检索结果-南通市图书馆

p73 G4C14 to A4T14 polymorphism is associated with colorectal cancer risk and survival

World Journal of Gastroenterology 2010年第35期16卷 4448-4454页

作者： Kyung-Eun lee Young-Seoub Hong Byoung-Gwon Kim Na-Young Kim kyoung-mu lee Jong-Young Kwak Mee-Sook Roh Department of Clinical Laboratory Science College of Health Sciences Catholic University of Pusan Department of Preventive Medicine Dong-A University College of Medicine Clinical Research Institute Seoul National University College of Medicine Medical Research Center for Cancer Molecular Therapy Dong-A University College of Medicine Department of Pathology Dong-A University College of Medicine

AIM:To analyze the association between the p73 G4C14-to-A4T14 polymorphism(a.k.a.,the GC/AT variation) and colorectal cancer risk and survival in the Korean population,and to evaluate the relationships between p73 polymorphism and the p73 protein expression or clinicopathological characteristics of colorectal ***:Three hundred and eighty-three histologically confirmed cases and 469 healthy controls,recruited at one teaching hospital in Pusan,Korea from 2001 and 2007,were genotyped for p73 G4C14-to-A4T14 by PCR with confronting two-pair primers(PCR-CTPP) and the expression profile of p73 in cancer tissues(n=383) was analyzed by ***:Odds ratios(ORs) and 95% confidence intervals(CIs) were calculated by unconditional logistic regression model adjusted for age and *** with the GC/GC genotypes,the GC/AT and AT/AT genotypes were significantly associated with colorectal cancer risk(GC/AT vs GC/GC:OR = 1.46,95% CI:1.10-1.94;AT/AT vs GC/GC:1.72,0.98-3.03;Ptrend=0.01).When stratified by age and gender,the association was restricted to those less than 60 years of age(GC/AT or AT/AT vs GC/GC:2.22,1.39-3.55) and male(GC/AT or AT/AT vs GC/GC:1.91,1.31-2.77).The expression of p73 was associated with invasion depth(P = 0.003) and advanced Duke's stage(P = 0.06) of colorectal *** patients with the GC/GC genotype were associated with worse survival compared with those with the other genotypes(P = 0.02).However,no signif icant relationship was observed between the p73 G4C14-to-A4T14 polymorphism and p73 protein expression in cancer ***:Our results suggest that the p73 GC/AT polymorphism is associated with an increased colorectal cancer risk and survival in the Korean population.

关键词： p73 G4C14 to A4T14 polymorphism Colorectal cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evolution of nonmetallic inclusions in 80-t 9CrMoCoB large-scale ingots during electroslag remelting process

引用

International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1525-1539页

作者： Shengchao Duan Min Joo lee Yao Su Wangzhong mu Dong Soo Kim Joo Hyun Park School of Mechanical and Materials Engineering North China University of TechnologyBeijing 100144China Department of Materials Science and Chemical Engineering Hanyang UniversityAnsan 15588Rep.of Korea Department of Materials Science and Engineering KTH Royal Institute of TechnologyBrinellvägen 23Stockholm 10044Sweden Department of Engineering Science and Mathematics Division of Materials ScienceLuleåUniversity of Technology97187 LuleåSweden Casting&Forging Business Unit Nuclear Business GroupDoosan EnerbilityChangwon 51711Rep.of Korea

