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α1-COP modulates plasmodesmata function through sphingolipid enzyme regulation

Journal of Integrative Plant Biology 2024年第8期66卷 1639-1657页

作者： Arya Bagus Boedi Iswanto Minh Huy Vu Jong Cheol Shon Ritesh Kumar Shuwei Wu Hobin Kang Da-Ran Kim Geon Hui Son Woe Yoen Kim Youn-Sig Kwak kwang hyeon liu Sang Hee Kim Jae-Yean Kim Division of Applied Life Science(BK21 FOUR Program) Plant Molecular Biology and Biotechnology Research CenterGyeongsang National UniversityJinju 52828Korea College of Pharmacy and Research Institute of Pharmaceutical Sciences Kyungpook National UniversityDaegu 702-701Korea Departement of Plant Medicine Gyeongsang National UniversityJinju 52828Korea Division of Life Science Gyeongsang National UniversityJinju 52828Korea

Callose,aβ-1,3-glucan plant cell wall polymer,regulates symplasmic channel size at plasmodesmata(PD)and plays a crucial role in a variety of plant ***,elucidating the molecular mechanism of PD callose homeostasis is *** screened and identified an Arabidopsis mutant plant with excessive callose deposition at PD and found that the mutated gene wasα1-COP,a member of the coat protein I(COPI)coatomer *** report that loss of function ofα1-COP elevates the callose accumulation at PD by affecting subcellular protein localization of callose degradation enzyme Pd *** process is linked to the functions of ERH1,an inositol phosphoryl ceramide synthase,and glucosylceramide synthase through physical interactions with theα1-COP ***,the loss of function ofα1-COP alters the subcellular localization of ERH1 and GCS proteins,resulting in a reduction of Glc Cers and Glc HCers molecules,which are key sphingolipid(SL)species for lipid raft *** findings suggest thatα1-COP protein,together with SL modifiers controlling lipid raft compositions,regulates the subcellular localization of GPI-anchored PDBG2 proteins,and hence the callose turnover at PD and symplasmic movement of *** findings provide the first key clue to link the COPI-mediated intracellular trafficking pathway to the callose-mediated intercellular signaling pathway through PD.

关键词： callose coatomer proteins membrane-bound vesicle plasmodesmata sphingolipid enzymes

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Glucose-mediated mitochondrial reprogramming by cholesterol export at TM4SF5-enriched mitochondria-lysosome contact sites

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Cancer Communications 2024年第1期44卷 47-75页

作者： Ji Eon Kim So-Young Park Chulhwan Kwak Yoonji Lee Dae-Geun Song Jae Woo Jung Haesong Lee Eun-Ae Shin Yangie Pinanga Kyung-hee Pyo Eun Hae Lee Wonsik Kim Soyeon Kim Chang-Duck Jun Jeanho Yun Sun Choi Hyun-Woo Rhee kwang-hyeon liu Jung Weon Lee Department of Pharmacy College of PharmacySeoul National UniversitySeoulRepublic of Korea Research Institute of Pharmaceutical Sciences College of PharmacySeoul National UniversitySeoulRepublic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of Pharmacy and Research Institute of Pharmaceutical SciencesKyungpook National UniversityDaeguRepublic of Korea Department of Chemistry Seoul National UniversitySeoulRepublic of Korea College of Pharmacy Chung-Ang UniversitySeoulRepublic of Korea Natural Product Informatics Research Center Korea Institute of Science and Technology(KIST)Gangneung-siGangwon-doRepublic of Korea School of Life Sciences Gwangju Institute of Science and Technology(GIST)GwangjuRepublic of Korea Department of Biochemistry College of MedicineDong-A UniversityBusanRepublic of Korea Global AI Drug Discovery Center College of Pharmacy and Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulRepublic of Korea Interdisciplinary Program in Genetic Engineering Seoul National UniversitySeoulRepublic of Korea

