检索结果-南通市图书馆

Coronary artery aneurysm combined with myocardial bridge:A case report

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Cases 2021年第16期9卷 3996-4000页

作者： Zhen Ye Xian-Feng Dong yuan-Ming Yan yu-kun luo Department of Cardiology Fujian Medical University Union HospitalFuzhou 350001Fujian ProvinceChina Fujian Institute of Coronary Artery Disease Fuzhou 350001Fujian ProvinceChina Fujian Heart Medical Center Fuzhou 350001Fujian ProvinceChina

BACKGROUND Coronary artery aneurysm combined with myocardial bridge is a very rare clinical *** prognosis of this clinical situation is not yet *** SUMMARY A coronary artery aneurysm and myocardial bridge in the same segment of the coronary artery were found in a 54-year-old female patient who underwent coronary angiography and intravascular ultrasound *** conservative treatment,the patient was discharged from the hospital smoothly,and she was in good condition during 5 mo of *** Coronary artery aneurysm combined with myocardial bridge seems to have a good prognosis,but due to the rarity of this clinical situation,further research and follow-up are needed.

关键词： Coronary artery aneurysm Myocardial bridge Coronary angiography Intravascular ultrasound Chest pain Case report

Tilting homeostatic and dyshomeostatic microglial balance in health and disease:transforming growth factor-beta1 as a critical protagonist

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第10期20卷 2895-2897页

作者： Nicolas Hugues yu luo Department of Molecular and Cellular Biosciences University of CincinnatiCincinnatiOHUSA Neuroscience Graduate Program University of CincinnatiCincinnatiOHUSA Division of Immunobiology Cincinnati Children’s Hospital Medical CenterUniversity of Cincinnati College of MedicineCincinnatiOHUSA

Adult microglia,by continuously sensing changes in their environment and communicating with nearly all brain cell types,are considered to be the immune sentinels of the *** the healthy central nervous system(CNS),microglia display a unique molecular homeostatic signature(i.e.,Tmem119,P2ry12,Sall1,Siglech,Gpr34,and Hexb)(Figure 1A).

关键词： Figure signature critical

Laparoscopic liver resection utilizing the ventral avascular area of the inferior vena cava:A retrospective cohort study

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 42-57页

作者： kun Huang Zhu Chen Heng Xiao Hai-Yang Hu Xing-yu Chen Cheng-You Du Xiang Lan Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical UniversityChongqing 400000China Department of General Surgery Mianyang Hospital of Traditional Chinese MedicineMianyang 621000Sichuan ProvinceChina

BACKGROUND Laparoscopic liver resection(LLR)can be challenging due to the difficulty of establishing a retrohepatic tunnel under *** the third hepatic hilum before parenchymal transection often leads to significant liver mobilization,tumor compression,and bleeding from the short hepatic veins(SHVs).This study introduces a novel technique utilizing the ventral avascular area of the inferior vena cava(IVC),allowing SHVs to be addressed after parenchymal transection,thereby reducing surgical complexity and improving outcomes in in situ *** To introduce and evaluate a novel LLR technique using the ventral avascular area of the IVC and compare its short-term outcomes with conventional *** The clinical cohort data of patients with pathologically confirmed hepatocellular carcinoma or intrahepatic cholangiocarcinoma who underwent conventional LLR and novel LLR between July 2021 and July 2023 at the First Affiliated Hospital of Chongqing Medical University were retrospectively *** novel LLR,we initially separated the caudate lobe from the IVC using dissecting forceps along the ventral avascular area of the ***,we transected the parenchyma of the left and right caudate lobes from the caudal side to the cephalic side using the avascular area as a ***,we addressed the SHVs and finally dissected the root of the right hepatic vein or left hepatic *** short-term postoperative outcomes and oncological results of the two approaches were evaluated and *** A total of 256 patients were included,with 150(58.59%)undergoing conventional LLR and 106(41.41%)undergoing novel *** novel technique resulted in significantly larger tumor resections(6.47±2.96 cm vs 4.01±2.33 cm,P<0.001),shorter operative times(199.57±60.37 minutes vs 262.33±83.90 minutes,P<0.001),less intraoperative blood loss(206.92±37.09 mL vs 363.34±131.27 mL,P<0.001),and greater resection volume(345.11±31.40 mL vs 264.38±31.98 mL,P<0.001)comp

