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Diaphragm disease compared with cryptogenic multifocal ulcerous stenosing enteritis

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World Journal of Gastroenterology 2011年第23期17卷 2873-2876页

作者： Sook Hee Chung Yunju Jo Sang Ryol Ryu Sang Bong Ahn Byoung kwan Son Seong Hwan Kim young Sook Park young Ok Hong Department of Internal Medicine Eulji University School of MedicineSeoul 139-711South Korea Department of Pathology Eulji University School of MedicineSeoul 139-711Korea

As the use of drugs such as nonsteroidal anti-inflammatory drugs (NSAIDs) increases,so too do gastrointestinal ulcers,bleeding,perforation and *** disease of the small intestine is formed by submucosal fibrosis and destruction of lamina muscularis due to chronic ulceration,which corresponds to the most severe stage of NSAID *** may lead to stricture of the small *** such ulcerations and strictures in the small intestine are multiple,differential diagnosis is between diaphragm disease and cryptogenic multifocal ulcerous stenosing enteritis (CMUSE),because the gross findings of diaphragm disease are similar to those of *** report a rare case of diaphragm disease caused by *** has been finally confirmed by capsule endoscopy and the origin of chronic obscure gastrointestinal bleeding was found to be multiple ulcers and strictures in the small *** operation,we diagnosed the patient with diaphragm disease rather than CMUSE.

关键词：溃疡性疾病狭窄肠炎膜片消化道出血鉴别诊断消化道溃疡

Soluble components of Hericium erinaceum induce NK cell activation via production of interleukin-12 in mice splenocytes

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Acta Pharmacologica Sinica 2007年第6期28卷 901-907页

作者： Myung-hyun YIM Jang-woo SHIN Jin-young SON Se-mi OH Seung-hyun HAN Jung-hyo CHO Chong-kwan CHO Hwa-seung YOO Yeon-weol lee Chang-gue SON East-West Cancer Center Dunsan Oriental Hospital of Daejeon UniversityDaejeon 302-122Korea

Aim:To investigate the immunoregulatory functions of water extracts of Hericiumerinaceum （WEHE） focusing on natural killer （NK） cell-based anticancer ***:Mouse splenocytes or purely isolated NK ceils were stimulated with1-100 mg/L WEHE for 24 h followed by co-culture with51Cr-labled Yac-1 cells for4 h,then NK cell-derived cytolytic activity was measured using a *** antibodies against mouse interleukin-12 （IL-12） were addedinto the WEHE-stimulated splenocytes,thereafter,cytotoxicity was measured toexamine the involvement of ***-PCR and ELISA analyses were performed toconfirm the induction of transcription and the translation of IL-12 and interferon-gamma （IFN-gamma） in the WEHE-treated ***:WEHE enhancedthe cytolytic activity of total splenocytes towards Yac-1 ceils in a ***,this activation was not observed when the NK cells isolatedfrom the splenocytes were treated with ***,the treatment withantibodies against IL-12 abolished the effect of WEHE on splenocyte-derivedcytolytic ***-PCR and ELISA analyses showed the induction of IL-12 andIFN-gamma in the WEHE-treated ***:WEHE indirectlyactivates the cytolytic ability of NK cells via the induction of IL-12 in totalsplenocytes,and possibly via other immuno-mediators or cellular components.

关键词： Hericium erinaceum NK cells interleukin-12

How good is cola for dissolution of gastric phytobezoars?

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World Journal of Gastroenterology 2009年第18期15卷 2265-2269页

作者： Beom Jae lee Jong-Jae Park Hoon Jai Chun Ji Hoon Kim Jong Eun Yeon Yoon Tae Jeen Jae Seon Kim kwan Soo Byun Sang Woo lee Jae Hyun Choi Chang Duck Kim Ho Sang Ryu young-Tae Bak Division of Gastroenterology Department of Internal MedicineKorea University College of MedicineSeoul 152-703South Korea