Background:Transmembrane 4 L six family member 5(TM4SF5)translocates subcellularly and functions metabolically,although it is unclear how intracellu-lar TM4SF5 translocation is linked to metabolic *** is thus of interests to understand how the traffic dynamics of TM4SF5 to subcellular endosomal membranes are correlated to regulatory roles of ***:Here,we explored the metabolic significance of TM4SF5 localization at mitochondria-lysosome contact sites(MLCSs),using in vitro cells and in vivo animal systems,via approaches by immunofluorescence,proximity labelling based proteomics analysis,organelle reconstitution ***:Upon extracellular glucose repletion following depletion,TM4SF5 became enriched at MLCSs via an interaction between mitochondrial FK506-binding protein 8(FKBP8)and lysosomal *** labeling showed molecular clustering of phospho-dynamic-related protein I(DRP1)and certain mitophagy receptors at TM4SF5-enriched MLCSs,leading to mitochondrial fis-sion and ***4SF5 bound NPC intracellular cholesterol transporter 1(NPC1)and free cholesterol,and mediated export of lysosomal cholesterol to mitochondria,leading to impaired oxidative phosphorylation but intact tri-carboxylic acid(TCA)cycle andβ-*** mouse models,hepatocyte Tm4sf5 promoted mitophagy and cholesterol transport to mitochondria,both with positive relations to liver ***:Our findings suggested that TM4SF5-enriched MLCSs regu-late glucose catabolism by facilitating cholesterol export for mitochondrial reprogramming,presumably while hepatocellular carcinogenesis,recapitulating aspects for hepatocellular carcinoma metabolism with mitochondrial repro-gramming to support biomolecule synthesis in addition to glycolytic energetics.

关键词： cholesterol fluorescent imaging glucose catabolism hepatocellular carcinogenesis mem-brane contact sites mitochondria function mitophagy oxidative phosphorylation protein-protein interaction tetraspanin

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Novel Time-dependent Multi-omics Integration in Sepsis-associated Liver Dysfunction

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Genomics, Proteomics & Bioinformatics 2023年第6期21卷 1101-1116页

作者： Ann-Yae Na Hyojin Lee Eun Ki Min Sanjita Paudel So Young Choi HyunChae Sim kwang-hyeon liu Ki-Tae Kim Jong-Sup Bae Sangkyu Lee Research Institute of Pharmaceutical Sciences Kyungpook National UniversityDaegu 41566Republic of Korea Department of Environmental Engineering Seoul National University of Science and TechnologySeoul 01811Republic of Korea BK21 FOUR Community-Based Intelligent Novel Drug Discovery Education Unit College of PharmacyKyungpook National UniversityDaegu 41566Republic of Korea School of Pharmacy Sungkyunkwan UniversitySuwon 16419Republic of Korea

The recently developed technologies that allow the analysis of each single omics have provided an unbiased insight into ongoing disease ***,it remains challenging to specify the study design for the subsequent integration strategies that can associate sepsis pathophysiology and clinical ***,we conducted a time-dependent multi-omics integration(TDMI)in a sepsis-associated liver dysfunction(SALD)*** successfully deduced the relation of the Toll-like receptor 4(TLR4)pathway with *** TLR4 is a critical factor in sepsis progression,it is not specified in single-omics analyses but only in the TDMI *** finding indicates that the TDMI-based approach is more advantageous than single-omics analyses in terms of exploring the underlying pathophysiological mechanism of ***,TDMI-based approach can be an ideal paradigm for insightful biological interpretations of multi-omics datasets that will potentially reveal novel insights into basic biology,health,and diseases,thus allowing the identification of promising candidates for therapeutic strategies.

