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Management of non-variceal upper gastrointestinal tract hemorrhage:Controversies and areas of uncertainty

world Journal of Gastroenterology 2012年第11期18卷 1159-1165页

作者： Eric p Trawick patrick s Yachimski Division of Gastroenterology Hepatology and NutritionVanderbilt University Medical Center

Upper gastrointestinal tract hemorrhage （UGIh） remains a common presentation requiring urgent evaluation and treatment. Accurate assessment, appropriate intervention and apt clinical skills are needed for proper management from time of presentation to discharge. The advent of pharmacologic acid suppression, endoscopic hemostatic techniques, and recognition of helicobacter pylori as an etiologic agent in peptic ulcer disease （pUD） has revolutionized the treatment of UGIh. Despite this, acute UGIh still carries considerable rates of morbidity and mortality. This review aims to discuss current areas of uncertainty and controversy in the management of UGIh. Neoadjuvant proton pump inhibitor （ppI） therapy has become standard empiric treatment for UGIh given that pUD is the leading cause of non variceal UGIh, and ppIs are extremely effective at promoting ulcer healing. howeve, neoadjuvant ppI administration has not been shown to affect hard clinical outcomes such as rebleeding or mortality. The optimal timing of upper endoscopy in UGIh is often debated. Upon completion of volume resuscitation and hemodynamic stabilization, upper endoscopy should be performed within 24 h in all patientswith evidence of UGIh for both diagnostic and therapeutic purposes. with rising healthcare cost paramount in today＇s medical landscape, the ability to appropriately triage UGIh patients is of increasing value. Upper en- doscopy in conjunction with the clinical scenario allows for accurate decision making concerning early discharge home in low risk lesions or admission for further moni toring and treatment in higher risk lesions. Concomitant pharmacotherapy with non steroidal antiinflammatory drugs （NsAIDs） and antiplatelet agents, such as clopidogrel, has a major impact on the etiology, severib/, and potential treatment of UGIh. Long term ppI use in patients taking chronic NsAIDs or clopidogrel is discussed thoroughly in this review.

关键词： hemorrhage proton pump inhibitors he/i-cobacter py/ori prokinetic agents hemostasis Thieno-pyridines

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A fast-running method for blast load prediction shielding by a protective barrier

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Defence Technology（防务技术） 2020年第2期16卷 308-315页

作者： s.-h.sung J.-w.Chong Agency for Defense Development Yuseong P.O.Box 35DaeJeon395-600South Korea

This study presents a simplified blast load prediction method on structures behind a protective *** proposed method is basically an empirical approach based on Kingery-Bulamsh(K-B)chart and finite element(FE)analysis *** this end,this study divides the structure into three regions by three critical *** loads at each critical point can be calculated based on K-B chart and an approximation according to FE analysis ***,peak reflected overpressure and impulse distributed on the structure can be approximately estimated by linearly connecting blast loads at each critical *** order to confirm a feasibility of the proposed method,a series of numerical simulations were carried *** simulation results were compared with FE analysis results which are presented in the open *** such comparisons,it was found that the proposed method is applicable to predict blast loads on structures behind a protective barrier.

关键词： Blast loads protective barrier shock wave Fast running model Kingery-Bulmash

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Microstructures and mechanical properties of Ti3Al/Ni-based superalloy joints brazed with AuNi filler metal

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Journal of Materials science & Technology 2019年第9期35卷 2070-2078页

作者： h.s. Ren h.p.Xiong w.M. Long B. Chen Y.X. shen J. pang welding and plastic Forming Division Beijing Institutes of Aeronautical MatericalBeijing 100095China state Key Laboratory of Advanced Brazing Filler Metals and Technology Zhengzhou Research Institute of Mechanical EngineeringZhengzhou 450001 China Department of Material science and Engineering Beihang UniversityBeijing 100191China

For the purpose of high-temperature service and the weight reduction in aviation engineering applications, the dissimilar joining of Ti3Al-based alloy to Ni-based superalloy (Gh536) was conducted using Au-17.5Ni (wt%) brazing filler metal. The microstructure and chemical composition at the interfaces were investigated by scanning electron microscope, X-ray diffraction and transmission electron microscope. The diffusion behaviors of elements were analyzed as well. The results indicated that the Ti3Al/Gh536 joint microstructure was characterized by multiple layer structures. Element Ni from Au-Ni filler metal reacted with Ti3Al base metal, leading to the formation of AlNi2Ti and NiTi compounds. Element Ni from Ti3Al base metal reacted with Ni and thus Ni3Nb phase was detected in the joint central area. Due to the dissolution of Ni-based superalloy,(Ni,Au) solid solution ((Ni,Au)ss) and Ni-rich phase were visible adjacent to the superalloy side. The average tensile strength of all the joints brazed at 1253 K for 5-20 min was above 356 Mpa at room-temperature. In particular, the joints brazed at 1253 K/15 min presented the maximum tensile strength of434 Mpa at room-temperature, and the strength of 314 Mpa was maintained at 923 K. AlNi2Ti compound resulted in the highest hardness area and the fracture of the samples subjected to the tensile test mainly occurred in this zone.

