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Identification of anomalous fast bulk events in a p-type point-contact germanium detector

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Nuclear Science and Techniques 2022年第5期33卷 53-67页

作者： Ren-Ming-Jie Li Shu-kui Liu Shin-Ted Lin Li-Tao yang Qian yue Chang-Hao Fang Hai-Tao Jia Xi Jiang Qian-Yun Li Yu Liu Yu-Lu Yan Kang-Kang Zhao Lei Zhang Chang-Jian Tang Hao-yang Xing Jing-Jun Zhu College of Physics Sichuan UniversityChengdu 610065China Key Laboratory of Particle and Radiation Imaging(Ministry of Education)and Department of Engineering Physics Tsinghua UniversityBeijing 100084China

The ultralow detection threshold,ultralow intrinsic background,and excellent energy resolution of ptype point-contact germanium detectors are important for rare-event searches,in particular for the detection of direct dark matter interactions,coherent elastic neutrino-nucleus scattering,and neutrinoless double beta *** bulk events with an extremely fast rise time are observed in the CDEX-1B *** report a method of extracting fast bulk events from bulk events using a pulse shape simulation and reconstructed source experiment *** data and the distribution of X-rays generated by intrinsic radioactivity verified that the fast bulk experienced a single hit near the passivation *** performance of this germanium detector indicates that it is capable of single-hit bulk spatial resolution and thus provides a background removal technique.

关键词： p-type point-contact germanium detector Dark matter Pulse shape analysis Anomalous fast bulk events

The collagen type Ⅰ alpha 1 chain gene is an alternative safe harbor locus in the porcine genome

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Journal of Integrative Agriculture 2023年第1期22卷 202-213页

作者： XIANG Guang-ming ZHANG Xiu-ling XU Chang-jiang FAN Zi-yao XU kui WANG Nan WANG yue CHE Jing-jing XU Song-song MU Yu-lian LI kui LIU Zhi-guo State Key Laboratory of Animal Nutrition/Key Laboratory of Animal Genetics Breeding and Reproduction of Ministry of Agriculture and Rural Affairs of China Institute of Animal SciencesChinese Academy of Agricultural SciencesBeijing 100193P.R.China School of Life Science and Engineering Foshan UniversityFoshan 528231P.R.China Genome Analysis Laboratory of the Ministry of Agriculture and Rural Affairs Agricultural Genomics Institute at ShenzhenChinese Academy of Agricultural SciencesShenzhen 518120P.R.China

Efficient and stable expression of foreign genes in cells and transgenic animals is important for gain-of-function studies and the establishment of *** harbor loci in the animal genome enable consistent overexpression of foreign genes,without side ***,relatively few safe harbor loci are available in pigs,a fact which has impeded the development of multi-transgenic pig *** report a strategy for efficient transgene knock-in in the endogenous collagen type I alpha 1 chain(COL1A1)gene using the clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9(CRISPR/Cas9)*** the knock-in of a 2A peptide-green fluorescence protein(2A-GFP)transgene in the last codon of COL1A1 in multiple porcine cells,including porcine kidney epithelial(PK15),porcine embryonic fibroblast(PEF)and porcine intestinal epithelial(IPI-2I)cells,quantitative PCR(qPCR),Western blotting,RNA-seq and CCK8 assay were performed to assess the safety of COL1A1 *** qPCR results showed that the GFP knock-in had no effect(P=0.29,P=0.66 and P=0.20 for PK15,PEF and IPI-2I cells,respectively)on the mRNA expression of COL1A1 ***,no significant differences(P=0.64,P=0.48 and P=0.80 for PK15,PEF and IPI-2I cells,respectively)were found between the GFP knock-in and wild type cells by Western ***-seq results revealed that the transcriptome of GFP knock-in PEF cells had a significant positive correlation(P<2.2e–16)with that of the wild type cells,indicating that the GFP knock-in did not alter the global expression of endogenous ***,the CCK8 assay showed that the GFP knock-in events had no adverse effects(P_(24)h=0.31,P_(48)h=0.96,P_(72)h=0.24,P_(96)h=0.17,and P_(120)h=0.38)on cell proliferation of PK15 *** results indicate that the COL1A1 locus can be used as a safe harbor for foreign genes knock-in into the pig genome and can be broadly applied to farm animal breeding and biomedical model establishment.

