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Comparing 11 early warning scores and three shock indices in early sepsis prediction in the emergency department

World Journal of Emergency Medicine 2024年第4期15卷 273-282页

作者： Rex Pui Kin Lam Zonglin Dai Eric ho Yin Lau Carrie Yuen Ting Ip ho Ching Chan Lingyun Zhao Tat ChiTsang Matthew Sik hon Tsui Timothy Hudson Rainer Department of Emergency Medicine School of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina School of Public Health Li Ka Shing Faculty of Medicinethe University of Hong KongHong KongChina Accident and Emergency Department Queen Mary HospitalHong KongChina

BACKGROUND:This study aimed to evaluate the discriminatory performance of 11 vital sign-based early warning scores(EWSs)and three shock indices in early sepsis prediction in the emergency department(ED).METhoDS:We performed a retrospective study on consecutive adult patients with an infection over 3 months in a public ED in hong *** primary outcome was sepsis(Sepsis-3 definition)within 48 h of ED *** c-statistics and the DeLong test,we compared 11 EWSs,including the National Early Warning Score 2(NEWS2),Modified Early Warning Score,and Worthing Physiological Scoring System(WPS),etc.,and three shock indices(the shock index[SI],modified shock index[MSI],and diastolic shock index[DSI]),with Systemic Inflammatory Response Syndrome(SIRS)and quick Sequential Organ Failure Assessment(qsoFA)in predicting the primary outcome,intensive care unit admission,and mortality at different time ***:We analyzed 601 patients,of whom 166(27.6%)developed ***2 had the highest point estimate(area under the receiver operating characteristic curve[AUROC]0.75,95%CI 0.70-0.79)and was significantly better than SIRS,qsoFA,other EWSs and shock indices,except WPS,at predicting the primary ***,the pooled sensitivity and specificity of NEWS2≥5 for the prediction of sepsis were 0.45(95%CI 0.37-0.52)and 0.88(95%CI 0.85-0.91),*** discriminatory performance of all EWSs and shock indices declined when used to predict mortality at a more remote time ***:NEWS2 compared favorably with other EWSs and shock indices in early sepsis prediction but its low sensitivity at the usual cut-off point requires further modification for sepsis screening.

关键词： Sepsis Emergency department Clinical prediction rule Early warning score Shock index

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Photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes to promote PD-L1 multivalent binding for effective immune checkpoint blockade therapy

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1428-1440页

作者： Youngjoo Lee Sukyung song Suah Yang Jinseong Kim Yujeong Moon Nayeon Shim hong Yeol Yoon Sehoon Kim Man kyu Shim Kwangmeyung Kim KU-KIST Graduate School of Converging Science and Technology Korea UniversitySeoul 02841Republic of Korea Medicinal Materials Research Center Biomedical Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea College of Pharmacy Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoul 03760Republic of Korea Department of Bioengineering Korea UniversitySeoul 02841Republic of Korea

Immune checkpoint blockade(ICB)therapy targeting PD-L1 via monoclonal antibody(m Ab)has shown extensive clinical benefits in the diverse types of advanced ***,most patients are completely refractory to ICB therapy owing to the PD-L1 recycling ***,we propose photo-induced crosslinked and anti-PD-L1 peptide incorporated liposomes(immune checkpoint blockade liposomes;ICB-LPs)to promote PD-L1 multivalent binding for inducing lysosomal degradation of PD-L1 in tumor *** ICB-LPs are prepared by formulation of DC_(8,9)PC with photo-polymerized diacetylenic moiety,1,2-dipalmitoylphosphatidylcholine(DPPC)and anti-PD-L1peptide(D-form NYSKPTDRQYHF)-conjugated DSPE-PEG_(2k)(anti-PD-L1-DSPE-PEG_(2k))in a molar ratio of 45:45:10,followed by cross-linking of liposomal bilayer upon UV *** 10 mol% antiPD-L1-DSPE-PEG_(2k)incorporated ICB-LPs have a nano-sized lipid bilayer structure with an average diameter of 137.7±1.04 nm,showing a high stability in serum ***,the ICB-LPs efficiently promote the multivalent binding with PD-L1 on the tumor cell membrane,which are endocytosed with aim to deliver PD-L1 to the lysosomes,wherein the durable PD-L1 degradation is observed for72 h,in contrast to anti PD-L1 m Abs showing the rapid PD-L1 recycling within 9 *** in vitro coculture experiments with CD8^(+)T cells show that ICB-LPs effectively enhance the T cell-mediated antitumor immune responses against tumor cells by blocking the PD-L1/PD-1 *** ICB-LPs are intravenously injected into colon tumor-bearing mice,they efficiently accumulate within the targeted tumor tissues via both passive and active tumor targeting,inducing a potent T cell-mediated antitumor immune response by effective and durable PD-L1 ***,this study demonstrates the superior antitumor efficacy of crosslinked and anti-PD-L1 peptide incorporated liposome formulation that promotes PD-L1 multivalent binding for trafficking of PD-L1 toward

