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Insights into Free and Conjugated Forms of Neonicotinoid Insecticides in Human Serum and Their Association with Oxidative Stress

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Environment & Health 2023年第2期1卷 121-129页

作者： Ya-Nan Yao Shiming Song Yingyan Huang kurunthachalam kannan Hongwen Sun Tao Zhang School of Environmental Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China School of Chemistry and Environment Jiaying UniversityMei Zhou 514015China Guangzhou Hexin Instrument Co. Ltd.Guangzhou 510530China Wadsworth Center New York State Department of HealthAlbanyNew York 12137United States MOE Key Laboratory of Pollution Processes and Environmental Criteria College of Environmental Science and EngineeringNankai UniversityTianjin 300071China

Following exposure,neonicotinoid insecticides(NEOs)can be metabolized by both Phase Ⅰ and Phase Ⅱ reactions catalyzed by human cytochrome P450 ***,toxicities of parent NEOs and their metabolites are still unclear,and little is known about biotransformation rates and pathways of NEOs in *** this study,98 serum samples collected in China were analyzed for free,conjugated and total forms of six parent NEOs(i.e.,acetamiprid(ACE),imidacloprid(IMI),clothianidin(CLO),thiacloprid(THD),thiamethoxam(THM),and dinotefuran(DIN))and four metabolites(i.e.,N-desmethyl-acetamiprid(N-dm-ACE),1-methyl-3-(tetrahydro-3-furylmethyl)(DIN-U),5-hydroxy-imidacloprid(5-OH-IMI),olefin-imidacloprid(Of-IMI)).NEOs and their metabolites were detected in all serum samples,and the total median concentrations of free,conjugated,and total forms of 10 NEOs were 2.04,2.01,and 5.12 ng/mL,*** forms of NEOs accounted for only half(53%)of the total forms of *** on the profiles of Phase Ⅰ and Phase Ⅱ metabolites of NEOs in serum,it was found that age is a determinant in Phase Ⅰmetabolism of DIN and Phase Ⅱ metabolism of *** Phase Ⅱmetabolites of NEOs are associated with oxidative DNA damage,and the conjugated forms of IMI,DIN,and 5-OH-IMI in serum were significantly positively correlated with oxidative ***,the amount of NEOs present in conjugated forms in human serum was determined to document the existence of a considerable proportion of free forms of these insecticides.

关键词： Neonicotinoid insecticides metabolites conjugated forms free forms oxidative stress human serum

Urinary Bisphenol A Concentrations and Their Implications for Human Exposures in Several Asian Countries

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Urinary Bisphenol A Concentrations and Their Implications fo...

Placental transfer of bisphenol diglycidyl ethers (BDGEs) and its association with maternal health in a population in South of China

持久性有机污染物论坛2011暨第六届持久性有机污染物全国学术研讨会

作者： kurunthachalam kannan International Joint Research Center for Persistent Toxic Substances State Key Laboratory of Urban Water Resource and EnvironmentHarbin Institute of Technology Wadsworth Center New York State Department of Healthand Department of Environmental Health SciencesSchool of Public HealthState University of New York at AlbanyEmpire State PlazaP.O.Box 509AlbanyNew York 12201-0509

*** Bisphenol A(BPA) is primarily used in the production of polycarbonate plastics and epoxy resins, which are widely used in applications such as baby feeding bottles,toys,epoxy food-can linings, medical equipment and tubing,and consumer *** is one of the highest production volume chemicals,with six billion pounds produced each year *** of the potential for human exposure and adverse health effects,information regarding body burdens and sources of BPA is necessary to develop strategies to mitigate *** is known on human exposures and body

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Eco-Environment & Health 2022年第4期1卷 244-250页

