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Genetic variant of cyclooxygenase-2 in gastric cancer:More inflammation and susceptibility

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World Journal of Gastroenterology 2021年第28期27卷 4653-4666页

作者： Xuan-Ke Ji Sailaja Vatsalya Madhurapantula Gui He kun-yan wang Chun-Hua Song Jian-Ying Zhang Kai-Juan wang College of Public Health Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina Department of Epidemiology College of Public HealthZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Key Laboratory of Tumor Epidemiology of Henan Province Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina State Key Laboratory of Esophageal Cancer Prevention and Treatment Zhengzhou UniversityZhengzhou 450001Henan ProvinceChina

Gastric cancer accounts for the majority cancer-related deaths *** various methods have considerably improved the screening,diagnosis,and treatment of gastric cancer,its incidence is still high in Asia,and the 5-year survival rate of advanced gastric cancer patients is only 10%-20%.Therefore,more effective drugs and better screening strategies are needed for reducing the incidence and mortality of gastric ***-2(COX-2)is considered to be the key inducible enzyme in prostaglandins(PGs)synthesis,which is involved in multiple pathways in the inflammatory *** example,inflammatory cytokines stimulate innate immune responses via Toll-like receptors and nuclear factor-kappa B to induce COX-2/PGE2 *** these processes,the production of an inflammatory microenvironment promotes the occurrence of gastric *** studies have also indicated that non-steroidal antiinflammatory drugs can reduce the risk of malignant tumors of the digestive system by blocking the effect of ***,clinical use of COX-2 inhibitors to prevent or treat gastric cancer may be limited because of potential side effects,especially in the cardiovascular *** these side effects and low treatment efficacy,new therapeutic approaches and early screening strategies are urgently *** studies have shown that genetic variation in COX-2 also play an important role in ***,the genetic variation analysis in these studies is incomplete and isolated,pointing out only a few single nucleotide polymorphisms(SNPs)and the risk of gastric cancer,and no comprehensive study covering the whole gene region has been carried *** addition,copy number variation(CNV)is not *** this review,we summarize the SNPs in the whole COX-2 gene sequence,including exons,introns,and both the 5’and 3’untranslated *** suggest that COX-2 does not increase its expression through the CNV and the SNPs in COX-2 may serve as the p

关键词： Cyclooxygenase-2 Inflammation Genetic variant Gastric cancer Prostaglandin E2

Engineered Cancer Nanovaccines:A New Frontier in Cancer Therapy

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Nano-Micro Letters 2025年第2期17卷 134-168页

作者： Yijie wang Congrui Liu Chao Fang Qiuxia Peng Wen Qin Xuebing yan kun Zhang Central Laboratory and Department of Medical Ultrasound Sichuan Academy of Medical SciencesSichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaNo.32West Second SectionFirst Ring RoadChengdu 610072People’s Republic of China Department of Stomatology and Central Laboratory School of MedicineShanghai Tenth People’s HospitalTongji UniversityNO.301 Yan‑Chang‑Zhong RoadShanghai 200072People’s Republic of China Jiangsu Provincial Innovation and Practice Base for Postdoctors Suining People’s HospitalAffiliated Hospital of Xuzhou Medical UniversityNo.2Bayi West RoadSuiningXu Zhou 221000Jiangsu ProvincePeople’s Republic of China

Vaccinations are essential for preventing and treating disease,especially cancer nanovaccines,which have gained considerable interest recently for their strong anti-tumor immune *** can prompt the immune system to generate antibodies and activate various immune cells,leading to a response against tumor tissues and reducing the negative effects and recurrence risks of traditional chemotherapy and *** enhance the flexibility and targeting of vaccines,nanovaccines utilize nanotechnology to encapsulate or carry antigens at the nanoscale level,enabling more controlled and precise drug delivery to enhance immune *** nanovaccines function by encapsulating tumor-specific antigens or tumor-associated antigens within *** small size of these nanomaterials allows for precise targeting of T cells,dendritic cells,or cancer cells,thereby eliciting a more potent anti-tumor *** this paper,we focus on the classification of carriers for cancer nanovaccines,the roles of different target cells,and clinically tested cancer nanovaccines,discussing strategies for effectively inducing cytotoxic T lymphocytes responses and optimizing antigen presentation,while also looking ahead to the translational challenges of moving from animal experiments to clinical trials.