In combination with theoretical calculations,experiments were conducted to investigate the evolution behavior of nonmetallic inclusions(NMIs)during the manufacture of large-scale heat-resistant steel ingots using 9CrMoCoB heat-resistant steel and CaF_(2)–CaO–Al_(2)O_(3)–SiO_(2)–B_(2)O_(3)electroslag remelting(ESR)-type slag in an 80-t industrial ESR *** main types of NMI in the consumable electrode comprised pure alumina,a multiphase oxide consisting of an Al_(2)O_(3)core and liquid CaO–Al_(2)O_(3)–SiO_(2)–MnO shell,and M_(23)C_(6)carbides with an MnS *** Al_(2)O_(3)and MnS inclusions had higher precipitation temperatures than the M_(23)C_(6)-type carbide under equilibrium and nonequilibrium solidification ***,inclusions can act as nucleation sites for carbide layer *** ESR process completely removed the liquid CaO–Al_(2)O_(3)–SiO_(2)–MnO oxide and MnS inclusion with a carbide shell,and only the Al_(2)O_(3)inclusions and Al_(2)O_(3)core with a carbide shell occupied the remelted *** M_(23)C_(6)-type carbides in steel were determined as Cr_(23)C_(6)based on the analysis of transmission electron microscopy *** substitution of Cr with W,Fe,or/and Mo in the Cr_(23)C_(6)lattice caused slight changes in the lattice parameter of the Cr_(23)C_(6)***,Cr_(21.34)Fe_(1.66)C_(6),(Cr_(19)W_(4)C_(6),Cr_(18.4)Mo_(4.6)C_(6),and Cr_(16)Fe_(5)Mo_(2)C_(6)can match the fraction pattern of Cr_(23)C_(6)*** Al_(2)O_(3)inclusions in the remelted ingot formed due to the reduction of CaO,SiO_(2),and MnO components in the liquid *** increased Al content in liquid steel or the higher supersaturation degree of Al_(2)O_(3)precipitation in the remelted ingot than that in the electrode can be attributed to the evaporation of CaF_(2)and the increase in CaO content in the ESR-type slag.

关键词： nonmetallic inclusion heat-resistant steel electroslag remelting M_(23)C_(6) carbide MnS inclusion supersaturation degree

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Splitting of the virtual class for genus one stable quasimaps

引用

Science China Mathematics 2024年

作者： Sanghyeon lee mu-Lin Li Shanghai Center for Mathematical Sciences Fudan University School of Mathematics Hunan University

We analyze the local structure of the moduli space of genus one stable quasimaps. Combining it with the p-fields theory developed by Chang and Li（2020）, we prove the splitting formula for the virtual cycle of stable...

关键词：

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Microstructural evolution in lithium plating process and its effect on the calendar storage life

引用

Nano Research 2024年第10期17卷 8834-8841页

作者： Ki Hwan Koh Dong Ju lee Anthony mu Kangwoon Kim Taehee Kim Zheng Chen Department of Chemical and Nano Engineering University of California San DiegoLa JollaCA 92093USA Program of Materials Science and Engineering University of California San DiegoLa JollaCA 92093USA Sustainable Power and Energy Center University of California San DiegoLa JollaCA 92093USA

The growing demand for electric vehicles highlights the need for energy storage solutions with higher densities,spotlighting Li metal anodes as potential successors to traditional Li-ion batteries(LIBs).Achieving longer calendar aging life for Li metal anodes is crucial for their practical use,given their propensity for corrosion due to a low redox potential,which leads to compromised cycling stability and significant capacity loss during *** research investigated that this susceptibility is mainly dependent on the surface area of Li metal anode and the properties of the solid electrolyte interphase(SEI),particularly its stability and growth *** research adds to this understanding by demonstrating that the amount of Li plating is a key factor in its corrosion during open-circuit storage,as assessed across various *** discovered that increasing the Li plating amount effectively reduces Coulombic efficiency(C.E.)loss during aging,due to a lower surface area-to-Li *** implies that the choice of electrolyte for optimal storage life should consider the amount of Li plating,with higher capacities promoting better storage characteristics.

关键词： lithium metal batteries anode-free batteries calendar life of batteries lithium anode corrosion

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

multistage hydraulic fracturing of a horizontal well for hard roof related coal burst control:Insights from numerical modelling to field application

引用

International Journal of Mining Science and Technology 2024年第8期34卷 1095-1114页

作者： Jiaxin Zhuang Zonglong mu Wu Cai Hu He lee J.Hosking Guojun Xi Biao Jiao Jiangsu Engineering Laboratory of Mine Earthquake Monitoring and Prevention Xuzhou 221116China School of Mines China University of Mining and TechnologyXuzhou 221116China State Key Laboratory for Fine Exploration and Intelligent Development of Coal Resources Xuzhou 221116China School of Resources and Geosciences China University of Mining and TechnologyXuzhou 221116China Department of Civil and Environmental Engineering Brunel University LondonUxbridgeMiddlesex UB83PHUK Shaanxi Binchang Hujiahe Mining Company Limited Xianyang 713602China

