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Efficacy and safety of oral SK3530 for the treatment of erectile dysfunction in Korean men： a multicenter, randomized, doubleblind, placebo-controlled, fixed dose, parallel group clinical trial

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Asian Journal of Andrology 2008年第5期10卷 791-798页

作者： Jae-Seung Paick Hyung-Ki Choi Sae-Chul Kim Tai-young Ahn Je-Jong Kim Jong-kwan Park kwang-Sung Park Sung-Won lee Sae-Woong Kim kwanjin Park Hyonggi Jung Nam-Cheol Park Department of Urology Seoltl National University Hospital Seoul 110-744 Korea Department of Urology Yonsei University Yongdong Severance Hospital Seoul 135-720 Korea Department of Urology Chung-ang University Yongsan Hospital Seoul 140-757 Korea Department of Urology University of Ulsan Asan Medical Center Seoul 138-736 Korea Department of Urology Korea University Anam Hospital Seoul 136-705 Korea Department of Urology Chonbuk National University Hospital Jeonju 561-712 Korea Department of Urology Chonnam National University Hospital Gwangju 501-757 Korea Department of Urology Sungkyunkwan University Samsung Medical Center Seoul 135-710 Korea Department of Urology Catholic University St. Mary＇s Hospital Seoul 150-713 Korea Department of Urology Korea Cancer Center Hospital Seoul 139-706 Korea Department of Biostatistics Seokyeong University Seoul 136- 704 Korea Department of Urology Pusan National University Hospital Busan 602-739 Korea

Aim： To evaluate the efficacy and safety of SK3530, a newly developed type 5 phosphodiesterase inhibitor （PDE5I）, in Korean men with erectile dysfunction （ED）. Methods： A total of 119 patients were randomized at 10 centers in Korea to receive either SK3530 （50, 100, or 150 mg; n = 89） or placebo （n = 30） taken 1 h before anticipated sexual activity for an 8-week period. The patients were evaluated at baseline and 4 and 8 weeks after beginning therapy. Efficacy was assessed using the International Index of Erectile Function （IIEF）, Sexual Encounter Profile （SEP）, and the Global Assessment Question （GAQ）. Safety was analyzed by adverse events, laboratory values and vital signs. Results： At the end of the study, all the primary and secondary efficacy end-points were statistically significantly improved by SK3530 compared with placebo （P 〈 0.05）. Of the 89 patients in the treatment arm, 36 （42.3 %） achieved normal erectile function after treatment, including six patients with severe ED. Treatment-related adverse events occurred in 32 patients. The most common adverse events were flushing, headache, dizziness and eye redness （10.9%, 7.6%, 2.5% and 2.5%, respectively）, and most were mild. Only two patients discontinued treatment during the study period because of adverse events. Conclusion： The results of our phase Ⅱ study have confirmed the efficacy and safety of SK3530 in a broad population of men with ED of various etiologies and severity. The optimal doses in terms of efficacy and safety were determined to be 50 mg and 100 mg, respectively.

关键词： erectile dysfunction phosphodiesterase sildenafil citrate

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Realization of high-performance blue organic light-emitting diodes using multi-emissive layers

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Chinese Optics Letters 2014年第1期12卷 55-58页

作者： Ju-An Yoon You-Hyun Kim Nam Ho Kim Chul Gyu Jhun Song Eun lee young kwan Kim Fu Rong Zhu Woo young Kim Department of Green Energy & Semiconductor Engineering Hoseo University Department of Information Display Hongik University Department of Physics Hong Kong Baptist University Department of Engineering Physics McMaster University

High-performance blue organic light-emitting diodes （OLEDs） are developed. A concept of using multiple-emissive layer （EML） configuration is adopted. In this letter, bis（2-methyl-8-quinolinolate）-4- （phenylphenolato）A1 （BAlq） and 9,10-di（naphtha-2-yl）anthracene （ADN）, which serve n- and p-type EMLs, respectively, are used to evaluate and demonstrate the multi-EML concept for blue OLEDs. The thickness effect of individual EMLs and the number of EMLs, e.g., triple and quadruple EML components, on the power efficiency of blue OLEDs are systematically investigated. To illustrate the point, the total thickness of the emissive region in different blue OLEDs are kept contact at 30 nm for comparison. The power efficiency of blue OLEDs with a quadruple EML structure of BAlq/ADN/BAlq/ADN is about 40% higher than that of blue OLEDs having a single EML unit. The Commission Internationale deL＇eclairage color coordinates of multi-EML OLEDs have values that represent the average of blue emissions from individual EMLs of BAlq and ADN.

