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Rim-differentiation vs. mixture of constitutional isomers: A binding study between pillar[5]arene-based glycoclusters and lectins from pathogenic bacteria

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中国化学快报：英文版 2023年第2期34卷 214-218页

作者： Zhiping Liu Fanny Demontrond anne Imberty Andrew C.-H.Sue Sébastien Vidal Hongxia Zhao Tianjin Key Lab for Modern Drug Delivery and High-Efficiency School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China Institut de Chimie et Biochimie Moléculaires et Supramoléculaires Laboratoire de Chimie Organique 2-GlycochimieUMR 5246CNRSUniversitéClaude Bernard Lyon 1Universitéde LyonVilleurbanne 69622France CNRS Univ.Grenoble AlpesCERMAVGrenoble 38000France College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China CNRS Institut de Chimie des Substances NaturellesUniversitéParis-SaclayUPR 2301Gif-sur-Yvette 91198France

Macrocycle-based glycoclusters, on account of their promising anti-adhesive properties against bacteria,are potential therapeutic alternatives to classic antibiotics through the much less explored anti-adhesive strategy. In this study, a series of constitutionally-pure pentavalent glycoclusters was prepared by conjugating assorted azido-carbohydrates onto a penta-propargyl rim-differentiated pillar[5]arene(RD-P[5])scaffold through Cu(I)-catalyzed azide–alkyne cycloaddition “click” reactions. Their binding towards therapeutically relevant bacterial lectins, such as Lec A and Lec B from Pseudomonas aeruginosa and concanavalin A(Con A), were evaluated subsequently by isothermal titration calorimetric studies. Most of these isomerfree RD-P[5] pentavalent glycoclusters, except the fucosylated ones, display good affinities to ***, the dissociation constants observed are similar to those displayed by an analogous pentavalent glycocluster consisting of four P[5] constitutional isomers, in which the RD-P[5] component merely accounts for 7% in the mixture. Our results revealed that high constitutional purity is not essential for achieving effective multivalent interactions between P[5]-based glycoclusters and lectins, presumably as a result of the conformationally labile nature of the P[5] scaffold. This information provides valuable design principles for low-cost and facile syntheses of glycosylated P[5]s for biomedical applications.

关键词： Glycocluster Lectin Pillararene Multivalency Constitutional purity

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Effects of personalized exercise prescriptions and social media delivered through mobile health on cancer survivors’physical activity and quality of life

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Journal of Sport and Health Science 2023年第6期12卷 705-714页

作者： Zan Gao Suryeon Ryu Wanjiang Zhou Kaitlyn Adams Mohamed Hassan Rui Zhang anne Blaes Julian Wolfson Ju Sun School of Kinesiology University of MinnesotaMinneapolisMN 55455USA Department of Kinesiology Recreationand Sport StudiesThe University of TennesseeKnoxvilleTN 37996USA Department of Pharmaceutical Care&Health Systems and Institute for Health Informatics University of MinnesotaMinneapolisMN 55455USA Department of Hematology School of MedicineUniversity of MinnesotaMinneapolisMN 55455USA School of Public Health University of MinnesotaMinneapolisMN 55455USA Department of Computer Science&Engineering University of MinnesotaMinneapolisMN 55455USA

Purpose This study aimed to examine the effects of a multi-component mobile health intervention(wearable,apps,and social media)on cancer survivors’(CS')physical activity(PA),quality of life,and PA determinants compared to exercise prescription only,social media only,and attention control *** A total of 126 CS(age=60.37±7.41 years,mean±SD)were recruited from the United *** study duration was 6 months and participants were randomly placed into 4 *** participants received a Fitbit tracker and were instructed to install its companion app to monitor their daily ***(1)received previously established weekly personalized exercise prescriptions via email,(2)received weekly Facebook health education and interacted with one another,(3)received both Conditions 1 and 2,or(4)were part of the control condition,meaning they adopted usual *** PA daily steps,quality of life(i.e.,physical health and mental health),and PA determinants(e.g.,self-efficacy,social support)were measured at baseline,3 months,and 6 *** The final sample size included 123 *** results revealed only the multi-component condition had greater improvements in PA daily steps than the control condition post-intervention(95%confidence interval(95%CI):368–2951;p<0.05).Similarly,those in the multi-component condition had significantly greater increased physical health than the control condition(95%CI:–0.41 to–0.01;p<0.05)over *** addition,the social media condition had significantly greater increased perceived social support than the control condition(95%CI:0.01–0.93;p<0.05).No other significant differences on outcomes were *** The study findings suggest that the implementation of a multi-component mobile health intervention had positive effects on CS PA steps and physical ***,offering social media intervention has the potential to improve CS perceived social support.