关键词： Cancer immunotherapy Immune checkpoint blockade PEGylated liposome Crosslinked lipid nanoparticles Anti-PD-L1 peptide Tumor-targeting PD-L1 multivalent binding Lysosomal PD-L1 degradation

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High Na-ion conductivity andmechanical integrity of anion-exchanged polymeric hydrogel electrolytes for flexible sodium ion hybrid energy storage

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SusMat 2024年第1期4卷 140-153页

作者： JungWoo hong Harpalsinh H.Rana Jeong Hee Park Jun Su Kim Sang Joon Lee Gun Jang Tae hoon Kang Kang ho Shin Sang Ha Baek Wooseok Yang Kwang ho Kim Ju-Hyuk Lee ho Seok Park School of Chemical Engineering Sungkyunkwan UniversitySuwonRepublic of Korea Clean Energy Research Center Korea Institute of Science and Technology(KIST)SeoulRepublic of Korea KIST-SKKU Carbon-Neutral Research Center Sungkyunkwan University(SKKU)SuwonRepublic of Korea SKKU Institute of Energy Science and Technology(SIEST) Sungkyunkwan UniversitySuwonRepublic of Korea COSMOS LAB/92 Jomaru-ro 385beon-gilBucheon-siRepublic of Korea SKKU Advanced Institute of Nano Technology(SAINT) Sungkyunkwan UniversitySuwonRepublic of Korea Department of Health Sciences and Technology Samsung Advanced Institute for Health Sciences and Technology(SAIHST)Sungkyunkwan UniversitySuwonRepublic of Korea

The polymeric gel electrolytes are attractive owing to their higher ionic conductivities than those of dry polymer electrolytes and lowered water activity for enlarged potential ***,the ionic conductivity and mechanical strength of the Na-ion conducting polymeric gel electrolytes are limited by below 20 mS cm−1 and 2.2 ***,we demonstrate Na-ion conducting and flexible polymeric hydrogel electrolytes of the chemically coupled poly(diallyldimethylammonium chloride)-dextrin-N,N′-methylene-bisacrylamide film immersed in NaClO_(4) solution(ex-DDA-Dex+NaClO_(4))for flexible sodium-ion hybrid capacitors(f-NIHC).In particular,the anion exchange reaction and synergistic interaction of ex-DDA-Dex with the optimum ClO_(4)−enable to greatly improve the ionic conductivity up to 27.63 mS cm−1 at 25◦C and electrochemical stability window up to 2.6 V,whereas the double networking structure leads to achieve both the mechanical strength(7.48 MPa)and softness of hydrogel ***,the f-NIHCs with the ex-DDA-Dex+NaClO_(4) achieved high specific and high-rate capacities of 192.04 F g^(−1)at 500 mA g^(−1)and 116.06 F g^(−1)at 10000 mA g^(−1),respectively,delivering a large energy density of 120.03Wh kg^(−1)at 906Wkg^(−1)and long cyclability of 70%over 500 cycles as well as demonstrating functional operation under mechanical stresses.

