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Biomarker bust:meta-analyses reveal unreliability of neuronal extracellular vesicles for diagnosing parkinsonian disorders

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Neural Regeneration Research 2025年第1期20卷 201-202页

作者： Hash brown Taha Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCAUSA

A range of neurodegenerative disorders,collectively termed parkinsonian disorders,present with a complex array of both motor and non-motor *** in this group are Parkinson’s disease(PD),dementia with Lewy bodies(DLB),multiple system atrophy(MSA),corticobasal syndrome(CBS),and progressive supranuclear palsy(PSP).These disorders are differentiated neuropathologically by their dominant protein pathologies involvingα-synuclein(α-syn)and/or tau,the types of brain cells affected,such as neurons,oligodendroglia,and astrocytes,and the specific brain regions involved(Tolosa et al.,2021).

关键词： disorders parkin

Immunoassay development guidelines for neurodegenerative disorders:lessons from a failed pS129-α-synuclein electrochemiluminescence immunoassay

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Neural Regeneration Research 2025年第10期20卷 2906-2908页

作者： Hash brown Taha Alanna Morris Leonard Davis School of Gerontology University of Southern CaliforniaLos AngelesCAUSA Deparmtent of Neurobiology David Geffen School of MedicineUniversity of California Los AngelesLos AngelesCAUSA

An aging population is a double-edged *** one hand,advancements in biotechnology and healthcare allow more people to enjoy longer *** the other hand,increases in the aging population accompany a surge in age-associated diseases,particularly neurodegenerative *** aging is the primary risk factor for many neurodegenerative disorders,living longer does not necessarily equate to maintaining a reasonable quality of life(Feigin et al.,2020).

关键词： aging degenerative necessarily

Projective Hilbert modules and sequential approximations

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Science China Mathematics 2025年第1期 137-168页

作者： Lawrence G.brown Huaxin Lin Department of Mathematics Purdue University Department of Mathematics East China Normal University Department of Mathematics University of Oregon Shanghai Institute for Mathematics and Interdisciplinary Sciences

We show that when A is a separable C*-algebra,every countably generated Hilbert A-module is projective（with bounded module maps as morphisms）.We also study the approximate extensions of bounded module *** the case where A is a σ-unital simple C*-algebra with strict comparison,and every strictly positive lower semicontinuous affine function on quasitraces can be realized as the rank of an element in the Cuntz semigroup,we show that the Cuntz semigroup is equivalent to unitarily equivalent classes of countably generated Hilbert A-modules if and only if A has stable rank one.

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Gene therapy for spinal muscular atrophy:perspectives on the possibility of optimizing SMN1 delivery to correct all neurological and systemic perturbations

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Neural Regeneration Research 2025年第7期20卷 2011-2012页

作者： Sharon J.brown Rafael J.Yáñez-Muñoz Heidi R.Fuller School of Pharmacy and Bioengineering Keele UniversityKeeleUK Wolfson Center for Inherited Neuromuscular Disease TORCH BuildingRJAH Orthopaedic HospitalOswestryUK *** Center of Gene and Cell TherapyDepartment of Biological SciencesSchool of Life Sciences and the EnvironmentRoyal Holloway University of LondonEghamUK

Spinal muscular atrophy(SMA)is a genetic condition that results in selective lower motor neuron loss with concomitant muscle weakness and *** genetic cause of SMA was understood in 1995 when loss or impairment of the survival motor neuron 1(SMN1)gene was identified as the main contributing factor(Lefebvre et al.,1995).This,in combination with the discovery that humans have a“back-up”gene,SMN2,which can produce low levels(approximately 10%)of the full-length functional SMN protein,has led to the generation of SMA-specific gene *** was traditionally classified according to age of symptom onset and developmental milestones achieved,with life expectancy and severity varying between ***,SMN2 copy number is used as a proxy for the prediction of disease severity,with higher SMN2 copy number typically being associated with reduced severity of SMA,although this relationship is not absolute:some individuals with low SMN2 copy number have less severe SMA phenotypes and vice ***,the etiology of SMA is further complicated by other factors,such as non-typical nucleotide variants and SMN2-independent modifiers of disease severity.

关键词： atrophy traditionally absolute

Clinical Factors Associated with Hepatocellular Iron Deposition in end-stage Liver Disease

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Journal of Clinical and Translational Hepatology 2020年第3期8卷 231-239页

作者： Amelia Fierro-Fine Leana Guerin Hasan Hicsasmaz kyle.e.brown Department of Pathology University of Iowa Roy J.and Lucille A.Carver College of MedicineIowa CityIAUSA ObjectRelational LLP Iowa CityIAUSA Division of Gastroenterology-Hepatology University of Iowa Roy J.and Lucille A.Carver College of MedicineIowa CityIAUSA Program in Free Radical and Radiation Biology University of Iowa Roy J.and Lucille A.Carver College of MedicineIowa CityIAUSA Iowa City Veterans Administration Medical Center Iowa CityIAUSA