关键词： Multi-omics Omics technology Sepsis-associated liver dysfunction Single omics Time-dependent integration

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Stable operation of highly loaded pure Si-Fe anode under ambient pressure via carboxy silane-directed robust solid electrolyte interphase

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Journal of Energy Chemistry 2024年第7期94卷 568-576页

作者： Guntae Lim Dong Guk Kang hyeon Gyu Lee Yen Hai Thi Tran Kihun An Junghyun Choi kwang Chul Roh Do Youb Kim Seung-Wan Song Department of Chemical Engineering&Applied Chemistry Chungnam National University Daejeon 34134Republic of Korea Energy Storage Materials Center Korea Institute of Ceramic Engineering&TechnologyJinju 52851Republic of Korea Advanced Energy Materials Research Center Korea Research Institute of Chemical TechnologyDaejeon 34114Republic of Korea

Incorporation of higher content Si anode material beyond 5 wt% to Li-ion batteries(LIBs)is challenging,owing to large volume change,swelling,and solid electrolyte interphase(SEI)instability ***,a strategy of diacetoxydimethylsilane(DAMS)additive-directed SEI stabilization is proposed for a stable operation of Si-0.33FeSi_(2)(named as Si-Fe)anode without graphite,which provides siloxane inorganics and organics enrichment that compensate insufficient passivation of fluoroethylene carbonate(FEC)additive and reduce a dependence on *** stable cycling performance of highly loaded(3.5 mA h cm^(-2))pure Si-Fe anode is achieved with 2 wt%DAMS combined with 9 wt%FEC additives under ambient pressure,yielding high capacity 1270 mA h g^(-1)at 0.5 C and significantly improved capacity retention of 81% after 100 cycles,whereas short circuit and rapid capacity fade occur with FEC only ***-directed robust SEI layer dramatically suppresses swelling and particles crossover through separator,and therefore prevents short circuit,demonstrating a possible operation of pure Si or Sidominant anodes in the next-generation high-energy-density and safe LIBs.

关键词： High-energy Li-ion battery Pure Si-Fe anode without graphite Silane additive SEI layer Suppressed swelling

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Pressure-induced hydrogen-dominant high-temperature superconductors

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National Science Review 2024年第7期11卷 14-16页

作者： Ho-kwang Mao Shanghai Advanced Research in Physical Sciences Center for High Pressure Science and Technology Advanced Research

Recent studies of hydrogen-dominant（superhydride） materials have led to putative discoveries of near-room temperature superconductivity at high pressures. The idea started more than half-a-century ago as a by-product of the quest for metallic hydrogen for which a natural consequence of its very high Debye temperature and phonon frequency due to the very low mass of the hydrogen atoms would lead to a high superconducting critical temperature （Tc） in weak coupling Bardeen-Cooper-Schrieffer（BCS） expression.

关键词： HYDRIDE LANTHANUM

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Optimizing multi-parameter distributed fiber sensors:a hybrid Rayleigh-Brillouin-Raman System approach

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Light(Science & Applications) 2024年第3期13卷 393-395页

作者： kwang Yong Song Dept.of Physics Chung-Ang University84 Heukseok-roDongjak-guSeoul 06974Korea

An optimized single-end hybrid Rayleigh,Brillouin,and Raman distributed fiber sensing system has been developed for simultaneous measurement of multiple *** system integrates 3-bit pulse coding for the Raman signal and the Brillouin amplification of the Rayleigh-backscattered signal,discriminating strain,temperature,and vibration using a single sensing fiber.

关键词： fiber Rayleigh signal

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Editorial for Machine learning and AI for underground metaverse

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Underground Space 2024年第6期19卷 1-3页

作者： Kok-kwang Phoon Qiujing Pan Chong Tang Information Systems Technology and Design/Architecture and Sustainable Design Singapore University of Technology and DesignSingapore 487372 School of Civil Engineering Central South UniversityChangsha 410075China State Key Laboratory of Coastal and Offshore Engineering Dalian University of TechnologyDalian 116024China

It is widely recognized that civil engineering practice,including underground construction,is lagging the fast pace digital transformation taking place in many *** key reason for this revolution is the emergence and convergence of digital technologies that include machine learning,artificial intelligence(AI),blockchain,cloud/edge computing,Internet of Things,5G communication,automation,digital twin,and *** parallel,Industry 4.0 is now complemented by Industry 5.0 that advocates a shift from economic value to societal value(sustainability,well-being,etc.).This means a shift from enterprises benefiting shareholders(profits)to stakeholders(people).

