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Clinical outcomes and predictive factors in oral corticosteroid-refractory active ulcerative colitis

World Journal of Gastroenterology 2013年第2期19卷 265-273页

作者： Han Ho Jeon Hyun jung Lee Hui Won Jang Jin Young Yoon Yoon Suk jung Soo jung Park Sung Pil Hong Tae Il Kim Won Ho Kim Jae Hee cheon Department of Internal Medicine Institute of GastroenterologyYonsei University College of MedicineSeoul 120-752South Korea Brain Korea 21 Project for Medical Science Yonsei University College of MedicineSeoul 120-752South Korea

AIM:To evaluate the clinical outcomes and prognostic factors after intravenous corticosteroids following oral corticosteroid failure in active ulcerative colitis ***:Consecutive patients with moderate to severe ulcerative colitis who had been treated with a course of intravenous corticosteroids after oral corticosteroid therapy failure between January 1996 and July 2010 were recruited at Severance Hospital,Seoul,South *** disease activity was measured by the Mayo score,which consists of stool frequency,rectal bleeding,mucosal appearance at flexible sigmoidoscopy,and Physician Global *** retrospectively evaluated clinical outcomes at two weeks,one month,three months,and one year after the initiation of intravenous corticosteroid *** weeks outcomes were classified as responders or *** month,three month and one year outcomes were classified into prolonged response,steroid dependency,and ***:Our study included a total of 67 eligible *** two weeks,56(83.6%) patients responded to intravenous *** one month,complete remission was documented in 18(32.1%) patients and partial remission in 26(46.4%).Eleven patients(19.7%) were refractory to the *** three months and one year,we found 37(67.3%) and 25(46.3%) patients in prolonged response,ten(18.2%) and 23(42.6%) patients in corticosteroid dependency,8(14.5%) and 6(11.1%) patients with no response,*** 9 patients were underwent elective proctocolectomy within 1 *** duration of oral corticosteroid therapy(> 14 d vs ≤ 14 d,P = 0.049) and lower hemoglobin level(≤ 11.0 mg/dL vs >11.0 mg/dL,P = 0.02) were found to be poor prognostic factors for response at two *** one year outcome,univariate analysis revealed that only a partial Mayo score(≥ 6 vs <6,P = 0.057) was found to be associated with a poor ***:The duration of oral corticosteroid therapy and lower hemoglobin level were strongly associ

关键词： Clinical outcome Prognosis Corticosteroid Ulcerative colitis

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Soybean isoflavones alter parvalbumin in hippocampus of mid-aged normal female,ovariectomized female,and normal male rats

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Acta Pharmacologica Sinica 2006年第1期27卷 59-65页

作者： In Koo HWANG Yoon-bok LEE Ki-yeon YOO Tae-cheon KANG Soon Sung LIM Sang Moo KIM Heon-soo SOHN Woo-jung KIM Hyun Kyung SHIN Moo Ho WON Department of Anatomy College of MedicineHallym UniversityChunchon 200-702Korea Department of Laboratory Animal Research.Central Research Institute Dr Chung's Food Co Ltd.Cheongju 361-782Korea Division of Life Science and Silver Biotechnology Research Center Korea Faculty of Marine Bioseience and Technology.Kangneung National University Kangneung 210-702Korea Faculty of Food Science and Technology College of Life SciencesSejong UniversitySejong 143-747Korea

Aim:To investigate the long-term effect of soybean isoflavones on changes inparvalbumin (PV) immunoreactivity in the hippocampus in normal female,ovariec-tomized (OVX) female and normal male ***:Ten-month-old rats wereassigned to one of 9 groups (n=7 in each group) based on body weight using arandomized complete-block *** groups were:control diet-treated females,OVX females,and males;0.3g/kg isoflavone-treated females,OVX females,andmales;and 1.2g/kg isoflavone-treated females,OVX females,and *** PVimmunostaining was conducted by using the standard avidin-biotin ***:PV immunoreactivity and the number of PV-immunoreactiveneurons in all the groups after isoflavone treatment were significantly changed inthe hippocampal CA1 region and in the dentate gyrus,but not in the hippocampalCA2/3 *** immunoreactivity and the number of PV-immunoreactive neu-rons in the control diet OVX females were similar to those in the control diet,andwere greater than those in the control diet normal *** immunoreactivityand the number of PV-immunoreactive neurons in all the isoflavone-treated groupsdecreased dose-dependently after isoflavone ***:Long-termadministration of isoflavones may induce a reduction of PV in interneurons in thehippocampal CA1 region and in the dentate *** reduction of PV in theseregions suggests that the long-term administration of isoflavones may cause achange in calcium homeostasis in the hippocampal CA1 region and in the dentategyrus.