Background and Aims: Hepatocellular iron accumulation in patients with chronic liver disease has been linked to adverse outcomes. The objective of this study was to identify clinical factors associated with hemosiderosis. Methods: A total of 103 consecutive liver transplant recipients were identified, in whom liver biopsy had been performed prior to transplantation. Laboratory and clinical data at biopsy and transplant were abstracted from the medical records and hepatocyte iron was graded in the biopsy and explant. The association of change in iron score from biopsy to transplant, with the time interval between these two events, was examined using linear mixed model analysis for repeated measures. Results: Most subjects had advanced fibrosis (F3-F4) at liver biopsy, which was performed on average about 2.5 years before transplant. Over 80% of patients had no or 1+ hepatocyte iron at biopsy;iron increased between biopsy and transplant in about 40%. The only demographic or clinical feature that correlated with increased iron was the presence of a transjugular intrahepatic portosystemic shunt. Increased iron at transplant was associated with higher serum iron and transferrin saturation at biopsy, and with lower hemoglobin level, greater mean corpuscular volume, mean corpuscular hemoglobin and mean corpuscular hemoglobin concentration, higher ferritin and model for end-stage liver disease score at ***: The development of hemosiderosis in end-stage liver disease is associated with lower hemoglobin levels and alterations in red blood cell indices that are suggestive of hemolysis. These observations suggest that extravascular hemolysis may play a role in the development of secondary iron overload.

关键词： erythrocyte indices end-stage liver disease Hemolysis Hemosiderosis Humans Iron

Reducing risks in the investigation, design and construction of large concrete dams

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Journal of Rock Mechanics and Geotechnical engineering 2017年第2期9卷 197-209页

作者： e.T.brown Golder Associates Pty. Ltd. BrisbaneAustralia

An overview of the GeoSafe 2016 Symposium topic is provided using the example of large concrete dams for purposes of *** is essential that the risks associated with large dams be evaluated rigorously and managed proactively at all stages of their lives so that the risk of failure remains As Low As Reasonably Practicable(ALARP).Rock engineering features of large concrete dams that require particular attention,assessment and monitoring during the investigation,design,construction,initial filling,inservice operation,and subsequent repair and upgrade stages of the lives of concrete dams are identified and illustrated by examples from recorded experiences.A number of major concrete dam failures,including that of the *** dam,California,U.S.A.,in 1928,have led to significant developments in rock mechanics and rock engineering knowledge and techniques,as well as in dam design and review *** recent advances include a range of analytical,numerical modelling,probabilistic,reliability,failure mode and risk assessment approaches.

关键词： Concrete dam failure Dam engineering Risk assessment Rock engineering design Site investigation

The Hoeke-brown failure criterion and GSI-2018 edition

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Journal of Rock Mechanics and Geotechnical engineering 2019年第3期11卷 445-463页

作者： e.Hoek e.T.brown North Vancouver British ColumbiaV7R 4H7Canada Brisbane Queensland 4169Australia

The Hoekebrown criterion was introduced in 1980 to provide input for the design of underground excavations in *** criterion now incorporates both intact rock and discontinuities,such as joints,characterized by the geological strength index(GSI),into a system designed to estimate the mechanical behaviour of typical rock masses encountered in tunnels,slopes and *** strength and deformation properties of intact rock,derived from laboratory tests,are reduced based on the properties of discontinuities in the rock *** nonlinear Hoekebrown criterion for rock masses is widely accepted and has been applied in many projects around the ***,in general,it has been found to provide satisfactory estimates,there are several questions on the limits of its applicability and on the inaccuracies related to the quality of the input *** paper introduces relatively few fundamental changes,but it does discuss many of the issues of utilization and presents case histories to demonstrate practical applications of the criterion and the GSI system.

关键词： Hoek-brown criterion Geological strength index(GSI) Rock mass strength Uniaxial compressive strength(UCS) Tension cut-off Rock mass deformation modulus

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editorial

Journal of Rock Mechanics and Geotechnical engineering 2017年第2期9卷 195-196页

作者： e.T. brown Golder Associates Pty. Ltd. P.O. Box 1734 Milton QLD 4064 Australia

The Aims and Scope of the Journal of Rock Mechanics and Geotechnical engineering(JRMGe)indicate that it"is concerned with the latest research achievements in rock mechanics and geotechnical engineering The topics covered by the JRMGe include new theories,new technologies,new methods and experiences,in-situ and laboratory tests,new developments,case studies and timely reviews on selected subjects in rock mechanics and geotechnical engineering."

关键词： AIMS SCOPe MeCHANICS

Back Analysis in Rock engineering

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Journal of Rock Mechanics and Geotechnical engineering 2018年第3期10卷 611-612页

作者： e.T.brown Golder Associates Pty Ltd

This volume is the fourth in the International Society for Rock Mechanics and Rock engineering(ISRM)Book Series,edited by Professor Xia-Ting Feng,ISRM Past-President and Vice editor-in-Chief of this *** author,Professor Shunsuke Sakurai,of Kobe University,Japan,has also had a long and distinguished association with the ISRM,having served as the Society’s ninth President in the

关键词： In Back Analysis in Rock engineering