关键词： learning artificial underground

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Magnetic methods in studies of new superconducting hydrides in a diamond anvil cell

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National Science Review 2024年第7期11卷 16-18页

作者： Viktor V.Struzhkin Ho-kwang Mao Center for High Pressure Science&Technology Advanced Research

In recent years, we have witnessed great success in discoveries of high-transition-temperature（Tc） hydrides using high-pressure experiments. This has been achieved by creating metallic hydrogen‘alloys’ with other ...

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Pyrometallurgical recycling of end-of-life lithium-ion batteries

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International Journal of Minerals,Metallurgy and Materials 2024年第7期31卷 1554-1571页

作者： Juheon Lee kwang Won Park Il Sohn Sanghoon Lee Department of Materials Science and Engineering Seoul 03722Korea Yonsei Industry Cooperation Center Yonsei UniversitySeoul 03722Korea RD Solution Wanju gunJeollabuk do 55365Korea

The global importance of lithium-ion batteries(LIBs)has been increasingly underscored with the advancement of high-performance energy storage ***,the end-of-life of these batteries poses significant challenges from environmental,economic,and resource management *** review paper focuses on the pyrometallurgy-based recycling process of lithium-ion batteries,exploring the fundamental understanding of this process and the importance of its *** on the high energy consumption and emission gas issues of the pyrometallurgical recycling process,we systematically analyzed the capital-intensive nature of this process and the resulting technological ***,we conducted an in-depth discussion on the future research directions to overcome the existing technological barriers and *** review will provide valuable insights for researchers and industry stakeholders in the battery recycling field.

关键词： spent lithium-ion batteries recycling sustainability lithium valuable metal

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Feasibility and safety of minimally invasive multivisceral resection for T4b rectal cancer:A 9-year review

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 777-789页

作者： Kai Siang Chan Biquan liu Ming Ngan Aloysius Tan kwang Yeong How Kar Yong Wong Department of General Surgery Tan Tock Seng HospitalSingapore 308433Singapore

BACKGROUND Colorectal cancer is the third most common cancer and the second highest cause of cancer-related mortality *** 5%-10%of patients are diagnosed with locally advanced rectal cancer(LARC)on *** LARC invading into other structures(i.e.T4b),multivisceral resection(MVR)and/or pelvic ex-enteration(PE)remains the only potential curative surgical *** and/or PE is a major and complex surgery with high post-operative *** invasive surgery(MIS)has been shown to improve short-term post-operative outcomes in other gastrointestinal malignancies,but there is little evi-dence on its use in MVR,especially so for robotic *** is a single-center retrospective cohort study from 1st January 2015 to 31st March *** criteria were patients diagnosed with cT4b rectal cancer and underwent MVR,or stage 4 disease with resectable systemic ***-tients who underwent curative MVR for locally recurrent rectal cancer,or me-tachronous rectal cancer were also *** criteria were patients with systemic metastases with non-resectable *** patients planned for elective surgery were enrolled into the standard enhanced recovery after surgery pathway with standard peri-operative management for colorectal *** sur-gery was defined based on technical difficulty of surgery(*** PE,bladder-sparing prostatectomy,pelvic lymph node dissection or need for flap creation).Our primary outcomes were the margin status,and complication ***-gorical values were described as percentages and analysed by the chi-square *** variables were expressed as median(range)and analysed by Mann-Whitney U *** overall survival(OS)and recurrence-free survival(RFS)were analysed using Kaplan-Meier estimates with life table ***-rank test was performed to determine statistical significance between cumulative *** significance was defined as P<*** estimates with li

关键词： Laparoscopy Minimally invasive surgical procedures Multivisceral resection Pelvic Exenteration Rectal neoplasms Robotic surgical procedures

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