multistage hydraulic fracturing of horizontal wells(MFHW)is a promising technology for controlling coal burst caused by thick and hard roofs in ***,challenges remain regarding the MFHW control mechanism of coal burst and assessment of the associated fracturing *** this study,these challenges were investigated through numerical modelling and field applications,based on the actual operating parameters of MFHW for hard roofs in a Chinese coal mine.A damage parameter(D)is proposed to assess the degree of hydraulic fracturing in the *** mechanisms and effects of MFHW for controlling coal burst are analyzed using microseismic(MS)data and front-abutment stress *** show that the degree of fracturing can be categorized into lightly-fractured(D≤0.3),moderately fractured(0.3

关键词： Coal burst multistage hydraulic fracturing of horizontal wells Mining-induced seismicity Mining-induced stress Effectiveness evaluation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Interventional urethral balloon dilatation before endoscopic visual internal urethrotomy for post-traumatic bulbous urethral stricture:A case report

引用

World Journal of Clinical Cases 2022年第34期10卷 12787-12792页

作者： Ji Yong Ha mu Sook lee Department of Urology Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea Department of Radiology Keimyung University Dongsan HospitalKeimyung University School of MedicineDaegu 42601South Korea

BACKGROUND While several treatment options are available for pediatric urethral strictures,the appropriate treatment must be based on several *** endoscopic visual internal urethrotomy(EVIU)could be a first-line treatment option for short pediatric urethral strictures,it is not feasible if the urethroscope cannot pass through the stricture ***,we present a pediatric case of severe posttraumatic bulbous urethral stricture that was successfully treated by EVIU after securing the urethral route via interventional balloon *** SUMMARY A 12-year-old boy presented at our outpatient clinic with the inability to *** had sustained a straddle injury three months *** post-void residual urine volume was 644 mL,and retrograde urethrography confirmed severe stricture of the bulbous *** was planned;however,the first attempt to treat the stricture failed because the urethroscope could not pass through the stricture *** urethral route was subsequently secured via balloon dilatation of the stricture,which was performed in collaboration with specialists from the department of interventional *** urethroscope was then able to pass,and the repeat EVIU was *** Interventional urethral balloon dilatation before EVIU may help secure the urethral route in the treatment of pediatric urethral strictures.

关键词： Urethral stricture Endoscopic visual internal urethrotomy Urethroplasty Urethral balloon dilatation Interventional radiology Case report

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Control of petroleum-hydrocarbon contaminated groundwater by intrinsic and enhanced bioremediation

引用

Journal of Environmental Sciences 2010年第6期22卷 864-871页

作者： Chih-Ming Kao Rao Y.Surampalli mu-Sheng lee Institute of Environmental Engineering "National" Sun Yat-Sen University U.S.Environmental Protection Agency Environmental Protection Bureau Kaohsiung City Government

In the first phase of this study, the effectiveness of intrinsic bioremediation on the containment of petroleum hydrocarbons was evaluated at a gasoline spill site. Evidences of the occurrence of intrinsic bioremediation within the BTEX （benzene, toluene, ethylbenzene, and xylenes） plume included （1） decreased BTEX concentrations; （2） depletion of dissolved oxygen （DO）, nitrate, and sulfate; （3） production of dissolved ferrous iron, methane, and CO2; （4） deceased pH and redox potential; and （5） increased methanogens, total heterotrophs, and total anaerobes, especially within the highly contaminated areas. In the second phase of this study, enhanced aerobic bioremediation process was applied at site to enhance the BTEX decay rates. Air was injected into the subsurface near the mid-plume area to biostimulate the naturally occurring microorganisms for BTEX biodegradation. Field results showed that enhanced bioremediation process caused the change of BTEX removal mechanisms from anaerobic biodegradation inside the plume to aerobic biodegradation. This variation could be confirmed by the following field observations inside the plume due to the enhanced aerobic bioremediation process：（1） increased in DO, CO2, redox potential, nitrate, and sulfate, （2） decreased in dissolved ferrous iron, sulfide, and methane, （3） increased total heterotrophs and decreased total anaerobes. Field results also showed that the percentage of total BTEX removal increased from 92% to 99%, and the calculated total BTEX first-order natural attenuation rates increased from 0.0092% to 0.0188% per day, respectively, after the application of enhanced bioremediation system from the spill area to the downgradient area （located approximately 300 m from the source area）.

