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Apolipoprotein A-I binding protein-mediated neuroprotection in glaucomatous neuroinflammation and neurodegeneration

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Neural Regeneration Research 2025年第5期20卷 1414-1415页

作者： Sinwoo Hwang Seunghwan Choi Soo-Ho Choi Keun-young Kim Yury I.Miller Won-kyu Ju Hamilton Glaucoma Center and Shiley Eye Institute The Viterbi Family Department of OphthalmologyUniversity of California San DiegoLa JollaCAUSA Department of Medicine University of California San DiegoLa JollaCAUSA National Center for Microscopy and Imaging Research Department of NeurosciencesUniversity of California San DiegoLa JollaCAUSA

Glaucoma is a multifactorial eye disorder that can cause vision loss and irreversible blindness,affecting individ uals aged 40 to 80 yea rs *** to the aging population,it is expected that the number of people affected by glaucoma will surpass 111 million by 2040 as the disease becomes more *** primarily contributes to optic nerve axon loss and the progressive degeneration of retinal ganglion cells (RGCs),subsequently leading to vision impairment.

关键词： irreversible pass primarily

2.47 GPa grade ultra-strong 15Co-12Ni secondary hardening steel with superior ductility and fracture toughness

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Journal of Materials Science & Technology 2021年第7期66卷 36-45页

作者： young-kyun Kim kyu-Sik Kim young-Beum song Jung Hyo Park Kee-Ahn Lee Department of Materials Science and Engineering Inha UniversityIncheon22212Republic of Korea Agency for Defense Development(ADD) Yuseong-guDaegeon34186Republic of Korea

This study investigated the effect of multi-step heat treatment on the microstructure, mechanical properties and fracture behavior of thick 15 Co-12 Ni secondary hardening steel. As-quenched sample was found to have elongated prior austenite grain(PAG) and coarse lenticular martensitic structure. On the other hand, heat-treated sample was observed to have fine lenticular martensitic structure due to fine PAG size and a lot of nano-sized carbides. Also, after heat treatment, nano-scale reverted austenite film was formed at the martensite interfaces. The heat-treated sample showed 2.47 GPa superior tensile strength and superior elongation of about 12 %. The high strength was mainly due to fine block size and high number density of nano-sized carbides. The average value of plane strain fracture toughness(KIC) was 29.3 MPa m1/2, which indicated a good fracture toughness even with the high tensile strength. The tensile fracture surface was observed to have ductile fracture mode(cup-and-cone) and the formation of about ~1 μm ultra-fine dimples. In addition to this, nano-sized carbides were observed within the *** findings suggested that the nano-sized carbide had a positive effect not only on the strength but also on the ductility of the alloy. The fractured surface after toughness test, also showed ductile fracture mode with a lot of dimples. Based on the above results, correlation among microstructural evolution,deformation and fracture mechanisms along the heat-treatment was also discussed.

关键词： Ultra-high strength High Co-Ni secondary hardening steel Microstructure Tensile properties Fracture toughness Reverted austenite

Improved Hybrid Precoding Technique with Low-Resolution for MIMO-OFDM System

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Computers, Materials & Continua 2021年第8期68卷 2205-2220页

作者： Seulgi Lee Ji-Sung Jung young-Hwan You Hyoung-kyu song Department of Information and Communication Engineering and Convergence for Intelligent DroneSejong UniversitySeoul05006Korea Department of Computer Engineering Sejong UniversitySeoul05006Korea

This paper proposes an improved hybrid beamforming system based on multiple-input multiple-output orthogonal frequency division multiplexing(MIMO-OFDM)*** proposed beamforming system improves energy efficiency compared to the conventional hybrid beamforming *** sub-connected and full-connected structure are considered to apply the proposed *** the conventional hybrid beamforming,the usage of radio frequency(RF)chains and phase shifter(PS)gives high power and hardware *** this paper,the phase over sampling(POS)with switches(SW)is used in hybrid beamforming system to improve the energy *** POS-SW structure samples the value of analog beamformer to make lower resolution than conventional *** number of output data in POS is decided by the resolution of POS *** limited number of POS decides the resolution of antenna array and the values of POSs are designed from maximum and minimum phase angle antenna *** efficiency without the phase shifter is high although channel capacity is nearly similar with conventional ***,the amplifier with POS-SW system is proposed to improve the BER *** to the data bits,the output signals of POS are *** system with 2,3 and 4 bits is simulated to prove the proposed *** order to overcome the loss of low-resolution system,the amplifier with POS-SW system using channel information is *** average sum-rate of 4 bits system shows the similar performance with the conventional hybrid beamforming *** structure can play an important role by increasing the energy efficiency of the wireless communication system that many antennas are *** is shown that the BER,average sum rate and energy efficiency of the proposed scheme are more improved than the conventional hybrid beamforming system.