关键词： Ti3Al-based alloy Ni-based superalloy Brazing Microstructure Tensile strength

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Thermo-electric behaviour of NiTi shape memory alloy

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Transactions of Nonferrous Metals society of China 2013年第8期23卷 2329-2335页

作者： h.N.BhARGAw M.AhMED p.sINhA CsIR-Advanced Materials and processes Research Institute Department of Electronics Institute of Engineering & Technology Barkatullah University

The thermo-electric behavior of shape memory alloy （sMA） wire was presented. when the wire was electrically heated above its transformation temperature by current, a large mechanical force is exerted due to transformation in its phases. In order to make use of sMA wire as an actuator, different parameters and their relationships were investigated. These parameters are recoverable strain （displacement）, temperature hysteresis and electrical resistance variation under different stress levels. Optimum safe heating current was assessed and phase transformation temperatures were estimated by heat transfer model. The wire was heated and cooled by 680 mA of current for 796 s under natural air convection. The strain recovered is 4.33% and corresponding change in resistance is 11.2% at 43 Mpa of stress. The resistance variation shows linearly with displacement and current during heating and cooling cycle respectively. This study will be useful in precisely controlling of sMA wire actuator with and without external sensor feedback.

关键词： shape memory alloy electrical resistance phase transformation hysteresis

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MRI直方图特征与局部进展期宫颈癌放化疗治疗效果的相关性

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国际医学放射学杂志 2021年第3期44卷 366-367页

作者： J.A.U.perucho M.wang K.Y.Tse p.p.C.Ip s.w.K.siu h.Y.s.Ngan 曹红举

摘要目的探讨T2wI及表观扩散系数(ADC)直方图特征与局部进展期宫颈癌(LACC)同步放化疗(CCRT)后的治疗效果的相关性。材料与方法回顾性分析58例接受4周

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CELLULAR AUTOMATA MODELLING OF GRAIN COARsENING DURING REhEATING AND VALIDATION wITh ThE EXpERIMENTAL REsULTs

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Acta Metallurgica sinica(English Letters) 2005年第2期18卷 113-120页

作者： w.h.Yu E.J.palmiere s.p.Banks J.T.han schoolofMaterialsscienceandEngineering UniversityofScienceandTechnologyBeijingBeijing100083China DepartmentofEngineeringMaterials UniversityofSheffieldSheffieldS13JDUK DepartmentofAutomaticControlandsystemsEngineering UniversityofSheffieldSheffieldS13J-DUK

A novel 2D cellular automata (CA) model has been developed for description of normal grain coarsening and abnormal grain coarsening process. The program reflects the grain coarsening quite well even through the average grain size becomes very large. Follow results have been obtained: (a) The model reflect the normal grain growth kinetics gradually increase with probability and grain growth speed can be controlled. Based on this result, temperature can be coupled in the model. (b) Abnormal grain growth is modelled successfully. (c) Methodology has been put forward to find the relationship between the experiment results and modelling results. The experimental work on the grain coarsening has been carried out. Graphical output matched the realistic microstructure in every detail. Because many physical parameters can be taken into account in the CA programme, this CA model could not only qualitatively demonstrate the grain growth process, but also quantitatively predict and analyse the grain coarsening process.

关键词： computer simulation grain growth microstructure reheating

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An Extrinsic Fiber Fabry-perot Interferometer for Dynamic Displacement Measurement

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photonic sensors 2015年第1期5卷 50-59页

作者： s. pULLTEAp h. C. sEAT Department of Mechanical Engineering Faculty of Engineering and Industrial Technology Silpakorn University(Sanam Chandra Palace Campus) Nakhon Pathom 73000 Thailand Optoelectronics for Embedded systems Group INPT-ENSEEIHT Rue Charles Camichel BP 7122-31071 Toulouse Cedex 7 France

A versatile fiber interferometer was proposed for high precision measurement. The sensor exploited a double-cavity within the unique sensing arm of an extrinsic-type fiber Fabry-perot interferometer to produce the quadrature phase-shifted interference fringes. Interference signal processing was carried out using a modified zero-crossing （fringe） counting technique to demodulate two sets of fringes. The fiber interferometer has been successfully employed for dynamic displacement measurement under different displacement profiles over a range of 0.7 p.m to 140 p.m. A dedicated computer incorporating the demodulation algorithm was next used to interpret these detected data as well as plot the displacement information with a resolution of 2/64. A commercial displacement sensor was employed for comparison purposes with the experimental data obtained from the fiber interferometer as well as to gauge its performance, resulting in the maximum error of 2.8% over the entire displacement range studied.

