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Generation of polarization-multiplexed terahertz orbital angular momentum combs via all-silicon metasurfaces

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Light(Advanced Manufacturing) 2024年第3期5卷 120-129页

作者： Ming-zhe Chong Yiwen Zhou Zong-kun Zhang Jin Zhao Yue-Yi Zhang Chong-Qi Zhang Xiaofei Zang Chao-Hai Du Pu-kun Liu Ming-Yao Xia School of Electronics Peking UniversityBeijing 100871China Terahertz Technology Innovation Research Institute and Shanghai Key Lab of Modern Optical SystemUniversity of Shanghai for Science and TechnologyNo.516 Jun Gong RoadShanghai 200093China State Key Laboratory of Advanced Optical Communication Systems and Networks School of ElectronicsPeking UniversityBeijing 100871China

Electromagnetic waves carrying orbital angular momentum(OAM),namely OAM beams,are important in various fields including optics,communications,and quantum ***,most current schemes can only generate single or several simple OAM ***-mode OAM beams are rarely *** paper proposes a scheme to design metasurfaces that can generate multiple polarization-multiplexed OAM modes with equal intervals and intensities(i.e.,OAM combs)working in the terahertz(THz)*** a proof of concept,we first design a metasurface to generate a pair of polarization-multiplexed OAM combs with arbitrary mode ***,another metasurface is proposed to realize a pair of polarization-multiplexed OAM combs with arbitrary locations and intervals in the OAM *** results agree well with full-wave simulations,verifying a great performance of OAM combs *** method may provide a new solution to designing high-capacity THz devices used in multi-mode communication systems.

关键词： Metasurfaces Terahertz Orbital angular momentum comb Polarization multiplexing

Targeting GPR65 alleviates hepatic inflammation and fibrosis by suppressing the JNK and NF-κB pathways

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Military Medical Research 2024年第4期11卷 500-520页

作者： kun Zhang Meng-Xia Zhang Xiao-Xiang Meng Jing Zhu Jia-Jun Wang Yi-Fan He Ye-Hua Li Si-Cong Zhao zhe-Min Shi Li-Na zheng Tao Han Wei Hong Department of Histology and Embryology School of Basic Medical SciencesTianjin Medical UniversityTianjin 300070China Department of Hepatology and Gastroenterology Tianjin Union Medical CenterTianjin Medical UniversityTianjin Union Medical Center Affiliated to Nankai UniversityTianjin 300000China

Background:G-protein coupled receptors(GPCRs)are recognized as attractive targets for drug ***,it remains poorly understood how GPCRs,except for a few chemokine receptors,regulate the progression of liver ***,we aimed to reveal the role of GPR65,a proton-sensing receptor,in liver fibrosis and to elucidate the underlying ***:The expression level of GPR65 was evaluated in both human and mouse fibrotic ***,Gpr65-deficient mice were treated with either bile duct ligation(BDL)for 21 d or carbon tetrachloride(CCl4)for 8 weeks to investigate the role of GPR65 in liver fibrosis.A combination of experimental approaches,including Western blotting,quantitative real-time reverse transcription-polymerase chain reaction(qRT-PCR),and enzyme-linked immunosorbent assay(ELISA),confocal microscopy and rescue studies,were used to explore the underlying mechanisms of GPR65’s action in liver ***,the therapeutic potential of GPR65 inhibitor in the development of liver fibrosis was ***:We found that hepatic macrophage(HM)-enriched GPR65 was upregulated in both human and mouse fibrotic ***,knockout of Gpr65 significantly alleviated BDL-and CCl4-induced liver inflammation,injury and fibrosis in vivo,and mouse bone marrow transplantation(BMT)experiments further demonstrated that the protective effect of Gpr65knockout is primarily mediated by bone marrow-derived macrophages(BMMs).Additionally,in vitro data demonstrated that Gpr65 silencing and GPR65 antagonist inhibited,while GPR65 overexpression and application of GPR65 endogenous and exogenous agonists enhanced the expression and release of tumor necrosis factor-α(TNF-α),interleukin-6(IL-6)and transforming growth factor-β(TGF-β),all of which subsequently promoted the activation of hepatic stellate cells(HSCs)and the damage of hepatocytes(HCs).Mechanistically,GPR65 overexpression,the acidic pH and GPR65 exogenous agonist induced up-regulation of