关键词： Laparoscopic liver resection Inferior vena cava Retrohepatic tunnel Short hepatic veins Complex liver tumors Intraoperative bleeding control

Loss-of-function mutations of microRNA-142-3p promote ASH1L expression to induce immune evasion and hepatocellular carcinoma progression

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2025年第1期31卷 126-145页

作者： Xing-Hui yu Yan Xie Jian yu kun-Ning Zhang Zhou-Bo Guo Di Wang Zhao-Xian Li Wei-Qi Zhang yu-Ying Tan Li Zhang Wen-Tao Jiang School of Medicine Nankai UniversityTianjin 300192China Tianjin Key Laboratory of Molecular Diagnosis and Treatment of Liver Cancer Tianjin First Center HospitalTianjin 300192China Department of Liver Transplantation Tianjin First Center HospitalTianjin 300192China First Central Clinical School Tianjin Medical UniversityTianjin 300192China

BACKGROUND Hepatocellular carcinoma(HCC)has been a pervasive malignancy throughout the world with elevated *** therapeutic targets are beneficial to treat and predict the ***,the exact molecular mechanisms leading to the progression of HCC are still *** has shown that the microRNA-142-3p level decreases in HCC,whereas bioinformatics analysis of the cancer genome atlas database shows the ASH1L expression increased among liver tumor *** this paper,we will explore the effects and mechanisms of microRNA-142-3p and ASH1L affect the prognosis of HCC patients and HCC cell bioactivity,and the association between *** To investigate the effects and mechanisms of microRNA-142-3p and ASH1L on the HCC cell bioactivity and prognosis of HCC *** In this study,we grouped HCC patients according to their immunohistochemistry results of ASH1L with pathological tissues,and retrospectively analyzed the prognosis of HCC ***,explored the roles and mechanisms of microRNA-142-3p and ASH1L by cellular and animal experiments,which involved the following experimental methods:Immunohistochemical staining,western blot,quantitative real-time-polymerase chain reaction,flow cytometric analysis,tumor xenografts in nude mice,*** statistical methods involved in this study contained t-test,one-way analysis of variance,theχ^(2)test,the Kaplan-Meier approach and the log-rank *** In this study,we found that HCC patients with high expression of ASH1L possess a more recurrence rate as well as a decreased overall survival ***1L promotes the tumorigenicity of HCC and microRNA-142-3p exhibits reduced expression in HCC tissues and interacts with ASH1L through targeting the ASH1L 3′untranslated ***,microRNA-142-3p promotes apoptosis and inhibits proliferation,invasion,and migration of HCC cell lines in vitro via *** the exploration mechanism,we found ASH1L may promote an immunosuppressive mi

关键词： Hepatocellular carcinoma MicroRNA-142-3p ASH1L Immune evasion Tumor immune microenvironment Apoptosis

Molecular mechanism and research progress of traditional Chinese medicine in the treatment of prostate cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Traditional Medicine Research 2025年第1期10卷 62-72页

作者： Hai-luo Wang Ruo-Ran Zhang Hao Wang Peng Xu Jing-Kai Wang Bo Chen Hao Xu Deng Pan yu-Yang Ma kun Pang Department of Urology Xuzhou Central HospitalXuzhou Clinical School of Xuzhou Medical CollegeXuzhou 221009China Graduate School Jiangsu UniversityZhenjiang 212013China Graduate School Bengbu Medical UniversityBengbu 233040China Department of Urology The Peixian People’s HospitalXuzhou 221699China.

Prostate cancer(PCa)is one of the most common malignant tumors in the male genitourinary system,ranking second in incidence *** Chinese medicine(TCM),as an important component of complementary and alternative medicine,shows unique advantages in cancer *** herbal medicine is usually composed of multiple ingredients and involves multiple signaling pathways,which showed function of inducing apoptosis of cancer cells,arresting the cell cycle,inhibiting invasion and metastasis,reducing drug resistance,and regulating immune *** therapy is also an important treatment of ***,Physical therapy such as acupuncture or Tai Chi and Qigong are gaining increased recognition in the management of PCa,particularly in addressing issues like urinary incontinence and bone metastasis-related *** article reviews the TCM treatment and therapy of PCa,in order to provide new research avenues and treatment options for the treatment of PCa with TCM and improve the quality of life of patients.

