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TNF-<i>α</i>and RANKL facilitates the development of orthodontically-induced inflammatory root resorption

Open Journal of Stomatology 2013年第9期3卷 52-58页

作者： Tadashi Kojima Masaru Yamaguchi Tomokazu Yoshino Mami Shimizu kunihiko yamada Takemi Goseki Kazutaka Kasai Department of Orthodontics Nihon University School of Dentistry at Matsudo Chiba Japan

Background: The objective of this study was to determine the levels of tumor necrosis factor-alpha (TNF-α) and receptor activator of NF-kB ligand (RANKL) in the gingival crevicular fluid (GCF) in patients with severe root resorption after orthodontic treatment. Materials and Methods: Ten patients who had been receiving orthodontic treatment (5-control subjects and 5-severe root resorption subjects) participated in this study. GCF was collected from all patients. Subjects with severe root resorption (>1/3 of the original root length) were identified. Control group subjects with no loss of the root structure undergoing orthodontic treatment were also identified. The GCF was collected non-invasively from the mesial and distal sides of each of the upper central and lateral incisors using filter paper strips. The eluted GCF was used for a Western blot analysis with Antibodies against TNF-α and soluble RANKL (sRANKL). Ten male 6-week-old Wistar rats were subjected to orthodontic force of 50 g to induce a mesially tipping movement of the upper first molars for 7 days. The expression levels of TNF-α and RANKL proteins were determined in periodontal ligament (PDL) by immunohistochemical analysis. Results: The Western blot analysis showed that the TNF-α and sRANKL expressions were significantly higher in the severe root resorption group than in the control group. In the experimental tooth movement in vivo, resorption lacunae with multinucleated cells were observed in 50 g group. The immunoreactivity for TNF-α and RANKL was detected in PDL tissue subjected to the orthodontic force on day 7. Conclusion: These results suggest that TNF-α and RANKL play important roles in inducing or facilitating the development of orthodontically-induced inflammatory root resorption (OIIRR).

关键词： TNF-α sRANKL Orthodontic Root Resorption Gingival Crevicular Fluid

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External apical root resorption and the release of interleukin-6 in the gingival crevucular fluid induced by a self-ligating system

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Open Journal of Stomatology 2012年第2期2卷 116-121页

作者： Ryoko Kawashima-Ichinomiya Masaru Yamaguchi Yasuhiro Tanimoto Masaki Asano kunihiko yamada Ryo Nakajima Shoji Fujita Kazutaka Kasai Department of Dental Biomaterials Nihon University School of Dentistry at Matsudo Chiba Japan Department of Orthodontics Nihon University School of Dentistry at Matsudo Chiba Japan

The aim of this study was to investigate the amount of external apical root resorption (EARR) and the release of interleukin (IL)-6 in the gingival crevicular fluid (GCF) in subjects treated with a low-force low-friction system. Sixty patients were assigned to two groups of thirty patients for each: one group received treatment with self-ligating brackets and the other with conventional ligated edgewise brackets. All patients were treated with extraction of the maxillary first premolars. The EARR of the maxillary central incisors was evaluated on the periapical radiographs and cephalograms, taken before and after orthodontic treatment. The GCF was also collected non-invasively from the mesial and distal sides of central incisors by using filter paper strips before and after orthodontic treatment. Enzyme-linked immunosorbent assay (ELISA) kits were used to determine the IL-6 levels in the GCF samples. A significant difference was found in the amount of EARR between the patients with self-ligating brackets and conventional brackets. The mean amount of EARR was significantly lower for self-ligating brackets than conventional brackets (p < 0.05). The GCF levels of IL-6 for the patients with self-ligating brackets appliance were significantly lower than for those with the conventional brackets (p < 0.05). These results show that the mean amount of EARR and the GCF levels of IL-6 were significantly lower in the patients treated using low-force low-friction appliances than conventional brackets. Therefore, self-ligating brackets may be a useful system for reducing inflammation and EARR.

关键词： IL-6 Gingival Crevucular Fluid External Apical Root Resorption Self-Ligating Brackets

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Unilateral branch retinal artery occlusion in association with COVID-19:a case report

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International Journal of Ophthalmology(English edition) 2024年第4期17卷 777-782页

作者： kunihiko Hirosawa Takenori Inomata Jaemyoung Sung Yuki Morooka Tianxiang Huang Yasutsugu Akasaki Yuichi Okumura Ken Nagino Kaho Omori Shintaro Nakao Department of Ophthalmology Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Digital Medicine Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Telemedicine and Mobile Health Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Hospital Administration Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan AI Incubation Farm Juntendo University Graduate School of Medicine2-1-1 HongoBunkyo-kuTokyo 113-0033Japan Department of Ophthalmology Tulane University School of MedicineNew OrleansLA 70112USA

Dear Editor,I am kunihiko Hirosawa of the Department of Ophthalmology at Juntendo University Hospital.I am writing to present a case of concomitant Coronavirus Disease 2019(COVID-19)with branch retinal artery occlusion(BRAO).BRAO presents as a sudden,painless loss of vision on the afflicted side and is most often focal in nature[1].