关键词： OLEDs blue Realization of high-performance blue organic light-emitting diodes using multi-emissive layers high

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Toxicological study of the hepatotherapeutic herbal formula,Chunggan extract,in beagle dogs

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World Journal of Gastroenterology 2006年第46期12卷 7497-7502页

作者： Woo-Jin Choi Jang-Woo Shin Jin-young Son Dong-Seok Seo Hark-Soo Park Seung-Hyun Han Ha-lung Sung Jung-Hyo Cho Chong-kwan Cho Hwa-Seung Yoo Yeon-Weol lee Chang-Gue Son East-West Cancer Center Dunsan Oriental Hospital of Oriental medical Collage of Daejeon University 1136Dunsan-dong Seo-gu Daejeon 302-122 South Korea Safety Assess-ment Center Korea Testing and Research Institute for Chemical Industry 7-6 Gomak-ri Wolgot-myeon Gimpo-si Kyonggi-doKorea Department of Oromaxillofacial Infection & Immunity and Dental Research Institute School of DentistrySeoul National University 28 Yongon-Dong Chongno-Gu Seoul110-749 South Korea

AIM: To evaluate the pharmaceutical safety of a Chinese herbal formula, Chunggan extract (CGX), traditionally prescribed as a hepatotherapeutic drug via systemic acute and subacute toxicological study. METHODS: Twenty male dogs and 20 female dogs were fed doses 50 times and 4 times greater than the clinically-recommended drug dosages in an acute and a subacute toxicological study, respectively. Adverse effects were examined by comparing the differences between normal and drug-administered groups using clinical signs, necropsies, histopathologic findings, haematology, urinalysis, and biochemical analysis. RESULTS: In the acute study no change in the body weight, diarrhoea, apetite, mortality rate and histopa- thology of major organs was observed in male or female dogs with a single administration of CGX at 5 g/kg. No drug-induced abnormalities at analysis of histopathology, haematology, urinalysis, and biochemistry were found with any dose of this drug. CONCLUSION: CGX is supposed to be very safe when used in a clinical application with a wide therapeutic index.

关键词： Hepatotherapeutics Herbal remedy Chung-gan extract Safety Toxicological study

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Contemporary trends in radical prostatectomy and predictors of recovery of urinary continence in men aged over 70 years:comparisons between cohorts aged over 70 and less than 70 years

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Asian Journal of Andrology 2020年第3期22卷 280-286页

作者： young Ju lee Jin-Woo Jung Sangchul lee Sang Wook lee Jeong Hyun Kim Sung Kyu Hong Seok-Soo Byun Sang Eun lee Seong Jin Jeong Departme nt of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Catholic Kwan dong Univerisity International St.Mary's HospitalIncheon 22711Korea Department of Urology Kangwon National University School of MedicineChuncheon 24341Korea.

We evaluated contemporary trends in radical prostatectomy(RP)in men aged>70 years and investigated associations of selected variables with recovery of urinary continence(UC)in two age groups:>70 and70 years[n=610]vs70 years gradually increased up to 30.0%,and the rate of robot-assisted RP and neurovascular bundle(NVB)saving increased continually to 80.0%and 67.4%of older patients,*** the rate of recovery of UC within 12 months(3 months)in patients aged>70 years was lower than that in those aged S70 years(81.5%[52.6%]vs 88.6%[60.9%],respectively;both P70 ***,unlike younger patients,only variables(age and MUL),possibly associated with the inhere nt fun ction of the urinary sphi ncter,were predictors of recovery of UC in patients aged>70 years.