关键词： Hybrid beamforming MIMO-OFDM system analog precoding POS-SW

Clinical outcomes of targeted therapies in elderly patients aged ≥ 80 years with metastatic colorectal cancer

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World Journal of Clinical Cases 2022年第28期10卷 10066-10076页

作者： Hee Ryeong Jang Hui-young Lee Seo-young song kyu-Hyoung Lim Department of Internal Medicine Kangwon National University HospitalKangwon National University School of MedicineChuncheon-siGangwon-do 24289South Korea

BACKGROUND The 5-fluorouracil-based chemotherapy combined with oxaliplatin or irinotecan is usually used in colorectal cancer(CRC).The addition of a targeted agent(TA) to this combination chemotherapy is currently the standard treatment for metastatic ***,the efficacy and safety of combination chemotherapy for metastatic CRC in patients aged above 80 years has yet to be *** To assess the clinical outcomes and feasibility of combination chemotherapy using a TA in extremely elderly patients with *** Eligibility criteria were:(1) Age above 80 years;(2) Metastatic colorectal cancer;(3) Palliative chemotherapy na?ve;(4) Eastern Cooperative Oncology Group performance status 0-1;and(5) Adequate organ *** received at least one dose of combination chemotherapy with or without *** was evaluated every 8 *** Of 30 patients,the median age of 15 patients treated with TA was 83.0 years and that of those without TA was 81.3 *** median progression-free survival(PFS) and overall survival(OS) in patients treated with TA were 7.4 mo and 15.4 mo,respectively,compared with 4.4 mo and 15.6 mo,respectively,in patients treated without *** was no significant difference in PFS(P:0.193) and OS(P:0.748) between patients treated with and without *** grade 3/4 hematologic toxicities were anemia(16.7%) and neutropenia(10.0%).After disease progression,the median OS of patients who were treated with and without salvage chemotherapy were 23.5 mo and 7.0 mo,respectively,suggesting significant difference in OS(P = 0.001).CONCLUSION Combination chemotherapy with TA for metastatic CRC may be considered feasible in patients aged above 80 years,when with careful *** chemotherapy can help improve OS in some selected of these elderly patients.

关键词： Combination chemotherapy Targeted agent Colorectal cancer Salvage chemotherapy Elderly patient

Adaptive Relay Selection Scheme for Minimization of the Transmission Time

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Computers, Materials & Continua 2021年第10期69卷 1361-1373页

作者： Yu-Jin Na Ji-Sung Jung young-Hwan You Hyoung-kyu song Department of Information and Communication Engineering and Convergence for Intelligent DroneSejong UniversitySeoul05006Korea Department of Computer Engineering and Convergence for Intelligent DroneSejong UniversitySeoul05006Korea

As the installation of small cells increases,the use of relay also *** relay operates as a base station as well as just an *** the roles and types of relays become more diverse,appropriate relay selection technology is an effective way to improve communication *** researches for relay selection have been studied to secure the reliability of relay *** this paper,the relay selection scheme is proposed for a cooperative system using decode-and-forward(DF)relaying scheme in the mobile communication *** maintain the transmission rate,the proposed scheme classifies a candidate group considering the outage probability of multiple *** the applicable candidate group,the proposed scheme selects the relay considering the amount of data allocated to each ***,the proposed scheme defines the unit transmission time through each user’s data and relay ***,the proposed scheme selects a relay that minimizes the total transmission time through the relay transmission time that calculates the unit transmission time for all *** this adaptive relay selection scheme,an optimal relay can be assigned for each *** the same transmission rate and the amount of data,the proposed scheme improves the performance of transmission time and *** results show that the proposed scheme reduces the total transmission time for the same amount of data and signal to noise ratio(SNR).

关键词： Relay selection cooperative relay MIMO outage probability transmission time

Step-growth polymerization of traptavidin-DNA conjugates for plasmonic nanostructures

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Chinese Chemical Letters 2020年第5期31卷 1137-1140页

作者： young-Youb Kim Yongbin Bang Dayoung Lee Mingyu Kang Yoon-kyu song Graduate School of Convergence Science and Technology Seoul National UniversitySeoul 08826Republic of Korea Advanced Institutes of Convergence Technology.Gyeonggi-do 16229 Republic of Korea

Here,we use two important biomaterials,protein and DNA,to construct self-assembled linear nanostructures through Watson-Crick base-paring of *** apply a simple magnetic separation method to purify traptavidin-DNA co njugates,and demonstrate synthesis of linear arrays of traptavidinDNA conjugates via the step-growth polymerization approach with pre-determined DNA *** the traptavidin-DNA array as a template,we assemble gold nanoparticles to form linear plasmonic nanostructures in a programmable *** traptavidin-DNA conjugates thus provide a convenient platform for one-dimensional assembly of biotinylated nanomaterials for many biomedical applications from drug delivery to bio-sensing.

