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Obesity is an important determinant of severity in newly defined metabolic dysfunction-associated fatty liver disease

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Hepatobiliary & Pancreatic Diseases International 2022年第3期21卷 241-247页

作者： Ji Hye Huh kwang Joon Kim Seung Up Kim Bong-Soo cha Byung-Wan Lee Division of Endocrinology and Metabolism Department of Internal MedicineHallym University Sacred Heart HospitalAnyang 14068Korea Division of Geriatrics Department of Internal MedicineYonsei University College of MedicineSeoul 03722Korea Division of Endocrinology and Metabolism Department of Internal MedicineYonsei University College of MedicineSeoul 03722Korea Institute of Gastroenterology Department of Internal MedicineYonsei University College of MedicineSeoul 03722Korea

Background: The recently proposed definition of metabolic dysfunction-associated fatty liver disease(MAFLD) is based on the co-existence of hepatic steatosis with other metabolic disorders, including obesity and metabolic risk abnormalities such as hyperglycemia, high blood pressure and dyslipidemia. This study aimed to assess MAFLD severity according to the presence of metabolic abnormalities and obesity. Methods: Using transient elastography, hepatic steatosis and fibrosis severity were assessed by measuring the controlled attenuation parameter and liver stiffness measurement. A total of 1163 patients with MAFLD were categorized into the following four groups according to metabolic risk abnormalities and obesity presence: non-obese without metabolic risk abnormality group(Group 1;reference group);nonobese with metabolic risk abnormality group(Group 2);obese without metabolic risk abnormality group(Group 3);and obese with metabolic risk abnormality group(Group 4). A multiple logistic regression analysis was performed to determine severe hepatic steatosis and fibrosis risk in each group in both unadjusted and adjusted models. Results: In the adjusted model, the odds ratios(ORs) [95% confidence interval(CI)] for severe hepatic steatosis in Groups 2, 3, and 4 were 1.07(0.61-1.88), 2.43(1.44-4.08), and 4.07(2.56-6.48), respectively( P trend < 0.001). For liver fibrosis, compared with Group 1, Group 2 showed no significant increases in OR, whereas Groups 3 and 4(obese groups) showed significant increases(OR = 4.70, 95% CI: 1.24-17.82 and OR = 6.43, 95% CI: 1.88-22.02, respectively). Conclusions: Obesity, rather than metabolic abnormality, is the principal determinant of severe hepatic steatosis and fibrosis in patients with MAFLD.

关键词： Metabolic dysfunction-associated fatty liver disease Metabolically-healthy obesity Liver fibrosis

Hepatotoxicity Associated with a Short Course of Rosuvastatin

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Chinese Medical Journal 2015年第12期128卷 1693-1694页

作者： Na Kyoung Hwang Jin Sup Park kwang Soo cha Jin suk Kang Division of Cardiology Department of Internal Medicine and Medical Research Institute Pusan National University Hospital Busan South Korea

Statins reduce cardiovascular morbidity and mortality with *** generally well-tolerated,dose-dependent adverse events develop in 10%-15% *** addition,up to 3% patients have mildly elevated serum aminotransferase level... 详细信息

关键词： Drug Hepatotoxicity Rosuvastatin

H_2S Sensing characteristics of Thin Film SnO_2 Sensor with N_2 Treatment

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稀有金属材料与工程 2006年第A3期35卷 385-388页

作者： Jong-Won Kim kwang-Hyun Yun Geon-Young cha Gi-Hong Rue Duk-Dong Lee Jeung-Soo Huh Department of Nano-Science and Technology Sangyuk-Dong 1370Bukgu DaeguKorea Department of Materials Science and Metallurgy Sangyuk-Dong 1370Bukgu DaeguKorea School of Electronic Engineering Kyungpook National UniversitySangyuk-Dong 1370Bukgu DaeguKorea Department of Nano-Science and Technology Department of Materials Science and MetallurgySangyuk-Dong 1370Bukgu DaeguKorea

SnO_2 thin film sensors were fabricated by a thermal evaporation *** sensors were heated for thermal *** high porosity,SnO_2 thin film sensors were treated in a N_2 *** sensors that were treated with O_2 after being treated with N_2 showed 70 % sensitivity for 1×10~ -6) of H_2S,which is higher than the sensors that were only treated with O_*** Ni metal,as a catalyst,was evaporated on the thin film Sn on the Al_2O_3 *** sensor was heated to grow the Sn nanowire in a tube furnace with N_2 *** nanowire was heated for *** sensitivity of SnO_2 nanowire sensor was measured for 500×10~ -9) of H_*** selectivity of the SnO_2 nanowire sensor was compared with the thin film and the thick film SnO_*** sensor was measured for H_2S,CO,and NH_3 in this study.

