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Epidemiology of insertional and midportion Achilles tendinopathy in runners:A prospective cohort study

Journal of Sport and Health Science 2024年第2期13卷 256-263页

作者： Wenbo Chen kyra l.a.cloosterman Sita M.A.Bierma-Zeinstra Marienke van Middelkoop Robert-Jan de Vos Department of Orthopaedic Surgery and Sports Medicine Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands Department of General Practice Erasmus MC University Medical CenterRotterdam 3015GDthe Netherlands Department of Sports Medicine Huashan HospitalFudan UniversityShanghai 200040China

Background:Achilles tendinopathy(AT)is a common problem among *** is only limited evidence for risk factors for AT,and most studies have not defined the AT *** study has compared the incidence and risk factors between insertional AT and midportion AT,though they are considered *** study aimed to assess incidence and risk factors of AT based on data from a large prospective *** secondary aim was to explore differences in risk factors between insertional and midportion ***:Participants were recruited from among registered runners at registration for running *** were completed at baseline,1 month before the event,1 week before the event,and 1 month after the *** concerning demographics,training load,registered events,and running-related injuries were collected at *** follow-up questionnaires collected information about new injuries.A pain map was used to diagnose midportion and insertional *** primary outcome was the incidence of *** logistic regression analysis was applied to identify risk factors for the ***:We included 3379 participants with a mean follow-up of 20.4 *** incidence of AT was 4.2%.The proportion of insertional AT was 27.7%and of midportion AT was 63.8%;the remaining proportion was a combined type of insertional and midportion *** had a significantly higher incidence(5%,95%confidence interval(95%CI):4.1%-6.0%)than women(2.8%,95%CI:2.0%-3.8%).AT in the past12 months was the most predominant risk factor for new-onset AT(odds ratio(OR)=6.47,95%CI:4.27-9.81).This was similar for both subcategories of AT(insertional:OR=5.45,95%CI:2.51-11.81;midportion:OR=6.96,95%CI:4.24-11.40).Participants registering for an event with a distance of 10/10.55 km were less likely to develop a new-onset AT(OR=0.59,95%CI:0.36-0.97)or midportion AT(OR=0.47,95%CI:0.23-0.93).Higher age had a significant negative association with insertional AT(OR=0.97,95%CI:0.9

关键词： Achilles tendon injury Incidence Risk factor Running-related injury

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Ethyl-iophenoxic acid as a quantitative bait marker for small mammals

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Integrative Zoology 2022年第6期17卷 981-990页

作者： kyra JACOBlINNERT Christian IMHOlT Detlef SCHENKE Jens JACOB Julius Kühn Institute(JKI) Federal Research Centre for Cultivated PlantsInstitute for Plant Protection in Horticulture and ForestsVertebrate ResearchMünsterGermany Department of Behavioral Biology University of OsnabrückOsnabrückGermany Julius Kühn Institute(JKI) Federal Research Centre for Cultivated PlantsInstitute for Ecological ChemistryPlant Analysis and Stored Product ProtectionBerlinGermany

Bait markers are indispensable for ecological research but in small mammals,most markers are invasive,expensive and do not enable quantitative analyses of ***-iophenoxic acid(Et-IPA)is a non-toxic,quantitative bait marker,which has been used for studying bait uptake in several carnivores and *** developed a bait with Et-IPA,assessed its palatability to common voles(Microtus arvalis),and determined the dose-residue-relation for this important agricultural pest rodent ***-IPA concentrations of 40 to 1280μg Et-IPA per g bait were applied to wheat using sunﬂower oil or polyethylene glycol 300 as potential *** a laboratory study,common voles were offered the bait and blood samples were collected 1,7,and 14 days after *** samples were analyzed with lC-ESI-MS/MS for blood residues of ***ﬂower-oil was the most suitable bait ***-IPA seemed to be palatable to common voles at all test ***-dependent residues could be detected in blood samples in a dose-dependent manner and up to 14 days after uptake enabling generation of a calibration curve of the dose-residue ***-IPA was present in common vole blood for at least 14 days,but there was dissipation by 33–37%depending on ***-IPA meets many criteria for an“ideal”quantitative bait marker for use in futureﬁeld studies on common voles and possibly other small mammal species.