作者： Bo Zhang Henglin Zhang Xueyuan Bai Tao Zhang Jingchuan Xue Shaoyou Lu kurunthachalam kannan School of Environmental Science and Engineering Sun Yat-Sen UniversityGuangzhou 510275China South China Institute of Environmental Sciences Ministry of Ecology and Environment of the People’s Republic of ChinaGuangzhou 510655China Guangdong Provincial Key Laboratory of Water Quality Improvement and Ecological Restoration for Watersheds Institute of Environmental and Ecological EngineeringGuangdong University of TechnologyGuangzhou 510006China School of Public Health(Shenzhen) Sun Yat-Sen UniversityGuangzhou 510006China Department of Pediatrics New York University School of MedicineNew York NY10016USA

Despite high production and usage,little is known about exposure to bisphenol diglycidyl ethers(BDGEs)and their derivatives in pregnant women and *** this study,we determined nine BDGEs in 106 paired maternal and cord serum samples collected from e-waste dismantling sites in South of *** A bis(2,3-dihydroxypropyl)glycidyl ether(BADGE⋅2H_(2)O),bisphenol A(3-chloro-2-hydroxypropyl)(2,3-dihydroxypropyl)glycidyl ether(BADGE⋅HCl⋅H_(2)O),and bisphenol F diglycidyl ether(BFDGE)were the major BDGEs,with median concentrations of 0.57,4.07,and 1.60 ng/mL,respectively,in maternal serum,and of 3.58,5.61,and 0.61 ng/mL,respectively,in cord *** transplacental transfer efficiencies(TTEs)were estimated for BDGEs found in samples,and median values were in the range of 0.98(BFDGE)to 5.91(BADGE⋅2H_(2)O).Our results suggested that passive diffusion plays a role in the placental transfer of BADGE⋅HCl⋅H_(2)O and BFDGE,whereas several mechanisms contribute to the high accumulation of BADGE⋅2H_(2)O in cord *** linear regression analysis indicated significant associations between maternal serum concentrations of BDGEs and blood clinical biomarkers,especially those related to liver injuries,such as alanine aminotransferase(ALT),aspartate aminotransferase(AST),alkaline phosphatase(ALP),and adenosine deaminase(ADA)(P<0.05).To our knowledge,this is the first study to report the occurrence of BDGEs in paired maternal–fetal serum samples and provide new insights into prenatal and fetal *** newly discovered TTEs in maternal–fetal pairs contribute to a fuller inventory of the transmission activity of pollutants in the human body,ultimately adding to a more significant comprehensive risk evaluation.

关键词： Bisphenol diglycidyl ethers Maternal–fetal pairs Transplacental transfer Exposure

Dechloranes in Surface Soil and Air in China

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Dechloranes in Surface Soil and Air in China

固相萃取/气相色谱质谱法测定灰尘中的氯代多环芳烃

持久性有机污染物论坛2011暨第六届持久性有机污染物全国学术研讨会

作者： Ed Sverko Eric J.Reiner kurunthachalam kannan Science and Technology Branch Environment CanadaToronto/BurlingtonOntarioCanada

*** Dechlorane 602(Dec 602,C14H4Cl12O),Dechlorane 603(Dec 603,C17H8Cl12),Dechlorane 604 (Dec 604,C 13 H4Br4Cl6),and Dechlorane Plus(DP,C 18H 12C112,also called Dechlorane 605),a series of highly chlorinated flame retardants,started to be used in 1970s as substitutes of nonagricultural mirex (also called Dechlorane).Mirex was banned because of its toxicity to marine *** has two isomers,among all 5 dechloranes,only DP has two isomers,syn-DP and *** Decs(Dec 602, 603,604,and DP) used as cable coatings,plastic roofing materials,and hard connectors in computers and televisions as flame-retardant *** 602 and 604 are on the Nondomestic Substances List

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环境化学 2012年第7期31卷 1101-1107页

作者：郑继三马静 Yuichi Horii kurunthachalam kannan Takeshi Ohura 徐刚吴明红上海大学环境与化学工程学院 Center for Environmental Science in Saitama Saitama347-0115Japan School of Public Health State University of New York at AlbanyAlbany12201-0509USA Environmental Sciences University of ShizuokaShizuoka422-8526Japan