关键词： SnO2 gas sensor N2 nanowire H2S

Proton pump inhibitor administration delays rebleeding after endoscopic gastric variceal obturation

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World Journal of Gastroenterology 2014年第45期20卷 17127-17131页

作者： Won Seok Jang Hyun Phil Shin Joung Ⅱ Lee kwang Ro Joo Jae Myung cha Jung Won Jeon Jun Uk Lim Department of Internal Medicine College of Medicine Kyung Hee University

AIM: To clarify the efficacy of proton pump inhibitors (PPIs) after endoscopic variceal obturation (EVO) with N-butyl-2-cyanoacrylate.

关键词： Cirrhosis Endoscopic variceal obturation N-butyl-2-cyanoacrylate Proton pump inhibitor Rebleeding interval

Computational design of Mg alloys with minimal galvanic corrosion

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Journal of Magnesium and Alloys 2022年第7期10卷 1972-1980页

作者： Krishnamohan Thekkepat Hyung-Seop Han Ji-Won Choi Seung-Cheol Lee Eul Sik Yoon Guangzhe Li Hyun-kwang Seok Yu-chan Kim Jae-Hun Kim Pil-Ryung cha Indo-Korea Science and Technology Center JakkurBangalore 560065India Division of Nano&Information Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea Electronic Materials Research Center Korea Institute of Science and TechnologySeoul 02792Republic of Korea Center for Biomaterials Biomedical Research InstituteKorea Institute of Science and TechnologySeoul 02792Republic of Korea Department of Plastic and Reconstructive Surgery Korea University College of MedicineSeoul 02841Republic of Korea Division of Bio-Medical Science and Technology KIST SchoolKorea University of Science and TechnologySeoul 02792Republic of Korea School of Advanced Materials Engineering Kookmin UniversitySeoul 02707Republic of Korea

Formation of galvanic cells between constituent phases is largely responsible for corrosion in Mg-based *** develop a methodology to calculate the electrochemical potentials of intermetallic compounds and alloys using a simple model based on the Born-Haber *** electrochemical potentials are used to predict and control the formation of galvanic cells and minimize *** demonstrate the applicability of our model by minimizing galvanic corrosion in Mg-3wt%Sr-x Zn alloy by tailoring the Zn *** methodology proposed in this work is applicable for any general alloy system and will facilitate efficient design of corrosion resistant alloys.

关键词： Galvanic corrosion First-principles Cluster expansion Thermodynamics Modeling Magnesium alloys

Efficacy and safety of a patient-positioning device(EZ-FIX)for endoscopic retrograde cholangiopancreatography

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World Journal of Gastroenterology 2015年第19期21卷 5995-6000页

作者： Seungho Lee Joung-Ho Han Hee Seung Lee Ki Bae Kim In-kwang Lee Eun-Jong cha Young Duck Shin Namgyu Park Seon Mee Park Department of Internal Medicine College of Medicine Chungbuk National University Department of Biomedical Engineering Chungbuk National University College of Medicine Department of Anesthesiology Chungbuk National University College of Medicine