关键词： baiting biomarker Microtus arvalis quantitative bait marker small mammals

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The status of fertility control for rodents—recent achievements and future directions

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Integrative Zoology 2022年第6期17卷 964-980页

作者： kyra JACOBlINNERT Jens JACOB Zhibin ZHANG lyn A.HINDS Julius Kühn-Institute(JKI) Federal Research Centre for Cultivated PlantsInstitute for Plant Protection in Horticulture and ForestsVertebrate ResearchMünsterGermany Department of Behavioral Biology University OsnabrückOsnabrückGermany State Key laboratory of Integrated Management on Pest Insects and Rodents Institute of ZoologyChinese Academy of SciencesBeijingChina CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijingChina CSIRO Health and Biosecurity CanberraACTAustralia

Management of overabundant rodents at a landscape scale is complex but often required to sustainably reduce rodent abundance below damage *** conventional techniques such as poisoning are not species speciﬁc,with some approaches becoming increasingly unacceptable to the general *** control,ﬁrst proposed for vertebrate pest management over 5 decades ago,has gained public acceptance because it is perceived as a potentially more species-speciﬁc and humane approach compared with many lethal *** ideal fertility control agent needs to induce infertility across one or more breeding seasons,be easily delivered to an appro-priate proportion of the population,be species speciﬁc with minimal side-effects(behavioral or social structure changes),and be environmentally benign and cost *** date,effective fertility control of rodents has not been demonstrated at landscape scales and very few products have achieved *** targets for fertility control include disrupting the hormonal feedback associated with the hypothalamic-pituitary-gonadal axis,gonad function,fertilization,and/or early *** review progress on the oral delivery of various agents for which laboratory studies have demonstrated efﬁcacy in females and/or males and synthesize progress with the development and/or use of synthetic steroids,plant extracts,ovarian speciﬁc peptides,and immunocontracep-tive *** are promising results forﬁeld application of synthetic steroids(levonorgestrel,quinestrol),chemosterilants(4-vinylcyclohexene diepoxide),and some plant extracts(triptolide).For most fertility control agents,more research is essential to enable their efﬁcient and cost-effective delivery such that rodent impacts at a population level are mitigated and food security is improved.

关键词： ecologically based rodent management levonorgestrel quinestrol triptolide 4-vinylcyclohexene diepoxide

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Tumor-intrinsic metabolic reprogramming and how it drives resistance to anti-PD-1/PD-l1 treatment

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Cancer Drug Resistance 2023年第3期6卷 611-641页

作者： kyra laubach Tolga Turan Rebecca Mathew Julie Wilsbacher John Engelhardt Josue Samayoa Computational Oncology AbbVieSouth San FranciscoCA 94080USA Immuno-Oncology AbbVieSouth San FranciscoCA 94080USA Immuno-Oncology AbbVieLake CountyIL 60064USA

The development of immune checkpoint blockade (ICB) therapies has been instrumental in advancing the field of immunotherapy. Despite the prominence of these treatments, many patients exhibit primary or acquired resistance, rendering them ineffective. For example, anti-programmed cell death protein 1 (anti-PD-1)/anti-programmed cell death ligand 1 (anti-PD-l1) treatments are widely utilized across a range of cancer indications, but the response rate is only 10%-30%. As such, it is necessary for researchers to identify targets and develop drugs that can be used in combination with existing ICB therapies to overcome resistance. The intersection of cancer, metabolism, and the immune system has gained considerable traction in recent years as a way to comprehensively study the mechanisms that drive oncogenesis, immune evasion, and immunotherapy resistance. As a result, new research is continuously emerging in support of targeting metabolic pathways as an adjuvant to ICB to boost patient response and overcome resistance. Due to the plethora of studies in recent years highlighting this notion, this review will integrate the relevant articles that demonstrate how tumor-derived alterations in energy, amino acid, and lipid metabolism dysregulate anti-tumor immune responses and drive resistance to anti-PD-1/PD-l1 therapy.