关键词： Daily steps Exercise app Fitbit Health wearable Physical activity determinantsTagedAPTARAEnd

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Abscess drain migration into the colon following laparoscopic cholecystectomy

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Journal of Interventional Medicine 2023年第3期6卷 137-139页

作者： Daniel K.Derrick Noah Fanous anne Wells Jorge Lopera Department of Radiology UT Health San AntonioSan AntonioTXUSA

Percutaneous abscess drainage is a procedure commonly performed by interventional radiologists to provide source control on infections using CT or ultrasound *** interventionalist has many different sizes and shapes of catheters to treat abscesses of varying sizes and locations,but the general approach to each abscess is similar:provide a percutaneous route for purulence,bacteria,necrotic tissue,and other debris to escape the *** generally considered a low-risk procedure,adverse events can occur due to operator error or other *** present a unique case of an abscess drain placed into a right upper quadrant abscess that formed following laparoscopic cholecystectomy that perforated and entered the *** physicians,both in the emergency department and the radiology reading room,were able to rapidly rule out more common post-operative complications and make the correct diagnosis,likely preventing dangerous sequelae from developing in this patient.

关键词： colon diagnosis drain

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Challenges in the implementation of food safety and quality assurance systems in small-scale fisheries

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Food Quality and Safety 2023年第1期7卷 178-186页

作者： Esther GarridoGamarro Cecilie Smith Svanevik anne-Katrine Lundebye Monica Sanden Enrica D'Agostino Marian Kjellevold Lauren Pincus Johannes Pucher Fisheries and Aquaculture Division Food and Agriculture Organization of the United NationsViale delle Terme di CaracallaRomeItaly Institute of Marine Research BergenNorway WorldFish Jalan Batu MaungBatu MaungPenangMalaysia German Federal Institute for Risk Assessment Department Experimental Toxicology and ZEBETBerlinGermany Shared first authorship

Ninety percent of the world’s fishers are directly involved in small-scale fisheries(SSFs),and many food safety and quality issues along the food value chains may be both irreversible and *** safe,high-quality aquatic products are key to sustaining life,promoting good health,and avoiding adverse health *** This paper aimed to highlight factors preventing the implementation of safety and quality assurance systems in SSFs by analysing the results from surveys on the implementation of Article 11 of the Food and Agriculture Organization of the United Nations(FAO)Code of Conduct for Responsible Fisheries(2017,2019,and 2022).Materials and methods The analysis considered responses to 15 closed-ended questions on food safety and quality obtained from 143 FAO Members and the European Union,and 87 open-ended replies addressing challenges in *** The major factors preventing the implementation of the Code’s food safety and quality provisions were lack of sanitation and monitoring programmes,lack of infrastructure(particularly refrigeration facilities)lack of technical capacities and limited management of food safety risks along the value *** and quality assurance efforts were focused on international markets,resulting in less attention being paid to domestic markets where a high degree of informality was *** Improved implementation of safety and quality assurance systems will lead to safer food with higher nutritional quality,extended shelf-life and reduced post-harvest *** awareness of food safety issues in SSFs is a prerequisite for achieving several of the UN Sustainable Development Goals.

关键词： Food security policy monitoring legislation value chain domestic market international trade

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Hereditary polyposis syndromes remain a challenging disease entity:Old dilemmas and new insights

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World Journal of Gastrointestinal Surgery 2023年第1期15卷 1-8页

作者： Frederik Rønne Pachler Anna Byrjalsen John Gásdal Karstensen anne Marie Jelsig Danish Polyposis Registry GastrounitCopenhagen University Hospital-Amager and Hvidovre HospitalHvidovre 2650Denmark Department of Clinical Genetics University Hospital of CopenhagenRigshospitaletCopenhagen 2100Denmark Department of Clinical Medicine University of CopenhagenHvidovre 2650Denmark