关键词： anion exchange chemistry flexible energy storage hybrid energy storage hydrogel electrolytes renewable electrolytes sodium storage

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p-wave resonances in the exponential cosine screened Coulomb potential

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Communications in Theoretical Physics 2024年第7期76卷 107-115页

作者： Yuan-Cheng Wang Li Guang Jiao Aihua Liu Yew Kam ho Stephan Fritzsche College of Physical Science and Technology Shenyang Normal University College of Physics Jilin University Helmholtz-Institut Jena GSI Helmholtzzentrum fur Schwerionenforschung GmbH Institute of Atomic and Molecular Physics Jilin University Institute of Atomic and Molecular Sciences Academia Sinica

We perform benchmark calculations of the p-wave resonances in the exponentially cosine screened Coulomb potential using the uniform complex-scaling generalized pseudo-spectral method. The present results show significant improvement in calculation accuracy compared to previous predictions and correct the misidentification of resonance electron configuration in previous works. It is found that the resonance states approximately follow an n2-scaling law which is similar to the bound counterparts. The birth of a new resonance would distort the trajectory of an adjacent higher-lying resonance.

关键词： complex-scaling method exponential cosine screened Coulomb potential generalized pseudospectral method shape resonance

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Correlation between hydration properties and electrochemical performances on Ln cation size effect in layered perovskite for protonic ceramic fuel cells

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Journal of Energy Chemistry 2024年第1期88卷 1-9,I0001页

作者： Inhyeok Cho Jiwon Yun Boseok Seong Junseok Kim Sun Hee Choi ho-Il Ji Sihyuk Choi Department of Mechanical Engineering Kumoh National Institute of TechnologyGumi 39177GyeongbukRepublic of Korea Department of Aeronautics Mechanical and Electronic Convergence EngineeringKumoh National Institute of TechnologyGumi 39177GyeongbukRepublic of Korea Center for Energy Materials Research Korea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Center for Hydrogen and Fuel Cell Research Clean Technology Research DivisionKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea Department of Energy and Environmental Engineering University of Science and TechnologySeoul 02792Republic of Korea Nanomaterials Science and Engineering Korea University of Science and Technology(UST)KIST CampusSeoul 02792Republic of Korea

PrBa_(0.5)Sr_(0.5)Co_(1.5)Fe_(0.5)O_(5+δ)(PrBSCF) has attracted much research interest as a potential triple ionic and electronic conductor(TIEC) electrode for protonic ceramic fuel cells(PCFCs). The chemical formula for Pr BSCF is AA'B_(2)O_(5+δ), with Pr(A-site) and Ba/Sr(A'-site) alternately stacked along the c-axis. Due to these structural features, the bulk oxygen ion diffusivity is significantly enhanced through the disorder-free channels in the PrO layer;thus, the A site cations(lanthanide ions) play a pivotal role in determining the overall electrochemical properties of layered perovskites. Consequently, previous research has predominantly focused on the electrical properties and oxygen bulk/surface kinetics of Ln cation effects,whereas the hydration properties for PCFC systems remain unidentified. Here, we thoroughly examined the proton uptake behavior and thermodynamic parameters for the hydration reaction to conclusively determine the changes in the electrochemical performances depending on LnBa_(0.5)Sr_(0.5)Co_(1.5)Fe_(0.5)O_(5+δ)(LnBSCF,Ln=Pr, Nd, and Gd) cathodes. At 500 ℃, the quantitative proton concentration of PrBSCF was 2.04 mol% and progressively decreased as the Ln cation size decreased. Similarly, the Gibbs free energy indicated that less energy was required for the formation of protonic defects in the order of Pr BSCF hodes, PCFC single cell measurements and analysis of the distribution of relaxation time were further investigated.

