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Recent progress and future directions of the research on nanoplastic-induced neurotoxicity

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Neural Regeneration Research 2024年第2期19卷 331-335页

作者： Seung-Woo Han Jinhee Choi kwon-yul ryu Department of Life Science University of SeoulSeoulSouth Korea School of Environmental Engineering University of SeoulSeoulSouth Korea

Many types of plastic products,including polystyrene,have long been used in commercial and industrial *** and nanoplastics,plastic particles derived from these plastic products,are emerging as environmental pollutants that can pose health risks to a wide variety of living organisms,including ***,it is not well understood how microplastics and nanoplastics affect cellular functions and induce stress *** can be exposed to polystyrene-microplastics and polystyrene-nanoplastics through ingestion,inhalation,or skin *** ingested plastics are excreted from the body,but inhaled plastics may accumulate in the lungs and can even reach the brain via the nose-to-brain ***-sized polystyrene-nanoplastics can enter cells by endocytosis,accumulate in the cytoplasm,and cause various cellular stresses,such as inflammation with increased pro-inflammatory cytokine production,oxidative stress with generation of reactive oxygen species,and mitochondrial *** induce autophagy activation and autophagosome formation,but autophagic flux may be impaired due to lysosomal *** permanently exposed to polystyrene-nanoplastics,they can be removed from cells by exocytosis and subsequently restore cellular ***,neurons are very susceptible to this type of stress,thus even acute exposure can lead to neurodegeneration without *** review focuses specifically on recent advances in research on polystyrene-nanoplastic-induced cytotoxicity and ***,in this review,based on mechanistic studies of polystyrene-nanoplastics at the cellular level other than neurons,future directions for overcoming the negative effects of polystyrene-nanoplastics on neurons were suggested.

关键词： autophagy cellular stress cytotoxicity endocytosis exocytosis inflammation microplastics nanoplastics neurotoxicity oxidative stress polystyrene

Ubiquitin homeostasis: from neural stem cell differentiation to neuronal development

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Neural Regeneration Research 2015年第8期10卷 1209-1210页

作者： Han-Wook ryu kwon-yul ryu Department of Life Science University of Seoul

Ubiquitin（Ub）is a well-known eukaryotic protein that exerts diverse signaling functions inside the cells,including targeting its substrates for proteasomal degradation（Hershko and Ciechanover,1998）.

关键词： Ubiquitin neuronal homeostasis eukaryotic sequential targeting diverse suppression maintain impaired

Effect of polyethylene glycol on electrochemically deposited trivalent chromium layers

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中国有色金属学会会刊：英文版 2009年第4期19卷 819-823页

作者： Joo-yul LEE Man KI M Sik-Chol kwon Department of Surface Technology Korea Institute of Materials Science

The structural characteristics of the trivalent chromium deposits and their interfacial behavior in the plating solution with and without polyethylene glycol molecules were observed by using various electrochemical methods such as cyclic voltammetry,open circuit potential transition,electrochemical impedance spectroscopy,scanning electron microscopy and X-ray photoelectron *** is shown that the polyethylene glycol molecules make the reductive current density lower in the trivalent chromium plating system and promote a hydrogen evolution reaction through their adsorption on the electrode *** the trivalent chromium layer formed from the polyethylene glycol-containing solution has somewhat higher density of cracks on its surface and results in a lower film resistance,lower polarization resistance,and higher capacitance in a corrosive *** is also revealed that the formation of chromium carbide layer is facilitated in the presence of polyethylene glycol,which means easier electrochemical codeposition of chromium and carbon,not single chromium deposition.

关键词：聚乙二醇电沉积层三价铬扫描电子显微镜电化学阻抗谱电极表面电化学方法乙二醇溶液

A Reprocessing Model for Complete Execution of RFID Access Operations on Tag Memory

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Journal of Computer Science & Technology 2012年第1期27卷 213-224页

作者： Wooseok ryu Bonghee Hong Joonho kwon Ge Yu Department of Computer Engineering Pusan National UniversityBusan 609-735Korea Institute of Logistics Information Technology Pusan National UniversityBusan 609-735Korea School of Information Science and Engineering Northeastern UniversityShenyang 110004China

This paper investigates the problem of inconsistent states of radio frequency identification （RFID） tag data caused by incomplete execution of read/write operations during access to RFID tag memory. Passive RFID tags require RF communication to access memory data. This study is motivated by the volatility of RF communication, where instability is caused by intermittent connections and uncertain communication. If a given tag disappears from the communication area of the reader during the reading or writing of tag data, the operation is incomplete, resulting in an inconsistent state of tag data. To avoid this inconsistency, it is necessary to ensure that any operations on tag memory are completed. In this paper, we propose an asynchronous reprocessing model for finalizing any incomplete execution of read/write operations to remove inconsistent states. The basic idea is to resume incomplete operations autonomously by detecting a tag＇s re-observation from any reader. To achieve this, we present a concurrency control mechanism based on continuous query processing that enables the suspended tag operations to be re-executed. The performance study shows that our model improves the number of successful operations considerably in addition to suppressing inconsistent data access completely.