In this editorial we present an overview and insights of the management of hereditary polyposis *** primary focus was on familial adenomatous polyposis,juvenile polyposis syndrome and Peutz-Jegher *** testing has become increasingly available and is easier than ever to integrate into clinical ***,several genes have been added to the expanding list of genes associated with hereditary polyposis syndromes,allowing for precise diagnostics and tailored *** evaluation of patients with hereditary polyposis syndromes is paramount in the surveillance *** endoscopic procedures include both diagnostic procedures and surveillance as well as therapeutic *** for endoscopic procedures in the upper and lower gastrointestinal canal were *** is still a key component in the management of patients with hereditary polyposis *** increased cancer risk in these patients often render prophylactic procedures or intended curative procedures in the case of cancer *** interventions in the upper and lower gastrointestinal canal were described with relevant *** of chemopreventive medications is *** drugs have been investigated,including nonsteroidal anti-inflammatory *** has been demonstrated that cyclooxygenase-2 inhibitors may lower the number of *** medications are currently under investigation,but none have,to date,consistently been able to prevent development of disease.

关键词： Hereditary polyposis Familial adenomatous polyposis Juvenile polyposis syndrome Peutz-Jegher syndrome

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National Antibiotic Resistance Strategy for Human Health in France

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China CDC weekly 2022年第49期4卷 1097-1100页

作者： Céline Pulcini anne Berger-Carbonne Bruno Coignard Jérôme Salomon The Ministerial Mission for the Prevention of Infections and Antibiotic Resistance Ministry of Health and PreventionParisFrance Infectious Diseases Division French National Public Health AgencySaint-MauriceFrance French Chief Medical Officer General Director for HealthWHO EB MemberHERA Board MemberMinistry of Health and PreventionParisFrance

France is a country with 67 million inhabitants and is part of the European *** consumption in humans is higher in France as compared to the European average,especially in outpatient settings(1–2).The burden of antibiotic resistance is also high,as compared to the European average,with an estimated 5,500 deaths per year associated with multidrug-resistant bacterial infections(3).Encouraging results have,however,been observed over the last several years:antibiotic consumption in the community,in nursing homes and in hospitals showed a decreasing trend,as well as certain resistant bacteria,such as 3rd-generation cephalosporin-or fluoroquinolone-resistant Escherichia coli(1–2,4–5).The COVID-19 pandemic has had a dramatic impact on antibiotic consumption and its long-term impact on antibiotic resistance is being carefully monitored(1).

关键词： Antibiotic nursing Strategy

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Animal Mix-Up

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小学生时代（大嘴英语） 2022年第2期 42-43页

作者： anne Reas 不详

The animals have mixed up their stripes, spots, feathers. Look carefully. Who has made a trade?

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Microbiological cultures and antimicrobial prophylaxis in patients undergoing total pancreatectomy with islet cell autotransplantation

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Hepatobiliary & Pancreatic Diseases International 2023年第4期22卷 426-429页

作者： Kristen R Szempruch anne M Lachiewicz Brittney M Williams Aman Kumar Xavier Baldwin Chirag S Desai Pharmacy Department University of North Carolina Medical CenterChapel HillNCUSA Division of Infectious Disease University of North Carolina Medical CenterChapel HillNCUSA Department of Surgery TransplantUniversity of North Carolina Medical CenterChapel HillNCUSA

To the Editor:Total pancreatectomy with islet cell autotransplantation(TPIAT)is a viable treatment option upon failed endoscopic and medical therapy for patients with chronic *** procedure involves surgical removal of the entire pancreas,isolation of islet cells and reinfusion of these cells into the liver via portal vein[1,2].The risk of contamination to the final islet cell product can occur at several stages of the isolation procedure[3].In order to ensure the sterility of the islet cell product,multiple samples from the preservation and cannulation solution,and the final islet cell product are sent for bacterial *** studies have found variable clinical consequences of these cultures on infectious com-plications or graft function[3-9].Herein we aimed to determine the incidence of infection in 60 days post-TPIAT and its association with the culture data.