关键词： GPR65 Hepatic fibrosis Hepatic macrophages Inflammation c-Jun N-terminal kinase Nuclear factorκB

Meta-analysis of Cohort Studies on Clinical Efficacy of Icodextrin Peritoneal Dialysate

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Asian Journal of Social Pharmacy 2024年第3期19卷 279-290页

作者： Ren Hongyan Wang Yaoling Hui Xu Li Xue Zhao kun Huang zhe School of Business Administration Shenyang Pharmaceutical UniversityShenyang 110016China China National Health Develo-pment Research Center Beijing 100000China School of Business Health Lanzhou UniversityLanzhou 730000China

Objective To evaluate the effect of real-world practices for icodextrin peritoneal dialysis solution on patients with end-stage renal disease(ESRD)by *** The PubMed and Embase databases were systematically searched for real-world research literature on icodextrin peritoneal dialysate in the treatment of ESRD patients,and RevMan5.4 statistical software was used for *** and Conclusion 12 studies with 114656 patients were ***-analysis results showed that icodextrin peritoneal dialysis had good effects on mortality[RR=0.72,95%CI(0.62,0.83),P<0.001],congestive heart failure[RR=0.67,95%CI(0.52,0.87),P=0.003],and risk of new-onset diabetes[RR=0.65,95%CI(0.49,0.86),P=0.003],which was consistent with the Meta-analysis based on clinical ***,there was no significant difference in PD technical failure rate[RR=0.67,95%CI(0.44,1.00),P=0.05],peritonitis[RR=1.02,95%CI(0.99,1.05),P=0.14],cardiovascular and cerebrovascular diseases[RR=0.79,95%CI(0.59,1.05),P=0.10],coronary artery disease[RR=0.99,95%CI(0.92,1.07),P=0.80],stroke[RR=0.86,95%CI(0.66,1.10),P=0.23],and atrial fibrillation[RR=0.73,95%CI(0.37,1.44),P=0.36].However,it might increase the risk of hypertension[RR=1.05,95%CI(1.03,1.07),P<0.001].Therefore,icodextrin can effectively reduce the risk of mortality,congestive heart failure,and new-onset diabetes,which is beneficial to ESRD patients.

关键词： icodextrin peritoneal dialysis fluid peritoneal dialysis end-stage renal disease mortality Meta-analysis

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企业ESG表现与审计意见购买

山西财经大学学报 2024年第1期46卷 114-126页

作者：沈喆张锟澎西南财经大学会计学院四川成都611130 上海立信会计金融学院会计学院上海201620

基于2010—2021年沪深A股上市公司,实证研究企业ESG表现对审计意见购买行为的影响。研究发现,较好的企业ESG表现会抑制审计意见购买行为,且这种抑制作用在非国有企业、分析师关注度较低的企业以及属于重污染行业的企业中更为显著。机制... 详细信息

基于2010—2021年沪深A股上市公司,实证研究企业ESG表现对审计意见购买行为的影响。研究发现,较好的企业ESG表现会抑制审计意见购买行为,且这种抑制作用在非国有企业、分析师关注度较低的企业以及属于重污染行业的企业中更为显著。机制分析表明,好的企业ESG表现能够通过提高信息披露质量和改善内部控制的方式抑制审计意见购买行为。分项检验发现,环境保护、社会责任和公司治理三个维度的表现均能够抑制审计意见购买行为。

关键词：企业ESG表现审计意见购买审计师变更信息披露质量内部控制

Inhibitory effect of saffron on head and neck squamous cell carcinoma via targeting of ESR1 and CCND1 by its active compound crocetin

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Traditional Medicine Research 2024年第7期9卷 25-34页

作者： Xiao-Jie Wang Ming-Jun Zhang Li-Mei Cui zhe-Ying Song Ya-Qi Wang Yu-Teng Yang Xiang-kun Zhao Ya-Kui Mou Yu-Mei Li Xi-Cheng Song School of Clinical Medicine Weifang Medical UniversityWeifang 261042China. Department of Otorhinolaryngology Head and Neck SurgeryYantai Yuhuangding HospitalQingdao UniversityYantai 264000China. Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases Yantai 264000China. Yantai Key Laboratory of Otorhinolaryngologic Diseases Yantai Yuhuangding HospitalYantai 264000China. The 2nd Medical College of Binzhou Medical University Yantai 264000China.

