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Long-term disease-free survival in a dog with appendicular osteosarcoma

畜牧与兽医 2012年第S2期44卷 62-62页

作者： kumiko ishigaki Kazushi Asno Yoshiya Yoshida Rikiya Nishimura Hiromi Aoki Gentoku Iida Orie Yoshida Mamiko Seki Kenji Teshima Kazuya Edamura Animal Medical Center Nihon University Laboratory of Veterinary Surgery Department of Veterinary Medicine College of Bioresource SciencesNihon University SHIMA Laboratories Co. LTD Laboratory of Comprehensive Veterinary Clinical Studies Department of Veterinary Medicine College of Bioresource SciencesNihon University

Postoperative prognosis is generally poor even with adjuvant chemotherapy in dogs with an appendicular osteosarcoma. The purpose of this report was to present the long-term disease-free survival time in a dog with appendicular osteosarcoma receiving amputation,adjuvant chemotherapy and adoptive immunotherapy. A 12-year-old spayed Golden retriever was referred to our hospital with a suspicion of osteosarcoma in right distal radius. The patient underwent the computed tomography (CT) and incisional biopsy on the next day after the first presentation. The CT revealed the osteolysis in the right distal radius and no metastases in the lungs and lymph nodes. The histopathologic diagnosis was made as an osteosarcoma. On the 13th day after,the patient underwent right forelimb amputation. Six doses of carboplatin (250 mg / m2) were postoperatively administered every 3 weeks. The intravenous infusion of lymphokine-activated killer (LAK) cells suspension was performed every 3 ~ 4 weeks after the adjuvant chemotherapy. At the time of our writing this abstract (on the 880thday after the first presentation),no recurrences and metastases were observed after the 32 transfers of LAK cells. In canine appendicular osteosarcoma,some reports have described that postoperative median survival times were 235 ~ 540 d with adjuvant chemotherapy. In our report,the disease free interval and survival time were prolonged compared with the previous reports. We strongly believed that early diagnosis and surgical intervention and adoptive immunotherapy had a great impact on the improvement of survival time in canine appendicular osteosarcoma.

关键词： adoptive immunotherapy adjuvant chemotherapy appendicular osteosarcoma,dog long-term disease-free survival

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维普期刊数据库

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Use of cone-shaped polypropylene mesh for perineal herniorrhaphy in dogs

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畜牧与兽医 2012年第S2期44卷 43-43页

作者： Kenji Teshima Kazushi Asano kumiko ishigaki Mamiko Seki Takahiro Suzuki Seri Komazaki Gentoku Iida Orie Yoshida Kazuya Edamura Shigeo Tanaka Animal Medical Center Nihon University Laboratory of Veterinary Surgery Department of Veterinary MedicineCollege of Bioresource SciencesNihon University Laboratory of Comprehensive Veterinary Clinical Studies Department of Veterinary MedicineCollege of Bioresource SciencesNihon University

Unilateral or bilateral perineal hernia results from the failure of the muscular pelvic diaphragm,and is commonly observed in male *** study aimed to investigate the outcome of herniorrhaphy technique with the cone-shaped polypropylene mesh in dogs with perineal hernia.1 Materials and Methods Between October 2008 and July 2012,39 dogs(71 perineal hernias)underwent herniorrhaphy with polypropylene mesh(PROLENE MeshJohnson&Johnson)formed in the shape of a *** apex of corn-shaped mesh was inserted into the hernia region,and the bottom was sutured to sacrotuberous ligament,internal obturator muscle,external anal sphincter and residual coccygeal muscle.