关键词： branch COV occlusion

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Novel aspects of extracellular adenosine dynamics revealed by adenosine sensor cells

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Neural Regeneration Research 2017年第6期12卷 881-885页

作者： kunihiko Yamashiro Mitsuhiro Morita Department of Biochemistry and Cellular Biology National Institute of Neuroscience National Center of Neurology and Psychiatry (NCNP) Department of NCNP Brain Physiology and Pathology Tokyo Medical and Dental University Graduate School of Medical and Dental Sciences Department of Biology Kobe University Graduate School of Sciences

Adenosine modulates diverse physiological and pathological processes in the brain, including neuronal activities, blood flow, and inflammation. However, the mechanisms underlying the dynamics of extracellular adenosine are not fully understood. We have recently developed a novel biosensor, called an adenosine sensor cell, and we have characterized the neuronal and astrocytic pathways for elevating extracellular adenosine. In this review, the physiological implications and therapeutic potential of the pathways revealed by the adenosine sensor cells are discussed. We propose that the multiple pathways regulating extracellular adenosine allow for the diverse functions of this neuromodulator, and their malfunctions cause various neurological and psychiatric disorders.

关键词： adenosine neuronal physiological understood astrocyte neurological Adenosine synaptic hippocampal psychiatric

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Large deformation simulations of geomaterials using moving particle semi-implicit method

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Journal of Rock Mechanics and Geotechnical Engineering 2018年第6期10卷 1122-1132页

作者： Shintaro Nohara Hiroshi Suenaga kunihiko Nakamura Central Research Institute of Electric Power Industry ChibaJapan

Numerical simulation tools are required to describe large deformations of geomaterials for evaluating the risk of geo-disasters. This study focused on moving particle semi-implicit(MPS) method, which is a Lagrangian gridless particle method, and investigated its performance and stability to simulate large deformation of geomaterials. A calculation method was developed using geomaterials modeled as Bingham fluids to improve the original MPS method and enhance its stability. Two numerical tests showed that results from the improved MPS method was in good agreement with the theoretical ***, numerical simulations were calibrated by laboratory experiments. It showed that the simulation results matched well with the experimentally observed free-surface configurations for flowing sand. In addition, the model could generally predict the time-history of the impact force. The MPS method could be a useful tool to evaluate large deformation of geomaterials.

关键词： Particle method Moving particle semi-implicit(MPS) method Large deformation analysis Geomaterials Bingham model

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Supercontinuum Lightwave Sources for Photonic Networks

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光学学报 2003年第S1期23卷 733-734页

作者： kunihiko Mori NTT Network Innovation Laboratories NTT Corporation 1-1 Hikari-no-oka Yokosuka Kanagawa 239-0847 Japan

WDM optical sources based on supercontinuum (SC) generation are reviewed. The design of an SC lightwave source is described that uses a scaling rule among the parameters in an SC generating fiber and a seed optical pu... 详细信息

关键词： for in et on SC Supercontinuum Lightwave Sources for Photonic Networks WDM

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Enhanced electrical property of graphite/Al_(2)O_(3) composite fabricated by reductive sintering of gel-casted body using cross-linked epoxy polymer

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Journal of Advanced Ceramics 2022年第4期11卷 523-531页

作者： Yoshiaki FUNAHASHI Yunzi XIN kunihiko KATO Huu Hien NGUYEN Takashi SHIRAI Department of Life Science and Applied Chemistry Graduate School of EngineeringNagoya Institute of TechnologyGokiso-choShowa-kuNagoyaAichi 466-8555Japan Advanced Ceramics Research Center Nagoya Institute of TechnologyGokiso-choShowa-kuNagoyaAichi 466-8555Japan

In the present study,graphite/alumina composites are fabricated via reductive sintering of gel-casted green bodies with structurally controlled cross-linked epoxy polymers for the first *** cross-linking degrees of polymers are tuned by the amount ratio of epoxy monomer/polyvinyl alcohol cross-linker utilized in gel-casting *** electrical properties with respect to 5-fold enhanced electrical conductivity and 2-fold higher carrier mobility are successfully achieved in graphite/alumina composite fabricated from cross-linked epoxy polymer,whose phenomenon is attributed to the excellent conductive path in ceramic matrix established by highly uniform network with improved graphitization degree.