AIM:To evaluate the efficacy of cola treatment for gastric phytobezoars,including ***:A total of 17 patients(range:48 to 78 years) with symptomatic gastric phytobezoars treated with cola and adjuvant endoscopic therapy were *** liters of cola lavage(10 cases) or drink(7 cases) were initially used,and then endoscopic fragmentation was done for the remnant bezoars by using a lithotripsy basket or a polypectomy *** overall success of dissolving a gastric phytobezoars with using three liters of cola and the clinical and endoscopic findings were compared retrospectively between four cases of complete dissolution by using only cola and 13 cases of partial dissolution with ***:After 3 L of cola lavage or drinking,a complete dissolution of bezoars was achieved in four patients(23.5%),while 13 cases(76.5%) were only partially ***(4 of 6 cases) were observed more frequently than diospyrobezoars(0 of 11) in the group that underwent complete dissolution(P = 0.006).Gender,symptom duration,size of bezoar and method of cola administration were not significantly different between the two *** of 13 patients with residual bezoars were completely treated with a combination of cola and endoscopic ***:The rate of complete dissolution with three liters of cola was 23.5%,but no case of diospyrobezoar was completely dissolved using this ***,pretreatment with cola may be helpful and facilitate endoscopic fragmentation of gastric phytobezoars.

关键词：可口可乐胃癌辅助内镜治疗残余结石持续时间碎石篮工作组预处理

C-176 loaded Ce DNase nanoparticles synergistically inhibit the cGAS-STING pathway for ischemic stroke treatment

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Bioactive Materials 2023年第11期29卷 230-240页

作者： Zhixin Zhu Haipeng Lu Lulu Jin Yong Gao Zhefeng Qian Pan Lu Weijun Tong Pik kwan Lo Zhengwei Mao Haifei Shi Department of Orthopedics 1st Affiliated Hospital of Zhejiang University School of MedicineQingchun Road 79Hangzhou31000China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang UniversityHangzhou310027China Department of Chemistry and State Key Laboratory of Marine Pollution City University of Hong KongTat Chee AvenueKowloonHong Kong

The neuroinflammatory responses following ischemic stroke cause irreversible nerve cell *** free-double strand DNA(dsDNA)segments from ischemic tissue debris are engulfed by microglia and sensed by their cyclic GMP-AMP synthase(cGAS),which triggers robust activation of the innate immune stimulator of interferon genes(STING)pathway and initiate the chronic inflammatory *** decomposition of immunogenic dsDNA and inhibition of the innate immune STING are synergistic immunologic targets for ameliorating *** combine the anti-inflammatory strategies of STING inhibition and dsDNA elimination,we constructed a DNase-mimetic artificial enzyme loaded with *** are self-assembled by amphiphilic copolymers(P[CL35-b-(OEGMA20.7-co-NTAMA14.3)]),C-176,and Ce^(4+)which is coordinated with nitrilotriacetic acid(NTA)group to form corresponding catalytic *** work developed a new nano-drug that balances the cGAS-STING axis to enhance the therapeutic impact of stroke by combining the DNase-memetic Ce^(4+)enzyme and STING inhibitor *** conclusion,it is a novel approach to modulating central nervus system(CNS)inflammatory signaling pathways and improving stroke prognosis.

关键词： Ischemic stroke Ce-based nano-nuclease The cGAS-STING signaling pathway Anti-inflammation

Efficacy and safety of oral SK3530 for the treatment of erectile dysfunction in Korean men： a multicenter, randomized, doubleblind, placebo-controlled, fixed dose, parallel group clinical trial

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Asian Journal of Andrology 2008年第5期10卷 791-798页

作者： Jae-Seung Paick Hyung-Ki Choi Sae-Chul Kim Tai-young Ahn Je-Jong Kim Jong-kwan Park kwang-Sung Park Sung-Won lee Sae-Woong Kim kwanjin Park Hyonggi Jung Nam-Cheol Park Department of Urology Seoltl National University Hospital Seoul 110-744 Korea Department of Urology Yonsei University Yongdong Severance Hospital Seoul 135-720 Korea Department of Urology Chung-ang University Yongsan Hospital Seoul 140-757 Korea Department of Urology University of Ulsan Asan Medical Center Seoul 138-736 Korea Department of Urology Korea University Anam Hospital Seoul 136-705 Korea Department of Urology Chonbuk National University Hospital Jeonju 561-712 Korea Department of Urology Chonnam National University Hospital Gwangju 501-757 Korea Department of Urology Sungkyunkwan University Samsung Medical Center Seoul 135-710 Korea Department of Urology Catholic University St. Mary＇s Hospital Seoul 150-713 Korea Department of Urology Korea Cancer Center Hospital Seoul 139-706 Korea Department of Biostatistics Seokyeong University Seoul 136- 704 Korea Department of Urology Pusan National University Hospital Busan 602-739 Korea