关键词： Immunotherapy resistance tumor-immune microenvironment immune checkpoint blockade energy metabolism amino acid metabolism lipid metabolism

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FIT FOR A KING France's Preeminent Ballet Troupe Remains Regally Defiant

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城市漫步（GBA版） 2016年第1期 38-39页

作者： ANDREW CHIN AND kyra lEI 不详

With roots in the royal court of louis XIV,the Paris Opera Ballet has been a dance monolith for over three *** world's oldest national ballet company returns to China for the first time in seven years,presenting a gal... 详细信息

关键词： Opera roots eminent

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A New Factorized Backprojection Algorithm for Stripmap Synthetic Aperture Radar

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Positioning 2013年第1期4卷 42-56页

作者： kyra Moon David G. long Microwave Earth Remote Sensing laboratory Brigham Young University Provo USA

Factorized backprojection is a processing algorithm for reconstructing images from data collected by synthetic aperture radar (SAR) systems. Factorized backprojection requires less computation than conventional time-domain backprojection with minimal loss in accuracy for straight-line motion. However, its implementation is not as straightforward as direct backprojection. This paper provides a new, easily parallelizable formulation of factorized backprojection designed for stripmap SAR data that includes a method of implementing an azimuth window as part of the factorized backprojection algorithm. We compare the performance of windowed factorized backprojection to direct backprojection for simulated and actual SAR data.

关键词： Backprojection Windows Synthetic Aperture Radar (SAR)

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生命之问宝宝的话

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2006年

作者： kyra Karmiloff Annette Karmiloff-Smith 张菱译

本书是一本帮助你更好地了解婴儿成长过程的书，试图深入婴儿的心理去探索，如果婴儿能够说话，他们会对自身以及他们所经历的一切提出什么样的问题？他们是如何感知这个世界的？我们必须了解婴儿是如何成为一个有思维的、独立的人的。

ISBN: (纸本)7533141717

关键词：婴儿心理学

来源：汇雅图书（南通市图书馆... 评论

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langerin (CD207) represents a novel interferon-stimulated gene in langerhans cells

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Cellular & Molecular Immunology 2020年第5期17卷 547-549页

作者： Ghizlane Maarifi Magdalena A.Czubala Justine lagisquet Matthew O.Ivory kyra Fuchs laure Papin James C.Birchall Sébastien Nisole Vincent Piguet Fabien P.Blanchet Institut de Recherche en Infectiologie de Montpellier(IRIM) Universitéde MontpellierCNRSMontpellierFrance Systems Immunity University Research Institute and Division of Infection and Immunity Cardiff University School of MedicineHeath ParkCardiffUK School of Pharmacy and Pharmaceutical Sciences Cardiff UniversityCardiffUK Division of Dermatology Women’s College HospitalTorontoCanada Division of Dermatology Department of MedicineUniversity of TorontoTorontoCanada

Interferons(IFNs)are“warning signal”cytokines released upon pathogen *** control the expression of interferonstimulated genes(ISGs),which are often crucial to restrict viral infections and establish a cellular antiviral state.1,2 langerin(CD207),a well-known surface receptor on langerhans cells(lC),belongs to the C-type lectin receptor(ClR)family and constitutes a major pathogen binding receptor able to regulate both innate and adaptive immune responses.3,4 Importantly,this ClR was reported as an antiviral receptor.

关键词： langerhans interferon belongs

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爱情在电影中沦陷

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男生女生（银版） 2009年第2期 57-61页

作者： kyra

像冬日阳光般令人惆怅的爱，忧伤贯穿全部，看完了，你会记住这段未曾发生的爱情。绝望的电影也好，隐忍的爱情也罢，都是如此危险和脆弱，触手可及，却各分东西。

关键词：爱情电影忧伤

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双碳时代:企业价值链间接减排“三步走”

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数字经济 2023年第7期 36-38页

作者： kyra Whitten 伟创力基金会伟创力

为了在2050年达到净零排放,企业必须解决间接的“范围3”排放和产生的其他直接排放。而要实现这个目标,企业需确保利益相关者能够认可并接受减排计划,确保双方能够建立相互支持、协同高效的伙伴关系,同时确保整个价值链排放测量方法的... 详细信息

为了在2050年达到净零排放,企业必须解决间接的“范围3”排放和产生的其他直接排放。而要实现这个目标,企业需确保利益相关者能够认可并接受减排计划,确保双方能够建立相互支持、协同高效的伙伴关系,同时确保整个价值链排放测量方法的标准化。成功解决“范围3”的排放需要企业基于与价值链伙伴的合作,做好“三步走”。

关键词：价值链利益相关者伙伴关系三步走零排放直接排放标准化

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