关键词： isoflavones ovariectomy hippocampus immunohistochemistry

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Macrophage PD-L1 strikes back: PD-1/PD-L1 interaction drives macrophages toward regulatory subsets

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Advances in Bioscience and Biotechnology 2013年第8期4卷 19-29页

作者： Yun-jung Lee Young-Hye Moon kyeong Eun Hyung Jong-Sun Yoo Mi Ji Lee Ik Hee Lee Byung Sung Go Kwang Woo Hwang Laboratory of Host Defense Modulation College of Pharmacy Chung-Ang University Seoul Korea

Activated macrophages have been simply de?ned as cells that secrete in?ammatory mediators and kill intracellular pathogens until few years ago. Recent studies have proposed a new classification system to separate activated macrophages based on their functional phenotypes: host defense, wound healing, and immune regulation. Regulatory macrophages can arise following innate or adaptive immune responses and hinder macrophage-mediated host defense and inflammatory functions by inhibiting the production of pro-inflammatory mediators. In this study, we investigated whether PD-1 and PD-L1 interaction between macrophages and T cells alters macrophage activities. Our data provide evidence for PD-1/PD-L1 engagement inducing a regulatory profile in macrophages. Regulatory macrophages derived from PD-L1 signaling lost their host defense activity, which consists of the production of pro-inflammatory cytokine IL-6 and the exhibition of increased IL-10, SPHK1 and LIGHT gene levels in early phases of LPS stimulation. This differentiation seems to occur through excessive activation of TLR4 downstream MAPK signaling pathways. Regulatory macrophages induced from PD-1/PD-L1 interaction decrease inflammatory mediators and produce anti-inflammatory cytokines, so this macrophage subset has been under considerable attention as a possible immune regulation mechanism. Understanding and modulating regulatory macrophages may lead to new approches to treat or prevent auto-immune diseases such as type I diabetes, rheumatic syndrome and hypersensitivity-related diseases, which are concerned with the overproduction of inflammatory cytokines in macroages.

关键词： Regulatory Macrophage PD-1 PD-L1

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Chemical characterization of rainwater over Suwon region during farming and non-farming periods

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Journal of Agricultural Chemistry and Environment 2013年第1期2卷 1-7页

作者： Min-kyeong Kim Jong-Sik Lee Goo-Bok jung Byong-Gu Ko Soon-Ik Kwon Min-Young Kim Kyu-Ho So Sun-Gang Yun Department of Agricultural Environment National Academy of Agricultural Science Rural Development Administration (RDA) Suwon Republic of Korea Dresearch Planning Division Rural Development Administration Suwon Republic of Korea

Recently, special attention has been givento acid rain and its problem to environment such as acid precipitation and air pollution in East *** the present study, rainwater samples werecollected from Apr to Oct (farming period) and from Nov to Mar (non-farming period) in 2009 ~ 2011. The samples were chemically characterized for the assessment of emission sources. Suwon region, a typical agricultural area in Gyeonggi province (South Korea) was chosen as a study site. The content of ionic species and theirtemporal variation were used forfactor analysis, which was used to presume the natural and anthropogenic sources depending upon the farming and non-farming periods. The cationsobserved during farming and non-farming periods were?> Na+> Ca2+> K+> H+> Mg2+and Na+> N?>Ca2+> H+= Mg2+> K+, respectively. The anions during farming and non-farming periods were?>?> Cl- and?>?> Cl-, respectively. While the amounts of sulfate, one of the major dissolved components of rainwater were 113.5 and 177.0 ueq.L-1, the ones of NSS-?(Non-Sea Salt sulfate) were 93.7 and 87.1% during farming and non-farming periods, respectively. The comparison of observed pH values (pHobs) with the theoretical pH values (pHthe) showed that the neutralization of rainwater considerably went along during farming and non-farming periods. The highest amountof rainfall throughout the year was310.5 mmin August and its corre sponding nitrogen loading was5.03 kg·ha-1. The major ion contents for crop growth, , Ca2+, K+, Mg2+, were 49.4, 5.5, 18.1,1.4 kg·ha-1from April to October. The major contributions to the existing chemical ions in rainwaters during farming and non-farming periods were from the natural sources (sea and soil) and the anthropogenic sources (human and animal waste, vehicular emission + fossil fuels combustion), respectively.