关键词： polypropylene shaped hernia muscular bilateral obturator sphincter inserted ligament diaphragm

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维普期刊数据库

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Computed tomography characteristics and complete resection of large thymoma in a cat

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畜牧与兽医 2012年第S2期44卷 31-31页

作者： Hiromi Aoki Kazushi Asano Rui Kano Kenji Teshima Kenji Kutara Chieko Ishikawa kumiko ishigaki Mamiko Seki Gentoku Iida Orie Yoshida Kazuya Edamura Animal Medical Center Nihon University Laboratory of Veterinary Surgery Department of Veterinary MedicineCollege of Bioresource SciencesNihon University Laboratory of Veterinary Pathobiology Department of Veterinary MedicineCollege of Bioresource SciencesNihon University Laboratory of Comprehensive Veterinary Clinical Studies Department of Veterinary MedicineCollege of Bioresource SciencesNihon University

Thymoma is an intrathoracic malignant tumor occurring rarely in cats. Although surgery is the treatment of choice in feline thymomas,complete resection may be difficult in cases that the large vessels are involved into the ***,diagnostic imaging techniques including computed tomography( CT) are essential for the treatment of feline thymomas. This report aimed to present the CT characteristics and successful removal of very large thymoma in a cat with exfoliative *** 8-year-old spayed mongrel cat was referred to our hospital with chief complaints of chronic anorexia,alopecia,and desquamation. Tachypnea,tachycardia,and exfoliative dermatitis were observed in the first presentation. Thoracic radiography showed a very large mass in the craniomediastinal region. In the CT findings,the mass included multiple small cysts,and forced up the intrathoracic trachea,cranial vena cava,brachiocephalic trunk and left subclavian artery as well as heart and *** the 6th day after,the patient underwent a median sternotomy and diaphragmatic incision to expose the mass. The mass was completely resected with right phrenic nerve by using cautery and LigaSure. No postoperative complications were observed. The histopathologic diagnosis was made as a thymoma. Postoperative progress of the patient was excellent without the exfoliative *** enlarged thymoma could be completely resected in this patient,and the exfoliative dermatitis was postoperatively controlled. The paraneoplastic immune disorder was suggested to cause the dermatitis. CT has a great impact on the indication of surgery for the feline thymomas.

关键词： cat complete resection computed tomography exfoliative dermatitis thymoma

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Successful treatment of a large hepatocellular carcinoma and paraneoplastic hypoglycemia by central and left divisional hepatic lobectomy in a dog

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畜牧与兽医 2012年第S2期44卷 41-41页

作者： Rikiya Nishimura Kazushi Asano Mamiko Seki Gentoku Iida kumiko ishigaki Kenji Kutara Chieko Ishikawa Orie Yoshida Kenji Teshima Kazuya Edamura Manabu Sakai Animal Medical Center Nihon University Laboratory of Veterinary Surgery Department of Veterinary MedicineCollege of Bioresource SciencesNihon University Laboratory of Comprehensive Veterinary Clinical Studies Department of Veterinary MedicineCollege of Biore-source SciencesNihon University Laboratory of Veterinary Internal Medicine Department of Veterinary MedicineCollege of Bioresource SciencesNihon University

Hepatocellular carcinoma (HCC) is generally observed as a massive tumor originated from one lobe in *** is the treatment of choice in dogs with a massive HCC. However,complete resection is technically difficult in the cases with an extremely enlarged HCC pressing or involving the large vessels such as caudal vena cava and main hepatic veins. This study aimed to report the divisional hepatic lobectomy for complete resection of very large HCC and successful treatment of paraneoplastic hypoglycemic seizures in a dog.A 12-year-old spayed Yorkshire terrier was referred to our hospital with chief complaints of seizures and a very large hepatic mass. In the first presentation,serum liver enzymes levels increased,and serum glucose concentration was 29mg/dl. Computed tomography (CT) angiography revealed that a huge mass occurred in the right medial,quadrate,and left medial hepatic lobes and flattened caudal vena cava and main portal vein. The patient underwent surgical *** mass was approached with midline celiotomy,caudal median sternotomy,and bilateral paracostal laparotomy. En bloc resection of central and left divisional lobes including the mass was accomplished with surgical ligation of hepatic hilar vessels and hepatic veins. The hypoglycemic seizures were postoperatively resolved,and no clinical signs were *** hypoglycemic seizures were thought to be associated with the insulin-like growth factors (IGF). The right divisional lobes could serve the sufficient hepatic function. Divisional hepatic lobectomy based on CT angiography is very useful for the treatment of canine HCCs.

关键词： divisional hepatic lobectomy dog hepatocellular carcinoma hypoglycemia paraneoplastic syndrome

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