical ablation of the gallbladder using alcohol in cholecystitis after palliative biliary stenting

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World Journal of Gastroenterology 2009年第16期15卷 2041-2043页

作者： Tae Hoon Lee Sang-Heum Park Sang Pil kim Ji-Young Park Chang kyun Lee Il-Kwun Chung Hong Soo kim Sun-Joo kim Division of Gastroenterology Department of Internal MedicineSoonchunhyang University College of MedicineCheonan Hospital

Chemical ablation of the gallbladder is effective in patients at high risk of complications after surgery. Percutaneous gallbladder drainage is an effective treatment for cholecystitis; however, when the drain tube cannot be removed because of recurrent symptoms, retaining it can cause problems. An 82-year-old woman presented with cholecystitis and cholangitis caused by biliary stent occlusion and suspected tumor invasion of the cystic duct. We present successful chemical ablation of the gallbladder using pure alcohol, through a percutaneous gallbladder drainage tube, in a patient who developed intractable cholecystitis with obstruction of the cystic duct after receiving a biliary stent. Our results suggest that chemical ablation therapy is an effective alternative to surgical therapy for intractable cholecystitis.

关键词： Percutaneous cholecystostomy Cholecystitis Biliary stenting Alcohol Chemical therapy

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Supranutrition of microalgal docosahexaenoic acid and calcidiol improved growth performance,tissue lipid profiles,and tibia characteristics of broiler chickens

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Journal of Animal Science and Biotechnology 2023年第4期14卷 1542-1550页

作者： Sahil Kalia Andrew D.Magnuson Tao Sun Guanchen Liu Woo kyun kim Zackary Johnson Xin Gen Lei Department of Animal Science Cornell University252 Morrison HallIthacaNY 14850USA Department of Poultry Science University of GeorgiaAthensGAUSA Nicholas School of the Environment Duke UniversityBeaufortNCUSA

Background Docosahexaenoic acid(DHA)and calcidiol could be enriched in chicken for improving public nutrition and *** remains unclear if supranutritional levels of DHA and calcidiol impair growth performance or metabolism of broiler *** study was to determine singular and combined effects of high levels of supplemental DHA-rich microalgal biomass or oil and calcidiol on growth performance,concentrations of triglycerides,cholesterol,and nonesterfied fatty acids in plasma,liver,breast,and thigh,and biophysical properties of *** In Exp.1,144 day-old Cornish chicks were divided into 4 groups(6 cages/treatment,6 birds/cage),and were fed a corn-soybean meal basal diet(BD),BD+10,000 IU calcidiol/kg(BD+Cal),BD HA),and BD+1%DHA-rich Aurantiochytrium(1.2 g DHA/kg;BD+D+Cal+DHA for 6 *** Exp.2,180 day-old chicks were divided into5 groups,and were fed:BD,BD+DHA(0.33%to 0.66%oil,1.5 to 3.0 g DHA/kg),BD EPA/kg),BD+DHA+EPA(1.9%to 3.8%eicosapentaenoic acid-rich Nannochloropsis ***18,0.3 to 0.6 g BD+DHA+calcidiol(6000 to 12,000 IU/kg diet),and+DHA+EPA+Cal for 6 *** Birds fed BD+Cal diet in Exp.1 and BD lower(P+DHA<0.05)+EPA diet in Exp.2 had higher(P<0.05)body weight gain(10%-11%)and gain:feed ratio(7%),and total cholesterol and triglyceride concentrations in plasma(18%-54%),liver(8%-26%),breast(19%-26%),and thigh(10%-19%),respectively,over the *** two diets also improved(P<0.05)tibial breaking strength(8%-24%),total bone volume(2%-13%),and(or)bone mineral density(3%-19%)of *** Supranutrition of dietary calcidiol and DHA alone or together did not produce adverse effects,but led to moderate improvements of growth performance,lipid profiles of plasma and muscle,and bone properties of broiler chickens.