关键词： COL1A1 gene safe harbor knock-in CRISPR/Cas9 pig

Dealloying corrosion of anodic and nanometric Mg41Nd5 in solid solution-treated Mg-3Nd-1Li-0.2Zn alloy

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Journal of Materials Science & Technology 2021年第24期83卷 161-178页

作者： Gui-Jia Gao Mei-Qi Zeng En-Liang Zhang Rong-Chang Zeng Lan-yue Cui Dao-kui Xu Feng-Qin Wang M.Bobby Kannan Corrosion Laboratory for Light Metals College of Materials Science and EngineeringShandong University of Science and TechnologyQingdao266590China School of Materials Science and Engineering Zhengzhou UniversityZhengzhou450002China Key Laboratory of Nuclear Materials and Safety Assessment Institute of Metal ResearchChinese Academy of SciencesShenyang110016China School of Engineering University of NewcastleCallaghanNew South Wales 2308Australia

The microstructure and chemical compositions of the solid solution-treated Mg-3 Nd-1 Li-0.2 Zn alloy were characterized using optical microscope,scanning electron microscope(SEM),transmission electron microscope(TEM),electron probe micro-analyzer(EPMA)and X-ray photoelectron spectroscopy(XPS).The corrosion behaviour of the alloy was investigated via electrochemical polarization,electrochemical impedance spectroscopy(EIS),hydrogen evolution test and scanning Kelvin probe(SKP).The results showed that the microstructure of the as-extruded Mg-3 Nd-1 Li-0.2 Zn alloy containedα-Mg matrix and nanometric second phase Mg_(41)Nd_(5).The grain size of the alloy increased significantly with the increase in the heat-treatment duration,whereas the volume fraction of the second phase decreased after the solid solution *** surface film was composed of oxides(Nd_(2)O_(3),Mg O,Li_(2)O and Zn O)and carbonates(Mg CO3 and Li_(2)CO3),in addition to *** as-extruded alloy exhibited the best corrosion resistance after an initial soaking of 10 min,whereas the alloy with 4 h-solution-treatment possessed the lowest corrosion rate after a longer immersion(1 h).This can be attributed to the formation of Nd-containing oxide film on the alloys and a dense corrosion product *** dealloying corrosion of the second phase was related to the anodic Mg_(41)Nd_(5)with a more negative Volta potential relative toα-Mg *** preferential corrosion of Mg_(41)Nd_(5)is proven by in-situ observation and *** solid solution treatment of Mg-3 Nd-1 Li-0.2 Zn alloy led to a shift in corrosion type from pitting corrosion to uniform corrosion under long-term exposure.

关键词： Magnesium alloy Corrosion Second phase Rare metal Dealloying

不同剂量瑞芬太尼复合小剂量艾司氯胺酮用于腹腔镜妇科手术患者的效果及对麻醉效能、疼痛的影响

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现代生物医学进展 2024年第1期24卷 65-69页

作者：金成浩赵美一阴阅刘强李兴奎首都医科大学附属北京同仁医院麻醉科北京100005

目的:研究不同剂量瑞芬太尼复合小剂量艾司氯胺酮对腹腔镜妇科手术患者麻醉效果的影响。方法:选取2020年4月~2023年2月在本院接受腹腔镜妇科手术治疗的60例患者进行研究,根据瑞芬太尼静脉输注剂量将其分为小剂量组、中剂量组和大剂量组... 详细信息

目的:研究不同剂量瑞芬太尼复合小剂量艾司氯胺酮对腹腔镜妇科手术患者麻醉效果的影响。方法:选取2020年4月~2023年2月在本院接受腹腔镜妇科手术治疗的60例患者进行研究,根据瑞芬太尼静脉输注剂量将其分为小剂量组、中剂量组和大剂量组,每组各20例。三组均给予患者小剂量艾司氯胺酮(0.1μg·kg),小剂量组给予患者0.1μg/(Kg·min)瑞芬太尼,中剂量组给予患者0.3μg/(Kg·min)瑞芬太尼,大剂量组给予患者0.5μg/(Kg·min)瑞芬太尼。记录三组患者的麻醉起效时间、麻醉诱导时间、拔管时间和不良反应发生率,并检测其不同时间段的血流动力学和疼痛。结果:麻醉起效、麻醉诱导拔管时间比较,三组无显著差异(P>0.05)。平均动脉压(MAP)和心率(HR)比较,大剂量组和中剂量组T1、T2时间段均低于小剂量组,中剂量组T1、T2时间段低于大剂量组;三组T2时间段MAP、HR水平低于T0、T1时间段,T1时间段低于T0时间段(P0.05)。结论:不同剂量瑞芬太尼复合小剂量艾司氯胺酮均能保障腹腔镜妇科手术的麻醉效果和安全性,但中剂量瑞芬太尼的应用更有利于稳定血流动力学,并减轻患者的疼痛程度。