关键词： Cancer nanovaccines Immunotherapy Nanobiotechnology Immune targets Signaling pathway

哈拉沟煤矿垮落带破碎岩体溃砂的离散元数值模拟研究

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煤炭学报 2017年第2期42卷 470-476页

作者：梁艳坤隋旺华朱涛张新佳中国矿业大学资源与地球科学学院江苏徐州221116 中国矿业大学深部岩土力学与地下工程国家重点实验室江苏徐州221116 神东煤矿集团公司内蒙古鄂尔多斯017000

采用离散元模拟了垮落带波及到松散砂层时导致的突水溃砂灾害。以神东矿区哈拉沟煤矿22402工作面为原型,采用分形理论分析了垮落带破碎岩体的块度分布特征,并利用离散元方法(DEM)根据破碎岩体的块度分布生成不规则碎石,建立了垮落带破... 详细信息

采用离散元模拟了垮落带波及到松散砂层时导致的突水溃砂灾害。以神东矿区哈拉沟煤矿22402工作面为原型,采用分形理论分析了垮落带破碎岩体的块度分布特征,并利用离散元方法(DEM)根据破碎岩体的块度分布生成不规则碎石,建立了垮落带破碎岩体溃砂数值模型。模拟结果表明:垮落带破碎岩体间空隙较大且连通性好的通道会形成溃砂优势通道,垮落带残余的空洞空隙可以储存溃落的松散砂;大小不均、堆积混杂的垮落带破碎岩体对溃砂速度具有一定的阻挡作用,松散砂在溃砂通道内流动的速度分布呈纺锤形,通道中间的速度大于壁面的速度。

关键词：垮落带破碎岩体突水溃砂离散元

Application of Image Segmentation of Aero-engine Based on Genetic Algorithm and Region Growth

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Application of Image Segmentation of Aero-engine Based on Ge...

Helicobacter pylori and gastric cardia cancer:What do we know about their relationship?

2011 Chinese Control and Decision Conference（CCDC）

作者： Luo Yunlin is with the Aeronautical Automation College of Civil Aviation University of China,Tingyao yan,kun wang

Endoscope detection segmentation is important for the detection of numerous faults and plays an important role in the automatic endoscope detecting *** this paper,we propose a new image segmentation algorithm introducing threshold selecting based on the genetic algorithm into the region *** Algorithm is powerful in optimizing the feature vector through declining useless features and finding optimal *** GA is used to choose an optimal threshold to complete the seed ***-level and texture are used to merge regions with similar *** results show that the proposed segmentation effect of the method is ideal,and the efficiency is improved.

关键词： Genetic Algorithm Region Growth Endoscope Detection Threshold

来源： cnki会议评论

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World Journal of Meta-Analysis 2020年第2期8卷 89-97页

作者： Jing-Jing Yin Fu-Jiao Duan Sailaja Vatsalya Madhurapantula Yue-Hua Zhang Gui He kun-yan wang Xuan-Ke Ji Kai-Juan wang Department of Epidemiology and Health Statistics College of Public HealthZhengzhou UniversityZhengzhou 450001Henan ProvinceChina Key Laboratory of Tumor Epidemiology of Henan Province Zhengzhou 450052Henan ProvinceChina

The incidence of gastric cardia cancer is increasing around the *** the discovery of Helicobacter pylori(***),numerous studies have proved that it is a causative factor for many kinds of digestive system *** the literature on gastric cardia cancer and *** is not scarce,there are still many controversies on the relationship between gastric cardia cancer and *** Western research results showed that there was a negative or no correlation between *** infection and gastric cardia cancer,but in several studies in Asian countries,such as China,*** was demonstrated to be a risk factor for gastric cardia ***,we intended to analyze the related studies to find out the relationship between *** and gastric cardia cancer and find out the causes of the above *** also conducted a metaanalysis of the relationship between cagA positive expression of *** and gastric cardia cancer,to find out whether there is an effect between those *** primary purpose of this paper was to explore the relationship between gastric cardia cancer and *** analysis,the study showed the reasons for the controversies mentioned above:(1)Geographical factors could affect the relationship between *** and gastric cardia cancer;(2)The definition of gastric cardia cancer in various studies is *** result of a meta-analysis about the relationship between *** virulence factor cagA and gastric cardia cancer showed that there was no relationship between these two.