关键词： Protonic ceramic fuel cell Cathode Triple ionic and electronic conductor Hydration property Proton uptake Gibbs free energy

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Daytime-nighttime variations in the concentration of PM_(0.1) carbonaceous particles during a biomass fire episode in Chiang Mai,Thailand

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Particuology 2024年第4期87卷 316-324页

作者： Worradorn Phairuang Thaneeya Chetiyanukornkul Phuchiwan Suriyawong sotasing ho Phakphum Paluang Masami Furuuchi Muhammand Amin Mitsuhiko Hata Faculty of Gesciences and CivilEngineering Institute of Science and Enginering Kanazawa UniverityKanazawaIshkawa92192Japan Department of Geography Faculty of Social SciencesChiang Mai UniversityMuangChiang Mai 50200Thailand Department of Biology Faculty of ScienceChiang Mai UniversityMuangChiang Mai50200Thailand Research Unit for Eergyonomics and Eological Management Multidisciplinary Research Insttute Chiang Mai UniversityChiang Mai50200Thailand Management and Development Training Program Office National Institute of ScienceTechnology and Innovation120601Cambodia Faculty of Engineering Maritim University of Raja Ali HajTanjung PinangKepulauan Riau29115Indonesia

Carbonaceous aerosols affect air quality adversely,affect global warming,and human ***,our understanding of the impact of ultrafine(PM_(0.1))carbonaceous particulate matter is incomplete,particularly the effects during haze *** study monitored diurnal variations in PM_(0.1) in Chiang Mai,Thailand,from March to April *** investigated carbonaceous PM_(0.1) collected by an ambient nano-sampler and evaluated their effect by using a carbon analyzer(IMPROVE_TOR).The results showed that burning large open areas in the dry season was crucial for increasing the particle mass concentration because of the large open burnings that occurred in this *** majority of biomass fires near the sampling site occurred during the night,which would allow more particles to be released thus resulting in higher concentrations of PM_(0.1).Hence,the release of PM_(0.1) during the night would obviously result in higher concentrations than that during the *** the eight carbon profiles,organic carbon 3(OC3)was predicted to be a marker of biomass *** carbon indices displayed that PM_(0.1) was influenced by biomass burning both daytime and *** findings reported herein should be of great impor-tance in terms of establishing biomass burning control policies for mitigating heavy haze pollution in Thailand and elsewhere.

关键词： Biomass burning Carbon Forest fires Nanoparticles Ultrafine particles

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New characterization of Morrey–Herz spaces and Morrey–Herz–Hardy spaces with applications to various linear operators

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Acta Mathematica Sinica,English Series 2024年

作者： Kwok Pun ho Yoshihiro Sawano Department of Mathematics and Information Technology The Education University of Hong Kong Department of Mathematics Graduate School of Science and Engineering Chuo University

This paper is an offspring of the previous study on Herz spaces. A new characterization of Morrey–Herz spaces is given. As applications, the boundedness of various operators is obtained. For example, higher-order commutators generated by singular integral operators and BMO functions are proved to be bounded on Morrey–Herz spaces. The theory of Morrey–Herz–Hardy spaces is also developed.

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Enriching Middle School Students’Learning Through Digital Storytelling:A Multimodal Analytical Framework

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ECNU Review of Education 2024年第2期7卷 357-383页

作者： Deoksoon Kim ho-Ryong Park Oksana Vorobel Boston College Lynch School of Education-Teaching Curriculumand SocietyI40 Commonwealth AvenueChestnut HillMassachusetts 02467-3800US Murray State University City University of New York

Purpose This study investigates middle school students’learning experiences through digital storytelling,applying a multimodal analytical framework to uncover patterns in digital *** study explores how participants engage in pedagogical activities,reflect on their learning experiences,and articulate their voices through digital ***/Approach/Methods Employing qualitative case study methods,we purposefully selected three 12-year-old female students at an urban school in the northern *** of digital stories and other data sources(interviews,classroom observations,and reflective journals)show that the students were engaged in both teaching and *** The findings describe(1)participants and their learning experiences,(2)students’representational and interpersonal constructs as used in their digital stories,and(3)their participation as teachers as well as ***/Value Our multimodal analytical framework illuminates how students express themselves through digital *** discussion focuses on students’learning,their identity development,the effectiveness of the analytical framework,and pedagogical implications.