Aim： To evaluate the efficacy and safety of SK3530, a newly developed type 5 phosphodiesterase inhibitor （PDE5I）, in Korean men with erectile dysfunction （ED）. Methods： A total of 119 patients were randomized at 10 centers in Korea to receive either SK3530 （50, 100, or 150 mg; n = 89） or placebo （n = 30） taken 1 h before anticipated sexual activity for an 8-week period. The patients were evaluated at baseline and 4 and 8 weeks after beginning therapy. Efficacy was assessed using the International Index of Erectile Function （IIEF）, Sexual Encounter Profile （SEP）, and the Global Assessment Question （GAQ）. Safety was analyzed by adverse events, laboratory values and vital signs. Results： At the end of the study, all the primary and secondary efficacy end-points were statistically significantly improved by SK3530 compared with placebo （P 〈 0.05）. Of the 89 patients in the treatment arm, 36 （42.3 %） achieved normal erectile function after treatment, including six patients with severe ED. Treatment-related adverse events occurred in 32 patients. The most common adverse events were flushing, headache, dizziness and eye redness （10.9%, 7.6%, 2.5% and 2.5%, respectively）, and most were mild. Only two patients discontinued treatment during the study period because of adverse events. Conclusion： The results of our phase Ⅱ study have confirmed the efficacy and safety of SK3530 in a broad population of men with ED of various etiologies and severity. The optimal doses in terms of efficacy and safety were determined to be 50 mg and 100 mg, respectively.

关键词： erectile dysfunction phosphodiesterase sildenafil citrate

Contemporary trends in radical prostatectomy and predictors of recovery of urinary continence in men aged over 70 years:comparisons between cohorts aged over 70 and less than 70 years

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Asian Journal of Andrology 2020年第3期22卷 280-286页

作者： young Ju lee Jin-Woo Jung Sangchul lee Sang Wook lee Jeong Hyun Kim Sung Kyu Hong Seok-Soo Byun Sang Eun lee Seong Jin Jeong Departme nt of Urology Seoul National University Bundang HospitalSeongnam 13620Korea Department of Urology Catholic Kwan dong Univerisity International St.Mary's HospitalIncheon 22711Korea Department of Urology Kangwon National University School of MedicineChuncheon 24341Korea.

We evaluated contemporary trends in radical prostatectomy(RP)in men aged>70 years and investigated associations of selected variables with recovery of urinary continence(UC)in two age groups:>70 and70 years[n=610]vs70 years gradually increased up to 30.0%,and the rate of robot-assisted RP and neurovascular bundle(NVB)saving increased continually to 80.0%and 67.4%of older patients,*** the rate of recovery of UC within 12 months(3 months)in patients aged>70 years was lower than that in those aged S70 years(81.5%[52.6%]vs 88.6%[60.9%],respectively;both P70 ***,unlike younger patients,only variables(age and MUL),possibly associated with the inhere nt fun ction of the urinary sphi ncter,were predictors of recovery of UC in patients aged>70 years.

