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Surface Modification of Ni-Cr-Mo Steel by Multifunction Cavitation

材料科学与工程（中英文A版） 2017年第6期7卷 290-296页

作者： Masataka Ijiri Daichi Shimonishi Daisuke Nakagawa kumiko tanaka Toshihiko Yoshimura Tokyo University of Science Yamaguchi 1-1-1 Daigaku-Dori Sanyo-Onoda Yamaguchi 756-0084 Japan

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Genetic variations in triple-negative breast cancers undergoing neo-adjuvant chemotherapy

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Cancer Drug Resistance 2019年第3期2卷 877-884页

作者： Miki Mori Tomoko Watanabe Sadako Akashi-tanaka kumiko Ueda Reiko Makino Yuko Hirota Seigo Nakamura Department of Breast Surgical Oncology Showa UniversityShinagawakuTokyo 142-8666Japan Clinical Research Laboratory Showa UniversityShinagawakuTokyo 142-8666Japan Department of Pathology Showa UniversityShinagawakuTokyo 142-8666Japan

Aim:Triple negative breast cancer(TNBC)is known as aggressive subtype and have no identified targeted *** examined the relationship of neoadjuvant chemotherapy response to genetic variations of ***:The tumors used in this study were collected from Showa University Hospital,*** formalin-fixed paraffin-embedded tumors from Japanese TNBC patients who underwent neoadjuvant chemotherapy were used for *** these,eight surgically resected tumors showed progressive disease and/or recurrence after treatment(PD/REC),and biopsy tissues from five patients showing pathological complete response(pCR)were *** extracted from tissue sample were *** Miseq system and Trusight Tumor Sequence panel kit were used to sequence 174 amplicons over 82 exons of 26 cancer-related genes to identify genetic ***:Seven somatic non-synonymous variants were detected in three genes(FOXL2,PIK3CA,and TP53)in all five pCR patients,and six somatic non-synonymous variants in two genes(PTEN and TP53)were detected in six of eight PD/REC *** of 13 TNBC tumors were found to have TP53 pathogenic variants,in both pCR and PD/REC ***:Although TP53 variation was detected in both pCR and PD/REC cases,each location and type of the variant were *** could not identify genetic mutations associated with chemotherapy response and recurrence.

关键词： Triple negative breast cancer next generation sequence TP53 and neo adjuvant chemotherapy

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Intravenous immunoglobulin suppresses IL-10 production by activated B cells in vitro

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Open Journal of Immunology 2012年第4期2卷 149-160页

作者： Jun tanaka kumiko Hirano Yuzuru Sakamoto Akiko Sugahara-Tobinai Shota Endo Yumi Ito-Matsuoka Atsushi Nakano Masanori Inui Lars Nitschke Toshiyuki Takai Department of Experimental Immunology Institute of Development Aging and Cancer Tohoku University Sendai Japan Department of Genetics University of Erlangen Erlangen Germany Osaka Research Laboratory Benesis Corporation Osaka Japan

A therapeutic preparation of polyclonal human IgG, i.e., intravenous immunoglobulin (IVIg), has been employed to treat several inflammatory and autoimmune disorders. B cells are supposed to be a target of IVIg, but the molecular mechanism is elusive because of the lack of a suitable experimental system. To gain an insight into the beneficial effect of IVIg on B cells, we first established an experimental setting in which IVIg modulates a murine B cell function in vitro, and then aimed at identifying the mechanistic features at the molecular level. Here we show that IVIg down-regulates IL-10 production by CpG-activated B cells in vitro. The responsible component of IVIg was identified as the F(ab’)2 portion, whose polyclonality is mandatory for the suppressive effect. IVIg, bound to the surface of activated B cells, was found to be co-localized with intracellular SHP-1 on confocal laser microscopy, suggesting that B cell-surface immunoreceptor tyrosine-based inhibitory motif-harboring receptors that recruit SHP-1 are target molecules for IVIg in our experimental setting. Overall, we postulate a scenario in which IVIg attenuates B cells by suppressing IL-10 production, a B cell growth factor, and thus down-regulates the production of pathogenic antibodies.

关键词： F(ab’)2 Fragment Immune Inhibition ITIM Receptors Polyclonal IgG SHP-1

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Use of cone-shaped polypropylene mesh for perineal herniorrhaphy in dogs

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畜牧与兽医 2012年第S2期44卷 43-43页

作者： Kenji Teshima Kazushi Asano kumiko Ishigaki Mamiko Seki Takahiro Suzuki Seri Komazaki Gentoku Iida Orie Yoshida Kazuya Edamura Shigeo tanaka Animal Medical Center Nihon University Laboratory of Veterinary Surgery Department of Veterinary MedicineCollege of Bioresource SciencesNihon University Laboratory of Comprehensive Veterinary Clinical Studies Department of Veterinary MedicineCollege of Bioresource SciencesNihon University

Unilateral or bilateral perineal hernia results from the failure of the muscular pelvic diaphragm,and is commonly observed in male *** study aimed to investigate the outcome of herniorrhaphy technique with the cone-shaped polypropylene mesh in dogs with perineal hernia.1 Materials and Methods Between October 2008 and July 2012,39 dogs(71 perineal hernias)underwent herniorrhaphy with polypropylene mesh(PROLENE MeshJohnson&Johnson)formed in the shape of a *** apex of corn-shaped mesh was inserted into the hernia region,and the bottom was sutured to sacrotuberous ligament,internal obturator muscle,external anal sphincter and residual coccygeal muscle.

关键词： polypropylene shaped hernia muscular bilateral obturator sphincter inserted ligament diaphragm

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