关键词： Broiler Calcidiol Growth performance Microalgae Tibia

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Forest structure and carbon dynamics of an intact lowland mixed dipterocarp forest in Brunei Darussalam

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Journal of Forestry Research 2018年第1期29卷 199-203页

作者： Sohye Lee Jongyeol Lee Seongjun kim Yujin Roh Kamariah Abu Salim Woo-kyun Lee Yowhan Son Department of Environmental Science and Ecological Engineering Graduate School Korea University Environmental and Life Sciences Faculty of ScienceUniversiti Brunei Darussalam Department of Biological of Environmental Sciences Qatar University

Tropical forests play a critical role in mitigating climate change because they account for large amount o terrestrial carbon storage and ***,there are many uncertainties associated with the estimation o carbon *** estimated forest structure and carbon dynamics along a slope（17.3°–42.8°）and to assess the relations between forest structures,carbon dynamics,and slopes in an intact lowland mixed dipterocarp forest,in Kuala Belalong,Brunei *** biomass,basa area,stand density,crown properties,and tree family composition were measured for forest *** rate,litter production,and litter decomposition rates were also measured for carbon *** crown form index and the crown position index were used to assess crown properties,which we categorized into five stages,from very poor to *** living biomass,basal area and stand density were 261.5–940.7 Mg ha-1,43.6–63.6 m2ha-1and 6,675–8400 tree ha-1,*** average crown form and position index were 4,which means that the crown are mostly symmetrical and sufficiently exposed for *** mean biomass growth rate,litter production,litter decomposition rate were estimated as11.9,11.6 Mg ha-1a-1,and 7.2 g a-1,*** growth rate was significantly correlated with living biomass,basal area,and crown *** form appeared to strongly influence living biomass,basal area and biomass growth rate in terms of light ***,basal area,stand density,crown properties,and biomass growth rate did not vary by slope or tree family *** results indicate that carbon accumulation by tree growth in an intact lowland mixed dipterocarp forest depends on crown *** of any effect of tree family composition on carbon accumulation suggests that the main driver of biomass accumulation in old-growth forests of Borneo is not species-specific characteristics of tree species.

关键词： Carbon dynamics Growth rate Litter flux Lowland mixed dipterocarp forest Slope

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Tailored eradication strategy vs concomitant therapy for Helicobacter pylori eradication treatment in Korean patients

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World Journal of Gastroenterology 2021年第31期27卷 5247-5258页

作者： Youn I Choi Jun-Won Chung Kyoung Oh kim Kwang An Kwon Yoon Jae kim Jung Ho kim Ja Young Seo Dong kyun Park Division of Internal Medicine Department of GastroenterologyGachon University College of MedicineGil Medical CenterInchoen 21565South Korea Department of Laboratory Medicine Gil Medical CenterGachon UniversityInchoen 21565South Korea Health IT Research Center Gachon University Gil HospitalIncheon 21565South Korea

BACKGROUND Antibiotic resistance to Helicobacter pylori(***)infection,which ultimately results in eradication failure,has been an emerging issue in the clinical ***,to overcome this problem,an antibiotic sensitivity-based tailored therapy(TT)for *** infection has received *** To investigate the efficacy and safety profiles of TT for *** infection treatment compared to a non-bismuth quadruple therapy,concomitant therapy(CT)*** We included patients(>18 years)with an *** infection and without a history of Helicobacter eradication who visited the Gil Medical Center between March 2016 and October *** being randomly assigned to either the TT or CT treatment group in 1 to 1 manner,patient compliance,eradication success rate(ESR),and patient-reported side effects profiles were assessed and compared between the two *** infection was diagnosed using a rapid urease test,Giemsa stain,or dual priming oligonucleotide polymerase chain reaction(DPO-PCR).Tailored eradication strategy based through the presence of a 23S ribosomal RNA point *** the TT group,a DPO-PCR test,which detected A2142G and/or A2143G point mutations,and a clarithromycin resistance test were *** in the clarithromycin-resistant group were treated with a bismuth-containing quadruple combination therapy,while those with sensitive results were treated with the standard triple *** Of the 217 patients with a treatment naive *** infection,110 patients[mean age:58.66±13.03,men,n=55(50%)]were treated with TT,and 107 patients[mean age:56.67±10.88,men,n=52(48.60%)]were treated with *** compliance(TT vs CT,100%vs 98.13%,P=0.30),and follow-up loss rates(8.18%vs 9.35%,P=0.95)were not significantly different between the *** ESR after treatment was also not statistically different between the groups(TT vs CT,82.73%vs 82.24%,P=0.95).However,the treatment-related and patient-reported side effects were signifi