关键词： ceramic composite gel-casting reductive sintering cross-linking electrical property graphitization

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Strangulated hernia through a defect of the broad ligament and mobile cecum: A case report

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World Journal of Gastroenterology 2006年第9期12卷 1479-1480页

作者： kunihiko Hiraiwa Kyoei Morozumi Hiroshi Miyazaki Keiichi Sotome Akio Furukawa Makoto Nakamaru Department of Surgery Hamamatsu Red Cross Hospital HamamatsuShizuokaJapan Department of Surgery Fussa Hospital FussaTokyoJapan

We report a case of 28-year-old woman presenting with small bowel obstruction. She had neither prior surgery nor delivery. An upright abdominal radiograph revealed several air-fluid levels in the small bowel in the midabdomen and the pelvic cavity. Computed tomography demonstrated a dilated small bowel loop in the Douglas＇s fossa, but no definite diagnosis could be made. Supportive therapy with draining the intestinal fluid by a long intestinal tube did not result in improvement, which suggested the possibility of a strangulated hernia. Exploratory laparotomy revealed mobile cecum and a 20-cm length of the ileum herniated into a defect of the right broad ligament. As a gangrenous change was recognized in the incarcerated bowel, its resection was carried out, followed by endto-end anastomosis and closure of the defects of the broad ligament. The postoperative course was uneventful. Intestinal obstruction is a very common cause for presentation to an emergency department, while internal hernia is a rare cause of obstruction. Among internal hernias, those through defects of the broad ligament are extremely rare. Defects of the broad ligament can be either congenital or secondary to surgery, pelvic inflammatory disease, and delivery trauma. In conclusion, we emphasize that hernia of the broad ligament should be added to the list of differential diagnosis for female patients presenting with an intestinal obstruction. Early diagnosis and surgical repair reduce morbidity and mortality from strangulation.

关键词： Internal hernia Broad ligament Intestinal obstruction Mobile cecum

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Segmental gastrectomy with radical lymph node dissection for early gastric cancer

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World Journal of Gastroenterology 2010年第41期16卷 5247-5251页

作者： Takeru Matsuda kunihiko Kaneda Manabu Takamatsu Keishi Aishin Masahide Awazu Akiko Okamoto Katsunori Kawaguchi Department of Surgery Kobe Kaisei HospitalKobe 657-0078 Japan

AIM: To describe a new surgical technique and evaluate the early results of segmental gastrectomy (SG) with modified D2 lymph node (LN) dissection for early gastric cancer (EGC). METHODS: Fourteen patients with EGC underwent SG with modified D2 dissection from 2006 to 2008. Their operative results and postoperative courses were compared with those of 17 patients who had distal gastrectomy (DG) for EGC during the same period. RESULTS: Operating time, blood loss, and hospital stay were similar between the 2 groups. Postoperative complications developed significantly more frequently in the DG group than in the SG group. Mean number of dissected LNs per each station in the SG group was comparable with that in the DG group. Postoperative recovery of body weight was significantly better in the SG group than in the DG group. The incidence of reflux esophagitis and gastritis after surgery was less frequent in the SG group than in the DG ***: SG with modified D2 LN dissection may be a new function-preserving gastrectomy that is feasible for treatment of EGC with possible LN involvement.

关键词： Gastrectomy Early diagnosis Gastric can-cer Lymph node Metastasis Gastrointestinal surgical procedures

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A successful birth of severe secondary recurrent miscarriage case after a decline of phosphatidylserine-dependent anti-prothrombin antibody by intravenous immunoglobulin administration

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Open Journal of Obstetrics and Gynecology 2012年第2期2卷 156-160页

作者： Mika Kanaya kunihiko Nagasawa Tsuyoshi Baba Shinichi Ishioka Hideto yamada Toshiaki Endo Tsuyoshi Saito Department of Obstetrics and Gynecology School of Medicine Kobe University Kobe Japan Department of Obstetrics and Gynecology School of Medicine Sapporo Medical University Sapporo Japan Mika Ladies Clinic Sapporo Japan

A 33 years old woman was referred to our hospital since her sixth pregnancy had been revealed. In fact, at 19 years of age she had diagnosed as having systemic lupus erythematosus without organ failure. In addition, she had a past history of uncontrollable severe pregnancy-induced hypertension occurred during the second pregnancy, resulting in extremely premature delivery and following postpartum HELLP syndrome. It was so severe that we employed administration of dexamethasone and plasma exchange to ameliorate a life-threatening situation. In the course of her recovery it was revealed that she had been complicated with antiphospholipid antibodies, and at the same time we observed that phosphatidylserine-dependent anti-prothrombin antibody IgG levels were declining as her condition was getting better. There-after, she became pregnant three times, but all pregnancies ended in miscarriage despite administration of prednisolone and anticoagulant therapy. Therefore, we realized that her recurrent miscarriages could not be prevented with generally acceptable therapies, so we tried intravenous immunoglobulin shortly after fetal heart beats were detected. In fact, her sixth pregnancy was going well, but we had to terminate it at the 35th week of gestation due to the onset of HELLP syndrome-like condition. However, she could achieve an almost intact pregnancy outcome without neonatal complications or persistently worsening postpartum HELLP syndrome-like condition. Considering the etiologic relation overlapping between systemic lupus erythematosus, antiphospholipid syndrome and recurrent miscarriage, intravenous immunoglobulin can be one of the treatment options for severe secondary recurrent miscarriage, although the evidence of the treatment is always certain. In addition, a decline of phosphatidylserine-dependent anti-prothrombin antibody IgG levels we observed in this case may represent its therapeutic immunomodulatory effects.

关键词： Antiphospholipid Antibody Antiphospholipid Syndrome Intravenous Immunoglobulin Recurrent Miscarriage Systemic Lupus Erythematosus

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