关键词： asynchronous reprocessing concurrency control continuous query RFID tag access operation

Pan-TRK positive uterine sarcoma in immunohistochemistry without neurotrophic tyrosine receptor kinase gene fusions:A case report

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World Journal of Clinical Cases 2025年第2期13卷 39-49页

作者： Seungmee Lee Yu-Ra Jeon Changmin Shin Sun-Young kwon Sojin Shin Department of Obstetrics and Gynecology Keimyung University School of MedicineDaegu 42601South Korea Department of Pathology and Institute for Cancer Research Keimyung University School of MedicineDaegu 42601South Korea

BACKGROUND The classification of uterine sarcomas is based on distinctive morphological and immunophenotypic characteristics,increasingly supported by molecular genetic *** on neurotrophic tyrosine receptor kinase(NTRK)gene fusionpositive uterine sarcoma,potentially aggressive and morphologically similar to fibrosarcoma,are limited due to its recent ***-TRK immunohistochemistry(IHC)analysis serves as an effective screening tool with high sensitivity and specificity for NTRK-fusion *** SUMMARY We report a case of a malignant mesenchymal tumor originating from the uterine cervix,which was pan-TRK IHC-positive but lacked NTRK gene fusions,accompanied by a brief literature review.A 55-year-old woman presented to the emergency department with abdominal pain and distension,exhibiting significant ascites and multiple solid pelvic *** examination revealed a tumor encompassing the uterine cervix,extending to the vagina and uterine corpus.A punch biopsy of the cervix indicated NTRK sarcoma with positive immunochemical pan-TRK ***,subsequent next generation sequencing revealed no NTRK gene fusion,leading to a diagnosis of poorly differentiated,advanced-stage *** The clinical significance of NTRK gene fusion lies in potential treatment with TRK inhibitors for positive *** such rare tumors is crucial due to the potential applicability of tropomyosin receptor kinase inhibitor treatment.

关键词： Uterine sarcoma Cervical sarcoma Neurotrophic tyrosine receptor kinase gene fusion Next generation sequencing Case report

Cr/nanodiamond composite plating with cobalt cation additive

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中国有色金属学会会刊：英文版 2009年第4期19卷 975-978页

作者： Viet-Hue NGUYEN Thi-Nam HOANG Ngoc-Phong NGUYEN Sik-Chol kwon Man KIM Joo-yul LEE Institute of Materials Science Korea Institute of Materials Science

The effect of cationic additive on Cr/nanodiamond plating was *** plating was performed in Sargent *** of deposit was observed by scanning electron microscope(SEM);microhardness by hardness tester;wear rate by tribometer;amount of diamond in deposit by combustion method and passivity by potentiodynamic *** results show that in the presence of cobalt cation,the amount of nanodiamond particle in the deposit is *** increasing diamond particle amount,the metallurgical,mechanical and electrochemical properties of Cr/nanodiamond deposit are ***,this improvement seems to be *** the presence of 10 g/L of nanodiamond powder and 2.5 g/L of cobalt cation in the bath,the amount of diamond particle in deposit is increased by 4 times;and wear rate of Cr-Co/nanodiamond deposit is decreased by 2-3 times as compared with pure Cr/*** passive current of Cr-Co/nanodiamond composite deposit is decreased from 18 to 8 μ*** morphology of Cr/nanodiamond is smooth remarkably in the presence of cobalt cation.

关键词：纳米金刚石粉复合镀层钴离子镀铬添加剂金刚石颗粒扫描电子显微镜形态观察

Effect of SMAD7 gene overexpression on TGF-β1-induced profibrotic responses in fibroblasts derived from Peyronie＇s plaque

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Asian Journal of Andrology 2015年第3期17卷 487-492页

作者： Min Ji Choi Kang-Moon Song Jin-Mi Park Mi-Hye kwon Ki-Dong kwon Soo-Hwan Park Dong-Soo ryu Ji-Kan ryu Jun-Kyu Suh Department of Urology National Research Center for Sexual Medicine Inha University School of Medicine Incheon 400-711 Korea Department of Urology Changwon Samsung Medical Center Changwon 630-522 Korea Inha Research Institute for Medical Sciences Inha University School of Medicine Incheon 400-711 Korea