Background:Traditional Chinese medicine is promising for managing challenging and complex disorders,including cancer,and in particular,saffron is applied in treating various cancer ***,its potential therapeutic efficacy and active components in managing squamous cell carcinoma of the head and neck(HNSCC)remain unclear ***:Using network pharmacology approaches,active ingredients of saffron,their target genes,and HNSCC-related genes were *** analyses were conducted for determining molecular functions and pathways enriched by genes that overlapped between the saffron target gene set and the HNSCC gene *** the four known active ingredients of saffron,crocetin was found to have the strongest inhibitory impact on HNSCC,based on the findings of cell viability and migration ***,the potential target genes of crocetin in HNSCC cells were examined using molecular docking experiments and were confirmed by *** s:Four active ingredients of saffron and 184 of their target genes were ***,a total of 34 overlapping saffron-/HNSCC-associated targets related to the four active ingredients were screened,and crocetin was chosen for further investigation because it had the strongest inhibitory effect on HNSCC *** docking experiments indicated that ESR1 and CCND1 were the target genes of *** results were confirmed through qPCR analysis,in which crocetin was found to lower the expression of the ESR1 and CCND1 genes in AMC-HN-8 and FaDu ***:According to our results,crocetin is a primary active anti-cancer component of saffron that may have potential in the development of novel HNSCC-treating ***,more thorough molecular research is necessary for confirming these results and elucidating the anti-cancer mechanism underlying saffron.

关键词： saffron hub genes crocetin network pharmacology analysis HNSCC ESR1 CCND1

Prediction of treatment response to antipsychotic drugs for precision medicine approach to schizophrenia:randomized trials and multiomics analysis

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Military Medical Research 2024年第1期11卷 19-33页

作者： Liang-kun Guo Yi Su Yu-Ya-Nan Zhang Hao Yu zhe Lu Wen-Qiang Li Yong-Feng Yang Xiao Xiao Hao Yan Tian-Lan Lu Jun Li Yun-Dan Liao zhe-Wei Kang Li-Fang Wang Yue Li Ming Li Bing Liu Hai-Liang Huang Lu-Xian Lv Yin Yao Yun-Long Tan Gerome Breen Ian Everall Hong-Xing Wang Zhuo Huang Dai Zhang Wei-Hua Yue Institute of Mental Health Peking University Sixth HospitalBeijing 100191China National Clinical Research Center for Mental Disorders Peking University Sixth HospitalBeijing 100191China NHC Key Laboratory of Mental Health and Research Unit of Diagnosis and Treatment of Mood Cognitive Disorder(2018RU006) Chinese Academy of Medical SciencesBeijing 100191China Peking University Huilongguan Clinical Medical School Beijing Huilongguan HospitalBeijing 100096China Department of Psychiatry Jining Medical UniversityJining 272067ShandongChina Henan Key Lab of Biological Psychiatry the Second Affiliated Hospital of Xinxiang Medical UniversityXinxiang 435001HenanChina Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of ZoologyChinese Academy of SciencesKunming 650223China Institute of Psychiatry Psychology and NeuroscienceKing’s College LondonLondon WC2R 2LSUK State Key Laboratory of Cognitive Neuroscience and Learning Beijing Normal UniversityBeijing 100875China Analytic and Translational Genetics Unit Massachusetts General HospitalBostonMA 02114USA Stanley Center for Psychiatric Research the Broad Institute of MIT and HarvardCambridgeMA 02141USA Department of Medicine Harvard Medical SchoolBostonMA 02115USA Department of Biostatistics and Computational Biology School of Life SciencesFudan UniversityShanghai 200438China Department of Neurology Xuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Natural and Biomimetic Drugs Key Laboratory for Neuroscience for Ministry of EducationSchool of Pharmaceutical SciencesPeking University Health Science CenterBeijing 100191China PKU-IDG/McGovern Institute for Brain Research Peking UniversityBeijing 100871China Chinese Institute for Brain Research Beijing 102206China