关键词： Acidity Discharge Nutrient Rainwater

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比较3种加工方法及组成不同的人工移植材料的体内研究

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中国口腔医学继续教育杂志 2017年第6期20卷 316-321页

作者： Hyun-Chang Lim kyeong-Taek Kim jung-Seok Lee Ui-Won jung Seong-Ho Choi 黎艳珊滕伟不详中山大学光华口腔医学院·附属口腔医院广东省广州市越秀区陵园西路56号中山大学附属口腔医院510000

研究目的：本次研究旨在比较加工方法及组成不同的双磷酸钙（biphasic calcium phosphates,BCP）的骨引导的能力和骨愈合的模式。材料和方法：10只雄性新西兰白兔，每只兔子颅顶有4个8mm环形缺损．每个缺损代表一个组别：对照组．实验组... 详细信息

研究目的：本次研究旨在比较加工方法及组成不同的双磷酸钙（biphasic calcium phosphates,BCP）的骨引导的能力和骨愈合的模式。材料和方法：10只雄性新西兰白兔，每只兔子颅顶有4个8mm环形缺损．每个缺损代表一个组别：对照组．实验组：BCP1．70％HA（羟基磷灰石）．30％β-TCP（β-三磷酸钙）：BCP2，30％HA，70％p-TCP；BCP3，20％HA．80％D-TCP。兔子在第2周（n=5）或第8周（n=5）在处死后进行组织学及组织计量学分析。结果：在双磷酸钙（BCP）组的骨增量远大于对照组（P〈005）。第2周或第8周新骨形成量无明显差异。在第2周，BCP3组的双磷酸钙的吸收作用远大于BCP1和BCP2组．然而在第8周．BCP2和BCP3的这种差别变得不明显。BCP组问新骨形成的模式和材料的吸收有明显差异。在BCP1组中．新骨在剩余颗粒中呈线性排列，在BCP2组中，可观察到丝状伪足状新骨形成;在BCP3组中．可见分散在剩余颗粒中的胶原蛋白片段及颗粒表面的裂隙状不规则新骨形成。结论：在本研究中．特定的HA、β-TCP比例对新骨形成和空间的保持无明显影响。而组间观察到的骨愈合模式的差别可归因于加工方法不同所导致的双磷酸钙（BCPs）的物理化学属性的差异。

关键词：骨再生骨替代物双磷酸钙

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Risk factor for ischemic-type biliary lesion after ABO-incompatible living donor liver transplantation

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World Journal of Gastroenterology 2016年第30期22卷 6925-6935页

作者： Jun Bae Bang Bong-Wan Kim Young Bae Kim Hee-jung Wang Hyun Yeong Lee Joohyun Sim Taegyu Kim kyeong Lok Lee Xu-Guang Hu Wei Mao Department of Liver Transplantation and Hepatobiliary Surgery Ajou University School of Medicine Department of Pathology Ajou University School of Medicine Department of Biostatistics Ajou University School of Medicine

AIM: To evaluate the risk factors for ischemic-type biliary lesion(ITBL) after ABO-incompatible(ABO-I) adult living donor liver transplantation(ALDLT).METHODS: Among 141 ALDLTs performed in our hospital between 2008 and 2014, 27(19%) were ABO-I ALDLT and 114 were ABO-identical/compatible ALDLT. In this study, we extensively analyzed the clinico-pathological data of the 27 ABO-I recipients to determine the risk factors for ITBL after ABO-I ALDLT. All ABO-I ALDLT recipients underwent an identical B-cell depletion protocol with preoperative rituximab, plasma exchange(PE), and operative splenectomy. The median follow-up period after transplantation was 26 mo. The clinical outcomes of the 27 ABO-I ALDLT recipients were compared with those of 114 ABO-identical/compatible ALDLT ***: ITBL occurred in four recipients(14.8%) between 45 and 112 d after ABO-I ALDLT. The overall survival rates were not different between ABO-I ALDLT and ABO-identical/compatible ALDLT(P = 0.303). Among the ABO-I ALDLT recipients, there was no difference between patients with ITBL and those without ITBL in terms of B-cell and T-cell count, serum isoagglutinin titers, number of PEs, operative time and transfusion, use of graft infusion therapy, or number of remnant B-cell follicles and plasma cells in the spleen. However, the perioperative NK cell counts in the blood of patients with ITBL were significantly higher than those in the patients without ITBL(P 150/μL and postoperative NK cell count > 120/μL were associated with greater relative risks(RR) for development of ITBL(RR = 20 and 14.3, respectively, P < 0.05). CONCLUSION: High NK cell counts in a transplant recipient's blood are associated with ITBL after ABO-I ALDLT. Further research is needed to elucidate the molecular mechanism of NK cell involvement in the development of ITBL.