关键词： petroleum hydrocarbon groundwater natural attenuation intrinsic bioremediation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Superior antibody and membrane protein‑specific T‑cell responses to CoronaVac by intradermal versus intramuscular routes in adolescents

引用

World Journal of Pediatrics 2024年第4期20卷 353-370页

作者： Jaime S.Rosa Duque Samuel M.S.Cheng Carolyn A.Cohen Daniel Leung Xiwei Wang Xiaofeng mu Yuet Chung Tsun Ming Lau Manni Wang Wenyue Zhang Yanmei Zhang Howard H.W.Wong Leo C.H.Tsang Sara Chaothai Tsz Chun Kwan John K.C.Li Karl C.K.Chan Leo L.H.Luk Jenson C.H.Ho Wing Yan Li Amos M.T.lee Jennifer H.Y.Lam Sau Man Chan Wilfred H.S.Wong Issan Y.S.Tam Masashi Mori Sophie A.Valkenburg Malik Peiris Wenwei Tu Yu Lung Lau Department of Paediatrics and Adolescent Medicine The University of Hong KongHong KongChina School of Public Health The University of Hong KongHong KongChina HKU‑Pasteur Research Pole School of Public HealthThe University of Hong KongHong KongChina Research Institute for Bioresources and Biotechnology Ishikawa Prefectural UniversityNonoichiJapan Department of Microbiology and Immunology Peter Doherty Institute for Infectionand ImmunityUniversity of MelbourneMelbourneVICAustralia Center for Immunology and Infection C2i Hong KongChina

Background Optimising the immunogenicity of COVID-19 vaccines to improve their protection against disease is *** dosing by intradermal(ID)administration has been shown to be equally immunogenic as intramuscular(IM)administration for several vaccines,but the immunogenicity of ID inactivated whole severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)at the full dose is *** study(NCT04800133)investigated the superiority of antibody and T-cell responses of full-dose CoronaVac by ID over IM administration in *** Participants aged 11–17 years received two doses of IM or ID vaccine,followed by the 3rd dose 13–42 days *** and cellular immunogenicity outcomes were measured post-dose 2(IM-CC versus ID-CC)and post-dose 3(IMCCC versus ID-CCC).Doses 2 and 3 were administered to 173 and 104 adolescents,*** Spike protein(S)immunoglobulin G(IgG),S-receptor-binding domain(RBD)IgG,S IgG Fcγreceptor IIIa(FcγRIIIa)-binding,SNM[sum of individual(S),nucleocapsid protein(N),and membrane protein(M)peptide pool]-specific interleukin-2(IL-2)+CD4^(+),SNM-specific IL-2^(+)CD8^(+),S-specific IL-2^(+)CD8^(+),N-specific IL-2^(+)CD4^(+),N-specific IL-2^(+)CD8^(+)and M-specific IL-2^(+)CD4^(+)responses fulfilled the superior and non-inferior criteria for ID-CC compared to IM-CC,whereas IgG avidity was *** ID-CCC,S-RBD IgG,surrogate virus neutralisation test,90%plaque reduction neutralisation titre(PRNT90),PRNT50,S IgG avidity,S IgG FcγRIIIa-binding,M-specific IL-2^(+)CD4^(+),interferon-γ+CD8^(+)and IL-2^(+)CD8^(+)responses were superior and non-inferior to *** estimated vaccine efficacies were 49%,52%,66%and 79%for IM-CC,ID-CC,IM-CCC and ID-CCC,*** ID groups reported more local,mild adverse *** This is the first study to demonstrate superior antibody and M-specific T-cell responses by ID inactivated SARSCoV-2 vaccination and serves as the basis for future research to improve the

关键词： CoronaVac Coronavirus disease 2019 Immunity Intradermal Vaccine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Loss-induced phase transition in mid-infrared plasmonic metamaterials for ultrasensitive vibrational spectroscopy