关键词： Fabry-perot interferometer vibration analysis fringe counting technique displacement profile

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Target fabrication for laser-ion acceleration research at the Technological Laboratory of the LMU Munich

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Matter and Radiation at Extremes 2019年第3期4卷 25-31页

作者： J.szerypo w.Ma G.Bothmann D.hahner M.haug p.hilz Ch.Kreuzer R.Lange s.seuferling M.speicher F.stehr s.stork p.G.Thirolf J.schreiber h.-F.wirth Fakultat fur physik Ludwig-Maximilians-Universitat MunchenD-85748 GarchingGermany state Key Laboratory of Nuclear physics and Technology School of PhysicsPeking UniversityBeijing 100871China helmholtz-Institut Jena Frobelstieg 307743 JenaGermany

The Technological Laboratory of LMU Munich supplies various types of solid-state target for laser plasma experiments at the Centre for Advanced Laser Applications in *** main focus here is on the production of free-standing,thin foil targets,such as diamond-likecarbon foils,carbon nanotube foams(CNFs),plastic,and gold *** presented methods comprise cathodic arc deposition for DLC targets,chemical vapor deposition for CNFs,a droplet and spin-coating process for plastic foil production,as well as physical vapor deposition that has been optimized to provide ultrathin gold foils and tailored sacrifice *** paper reviews our current capabilities,which are a result of a close collaboration between target production processes and experiment,using high-power chirped pulse amplification laser systems over the past eight years.

关键词： acceleration laser coating

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Restoring nervous system structure and function using tissue engineered living scaffolds

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Neural Regeneration Research 2015年第5期10卷 679-685页

作者： Laura A.struzyna James p.harris Kritika s.Katiyar h.Isaac Chen D.Kacy Cullen Center for Brain Injury and Repair Department of NeurosurgeryPerelman School of MedicineUniversity of Pennsylvania Center for Neurotrauma Neurodegenerationand RestorationPhiladelphia Veterans Affairs Medical Center school of Biomedical Engineering Drexel University

Neural tissue engineering is premised on the integration of engineered living tissue with the host nervous system to directly restore lost function or to augment regenerative capacity following ner- vous system injury or neurodegenerative disease. Disconnection of axon pathways - the long-distance fibers connecting specialized regions of the central nervous system or relaying peripheral signals - is a common feature of many neurological disorders and injury. however, functional axonal regenera- tion rarely occurs due to extreme distances to targets, absence of directed guidance, and the presence of inhibitory factors in the central nervous system, resulting in devastating effects on cognitive and sensorimotor function. To address this need, we are pursuing multiple strategies using tissue engi- neered ＂living scaffolds＂, which are preformed three-dimensional constructs consisting of living neural cells in a defined, often anisotropic architecture. Living scaffolds are designed to restore function by serving as a living labeled pathway for targeted axonal regeneration - mimicking key developmental mechanisms- or by restoring lost neural circuitry via direct replacement of neurons and axonal tracts. we are currently utilizing preformed living scaffolds consisting of neuronal dusters spanned by long axonal tracts as regenerative bridges to facilitate long-distance axonal regeneration and for targeted neurosurgical reconstruction of local circuits in the brain. Although there are formidable challenges in predinical and clinical advancement, these living tissue engineered constructs represent a promising strategy to facilitate nervous system repair and functional recovery.

关键词： living scaffolds neural tissue engineering cell transplant biomaterials regeneration neurotrauma neurodegeneration axon pathfinding cell migration

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36Ar（n,p）36Cl截面测量

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科学通报 1989年第15期34卷 1199-1200页

作者：蒋崧生,T.K.hemmick,p.w.Kubik,D.Elmore,h.E.Gove,s.Tullui,T.Z.hossain 中国原子能科学研究院美国Rochester大学校结构实验室美国Rochester大学校结构实验室美国Rochester大学校结构实验室美国Rochester大学校结构实验室美国Rochester大学校结构实验室美国Esstman Kodak公司研究实验室分析技术部北京

研究自然界36Cl的形成在地球科学有重要意义。宇宙线中子在大气层通过36Ar（n,p）36Cl反应生成36Cl在当今被认为自然界36Cl的主要来源之一。1968年（Onufrier）曾假设慢中子引起36Ar（n,p）36Cl反应的截面与14N（n,p）14C截面（热中子... 详细信息

研究自然界36Cl的形成在地球科学有重要意义。宇宙线中子在大气层通过36Ar（n,p）36Cl反应生成36Cl在当今被认为自然界36Cl的主要来源之一。1968年（Onufrier）曾假设慢中子引起36Ar（n,p）36Cl反应的截面与14N（n,p）14C截面（热中子截面为1.8b）具有相同的数量级,由此计

关键词：反应 n,p Ar Cl

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