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Protective Role of C-Phycocyanin Against Secondary Changes During Sodium Selenite Mediated Cataractogenesis

Natural Products and Bioprospecting 2014年第2期4卷 81-89页

作者： Rasiah Pratheepa Kumari kumarasamy anbarasu Department of Marine Biotechnology Bharathidasan UniversityTiruchirappalli 620024Tamil NaduIndia

Age related cataract is the leading cause of blindness associated with accumulation of oxidative stress in the eye *** present investigation reveals the rational of the beneficial effects of the natural compound C-phycocyanin(CPC)is beneficial when administered to rat pups to protect against the secondary effects of sodium selenite induced cataractogenesis.A single subcutaneous dose of sodium selenite(19 lmol/kg body weight)on the 10th day of postpartum is adequate to induce cataract in rat *** biochemical parameters,such as the level of electrolytes,mean activities of anti-oxidant enzymes *** dismutase,catalase and reduced glutathione were observed to be significantly altered during selenite induced cataractogenic *** examination revealed signs of degradation of normal cell architecture in the liver,kidney and eye ***,the deleterious effects of sodium selenite toxicity were restored with the simultaneous treatment with *** results suggest that an administration of 200 mg/kg body weight of C-PC has the ability to prevent/alter the secondary changes reflected in the serum biochemical and histological modifications in rats exposed to sodium *** results complement the beneficial role of C-PC of cyanobacterial origin as a efficacious anti-cataractogenic agent against sodium selenite toxicity.

关键词： Cyanobacteria C-phycocyanin Cataract Sodium selenite Cataractogenesis

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