Transforming growth factor-β1 （TGF-β1） has been identified as one of the most important fibrogenic cytokines associated with Peyronie＇s disease （PD）. The mothers against decapentaplegic homolog 7 （SMAD7） is an inhibitory Smad protein that blocks TGF-J3 signaling pathway. The aim of this study was to examine the anti-fibrotic effect of the SMAD7 gene in primary fibroblasts derived from human PD plaques. PD fibroblasts were pretreated with the SMAD7 gene and then stimulated with TGF-β1. Treated fibroblasts were used for Western blotting, fluorescent immunocytochemistry, hydroxyproline determination, and terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling assays. Overexpression of the SMAD7 gene inhibited TGF-β1-induced phosphorylation and nuclear translocation of SMAD2 and SMAD3, transdifferentiation of fibroblasts into myofibroblasts, and quashed TGF-β1-induced production of extracellular matrix protein and hydroxyproline. Overexpression of the SMAD7 gene decreased the expression of cyclin D1 （a positive cell cycle regulator） and induced the expression of poly （ADP-ribose） polymerase 1, which is known to terminate Smad-mediated transcription, in PD fibroblasts. These findings suggest that the blocking of the TGF-β pathway by use of SMAD7 may be a promising therapeutic strategy for the treatment of PD.

关键词： cell culture decapentaplegic homolog 7 fibrosis Peyronie's disease transforming growth factor-beta

Absorption-Dominant mmWave EMI Shielding Films with Ultralow Reflection using Ferromagnetic Resonance Frequency Tunable M-Type Ferrites

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Nano-Micro Letters 2023年第6期15卷 1-23页

作者： Horim Lee Seung Han ryu Suk Jin kwon Jae ryung Choi Sang‑bok Lee Byeongjin Park Composites Research Division Korea Institute of Materials Science797 ChangwondaeroSeongsan‑GuChangwonGyeongsangnam‑Do 51508Republic of Korea

Although there is a high demand for absorption-dominant electromagnetic interference(EMI) shielding materials for 5G millimeter-wave(mmWave) frequencies, most current shielding materials are based on reflection-dominant conductive materials. While there are few absorption-dominant shielding materials proposed with magnetic materials, their working frequencies are usually limited to under 30 GHz. In this study, a novel multi-band absorption-dominant EMI shielding film with M-type strontium ferrites and a conductive grid is proposed. This film shows ultralow EMI reflection of less than 5% in multiple mmWave frequency bands with sub-millimeter thicknesses, while shielding more than 99.9% of EMI. The ultralow reflection frequency bands are controllable by tuning the ferromagnetic resonance frequency of M-type strontium ferrites and composite layer geometries. Two examples of shielding films with ultralow reflection frequencies, one for 39 and 52 GHz 5G telecommunication bands and the other for 60 and 77 GHz autonomous radar bands, are presented. The remarkably low reflectance and thinness of the proposed films provide an important advancement toward the commercialization of EMI shielding materials for 5G mmWave applications.

关键词： 5G communication MmWave EMI shielding M-type ferrites

Microbiology and risk factors for gram-positive Cocci bacteremia in biliary infections

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Hepatobiliary & Pancreatic Diseases International 2020年第5期19卷 461-466页

作者： Ik Hyun Jo Yeon-Ji Kim Woo Chul Chung Jaeyoung Kim Seonhoo Kim Eun Sun Lim Honggeun Ahn Seong yul ryu Division of Gastroenterology Department of Internal MedicineSt.Vincent’s HospitalCollege of MedicineThe Catholic University of KoreaSuwon 16247Korea

Background:The rapid antibiotics treatment targeted to a specific pathogen can improve clinical outcomes of *** aimed to evaluate the clinical characteristics and outcomes of biliary septicemia caused by cholangitis or cholecystitis according to causative ***:We performed a retrospective cohort study in 151 patients diagnosed with cholangitis or cholecystitis with bacterial septicemia from January 2013 to December *** patients showed clinical evidence of biliary tract infection and had blood isolates that demonstrated ***:Gram-negative,gram-positive,and both types of bacteria caused 84.1%(127/151),13.2%(20/151),and 2.6%(4/151)episodes of septicemia,*** most common infecting organisms were Escherichia coli among gram-negative bacteria and Enterococcus species(Enterococcus casseliflavus and Enterococcus faecalis)among gram-positive *** were no differences in mortality,re-admission rate,and need for emergency decompression procedures between the gram-positive and gram-negative septicemia *** univariate analysis,previous gastrectomy history was associated with gram-positive *** analysis also showed that previous gastrectomy history was strongly associated with gram-positive septicemia(Odds ratio=5.47,95%CI:1.19–25.23;P=0.029).Conclusions:Previous gastrectomy history was related to biliary septicemia induced by gram-positive *** information would aid the choice of empirical antibiotics.

关键词： Cholangitis Cholecystitis Septicemia Gram-positive bacterial infections