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Factors for early tumor recurrence of single small hepatocellular carcinoma after percutaneous radiofrequency ablation therapy

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World Journal of Gastroenterology 2005年第10期11卷 1439-1444页

作者： Hsien-ChungYu Jin-ShiungCheng kwok-hunglai Chi-PinLin Gin-HoLo Chiun-KuLin Ping-IHsu Hoi-HungChan Ching-ChuLo Wei-LunTsai Wen-ChiChen DivisionofGastroenterology DepartmentofInternalMedicineKaohsiungVeteransGeneralHospitalandNationalYang-MingUniversityTaiwanChina DivisionofGastroenterology DepartmentofInternalMedicineGod'sHelpHospitalTaiwanChina

AIM: To evaluate the factors affecting the early tumor recurrence within one year in cirrhotic patients having a single small hepatocellular carcinoma (HCC) after complete tumor necrosis by radiofrequency ablation (RFA)***: Thirty patients with a single small HCC received RFA therapy by a RFA 2000 generator with LeVeen needle. Tri-phase computerized tomogram was followed every 2 to3 mo after RFA. The clinical effects and tumor recurrence were ***: The initial complete tumor necrosis rate was 86.7%. Twenty-two patients were followed for more than one year. The local and overall recurrence rates were 13.6% and 36.4%, 33.3% and 56.2%, 46.6% and 56.2%at 12, 24 and 30 mo, respectively. No major complication or procedure-related mortality was found. The risk factors for early local tumor recurrence within one year were larger tumor size, poor pathologic differentiation of tumor cells and advanced tumor staging. The age of patients with new tumor formation within one year was relatively younger (55.1±8.3 vs 66.7±10.8, P = 0.029).CONCLUSION: Large tumor size, poor pathologic differentiation of tumor cells and advanced tumor staging are the risk factors for early local tumor recurrence within one year, and young age is the positive predictor for new tumor formation within one year.

关键词： Recurrence Radiofrequency Hepatocellular carcinoma

Endoscopic banding ligation can effectively resect hyperplastic polyps of stomach

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World Journal of Gastroenterology 2003年第12期9卷 2805-2808页

作者： Ching-ChuLo Ping-IHsu Gin-HoLo Hui-HwaTseng Hui-ChunChen Ping-NingHsu Chiun-KuLin Hoi-HungChan Wei-LunTsai Wen-ChiChen E-MingWang kwok-hunglai DivisionofGastroenterology DepartmentofInternalMedlcinelPathologyKaohsiungVeteransGeneralHospitalandNationalYangMingUniversityTaipeiTaiwanChina DivisionofPathology KaohsiungVeteransGeneralHospitalandNationalYang-MingUniversityTaipeiTaiwanChina DepartmentofRadiationOncology KaohsiungChang-GangMemorialHospitalChang-GangUniversityTaoyuanTaiwanChina

AIM: Bleeding and perforation are the major and serious complications associated with endoscopic polypectomy. To develop a safe and effective method to resect hyperplastic polyps of the stomach, we employed rubber bands to strangulate hyperplastic polyps and to determine the possibility of inducing avascular necrosis in these ***: Forty-seven patients with 72 hyperplastic polyps were treated with endoscopic banding ligation (EBL). On 14 days after endoscopic ligation, follow-up endoscopies were performed to assess the outcomes of the strangulated ***: After being strangulated by the rubber bands,all of the polyps immediately became congested (100 %),and then developed cyanotic changes (100 %) approximately 4 minutes later. On follow-up endoscopy 2 weeks later, all the polyps except one had dropped off. The only one residual polyp shrank with a rubber band in its base, and it also dropped off spontaneously during subsequent *** complications occurred during or following the ligation ***: Gastric polyps develop avascular necrosis following ligation by rubber bands. Employing suction equipment, EBL can easily capture sessile polyps. It is an easy, safe and effective method to eradicate hyperplastic polyps of the stomach.