Background:Choosing the appropriate antipsychotic drug(APD)treatment for patients with schizophrenia(SCZ)can be challenging,as the treatment response to APD is highly variable and difficult to predict due to the lack of effective *** studies have indicated the association between treatment response and genetic and epigenetic factors,but no effective biomarkers have been ***,further research is imperative to enhance precision medicine in SCZ ***:Participants with SCZ were recruited from two randomized *** discovery cohort was recruited from the CAPOC trial(n=2307)involved 6 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,Quetiapine,Aripiprazole,Ziprasidone,and Haloperidol/Perphenazine(subsequently equally assigned to one or the other)*** external validation cohort was recruited from the CAPEC trial(n=1379),which involved 8 weeks of treatment and equally randomized the participants to the Olanzapine,Risperidone,and Aripiprazole ***,healthy controls(n=275)from the local community were utilized as a genetic/epigenetic *** genetic and epigenetic(DNA methylation)risks of SCZ were assessed using the polygenic risk score(PRS)and polymethylation score,*** study also examined the genetic-epigenetic interactions with treatment response through differential methylation analysis,methylation quantitative trait loci,colocalization,and promoteranchored chromatin *** learning was used to develop a prediction model for treatment response,which was evaluated for accuracy and clinical benefit using the area under curve(AUC)for classification,R^(2) for regression,and decision curve ***:Six risk genes for SCZ(LINC01795,DDHD2,SBNO1,KCNG2,SEMA7A,and RUFY1)involved in cortical morphology were identified as having a genetic-epigenetic interaction associated with treatment *** developed and externally validated predictio

关键词： Schizophrenia Antipsychotic drug Treatment response Prediction model Genetics Epigenetics

Taming heat with tiny pressure

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The Innovation 2024年第2期5卷 70-78页

作者： kun Zhang zhe Zhang Hailong Pan Haoyu Wang Xueting Zhao Ji Qi Zhao Zhang Ruiqi Song Chenyang Yu Biaohong Huang Xujing Li Huaican Chen Wen Yin Changlong Tan Weijin Hu Michael Wüubbenhorst Jiangshui Luo Dehong Yu Zhidong Zhang Bing Li Shenyang National Laboratory for Materials Science Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China Laboratory for Soft Matter and Biophysics Department of Physics and AstronomyKU Leuven3001 LeuvenBelgium Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China Spallation Neutron Source Science Center Dongguan 523803China College of Materials Science and Engineering Sichuan UniversityChengdu 610064China School of Materials Science and Chemical Engineering Harbin University of Science and TechnologyHarbin 150080China Australian Nuclear Science and Technology Organisation Lucas HeightsNSW 2234Australia

Heat is almost *** electricity,which can be easily manipulated,the current ability to control heat is still highly limited owing to spontaneous thermal dissipation imposed by the second law of *** illumination and pressure have been used to switch endothermic/exothermic responses of materials via phase transitions;however,these strategies are less cost-effective and ***,we spectroscopically demonstrate the glassy crystal state of 2-amino-2-methyl-1,3-propanediol(AMP)to realize an affordable,easily manageable approach for thermal energy *** supercooled state of AMP is so sensitive to pressure that even several megapascals can induce crystallization to the ordered crystal,resulting in a substantial temperature increase of 48 K within 20 ***,we demonstrate a proof-of-concept device capable of programable heating with an extremely high work-to-heat conversion effi-ciency of*** delicate and efficient tuning of heat may remarkably facilitate rational utilization of waste heat.