建立了固相萃取(SPE)/气相色谱质谱(GC/MS)联用检测灰尘中氯代多环芳烃(ClPAHs)的方法.以正己烷和二氯甲烷混合液为提取溶剂,索氏提取灰尘样品中的20种ClPAHs,活性硅胶层析柱与活性炭混合硅胶SPE柱协同净化.净化后的提取液采用GC/MS测定... 详细信息

建立了固相萃取(SPE)/气相色谱质谱(GC/MS)联用检测灰尘中氯代多环芳烃(ClPAHs)的方法.以正己烷和二氯甲烷混合液为提取溶剂,索氏提取灰尘样品中的20种ClPAHs,活性硅胶层析柱与活性炭混合硅胶SPE柱协同净化.净化后的提取液采用GC/MS测定,SIM模式扫描,并用质谱特征离子定量分析.结果表明,填充量为0.2 g(W(活性炭)∶W(硅胶)=1∶40)的活性炭混合硅胶SPE小柱能有效地将ClPAHs分离出来,载样后采用反向溶剂洗脱,既提高了回收率又减少了洗脱剂甲苯的用量,净化效果好.处理灰尘样品后检测分析,20种ClPAHs的平均回收率稳定在60.4%—120.1%,相关系数>0.99,检出限为0.04—0.17 ng.g-1,相对标准偏差为1.6%—10.2%.本方法前处理简单,定性、定量准确可靠,可广泛应用于环境介质中氯代多环芳烃的检测.

关键词：氯代多环芳烃固相萃取气相色谱质谱灰尘

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全球有机氯污染趋势:概述

人类环境杂志 1994年第3期23卷 181-185页

作者： Bommanna G.Loganathan kurunthachalam kannan 姚壁君 Skidaway 海洋研究所环境保护系

本文根据时间趋势研究的成果,对地球环境中有机氯浓度的新动向进行了讨论。发达国家和发展中国家的人体组织中有机氯的残留量表明,那里的人民继续暴露在多氯联苯(PCBs)中,而发达国家中人的DDT含量是在下降。陆地环境中有机氯的下降速度... 详细信息

本文根据时间趋势研究的成果,对地球环境中有机氯浓度的新动向进行了讨论。发达国家和发展中国家的人体组织中有机氯的残留量表明,那里的人民继续暴露在多氯联苯(PCBs)中,而发达国家中人的DDT含量是在下降。陆地环境中有机氯的下降速度是慢的。河鱼的有机氯浓度提示,当这些化合物被限制使用后,它的清除率很快。半封闭海和沿海海域内的清除率慢。海水样品分析结果指出,有机氯从大陆不断输入,所以公海继续成为这些化合物的汇。从热带点污染源国家来的有机氯的扩散,是影响现在全球污染的主要因素。尽管如此,由于涉及到的经济与政治问题,在南半球国家仍没有综合性的污染管理计划。可见在热带地区、半封闭海及在公海环境中,都需要对有机氯的动态进行周期性的监测调查。

关键词：有机氯杀虫剂环境污染

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鱼肝油中的有机氯杀虫剂和多氯联苯:北大西洋、挪威海、北海与波罗的海

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人类环境杂志 1994年第4期23卷 283-293页

作者： Jerzy Falandysz kurunthachalam kannan Shinsuke Tanabe Ryo Tatssukawa 周光义波兰格但斯克大学化学系印度泰米尔纳德农业大学日本爱媛大学

选取80年代产自冰岛北大西洋和北大西洋东部海域的鱼肝油,对其中含有的耐分解有机氯化合物浓度进行了测定,以了解有机氯分布的空间变化,跟踪其可能来源和传送到挪威北极的途径。测定的化合物有多氯联苯、滴滴涕、六六六、六氯苯、氯丹... 详细信息