关键词：肥大型胃息肉内镜下绑扎术术中出血胃穿孔并发症预防

Association of the myeloperoxidase ^(468)G→K polymorphism with gastric inflammation and duodenal ulcer risk

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World Journal of Gastroenterology 2005年第18期11卷 2796-2801页

作者： Ping-IHsu Jyh-JenJwo Hui-HwaTseng kwok-hunglai Gin-HoLo Ching-ChuLo Chung-JenWu Seng-KeeChuah II-RanHwang Jin-LiangChen Yu-ShanChen AngelaChen DivisionofGastroenterology DepartmentofInternalMedicineKaohsiungVeteransGeneralHospitalNationalYang-MingUniversityKaohsiungTaiwanChina DepartmentofPathology KaohsiungVeteransGeneralHospitalNationalYang-MingUniversityKaohsiungTaiwanChina AngelaChen InstituteofBiomedicalSciencesNationalSunYat-SenUniversityKaohsiungTaiwanChina DepartmentofInternalMedicine KaohsiungChangGungMemorialHospitalKaohsiungTaiwanChina DepartmentofInternalMedicine DankookUniversityHospitalSouthKorea DepartmentofHealthCareandHospitalAdministration Chia-NanUniversityofPharmacyandScienceTainanTaiwanChina

AIM: To elucidate the relations between the myeloperoxidase ^(-468)G→a polymorphism and the development of duodenal ulcer (DU), and to investigate the impacts of this host genetic polymorphism on the histopathological features of Helicobacter pylori (H py/ori)-related gastritis. METHODS: In a case-control study of 115 consecutive DU patients and 182 controls, the myeloperoxidase ^(-468)G→A polymorphism was genotyped. Additionally, gastric mucosal changes were examined according to the updated Sydney System. RESULTS: The two study groups differed in the distributions of myeloperoxidase genotypes (P=0.008). All six individuals carrying myeloperoxidase A/A genotypes were in the DU group. The carriage of myeloperoxidase allele A and H pylori infection were associated with an increased risk of DU with odds ratios (OR) of 2.3 and 5.8, respectively. The combined risk of the carriage of myeloperoxidase allele A and H pylori infection for DU was 8.7 (95% CI, 3.5-21.8). In the H pylori-infected individuals, allele A carriers displayed higher bacterial density scores (P=0.04) in the antrum than did non-carriers. CONCLUSION: This work verifies for the first time the association of myeloperoxidase ^(-468)G→A polymorphism with antral H pylori density and DU disease. The mechanisms underlying this genetic polymorphism in developing DU disease merit further investigations.

关键词： Duodenal ulcer Helicobacter pylorr Myeloperoxidase Polymorphism

Polymerase chain reaction: A sensitive method for detecting Helicobacter pyloriinfection in bleeding peptic ulcers

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World Journal of Gastroenterology 2005年第25期11卷 3909-3914页

作者： Ching-ChuLo kwok-hunglai Nan-JingPeng Gin-HoLo Hui-HwaTseng Chiun-KuLin Chang-BihShie Chao-MingWu Yu-ShanChen Wen-KeuiHuang AngelaChen Ping-IHsu DivisionofGastroenterology DepartmentofInternalMedicineKaohsiungVeternansGeneralHospitalNationalYang-MingUniversityTaiwanChina DepartmentofNuclearMedicine KaohsiungVeternansGeneralHospitalNationalYang-MingUniversityTaiwanChina DepartmentofPathology KaohsiungVetemansGeneralHospitalNationalYang-MingUniversityTaiwanChina DivisionofInfectiousDiseases DepartmentofInternalMedicineKaohsiungVetemansGeneralHospitalNationalYang-MingUniversityTaiwanChina InstituteofBiomedicalSciences NationalSunYat-SenUniversityKaohsiungTaiwanChina

AIM: To assess the sensitivity and specificity of polymerase chain reaction (PCR) in detecting Helicobacter pylori(H pylon) infection in patients with bleeding peptic ulcers, and to compare its diagnostic efficacy with other invasive and non-invasive tests. METHODS: From April to September 2002, H pylori status in 60 patients who consecutively presented with gastroduodenal ulcer bleeding was examined by rapid urease tests (RUT), histology, culture, PCR, serology and urea breath tests (UBT). RESULTS: The sensitivity of PCR was significantly higher than that of RUT, histology and culture (91% vs 66%, 43% and 37%, respectively; P = 0.01, <0.001, <0.001, respectively), but similar to that of serology (94%) and UBT (94%). Additionally, PCR exhibited a greater specificity than serology (100% vs 65%, P<0.01). However, the specificity of PCR did not differ from that of other tests. Further analysis revealed significant differences in the sensitivities of RUT, culture, histology and PCR between the patients with and those without blood in the stomach (P<0.01, P= 0.09, P<0.05, and P<0.05, respectively). CONCLUSION: PCR is the most accurate method among the biopsy-based tests to detect H pylori infection in patients with bleeding peptic ulcers. Blood may reduce the sensitivities of all biopsy-based tests.

关键词： Polymerase chain reaction Helicobacter pylorr, Bleeding peptic ulcers