关键词： illumination thermal rational

内外分幅的整体复合式高速公路交通指路标志布设方法

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交通信息与安全 2024年第3期42卷 62-73页

作者：胡鑫超戴喆奚坤长安大学运输工程学院西安710000

整体复合式高速公路具有特殊的道路结构和交通组织模式,所需传递的信息量较大。为提升指路标志引导效率,避免信息过载,改善整体复合式高速公路交通运行的安全性,针对该场景指路标志的布设展开研究。以广深高速公路为例,通过分析内外分... 详细信息

整体复合式高速公路具有特殊的道路结构和交通组织模式,所需传递的信息量较大。为提升指路标志引导效率,避免信息过载,改善整体复合式高速公路交通运行的安全性,针对该场景指路标志的布设展开研究。以广深高速公路为例,通过分析内外分幅交通组织模式下整体复合式高速公路特征,明确了指路标志的布设原则并据此提出了基于内外幅功能和基于车道功能的信息指引方法以及适用于复合式高速公路的指路信息分级方式。借助驾驶模拟技术,进行了指路标志的信息阈值和版面设计试验。先后测得不同信息数量指路标志驾驶人目标搜寻时间和被试人员驶出互通出口过程中横向偏移量、速度、加速度以及标志注视时间。信息阈值试验中,使用稳健估计理论处理目标信息搜寻时间,对比可供信息搜寻时间表,认为整体复合式高速公路指路标志信息阈值为8条。版面设计试验中,依据提出的2种信息指引方法和信息分级方式绘制的互通出口指路标志均能正确引导车辆到达目的地,但基于内外幅功能的指引方法信息传递效率更高,使得内外幅换道提前约250 m,驾驶速度提高5.88%,加速度标准差减小45.77%,并且缩短了驾驶人注视标志的时间。研究表明:在内外分幅的整体复合式高速公路中,使用基于内外幅功能的信息指引方法能提高指路标志视认性,有效引导交通运行,推荐整体复合式高速公路采用基于内外幅功能的信息指引方法布设指路标志。

关键词：交通工程复合式高速公路指路标志驾驶模拟试验内外分幅稳健估计

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中国东部季风区山地落叶阔叶林上线分布特征及其地理解释

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地理学报 2024年第1期79卷 240-258页

作者：王志勇韩芳李传荣李坤穆豪祥王哲山东理工大学建筑工程与空间信息学院淄博255049 山东农业大学林学院泰安271018

落叶阔叶林是中国东部季风区的典型植被。本文利用复合高程信息的地表覆盖精细分类产品数据,提取山地落叶阔叶林上线。构建山地落叶阔叶林上线分布高度云模型及其影响因子云模型,探讨山地落叶阔叶林上线及其影响因子的分布特征;构建多... 详细信息

落叶阔叶林是中国东部季风区的典型植被。本文利用复合高程信息的地表覆盖精细分类产品数据,提取山地落叶阔叶林上线。构建山地落叶阔叶林上线分布高度云模型及其影响因子云模型,探讨山地落叶阔叶林上线及其影响因子的分布特征;构建多尺度多元线性回归模型以及影响因子权系数云模型,比较分析影响因子对落叶阔叶林上线作用的尺度变化和空间分异,尝试探讨各山地落叶阔叶林上线对气候因子作用的敏感性差异。结果如下:①中国东部季风区山地落叶阔叶林上线高度自北向南先升高后降低,分布高度的期望、熵和超熵分别为965.77~1993.52 m、132.80~514.09 m和27.58~205.34 m。②山地落叶阔叶林上线的影响因子存在显著的尺度变化和空间分异:区域尺度上,非气候林线和气候林线的主导因子均为山体基面高度,贡献率分别为71.36%和44.06%,气候林线受温度影响高于降水,而非气候林线受降水影响高于温度;山系尺度上,山地落叶阔叶林上线主要受1月均温和年降水量影响,且大部分山地1月均温的作用高于年降水量;局地尺度上,除大别山外,山顶效应对各山地落叶阔叶林上线作用权重的期望最大,年降水量作用权重的期望均高于1月均温。③大别山和太行山落叶阔叶林上线对年降水量最敏感,吕梁山落叶阔叶林上线对1月均温最敏感。探讨山地落叶阔叶林上线的分布特征及其影响因素的空间分异,可以推动垂直带对气候变化响应差异的研究,并为区域生态安全监测体系的部署和管理提供理论支持。

关键词：山地落叶阔叶林上线影响因子云模型空间分异中国东部季风区