关键词： Analytical framework digital stories identity middle school students multimodality

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Optimized speed control for electric vehicles on dynamic wireless charging lanes: An eco-driving approach

Journal of Intelligent and Connected Vehicles

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Journal of Intelligent and Connected Vehicles 2024年第1期7卷 52-63页

作者： Lingshu Zhong ho Sheau En Mingyang Pei Jingwen Xiong Tao Wang School of Systems Science and Engineering Sun Yat-sen UniversityGuangzhou 510399China Faculty of Business and Management UCSI UniversityKuala Lumpur 56000Malaysia Department of Civil Engineering and Transportation South China University of TechnologyGuangzhou 510641China School of Automotive and Transportation Engineering Hefei University of TechnologyHefei 230000China

As the adoption of Electric Vehicles(EVs)intensifies,two primary challenges emerge:limited range due to battery constraints and extended charging *** traditional charging stations,particularly those near highways,exacerbate these issues with necessary detours,inconsistent service levels,and unpredictable waiting *** emerging technology of dynamic wireless charging lanes(DWCLs)may alleviate range anxiety and eliminate long charging stops;however,the driving speed on DWCL significantly affects charging efficiency and effective charging ***,the existing research has addressed load balancing optimization on Dynamic Wireless Charging(DWC)systems to a limited *** address this critical issue,this study introduces an innovative eco-driving speed control strategy,providing a novel solution to the multi-objective optimization problem of speed control on *** utilize mathematical programming methods and incorporate the longitudinal dynamics of vehicles to provide an accurate physical model of *** objective functions are formulated to tackle the challenges at hand:reducing travel time,increasing charging efficiency,and achieving load balancing on DWCL,which corresponds to four control *** results of numerical tests indicate that a comprehensive control strategy,which considers all objectives,achieves a minor sacrifice in travel time reduction while significantly improving energy efficiency and load ***,by defining the energy demand and speed range through an upper operation limit,a relatively superior speed control strategy can be *** work contributes to the discourse on DWCL integration into modern transportation systems,enhancing the EV driving experience on major roads.

关键词： dynamic wireless charging(DWC) electric vehicle(EV) eco-driving speed control load balancing

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Exploring the genetic basis of pre-harvest sprouting in rice through a genome-wide association study-based haplotype analysis

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Journal of Integrative Agriculture 2024年第8期23卷 2525-2540页

作者： Myeong-Hyeon Min Aye Aye Khaing Sang-ho Chu Bhagwat Nawade Yong-Jin Park Department of Plant Resources College of Industrial SciencesKongju National UniversityYesan 32439Republic of Korea Department of Agronomy Yezin Agricultural UniversityNay Pyi Taw 15013Myanmar

Pre-harvest sprouting(PHS)poses a significant global challenge to cereal production,impacting both yield and *** this study,we employed genome-wide association studies(GWAS)on diverse rice accessions to identify novel PHS-associated *** assessment of 127 cultivated accessions for panicle germination(PHS)and detached grain germination(germination rate of detached grains at the 14th day(D14))revealed considerable phenotypic variation among rice *** analysis identified 91 significant signals at–log10(P-value)>5,including 15SNPs for PHS and 76 SNPs for D14.A subsequent linkage disequilibrium(LD)block-based GWAS analysis detected 227 significant SNPs for both traits,consisting of 18 nonsynonymous substitutions located on the coding regions of nine *** haplotype analysis identified 32 haplotypes,with 10 specific to cultivated accessions,19 specific to the wild type,and three shared between them.A phenotypic assessment of major haplotypes revealed significant differences between resistant(Hap1 and Hap2)and susceptible haplotypes(Hap5,Hap27,and Hap28),distinguished by a G/A SNP within a novel gene,*** identified haplotypes offer promising prospects for haplotypebased breeding aimed at enhancing PHS resistance in rice.

关键词： rice PHS dormancy germination GWAS haplotype abiotic stress

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