关键词： elderly predictor prostate cancer radical prostatectomy urinary incontinence

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Calcifying fibrous tumor originating from the gastrohepatic ligament that mimicked a gastric submucosal tumor: A case report

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World Journal of Clinical Cases 2019年第18期7卷 2802-2807页

作者： Byung Soo kwan Dae Hyeon Cho Division of Gastroenterology and Hepatology Department of Internal Medicine Samsung Changwon Hospital Sungkyunkwan University School of Medicine

BACKGROUND Calcifying fibrous tumor (CFT) is a rare, benign soft tissue tumor usually occurring in children or young adults. Gastrohepatic ligament CFT with adhesion to the stomach is very rare. We present a case here. CASE SUMMARY A 25-year-old woman visited our hospital with abdominal pain. Computed tomography and endoscopy were performed, and a gastric submucosal tumor (SMT) with a size of 6.7 cm × 2.7 cm was detected, so endoscopic ultrasonography-guided fine needle biopsy was performed. The tumor was not diagnosed histologically, so surgical resection was planned and performed. The histopathologically confirmed mass size was 6.5 cm × 4.0 cm × 1.0 cm, and a calcified fibrous tumor that originated at the gastrohepatic ligament and adhered to the lesser curvature of the gastric antrum was identified. CONCLUSION Gastrohepatic ligament CFT is a very rare benign tumor. Since this disease may be confused with gastric SMT, the possibility of CFT should be kept in mind during clinical assessment of this disease.

关键词： Calcifying fibrous tumor Gastrohepatic ligament Submucosal tumor Case report

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Removal of press-through-packs impacted in the upper esophagus using an overtube

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World Journal of Gastroenterology 2006年第36期12卷 5909-5912页

作者： Yeon Seok Seo Jong-Jae Park Ji Hoon Kim Jin Yong Kim Jong Eun Yeon Jae Seon Kim kwan Soo Byun young-Tae Bak Department of Internal Medicine Korea University Medical Center Guro Hospital Seoul Korea Department of Internal Medicine Sungkyunkwan University School of Medicine Seoul Korea

Foreign bodies in the upper esophagus should be re-moved as soon as possible to avoid serious complica-tions. However, removals of foreign bodies in the upper esophagus are very difficult, especially if they have sharp edges, such as press-through-packs (PTPs). We expe-rienced four cases of the impacted PTPs in the upper esophagus which was successfully extracted endoscopi-cally with the overtube. Because two edges of PTPs were so firmly impacted in the esophageal wall in all cases, the PTPs were not movable in the upper esophagus. However, after insertion of the overtube, PTPs became movable and were successfully extracted and no serious complications occurred after extraction of PTPs. In one case, insertion of the overtube rapidly expanded the up-per esophagus and PTP progressed to the gastric cavity and it could be extracted with the endoscopic protector hood. The endoscopic removal with the overtube was a simple, safe and effective technique for the removal of the impacted PTPs in upper esophagus.

关键词： Esophagus Foreign body Endoscopy

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Effect of Chelated Vanadium Spray on Concentration of Vanadium and Organic Compounds in Tea Shoots

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茶叶 2013年第4期39卷 220-222页

作者： In-kwan Song Tethvoleak Srey Kyunguk lee Eun-Ui Oh Jian-Liang Lu Seung-Woon Song Bong-Chan Kim young-Jae lee kwan-Jeong Song Jeju Special Self-Governing Province Agricultural Research and Extension Services Faculty of Bioscience and Industry Jeju National University Department of Tea Sciences Zhejiang University College of Veterinary Medicine Jeju National University

The study aimed to develop vanadium tea products and evaluated the potential of chelated vanadium(V)absorption by tea shoots and effect of vanadium accumulation on tea quality during the first crop *** V application with three times foliar sprays at 5 days intervals starting from 15 days before plucking showed a significant increase in V content of new young shoots,which was much effective at higher ***,one or two times sprays had no increase in V content regardless of spray concentration compared to *** V accumulation in the treated at 3 to 9 times higher that of than the non-treated plants,there were no significant changes in contents of total amino acids,theanine,caffeine,total polyphenols,crude fiber,and cathechins between the treated and the non-treated.