关键词： Gastric cardia cancer Helicobacter pylori Cytotoxin-associated gene A Relationship Risk factors Meta-analysis

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伸缩缝刚度对大跨度悬索桥动力特性的影响

震灾防御技术 2017年第3期12卷 667-676页

作者：严琨王立新姜慧广东省地震局广州510070 中国地震局地震监测与减灾技术重点实验室广州510070 广东省地震预警与重大工程安全诊断重大实验室广州510070

伸缩缝作为大跨度桥梁与引桥之间的重要连接构件,其抗推刚度及可能存在的变异性对主桥及引桥动力特性的影响不可忽略。本文建立了大跨度悬索桥及引桥的有限元模型,采用弹簧单元模拟加劲梁与引桥箱梁之间的伸缩缝,分析伸缩缝刚度对悬索... 详细信息

伸缩缝作为大跨度桥梁与引桥之间的重要连接构件,其抗推刚度及可能存在的变异性对主桥及引桥动力特性的影响不可忽略。本文建立了大跨度悬索桥及引桥的有限元模型,采用弹簧单元模拟加劲梁与引桥箱梁之间的伸缩缝,分析伸缩缝刚度对悬索桥及引桥自振特性及其地震响应的影响规律。分析结果表明:伸缩缝刚度对加劲梁的横弯振型、竖弯与纵飘耦合振型的频率有明显的影响;伸缩缝刚度的变化会导致加劲梁与引桥的振型相互耦合,同时这些振型的频率发生相应的突变,当伸缩缝刚度较大时,加劲梁两个竖弯与纵飘的耦合振型解耦成为独立的竖弯和纵飘振型;当引桥与悬索桥加劲梁的纵飘振型发生耦合时,在纵向和竖向地震作用下的悬索桥及引桥的地震响应达到最小。伸缩缝刚度对悬索桥动力特性影响的分析可为悬索桥的模态参数确认、损伤识别、抗震性能分析提供有价值的借鉴。

关键词：大跨度悬索桥伸缩缝抗推刚度自振特性地震响应

VISUAL FIELD TOPOGRAPHY IN FROG ISTHMIC NUCLEUS

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Chinese Science Bulletin 1981年第5期26卷 478-479页

作者：王书荣颜坤王荫亭 Institute of Biophysics Academia Sinica Institute of Biophysics

The isthmic nucleus (IN) in the frog is a midbrain structure, located at the border between mesencephalic tegmentum and cerebellum. In recent years several anatomical, physiological and histochemical studies have shown that IN is a part of the frog visual system. We investigated visual responses of single units and a visual field topography in IN of

关键词： physiological histochemical border VISUAL nucleus anatomical eating topography 加功 ventral

Traditional Chinese medicine in the treatment of Helicobacter pylorirelated gastritis:The mechanisms of signalling pathway regulations

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World Journal of Gastroenterology 2025年第3期31卷 11-28页

作者： Pei-Pei Zhang Liang Li Hao-Yu Qu Guang-Yu Chen Meng-Zhou Xie yan-kun Chen School of Traditional Chinese Medicine Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Hunan Engineering Technology Research Center for Medicinal and Functional Food Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina Key Laboratory of Traditional Chinese Medicine Heart and Lung Syndrome Differentiation and Medicated Diet and Dietotherapy Hunan University of Chinese MedicineChangsha 410200Hunan ProvinceChina School of Informatics Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Precision Medicine Research and Development Center Zhuhai Institute of Advanced TechnologyChinese Academy of SciencesZhuhai 519000Guangdong ProvinceChina

Helicobacter pylori-associated gastritis(HPAG)is a common condition of the gastrointestinal ***,extensive and long-term antibiotic use has resulted in numerous adverse effects,including increased resistance,gastrointestinal dysfunction,and increased recurrence *** these concerns develop,traditional Chinese medicine(TCM)may have *** is based on the concept of completeness and aims to eliminate pathogens and strengthen the *** has the potential to prevent this condition while also boosting the rate of Helicobacter pylori *** review elaborates on the mechanism of TCM treatment for HPAG based on cellular signalling pathways,which reflects the flexibility of TCM in treating diseases and the advantages of multi-level,multipathway,and multi-target treatments for HPAG.

关键词： Helicobacter pylori Helicobacter pylori-associated gastritis Traditional Chinese medicine Signalling pathway Eliminate pathogens Strengthen the body

RECIPROCAL TOPOGRAPHY BETWEEN THE TOAD'S TECTUM AND NUCLEUS ISTHMI AND CELL CLASSIFICATION

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Chinese Science Bulletin 1983年第12期28卷 1681-1684页

作者：王荫亭颜坤王书荣 Institute of Biophysics Academia Sinica Beijing

Our preceding papers have shown that the nucleus isthmi (NI) is a secondary visual center in anuran amphibians. We, using HRP tracing and Golgi-Cox impregna-

关键词： CELL tracing labeled nucleus retaining ventral dorsal finer stained labeling