引用

InfoMat 2022年第12期4卷 85-102页

作者： Hong Zhou Dongxiao Li Zhihao Ren Xiaojing mu Chengkuo lee Department of Electrical and Computer Engineering National University of SingaporeSingaporeSingapore Key Laboratory of Optoelectronic Technology&Systems of Ministry of Education International R&D center of Micro-nano Systems and New Materials TechnologyChongqing UniversityChongqingPeople's Republic of China Center for Intelligent Sensors and MEMS(CISM) National University of SingaporeSingaporeSingapore National University of Singapore Suzhou Research Institute(NUSRI) SuzhouPeople's Republic of China NUS Graduate School—Integrative Sciences and Engineering Programme(ISEP) National University of SingaporeSingaporeSingapore

Metamaterials have proven their ability to possess extraordinary physical properties distinct from naturally available materials,leading to exciting sensing functionalities and ***,metamaterial-based sensing applications suffer from severe performance limitations due to noise interference and design ***,we propose a dual-phase strategy that leverages loss-induced different Fano-resonant phases to access both destructive and constructive signals of molecular *** the two reverse signals are innovatively combined,the noise in the detection system is effectively suppressed,thereby breaking through the noise-related ***,by utilizing loss optimization of the plasmon-molecule coupling system,our dual-phase strategy enhances the efficiency of infrared energy transfer into the molecule without any additional fabrication complex,thereby overcoming the trade-off dilemma between performance and fabrication *** to the pioneering breakthroughs in the limitations,our dual-phase strategy possesses an overwhelming competitive advantage in ultrasensitive vibrational spectroscopy over traditional metamaterial technology,including strong signal strength(×4),high sensitivity(×4.2),effective noise suppression(30%),low detection limit(13 ppm),and excellent selectivity among CO_(2),NH_(3),and CH_(4) *** work not only opens the door to various emerging ultrasensitive detection applications,including ultrasensitive in-breath diagnostics and high-information analysis of molecular information in dynamic reactions,but also gains new insights into the plasmon-molecule interactions in advanced metamaterials.

关键词： Fano resonance IR vibrational spectroscopy metamaterials phase transition ultrasensitive sensing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Endoscopic salvage therapy after failed biliary cannulation using advanced techniques:A concise review

引用

World Journal of Gastroenterology 2022年第29期28卷 3803-3813页

作者： Yung-Kuan Tsou Kuang-Tse Pan mu Hsien lee Cheng-Hui Lin Department of Gastroenterology and Hepatology Chang Gung Memorial HospitalTaoyuan 333Taiwan Department of Medicine Chang Gung UniversityTaoyuan 333Taiwan Department of Medical Imaging and Intervention Chang Gung Memorial HospitalTaoyuan 333Taiwan

Therapeutic endoscopic retrograde cholangiopancreatography(ERCP)begins with successful biliary ***,it is not always be *** failure of the initial ERCP is attributed to two main aspects:the papilla/biliary orifice is endoscopically accessible,or it is *** the papilla/biliary orifice is accessible,bile duct cannulation failure can occur even with advanced cannulation techniques,including double guidewire techniques,transpancreatic sphincterotomy,needle-knife precut papillotomy,or *** is currently no consensus on the next steps of treatment in this ***,this review aims to propose and discuss potential endoscopic options for patients who have failed ERCP due to difficult bile duct *** options include interval ERCP,percutaneous-transhepatic-endoscopic rendezvous procedures(PTE-RV),and endoscopic ultrasound-assisted rendezvous procedures(EUS-RV).The overall success rate for interval ERCP was 76.3%(68%-79% between studies),and the overall adverse event rate was 7.5%(0-15.9% between studies).The overall success rate for PTE-RV was 88.7%(80.4%-100%between studies),and the overall adverse event rate was 13.2%(4.9%-19.2% between studies).For EUS-RV,the overall success rate was 82%-86.1%,and the overall adverse event rate was 13%-15.6%.Because interval ERCP has an acceptably high success rate and lower adverse event rate and does not require additional expertise,facilities,or other specialists,it can be considered the first choice for salvage ***-RV can also be considered if local experts are *** patients in urgent need of biliary drainage,PTE-RV should be considered.

关键词： Difficult biliary cannulation Endoscopic ultrasound Rendezvous Endoscopic retrograde cholangiopancreatography Percutaneous transhepatic biliary drainage Interval

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：