关键词：钒(V) 茶产品喷雾剂螯合叶芽有机物品质影响叶面喷洒

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Uhwang Chungsim Won Decreases Blood Oxygen Level-Dependent fMRI Signal Response to A Motor Stimulation Task

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Chinese Journal of Integrative Medicine 2015年第7期21卷 493-499页

作者： Woo-Sang Jung Jong-Man Ryu young-Jee Kim Seong-Uk Park Geon-Ho Jahng Jung-Mi Park Sang-kwan Moon Chang-Nam Ko Ki-Ho Cho Department of Cardiovascular&Neurologic Diseases(Stroke Center) College of Oriental MedicineKyung Hee University Department of Radiology College of MedicineKyung Hee University

Objectives： TO evaluate the effect of Uhwang Chungsim Won [UC, Niuhuang Qingxin Pill （牛黄清心丸] on the blood oxygen level-dependent （BOLD） functional magnetic resonance imaging （fMRI） signal response to a motor stimulation task using a hand grasping paradigm. Methods： Ten healthy right-handed male volunteers were recruited. Their BOLD fMRI signal characteristics during hand grasping were determined before and 1 h after consuming UC. Results： With the administration of UC, BOLD responses to the right hand motor task showed a decrease in both hemispheres including the right cerebellar culmen, right and left medial frontal gyrus, right parahippocampal gyrus, right and left sublobar insula, right and left posterior cingulate, left precuneus, and right precentral gyrus. Decreased BOLD responses to the left hand motor task were shown in the right lingual gyrus, right cerebellar culmen, left superior temporal gyrus, right and left middle frontal gyrus, and right precentral gyrus after UC administration. Increased BOLD responses to the left hand motor task were shown in the left and right posterior cingulate, while there was no increased response to the right hand motor task after UC administration. Conclusions： UC administration significantly decreased fMRI BOLD signal responses to hand grasping in most of the brain areas including the primary motor cortex, but it is not clear whether these decreased responses were caused by a decrease in neuronal activities or by an increase in cerebral blood flow due to the cerebral vasodilatory effects of UC. Further studies using positron emission tomography or single photon emission computed tomography are needed to fully elucidate these findings.

关键词： Uhwang Chungsim Won Niuhuang Qingxin Pfll pharmacological fMRI cerebral blood flow

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Early-onset colorectal cancer:Current insights and future directions

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 230-241页

作者： Claudia Wing-kwan Wu Rashid N Lui Division of Gastroenterology and Hepatology Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong KongChina Department of Clinical Oncology The Chinese University of Hong KongHong KongChina

Early-onset colorectal cancer(EOCRC)has seen an alarming rise worldwide over the past two *** reason for this global trend is poorly *** appears to have its own unique clinical and molecular features when compared with late-onset colorectal *** patients appear to have more distal or rectal disease,a more advanced stage of disease at presentation,and more unfavorable histological *** risk factors for EOCRC is the first step in mitigating the rising burden of this *** we summarize several noteworthy biological factors and environmental exposures that are postulated to be responsible *** can hopefully translate in clinical practice to the development of better risk stratification tool for identifying highrisk individuals for early colorectal cancer screening,and identifying areas needed for further research to curb this rising trend.

关键词： Early-onset colorectal cancer young-onset colorectal cancer Risk factors Environmental exposures Microbiome Genetics

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Design and Performance Analysis of Single-phase Self-excitated Induction Generators

Design and Performance Analysis of Single-phase Self-excitat...

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2005国际电机与系统学术会议

作者： Kim Cherl-Jin lee kwan-Yong Kim young-Tae Shin Heung-Kyo Department of Electrical Engineering Halla UniversityGangwondoKorea Department of Electrical Engineering Halla UniversityGangwondoKorea Department of Electrical Engineering Wonju CollegeGangwondoKorea Department of Electrical Engineering Gyeongsang UniversityGyeongnamKorea

＜正＞ This paper describes the performance analysis and design of single-phase self-excited induction generators （SEIG）. In this study, it is proposed to design the proper capacitance for self-excitation and voltage regulation, also. These methods are based on the induced MMF equations between main and the auxiliary winding. For the least influence between the two capacitors, the self-excited capacitor is selected under no load condition, while the series capacitor is designed under loaded condition. For the steady state analysis, the equivalent circuit of single-phase induction generators is used as circuit modeling using the double-revolving field theory. The validity of proposal methods and designed generator system is verified by experimental and computed results.

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