关键词： elderly predictor prostate cancer radical prostatectomy urinary incontinence

Rapid re-emergence of YMDD mutation of hepatitis B virus with hepatic decompensation after lamivudine retreatment

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World Journal of Gastroenterology 2008年第27期14卷 4416-4419页

作者： So young Kwon Won Hyeok Choe Chang Hong lee Jong Eun Yeon kwan Soo Byun Department of Internal Medicine Konkuk University School of Medicine Department of Internal Medicine Korea University College of Medicine

Lamivudine has a high rate of antiviral resistance. Sequential treatment of anti-hepatitis B virus (HBV) is commonly used for lamivudine resistance. We report 4 cases of patients with rapid redetection of HBV mutants during the lamivudine retreatment. The four patients received lamivudine as an initial treatment of HBV and adefovir and lamivudine as a rescue therapy consecutively. HBV-DNA level, YMDD mutations and adefovir -resistant mutations (RFMP) were tested every 3 mo during the sequential treatment. All the patients showed YMDD mutations during the initial lamivudine therapy. After adefovir therapy for lamivudine resistance, they showed viral breakthrough. Adefovir was switched to lamivudine, however, it did not induce viral suppression at all, rather increased HBV-DNA with rapid reemergence of the YMDD mutations. All the patients had ALT flares, and hepatic decompensation occurred in two patients. After switching to adefovir combined with entecavir or lamivudine for a rescue therapy, the patients had reduction in HBV-DNA and ALT improvement. These cases demonstrated that lamivudine retreatment of patients with preexposed lamivudine resistance leads to rapid reemergence of YMDD mutation with significant viral rebounds and subsequent hepatic decompensation. Sequential administration of lamivudine in patients with a prior history of YMDD mutation should be abandoned.

关键词：乙肝基因突变肝代偿失调药物疗法

Calcifying fibrous tumor originating from the gastrohepatic ligament that mimicked a gastric submucosal tumor: A case report

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World Journal of Clinical Cases 2019年第18期7卷 2802-2807页

作者： Byung Soo kwan Dae Hyeon Cho Division of Gastroenterology and Hepatology Department of Internal Medicine Samsung Changwon Hospital Sungkyunkwan University School of Medicine

BACKGROUND Calcifying fibrous tumor (CFT) is a rare, benign soft tissue tumor usually occurring in children or young adults. Gastrohepatic ligament CFT with adhesion to the stomach is very rare. We present a case here. CASE SUMMARY A 25-year-old woman visited our hospital with abdominal pain. Computed tomography and endoscopy were performed, and a gastric submucosal tumor (SMT) with a size of 6.7 cm × 2.7 cm was detected, so endoscopic ultrasonography-guided fine needle biopsy was performed. The tumor was not diagnosed histologically, so surgical resection was planned and performed. The histopathologically confirmed mass size was 6.5 cm × 4.0 cm × 1.0 cm, and a calcified fibrous tumor that originated at the gastrohepatic ligament and adhered to the lesser curvature of the gastric antrum was identified. CONCLUSION Gastrohepatic ligament CFT is a very rare benign tumor. Since this disease may be confused with gastric SMT, the possibility of CFT should be kept in mind during clinical assessment of this disease.

关键词： Calcifying fibrous tumor Gastrohepatic ligament Submucosal tumor Case report

Effect of Chelated Vanadium Spray on Concentration of Vanadium and Organic Compounds in Tea Shoots

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茶叶 2013年第4期39卷 220-222页

作者： In-kwan Song Tethvoleak Srey Kyunguk lee Eun-Ui Oh Jian-Liang Lu Seung-Woon Song Bong-Chan Kim young-Jae lee kwan-Jeong Song Jeju Special Self-Governing Province Agricultural Research and Extension Services Faculty of Bioscience and Industry Jeju National University Department of Tea Sciences Zhejiang University College of Veterinary Medicine Jeju National University

The study aimed to develop vanadium tea products and evaluated the potential of chelated vanadium(V)absorption by tea shoots and effect of vanadium accumulation on tea quality during the first crop *** V application with three times foliar sprays at 5 days intervals starting from 15 days before plucking showed a significant increase in V content of new young shoots,which was much effective at higher ***,one or two times sprays had no increase in V content regardless of spray concentration compared to *** V accumulation in the treated at 3 to 9 times higher that of than the non-treated plants,there were no significant changes in contents of total amino acids,theanine,caffeine,total polyphenols,crude fiber,and cathechins between the treated and the non-treated.

关键词：钒(V) 茶产品喷雾剂螯合叶芽有机物品质影响叶面喷洒