关键词： Helicobacter pylori Eradication Tailored therapy Conco-mitant therapy regimen

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Enterovenous fistulization: A rare complication of Crohn's disease

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World Journal of Gastroenterology 2011年第47期17卷 5227-5230页

作者： Jeong Woo Lim kyung-Jo kim Byong Duk Ye Jeong-Sik Byeon Seung-Jae Myung Suk-kyun Yang Jin Ho kim Division of Gastroenterology Department of Internal Medicine University of Ulsan College of Medicine Asan Medical Center

The presence of hepatic portal venous gas (HPVG) is associated with numerous diseases, and has been regarded as a serious, even catastrophic condition. However, anecdotal reports mention that some patients with inflammatory bowel disease (IBD), who developed HPVG after diagnostic examinations of the colon, were successfully managed with antibiotic therapy and have followed benign courses. In contrast, among IBD patients, the development of HPVG is rarely caused by enterovenous fistula. We describe a 32-year-old man with Crohn's ileocolitis who presented with hypotension and fever associated with HPVG, as well as superior mesenteric vein thrombosis, possibly caused by enterovenous fistula, who was successfully managed by surgery. We also review the literature concerning portal venous gas associated with Crohn's disease.

关键词： Crohn's disease Enterovenous fistula Portal venous gas

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Two Types of Diurnal Variations in Heavy Rainfall during July over Korea

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Advances in Atmospheric Sciences 2021年第12期38卷 2201-2211页

作者： Chang-kyun PARK Minhee CHANG Chang-Hoi HO kyung-Ja HA Jinwon kim Byung-Ju SOHN School of Earth and Environmental Sciences Seoul National UniversitySeoul 08826Korea School of Earth and Environmental Systems Pusan National UniversityBusan 46241Korea Center for Climate Physics Institute for Basic ScienceBusan 46241Korea National Institute of Meteorological Sciences Korean Meteorological AdministrationJeju 63568Korea

This study examined the characteristics of the diurnal variations of heavy rainfall(≥110 mm in 12 hours)in Korea and the related atmospheric circulation for July from 1980−*** the analysis period,two dominant pattens of diurnal variation of the heavy rainfall emerged:all-day heavy rainfall(AD)and morning only heavy rainfall(MO)*** the AD-type,the heavy rainfall is caused by abundant moisture content in conjunction with active convection in the morning(0000−1200,LST;LST=UTC+9)and the afternoon hours(1200−2400 LST).These systems are related to the enhanced moisture inflow and upward motion induced by the strengthening of the western North Pacific subtropical high and upper-tropospheric *** the MO-type,heavy rainfall occurs mostly in the morning hours;the associated atmospheric patterns are similar to the *** find that the atmospheric pattern related to severe heavy rainfalls in 2020 corresponds to a typical AD-type and resembles the 1991 heavy-rainfall system in its overall synoptic/mesoscale *** present results imply that extremely heavy rainfall episodes in Korea during the 2020 summer may occur again in the future associated with the recurring atmospheric phenomenon related to the heavy rainfall.