关键词： Liver transplantation ABO-incompatibility Ischemic-type biliary lesion Natural killer cell

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Neuroprotective effects of roasted licorice,not raw form,on neuronal injury in gerbil hippocampus after transient forebrain ischemia

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Acta Pharmacologica Sinica 2006年第8期27卷 959-965页

作者： In-koo HWANG Soon-sung LIM Kyu-hyun CHOI Ki-yeon YOO Hyun-kyung SHIN Eun-ji KIM jung-han YOONPARK Tae-cheon KANG Young-sup KIM Dae-young KWON Dong-woo KIM Won-kook MOON Moo-ho WON Korea Central Research Institute.Natural F&P Co Ltd Chunchon 200-160Korea Silver Biotechnology Research Center Korea Silver Biotechnology Research Center Department of Food Science and Nutrition Hallym UniversityChunchon 200-702Korea Medical Science Division Korea Research Institute of Chemical TechnologyYuseong.Daejeon 305-343Korea Korea Central Research Institute.Natural F&P Co Ltd Chunchon 200-160Korea Korea Silver Biotechnology Research Center

Aim:To observe neuroprotective effects of raw and roasted licorice against hy-poxia and ischemic ***:When elucidating the protective effects ofraw and roasted licorice,we analyzed the lactate dehydrogenase (LDH) releaseusing PC12 cells after hypoxia in an in vitro study and after transient forebrainischemia in an in vivo study on Mongolian ***:Raw and roastedlicorice significantly reduced LDH release from PC12 cells exposed to an hypoxicchamber for *** the roasted licorice-treated group,the decrease of LDH releasewas more pronounced compared to that of the raw licorice-treated *** licorice-treated animals,approximately 66%-71% of CA1 pyramidal cellsin the ischemic hippocampus were stained with cresyl violet compared to thecontrol ***,in the raw licorice-treated animals,no significantneuroprotection against ischemic damage was *** addition,ischemic ani-mals in roasted licorice-treated group maintained the Cu,Zn-superoxide dismutase(SOD1) activity and protein levels compared to the control group,while in rawlicorice-treated group SOD1 activity and protein levels were reduced *** pressure liquid chromatography analysis showed that non-polar compoundscontaining glycyrrhizin-degraded products,such as glycyrrhetinic acid (GA) andglycyrrhetinic acid monoglucuronide (GM),were increased in roasted ***:Roasted licorice had neuroprotective effects against ischemic dam-age by maintaining the SOD1 *** addition,the difference in protectiveability between raw and roasted licorice may be associated with non-polarcompounds,such as GA and GM.

关键词： transient ischemic attack roasted licorice raw licorice neurons PC12 cells hippocampus pyramidal cells Gerbillinae superoxide dismutase

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Heavy metal chemistry in soils received long-term application of organic wastes

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Journal of Agricultural Chemistry and Environment 2012年第1期1卷 1-9页

作者： Soon-Ik Kwon Yeon-Ah Jang Kye-Hoon Kim Goo-Bok jung Min-kyeong Kim Hae Hwang Mi-Jin Chae Seung-Chang Hong Kyu-Ho So Sun-Gang Yun Kwon-Rae Kim Gyeongnam National University of Science and Technology Jinju South Korea National Academy of Agricultural Science (NAAS) RDA Suwon South Korea The University of Seoul Seoul South Korea