AIM: To assess the efficacy and safety of a patientpositioning device(EZ-FIX) for endoscopic retrograde cholangiopancreatography(ERCP).METHODS: A total of 105 patients were randomized to the EZ-FIX(n = 53) or non-EZ-FIX(n = 52) group in this prospective study. Midazolam and propofol,titrated to provide an adequate level of sedation during therapeutic ERCP, were administered by trained registered nurses under endoscopist *** outcome measures were the total dose of propofol and sedative-related complications, including hypoxia and hypotension. Secondary outcome measures were recovery time and sedation satisfaction of the endoscopist, nurses, and ***: There was no significant difference in the rate of hypoxia, but there was a statistical trend(EX-FIX group; n = 4, 7.55%, control group; n = 6, 11.53%,P = 0.06). The mean total dose of propofol was lower in the EZ-FIX group than in the non-EZ-FIX group(89.43 ± 49.8 mg vs 112.4 ± 53.8 mg, P = 0.025).In addition, the EZ-FIX group had a shorter mean recovery time(11.23 ± 4.61 mg vs 14.96 ± 5.12 mg, P< 0.001). Sedation satisfaction of the endoscopist and nurses was higher in the *** group than in the nonEZ-FIX group. Technical success rates of the procedure were 96.23% and 96.15%, respectively(P = 0.856).Procedure-related complications did not differ by group(11.32% vs 13.46%, respectively, P = 0.735).CONCLUSION: Using EZ-FIX reduced the total dose of propofol and the recovery time, and increased the satisfaction of the endoscopist and nurses.

关键词： EZ-FIX Patient-positioning device Propofol Sedation Endoscopic retrograde cholangiopancreaRandomizedtography

Efficient electron extraction of SnO_(2) electron transport layer for lead halide perovskite solar cell

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npj Computational Materials 2020年第1期6卷 836-843页

作者： Junu Kim kwang S.Kim chang Woo Myung Center for Superfunctional Materials Department of PhysicsSchool of Natural ScienceUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea Center for Superfunctional Materials Department of ChemistrySchool of Natural ScienceUlsan National Institute of Science and Technology(UNIST)Ulsan 44919Korea

SnO_(2) electron transport layer(ETL)has been spotlighted with its excellent electron extraction and stability over TiO_(2) ETL for perovskite solar cells(PSCs),rapidly approaching the highest power conversion ***,how... 详细信息

关键词： ETL layer perovskite

Multivalent network modifier upregulates bioactivity of multispecies biofilm-resistant polyalkenoate cement

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Bioactive Materials 2022年第8期7卷 219-233页

作者： Ji-Yeong Kim Woojin Choi Utkarsh Mangal Ji-Young Seo Tae-Yun Kang Joohee Lee Taeho Kim Jung-Yul cha Kee-Joon Lee kwang-Mahn Kim Jin-Man Kim Dohyun Kim Jae-Sung Kwon Jinkee Hong Sung-Hwan Choi Department of Orthodontics Institute of Craniofacial DeformityYonsei University College of Dentistry50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea BK21 FOUR Project Yonsei University College of Dentistry50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department of Chemical and Biomolecular Engineering Yonsei University50 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Department and Research Institute of Dental Biomaterials and Bioengineering Yonsei University College of Dentistry50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea Johns Hopkins University 3400 N.Charles St.Mason HallBaltimoreMD 21218USA Department of Oral Microbiology and Immunology School of Dentistry and Dental Research InstituteSeoul National UniversitySeoul 08826Republic of Korea Department of Conservative Dentistry Oral Science Research CenterYonsei University College of Dentistry50-1 Yonsei-roSeodaemun-guSeoul 03722Republic of Korea

Polyalkenoate cement(PAC)is a promising material for regenerative hard tissue *** ionically rich glass component of PAC encourages bioactive interaction *** release of essential ***,PAC bioactivity is restricted owing to(i)structurally inherent cationic network formers and(ii)surface bacterial biofilm *** two factors cause a deficiency in ion release,further complicated by secondary infections and premature therapeutic ***,a multivalent zwitterionic network modifier(mZM)is presented for upregulation of ionic exchange and bioactivity *** introducing a non-zero charged mZM into PACs,an increase in the proportion of non-bridging oxygen *** network modification promotes ion channel formation,causing a multiple-fold increase in ion release and surface deposition of hydroxy-carbonate apatite(ca.74%).Experiments ex vivo and animal models also demonstrate the efficient remineralization ability of the ***,divalent cationic interaction results in bacterial biofilm reduction(ca.68%)while also influencing a shift in the biofilm species composition,which favors commensal ***,PAC modification with mZM offers a promising solution for upregulation of bioactivity,even aiding in customization by targeting site-specific regenerative therapy in future applications.

关键词： Multivalent network modifier Bioactive materials Glass polyalkenoate cement Ion release Remineralization Multispecies biofilm resistance

A Systematic Approach to Safety Verification of Function Block Diagrams

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A Systematic Approach to Safety Verification of Function Blo...