关键词： islet patients viable

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(La0.8A0.2)MnO3(A=Sr,K) perovskite catalysts for NO and C10H22 oxidation and selective reduction of NO by C(10)H(22)

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催化学报 2014年第8期35卷 1299-1304页

作者： anne Giroir-Fendler Sonia Gil Alexandre Baylet Lyon University Lyon F-69003 Lyon 1 University CNRS UMR 5256 IRCEL YON Albert Einstein Avenue 2 Villeurbanne F-69622 France

In this work, we studied the catalytic activity of LaMnO3 and(La0.8A0.2)MnO3(A = Sr, K) perovskite catalysts for oxidation of NO and C10H22 and selective reduction of NO by C10H22. The catalytic per‐formances of these perovskites were compared with that of a 2 wt% Pt/SiO2 catalyst. The La site substitution increased the catalytic properties for NO or C10H22 oxidation compared with the non‐substituted LaMnO3 sample. For the most efficient perovskite catalyst,(La0.8Sr0.2)MnO3, the results showed the presence of two temperature domains for NO adsorption:(1) a domain corre‐sponding to weakly adsorbed NO, desorbing at temperatures lower than 270 °C and(2) a second domain corresponding to NO adsorbed on the surface as nitrate species, desorbing at temperatures higher than 330 °C. For the Sr‐substituted perovskite, the maximum NO2 yield of 80% was observed in the intermediate temperature domain (around 285 °C). In the reactant mixture of NO/C10H22/O2/H2O/He,(La0.8Sr0.2)MnO3 perovskite showed better performance than the 2 wt% Pt/SiO2 catalyst: NO2 yields reaching 50% and 36% at 290 and 370 °C, respectively. This activity improvement was found to be because of atomic scale interactions between the A and B active sites, Sr2+ cation and Mn4+/Mn3+ redox couple. Thus,(La0.8Sr0.2)MnO3 perovskite could be an alternative free noble metal catalyst for exhaust gas after treatment.

关键词：钙钛矿催化剂二氧化硅选择性还原 NO LaMnO3 钙钛矿型催化剂解吸温度尺度相互作用

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Systemic postnatal corticosteroid use for the prevention of bronchopulmonary dysplasia and its relationship to early neurodevelopment in extremely preterm

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World Journal of Pediatrics 2023年第6期19卷 586-594页

作者： Emilia Esterman Traci-anne Goyen Pranav Jani Gemma Lowe Jane Baird Rajesh Maheshwari Daphne D’Cruz Melissa Luig Dharmesh Shah Department of Neonatology Westmead HospitalWestmeadAustralia Faculty of Medicine and Health The University of SydneySydneyAustralia

Background Systemic postnatal corticosteroid use in extremely preterm infants poses a risk of adverse neurodevelopmental *** study explores their use beyond seven days of age with early neurodevelopmental assessments during the fidgety period(9-20 weeks postterm age).Methods This retrospective single-center cohort study included inborn extremely preterm infants from 1 January 2014 to 31 December *** infants,those with congenital or genetic abnormalities,and those who received postnatal cor-ticosteroids for nonrespiratory reasons were *** cohort was dichotomized based on the status of corticosteroid *** neurodevelopmental outcomes were reported using Prechtl's General Movements *** Of the 282 infants,67(23.75%)received *** these,34(50.75%)received them for dependency on invasive ventilation(intermittent positive-pressure ventilation),and the remainder received them for dependency on non-invasive ventilation continuous positive airway pressure(CPAP)or bi-level positive airway pressure(BiPAP).Abnormal or absent fidgety movements were observed in 13% of infants(7/54)who received corticosteroids compared to 2% of infants(3/146)who did *** increased odds for an abnormal general movements assessment from corticosteroid use after adjusting for gestational age[adjusted odds ratio(aOR)=5.5,95% confidence interval(CI)=1.14-26.56]was *** motor optimality scores differed between the two groups[corticosteroid group:25.5(23-26)versus no-corticosteroid group:26(24-28);z=-2.02].A motor optimality score<20 was observed in 14.8% of infants(8/54)in the corticosteroid group compared to 2% of infants(3/146)in the noncorticosteroid *** difference was significant after adjustment for gestational age(aOR 5.96,95%CI 1.28-27.74).Conclusions Abnormal early neurodevelopment was observed in infants who received systemic postnatal *** relationship between these findings and other factors influen

关键词： Corticosteroids Early neurodevelopment General movement assessment Preterm infants

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