关键词： heavy rainfall diurnal cycle of rainfall 2020 summer summer rainy season Korea

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Tailored eradication vs empirical bismuth-containing quadruple therapy for first-line Helicobacter pylori eradication: A comparative,open trial

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World Journal of Gastroenterology 2019年第46期25卷 6743-6751页

作者： Youn I Choi Jun Won Chung Dong kyun Park Kyoung Oh kim Kwang An Kwon Yoon Jae kim Ja Young Seo Department of Gastroenterology Gil Medical CenterGachon UniversityIncheon 21565South Korea Department of Laboratory Medicine Gil Medical CenterGachon UniversityIncheon 21565South Korea

BACKGROUND Few studies have compared the efficacy and safety profile of a tailored eradication(TR)strategy based on the presence of a 23S ribosomal RNA point mutation with those of empirical bismuth-based quadruple therapy(EBQT)for first-line eradication of Helicobacter pylori(***)in Korean *** To compare the efficacy and safety of a TR strategy and those of EBQT regimen as first-line eradication therapy for *** This is an open-label,comparative study in which we prospectively enrolled patients over 18 years of age with *** infection and retrospectively reviewed their ***-positive patients diagnosed by rapid urease test,Giemsa staining,or dual priming oligonucleotide polymerase chain reaction(DPO-PCR)were enrolled from May 2016 to September 2018 at Gil Medical *** with *** infection received either a TR regimen or the EBQT *** the tailored therapy group that underwent DPO-PCR testing,patients with A2142G and/or A2143G point mutations were treated with a bismuth-containing quadruple *** eradication rate,patient-reported side effect rate,and *** eradication success rate were evaluated and compared between the *** A total of 150 patients were assigned to the TR(n=50)or EBQT group(n=100).The first-line eradication rate of *** did not differ between the groups(96.0%vs 95.7%,P=0.9).The rate of eradication-related side effects for TR was 12.0%,which differed significantly from that of EBQT(43.0%)for first-line treatment(P<0.001).CONCLUSION DPO-PCR-based TR for *** eradication may be equally efficacious,with less treatment-related complications,compared to EBQT in Korea,where clarithromycin resistance is high.

关键词： Helicobacter pylori Eradication Tailored Empirical Quadruple

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Anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium-induced colitis model

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World Journal of Gastroenterology 2017年第25期23卷 4559-4568页

作者： Seung Kak Shin Jae Hee Cho Eui Joo kim Eun-kyung kim Dong kyun Park Kwang An Kwon Jun-Won Chung Kyoung Oh kim Yoon Jae kim Division of Gastroenterology and Hepatology Department of Internal Medicine Gachon University Gil Medical Center

To evaluate the anti-inflammatory and anti-apoptotic effects of rosuvastatin by regulation of oxidative stress in a dextran sulfate sodium (DSS)-induced colitis model. METHODSAn acute colitis mouse model was induced by oral administration of 5% DSS in the drinking water for 7 d. In the treated group, rosuvastatin (0.3 mg/kg per day) was administered orally before and after DSS administration for 21 d. On day 21, mice were sacrificed and the colons were removed for macroscopic examination, histology, and Western blot analysis. In the in vitro study, IEC-6 cells were stimulated with 50 ng/mL tumor necrosis factor (TNF)-α and then treated with or without rosuvastatin (2 μmol/L). The levels of reactive oxygen species (ROS), inflammatory mediators, and apoptotic markers were measured. RESULTSIn DSS-induced colitis mice, rosuvastatin treatment significantly reduced the disease activity index and histological damage score compared to untreated mice (P < 0.05). Rosuvastatin also attenuated the DSS-induced increase of 8-hydroxy-2’-deoxyguanosine and NADPH oxidase-1 expression in colon tissue. Multiplex ELISA analysis revealed that rosuvastatin treatment reduced the DSS-induced increase of serum IL-2, IL-4, IL-5, IL-6, IL-12 and IL-17, and G-CSF levels. The increased levels of cleaved caspase-3, caspase-7, and poly (ADP-ribose) polymerase in the DSS group were attenuated by rosuvastatin treatment. In vitro, rosuvastatin significantly reduced the production of ROS, inflammatory mediators and apoptotic markers in TNF-α-treated IEC-6 cells (P < 0.05). CONCLUSIONRosuvastatin had the antioxidant, anti-inflammatory and anti-apoptotic effects in DSS-induced colitis model. Therefore, it might be a candidate anti-inflammatory drug in patients with inflammatory bowel disease.

关键词： Oxidative stress Inflammatory bowel disease Rosuvastatin Apoptosis

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