关键词： Protein-DNA conjugate DNA nanostructure Supramolecular assembly Traptavidin Plasmonic nanostructure

The temporal and spatial variability of the Yellow Sea Cold Water Mass in the southeastern Yellow Sea, 2009–2011

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Acta Oceanologica Sinica 2013年第9期32卷 1-10页

作者： OH kyung-Hee LEE Seok song kyu-Min LIE Heung-Jae KIM young-Taeg Marine Environment and Conservation Research Division Korea Institute of Ocean Science and Technology Ocean Research Division Korea Hydrographic and Oceanographic Administration

The Yellow Sea Cold Water Mass （YSCWM） is one of the important water mass in the Yellow Sea （YS）. It is distributed in the lower layer in the Yellow Sea central trough with the temperature less than 10℃ and the salinity lower than 33.0. To understand the variability of the YSCWM, the hydrographic data obtained in April and August during 2009-2011 are analyzed in the southeastern Yellow Sea. In August 2011, relatively warm and saline water compared with that in 2009 and 2010 was detected in the lower layer in the Yellow Sea central area. Although the typhoon passed before the cruise, the salinity in the Yellow Sea central trough is much higher than the previous season. It means that the saline event cannot be explained by the typhoon but only by the intrusion of saline water during the previous winter. In April 2011, actually, warm and saline water （T 〉 10~C, S 〉34） was observed in the deepest water depth of the southeastern area of the Yellow Sea. The wind data show that the northerly wind in 2011 winter is stronger than in 2009 and 2010 winter season. The strong northerly wind can trigger the intrusion of warm and saline Yellow Sea Warm Current. Therefore, it is proposed that the strong northerly wind in winter season leads to the intrusion of the Yellow Sea Warm Current into the Yellow Sea central trough and influenced a variability of the YSCWM in summer.

关键词： Yellow Sea Cold Water Mass interannual variation saline event atmosphere variability Yellow Sea

Efficient Gauss-Seidel Precoding with Parallel Calculation in Massive MIMO Systems

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Computers, Materials & Continua 2022年第1期70卷 491-504页

作者： Hyun-Sun Hwang Jae-Hyun Ro Chan-Yeob Park young-Hwan You Hyoung-kyu song Department of Information and Communication Engineering Convergence Engineering for Intelligent DroneSejong UniversitySeoul05006Korea Department of Convergence Engineering for Intelligent Drone Sejong UniversitySeoul05006Korea Department of Computer Engineering Convergence Engineering for Intelligent DroneSejong UniversitySeoul05006Korea

A number of requirements for 5G mobile communication are satisfied by adopting multiple input multiple output(MIMO)*** inter user interference(IUI)which is an inevitable problem in MIMO systems becomes controllable when the precoding scheme is *** this paper,the horizontal Gauss-Seidel(HGS)method is proposed as precoding scheme in massive MIMO *** massive MIMO systems,the exact inversion of channel matrix is impractical due to the severe computational ***,the conventionalGauss-Seidel(GS)method is used to approximate the inversion of channel *** GS has good performance by using previous calculation results as ***,the required time for obtaining the precoding symbols is too long due to the sequential process of ***,the HGS with parallel calculation is proposed in this paper to reduce the required *** rows of channel matrix are eliminated for parallel calculation *** addition,HGSuses the ordered channelmatrix to prevent performance degradation which is occurred by parallel *** HGS with proper number of parallelly computed symbols has better performance and reduced required time compared to the traditional GS.

关键词： Massive MIMO GS matrix inversion linear precoding

Influence of new town development on the urban heat island-The case of the Bundang area

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Journal of Environmental Sciences 2005年第4期17卷 641-645页

作者： song young-bae School of Architecture Landscape Architecture and Civil Engineering Sung Kyun Kwan UniversityKorea

Five new towns have been developed around the Seoul metropolitan area since 1996 However, these new towns generate lots of traffic and related problems in the areas including those new towns and Seoul as a result of increases in population and a lack of ecological-self-sufficiency. Currently, construction of another new town is under deliberation, and what should be a major consider is the notion that the new town be located within a wide, green zone. Many studies have revealed that green space can play an important role in improving urban eco-meteorological capability and air quality. In order to analyze the urban heat island which will be created by the new urban development, and to investigate the local thermal environment and its negative effects caused by a change of land use type and urbanization, Landsat TM images were used for extraction of urban surface temperature according to changes of land use over the last 15 years. These data are analyzed together with digital land use and topographic information. As a study result, it was found the urban heat island of the study area from 1985 to 1999 rapidly developed which showed a difference of mean temperature above +2 0 Before the Bundang new town construction the temperature of the residential area was the same as a forest, but during the new town construction in 1991 analysis revealed the creation of an urban heat island. The temperature of a forest whose size is over 50% of the investigation area was lowest, and thus the presence of a forest is believed to have a direct cooling effect on the urban environment and its surroundings. The mean temperature of the residential and commercial areas in the study was found to be +4 5 higher than the forest, and therefore this part of land use is believed to be the main factor causing the temperature increase of the urban heat island.

关键词： urban heat island new town development urban climate landsat TM nand 6 air corridor