关键词： traditional Chinese medicine prostate cancer Chinese herbal medicine physical therapy

Deep learning applied to two-dimensional color Doppler flow imaging ultrasound images significantly improves diagnostic performance in the classification of breast masses:a multicenter study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Medical Journal 2021年第4期134卷 415-424页

作者： Teng-Fei yu Wen He Cong-Gui Gan Ming-Chang Zhao Qiang Zhu Wei Zhang Hui Wang yu-kun luo Fang Nie Li-Jun yuan Yong Wang Yan-Li Guo Jian-Jun yuan Li-Tao Ruan Yi-Cheng Wang Rui-Fang Zhang Hong-Xia Zhang Bin Ning Hai-Man Song Shuai Zheng Yi Li Yang Guang Department of Ultrasound Beijing Tian Tan HospitalCapital Medical UniversityBeijing 100070China Department of R&D CHISON Medical Technologies Co.LtdWuxiJiangsu 214028China Department of Ultrasound Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Department of Ultrasound The Third Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 9530031China Department of Ultrasound China-Japan Union Hospital of Jilin UniversityChangchunJilin 130033China Department of Ultrasound Chinese PLA General HospitalBeijing 100850China Department of Ultrasound Lanzhou University Second HospitalLanzhouGansu 730030China Department of Ultrasound Xi'an Tangdu Hospital of No.4 Military Medical UniversityXi'anShaanxi 710038China Department of Ultrasound Chinese Academy of Medical Sciences Cancer Institute and HospitalBeijing 100021China Department of Ultrasound The Third M ilitary Medical University Southwest HospitalChongqing 400038China Department of Ultrasound Henan Provincial People's HospitalZhengzhou cityHenan 450003China Department of Ultrasound Xi'an Jiaotong University Medical College First Affiliated HospitalXi'anShaanxi 710061China Department of Ultrasound Hebei Medical University First Affiliated HospitalZhangjiakouHebei 075061China Department of Ultrasound Zhengzhou University First Affiliated HospitalZhengzhouHenan 450052China.

Background:The current deep learning diagnosis of breast masses is mainly reflected by the diagnosis of benign and malignant *** China,breast masses are divided into four categories according to the treatment method:inflammatory masses,adenosis,benign tumors,and malignant *** categorizations are important for guiding clinical *** this study,we aimed to develop a convolutional neural network(CNN)for classification of these four breast mass types using ultrasound(US)***:Taking breast biopsy or pathological examinations as the reference standard,CNNs were used to establish models for the four-way classification of 3623 breast cancer patients from 13 *** patients were randomly divided into training and test groups(n=1810 vs.n=1813).Separate models were created for two-dimensional(2D)images only,2D and color Doppler flow imaging(2D-CDFI),and 2D-CDFI and pulsed wave Doppler(2D-CDFI-PW)*** performance of these three models was compared using sensitivity,specificity,area under receiver operating characteristic curve(AUC),positive(PPV)and negative predictive values(NPV),positive(LR+)and negative likelihood ratios(LR-),and the performance of the 2D model was further compared between masses of different sizes with above statistical indicators,between images from different hospitals with AUC,and with the performance of 37 ***:The accuracies of the 2D,2D-CDFI,and 2D-CDFI-PW models on the test set were 87.9%,89.2%,and 88.7%,*** AUCs for classification of benign tumors,malignant tumors,inflammatory masses,and adenosis were 0.90,0.91,0.90,and 0.89,respectively(95%confidence intervals[CIs],0.87-0.91,0.89-0.92,0.87-0.91,and 0.86-0.90).The 2D-CDFI model showed better accuracy(89.2%)on the test set than the 2D(87.9%)and 2D-CDFI-PW(88.7%)*** 2D model showed accuracy of 81.7%on breast masses≤1 cm and 82.3%on breast masses>1 cm;there was a significant difference between the two groups(P<0.001).The accu

关键词： Deep learning Ultrasonography Breast diseases Diagnosis

An economic evaluation method of coalbed methane resources during the target selection phase of exploration

在线全文

学校读者我要写书评

暂无评论

Petroleum Science 2015年第4期12卷 705-711页

作者： Dong-kun luo Liang-yu Xia School of Business Administration China University of Petroleum (Beijing)

Because forecasting a development program during the target selection phase of exploration for coalbed methane （CBM） is impossible, the conventional method that relies on a conceptual （or detailed） development pro- gram cannot be used during the economic evaluation of CBM resources. Hence, this study focuses on establishing an economic evaluation model based on the characteristics of the target selection phase. The discounted cashflow method is applied to the construction of the model with the assumption that there is a uniform distribution of produc- tion wells. The computational error generated by the assumption is corrected by introducing a correction factor based on the production profile of single CBM wells. The case study demonstrates that the blocks lacking economic value can be screened out, and the most advantageous targets can be found by computing the resource values in the best- and worst-case scenarios. This technique can help to reduce wasted investments and improve the quality of decision-making in selecting targets for exploration.