This study was carried out to understand the long-term effect of organic waste treatment on the fate of heavy metals originated from the organic wastes, together with examination of changes in soil properties. For this, the soils received three different organic wastes (municipal sewage sludge, alcohol fermentation processing sludge, pig manure compost) in three different rates (12.5, 25, 50 ton/ha/yr) for 7 years (1994 - 2000) were used. To see the long-term effect, plant growth study and soil examination were conducted twice in 2000 and 2010, respectively. There was no additional treatment of organic wastes for post ten years after ceasing organic waste treatment for seven years. Soil examination conducted in 2010 showed decreases in soil pH, EC, total nitrogen, organic matter, available phosphorus, exchangeable cations and heavy metal contents in all soils received organic wastes compared to the results obtained in 2000. Speciation of heavy metals in soil through sequential extraction showed that organically bound Cu was the dominant species in all treatment and exchangeable Cu was increased in the plots treated with municipal sewage sludge and alcohol fermentation processing sludge. organically bound Ni increased from 25% - 30% to 32% - 45% in 2010 inall treatment while Pb showed increase in carbonate form in all treatments. Zn existed mainly as sulfide and residual forms, showing increases in organically bound form in all treatment during post ten years.

关键词： Heavy Metal Long-Term Application Organic Wastes Sequential Extraction

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Comparison of double pants with single pants on satisfaction with colonoscopy

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World Journal of Gastroenterology 2013年第26期19卷 4177-4184页

作者： Sook Hee Chung Soo jung Park Jong Suk Hong Jee Young Hwang Sin Ae Lee Kyung Ran Kim Hye Sun Lee Sung Pil Hong Jae Hee cheon Tae Il Kim Won Ho Kim Department of Internal Medicine and Institute of Gastroenterology Yonsei University College of Medicine Department of Psychiatry Yonsei University College of Medicine Department of Biostatistics Yonsei University College of Medicine

AIM: To increase satisfaction and diminish anxiety and shame during colonoscopy, we developed novel double pants (NDP) which consist of doubled fabrics with an inner hole. The aim of study was to compare satisfaction, anxiety and shame between NDP and conventional single pants (CSP). METHODS: Total 160 consecutive examinees were randomly divided into NDP and CSP group. Before colonoscopy, questionnaires identifying state and trait anxiety were completed. After colonoscopy, questionnaires for overall satisfaction (Group Health Association of America 9) and pants-specific satisfaction (5-20), state anxiety (20-80), and shame (6-24) were interviewed. RESULTS: Pants-specific satisfaction scores regarding willingness to repeat colonoscopy using same pants (3.3 ± 0.8 vs 2.1 ± 0.9, P < 0.001) and recommendation of same pants to other people (3.3 ± 0.7 vs 2.0 ± 1.0, P < 0.001) were significantly higher in NDP than CSP groups. State anxiety (33.0 ± 7.0 vs 35.4 ± 6.9, P = 0.028) and shame (6.6 ± 1.5 vs 8.1 ± 3.2, P = 0.001) after colonoscopy was lower in NDP group compared with CSP group. CONCLUSION: The NDP contribute to increase satisfaction and decrease anxiety and shame after colonoscopy.

关键词： Pants Colonoscopy Satisfaction Shame Anxiety

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前牙间隙关闭后龈乳头及牙间牙槽骨垂直定位的变化

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中国口腔医学继续教育杂志 2017年第5期20卷 255-259页

作者： Yi-kyeong Kim Eun-Young Kwon Yun-jung Cho Ju-Youn Lee Sung-Jo Kim Jeomil Choi 邓洋译孟玉坤不详四川大学华西口腔医学院修复学系四川省成都市人民南路三段14号610041

医生将正畸间隙关闭作为一种恢复丧失的龈乳头的方法。我们进行了一次前瞻性分析来对正畸间隙关闭后龈乳头及牙槽嵴顶的水平进行评估。间隙关闭后龈乳头及牙槽嵴顶的水平得以提高。然而．牙根间距并不会影响龈乳头高度及龈乳头评分。有... 详细信息

医生将正畸间隙关闭作为一种恢复丧失的龈乳头的方法。我们进行了一次前瞻性分析来对正畸间隙关闭后龈乳头及牙槽嵴顶的水平进行评估。间隙关闭后龈乳头及牙槽嵴顶的水平得以提高。然而．牙根间距并不会影响龈乳头高度及龈乳头评分。有意思的是，牙齿的外形对龈乳头评分具有显著影响。结论：正畸间隙关闭可以显著提高龈乳头及牙槽嵴顶高度．提升美学效果。

关键词：后龈乳头间隙关闭牙槽骨前牙牙槽嵴顶前瞻性分析乳头高度美学效果

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