选取80年代产自冰岛北大西洋和北大西洋东部海域的鱼肝油,对其中含有的耐分解有机氯化合物浓度进行了测定,以了解有机氯分布的空间变化,跟踪其可能来源和传送到挪威北极的途径。测定的化合物有多氯联苯、滴滴涕、六六六、六氯苯、氯丹、环氧七氯以及狄氏剂等。产自上述海域的鱼肝油含有机氯浓度很高,尤以波罗的海产品含量最高。各类有机氯含量以多氯联苯和滴滴涕居首位,六氯苯、氯丹、六六六以及狄氏剂的浓度相对较低,并因地而异。空间变化最大的是滴滴涕类,其次是多氯联苯类、六氯苯、狄氏剂和氯丹类。除六六六类以外的所有有机氯,其在不同海域间的变化从统计上看是显著的(5%水平)。尽管由南向北、由近海到远洋有机氯浓度趋于降低,但其滴滴涕、氯丹和六六六的体/代谢物比率在不同取样海区有各自的组成特征。较易传送的滴滴涕、六六六和氯丹体/代谢物,在产自北大西洋遥远海域的鱼肝油中占较大比重,这说明挪威北极和北大西洋温水海域都受到可能来自大西洋东部和南部相同有机氯污染源或污染途径的影响。

关键词：鱼肝油农药残留有机氯杀虫剂多氯联苯

鱼肝油中的有机氯杀虫剂和多氯联苯:北大西洋、挪威海、北海与波罗的海

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AMBIO-人类环境杂志 1994年第Z1期23卷 288-293页

作者： Jerzy Falandysz kurunthachalam kannan Shinsuke Tanabe Ryo Tatssukawa 周光义波兰格但斯克大学化学系印度泰米尔纳德农业大学日本爱媛大学

关键词：波罗的海有机氯多氯联苯鱼肝油水产动物油挪威海

意大利的金枪鱼、箭鱼、鸬鹚以及家燕等体内的多氯萘、多氯联苯、多氯二苯—p—二恶英、多氯二苯并呋喃以及p,p′—DDE

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AMBIO－人类环境杂志 2002年第3期31卷 207-211页

作者： kurunthachalam kannan Simonetta Corsoline Takashi Imagaws Silvano Focardi Johnp Giesy 林宝法美国密歇根州东兰辛密歇根州立大学国家食品安全与毒理学中心意大利锡耶纳大学环境生物系日本筑波国家资源和环境研究所密歇根州立大学国家食品安全和毒理学中心

我们曾对从意大利收集的金枪鱼、箭鱼、普通鸬鹚以及家燕体内的p,(?)-DDE、多氯联苯同类物(PCBs)、多氯二苯-p-二恶英(PCDDs)、多氟二苯并呋喃(PCDFs)以及多氟萘(PCNs)浓度进行过测量。PCBs在金枪鱼、箭鱼、鸬鹅以及家燕肝脏内的平均浓... 详细信息

我们曾对从意大利收集的金枪鱼、箭鱼、普通鸬鹚以及家燕体内的p,(?)-DDE、多氯联苯同类物(PCBs)、多氯二苯-p-二恶英(PCDDs)、多氟二苯并呋喃(PCDFs)以及多氟萘(PCNs)浓度进行过测量。PCBs在金枪鱼、箭鱼、鸬鹅以及家燕肝脏内的平均浓度分别为930、745、1420和1230ng PCBs/g湿重,金枪鱼、箭鱼、鸬鹅以及家燕肝脏内的p,(?)-DDE平均浓度分别为82、135、166和95ng DDE/g湿重,在分析的所有样品中都发现有PCNs,不过浓度小于所报道的波罗的海生物体内的PCNs浓度。PCBs,特别是非正交、共面的PCBs占金枪鱼和箭鱼体内总毒性当量的80%～90%。鸬鹚和家燕体内PCDDs/DFs对毒性当量(TEQs)的相对贡献与鱼类相比更大一些。鸬鹚和家燕体内PCDD/DF同类物分别占总毒性当量的80%和45%。

关键词：意大利金枪鱼箭鱼鸬鹚家燕多氯萘多氯联苯多氯二苯-p-二恶英多氯二苯并呋喃生物监测

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