关键词： Coalbed methane Exploration targetselection Economic evaluation Scenario analysis

Multi-scale numerical simulation of fluidized beds: Model applicability assessment

在线全文

学校读者我要写书评

暂无评论

Particuology 2023年第9期80卷 11-41页

作者： Shuai Wang Chenshu Hu kun luo Jiahui yu Jianren Fan State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou310027China Shanghai Institute for Advanced Study of Zhejiang University Shanghai200120China

In the past few decades,multi-scale numerical methods have been developed to model dense gas-solidflow in fluidized beds with different resolutions,accuracies,and ***,ambiguity needsto be clarified in the multi-scale numerical simulation of fluidized beds:(i)the selection of the submodels,parameters,and numerical resolution;(ii)the multivariate coupling of operating conditions,bed configurations,polydispersity,and additional ***,a state-of-the-art review is performed to assess the applicability of multi-scale numerical methods in predicting dense gas-solid flow influidized beds at specific fluidization regimes(e.g.,bubbling fluidization region,fast fluidization regime),with a focus on the inter-particle collision models,inter-phase interaction models,collision parameters,and polydispersity effect.A mutual restriction exists between resolution and *** methods need more computational resources and thus are suitable for smaller-scale simulations to provide a database for closure ***-resolution methods require fewercomputational resources and thus underpin large-scale simulations to explore macro-scale *** validations need to be further conducted under multiple flow conditions and comprehensivemetrics(e.g.,velocity profiles at different heights,bubbles,or cluster characteristics)for furtherimprovement of the applicability of each numerical method.

关键词： Fluidized bed Dense gas-solid flows Multi-scale numerical methods Drag model Inter-particle collisions

Study of biomass gasification in an industrial-scale dual circulating fluidized bed(DCFB)using the Eulerian-Lagrangian method

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Particuology 2023年第12期83卷 156-168页

作者： Jiahui yu Shuai Wang kun luo Debo Li Jianren Fan State Key Laboratory of Clean Energy Utilization Zhejiang UniversityHangzhou310027China Shanghai Institute for Advanced Study of Zhejiang University Shanghai200120China Guangdong Diankeyuan Energy Technology Co. Ltd.Guangzhou510080China

Dual circulating fluidized bed(DCFB)has emerged as an efficient reactor for biomass gasification due to its unique feature of high gas-solid contact efficiency and separated reactions in two reactors,yet the understanding of complex in-furnace phenomena is still *** this study,biomass gasification in an industrial-scale DCFB system was numerically studied using a multiphase particle-in-cell(MP-PIC)method featuring thermochemical sub-models(e.g.,heat transfer,heterogeneous reactions,and homogeneous reactions)under the Eulerian-Lagrangian *** model validation,the hydrodynamics and thermochemical characteristics(i.e.,pressure,temperature,and species)in the DCFB are comprehensively *** results show that size-/density-induced segregation makes solid fuels concentrate on the bed *** momentum exchange leads to the continuous decrease of the gas pressure *** the gasifier and combustor,the lower heating value(LHV)of the gas products is 5.56 MJ/Nm^(3)and 0.2 MJ/Nm^(3)and the combustible gas concentration(CGC)is 65.5%and 1.86%,*** temperature in the combustor is about 100 K higher than that in the gasifier.A higher solid concentration results in a smaller value of particle heat transfer coefficient(HTC).The HTCs range from 50 to 150 W/(m^(2) K)for a solid concentration larger than 0.3 in the combustor while the HTCs range from 100 to 200 W/(m^(2 )K)in the *** Reynolds number of biomass particles is two orders of magnitude larger than that of the sand *** numerical results shed light on the reactor design and process optimization of biomass gasification in DCFBs.

关键词： Dual fluidized bed Biomass gasification Numerical simulation MP-PIC Heat transfer coefficient