关键词：瑞芬太尼不同剂量小剂量艾司氯胺酮腹腔镜妇科手术

Preparation of coated sand for selective laser sintering and optimization of baking process of sand moulds

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China Foundry 2023年第6期20卷 519-525页

作者： Peng-wei Wang Rui-long Yu Rui Tan Yan Wang Ying-wei Zhou yue-ting Ma Yan-hai Li Jia-jun Liu Shao-kui Yin Shenyang Research Institute of Foundry Co. Ltd.CAMShenyang 110022China National Key Laboratory of Advanced Casting Technologies Shenyang 110022China

A cold method was used to prepare coated sand for application in the selective laser sintering(SLS)*** strength,loss on ignition,gas evolution,and accuracy of the SLS samples were tested and analyzed,and the baking process was thoroughly *** with coated sand prepared by the hot method,the cold method yields a more uniform and complete resin film on the sand's surface,resulting in enhanced tensile strength and ***,the cold method requires a lower binder content to meet the same strength requirements,thereby minimizing gas evolution,reducing porosity defects,and ultimately improving casting *** coated sand samples prepared through the cold method exhibit superior accuracy,with a size error of within±0.4 *** contrast,the coated sand samples prepared by the hot method display a lower accuracy,with an average negative error of 2.1993 *** highest tensile strength could be attained by controlling the baking temperature within a suitable range(180-190°C),which can effectively reduce the generation of gas,thus contributing to improved overall performance.

关键词： selective laser sintering(SLS) coated sand cold method hot method baking

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高钼含量镍基合金低成本非真空感应炉冶炼

特殊钢 2024年第5期45卷 72-75页

作者：王树财郭京吴智龙韩魁赵越陈秀强抚顺特殊钢股份有限公司技术中心抚顺113000

基于抚顺特殊钢股份有限公司镍基合金生产平台,研究了“30 t非真空感应炉-炉外精炼-电渣重熔”工艺代替传统高成本工艺冶炼高钼含量镍基合金的可行性,并结合生产实际分析了生产效率和成本优势。结果表明,采用30 t非真空感应炉熔炼钢水,... 详细信息

基于抚顺特殊钢股份有限公司镍基合金生产平台,研究了“30 t非真空感应炉-炉外精炼-电渣重熔”工艺代替传统高成本工艺冶炼高钼含量镍基合金的可行性,并结合生产实际分析了生产效率和成本优势。结果表明,采用30 t非真空感应炉熔炼钢水,VOD吹氧脱碳后抽真空至67 Pa以下脱气冶炼工艺方案,成功实现了高钼含量镍基合金N06625、N10276产品的冶炼。电渣后的钢锭生产为204 mm锻材产品,化学成分、非金属夹杂物均满足行业标准要求,进一步提高了高钼镍基合金的生产保障及成本控制能力。

关键词：镍基合金非真空感应炉 VOD 电渣重熔低成本冶炼

Engineering an ultrathin amorphous TiO2 layer for boosting the weatherability of TiO2 pigment with high lightening power

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Chinese Journal of Chemical Engineering 2019年第11期27卷 2825-2834页

作者： yangyang Yu Kejing Wu Shiyu Lu kui Ma Shan Zhong Hegui Zhang Yingming Zhu Jing Guo Hairong yue Changjun Liu Siyang Tang Bin Liang Low-Carbon Technology and Chemical Reaction Engineering Laboratory School of Chemical EngineeringSichuan UniversityChengdu 610065China Institute of New Energy and Low-Carbon Technology Sichuan UniversityChengdu 610207China Institute for Clean Energy&Advanced Materials Faculty of Materials and EnergySouthwest UniversityChongqing 400715China Shanxi Province Key Laboratory of Higee-Oriented Chemical Engineering North University of ChinaTaiyuan 030051China

TiO2 pigments are typically coated with inert layers to suppress the photocatalytic activity and improve the weatherability. However, the traditional inert layers have a lower refractive index compared to TiO2, and therefore reduce the lightening power of TiO2. In the present work, a uniform, amorphous, 2.9-nm-thick TiO2 protective layer was deposited onto the surface of anatase TiO2 pigments according to pulsed chemical vapor deposition at room temperature, with Ti Cl4 as titanium precursor. Amorphous TiO2 coating layers exhibited poor photocatalytic activity, leading to a boosted weatherability. Similarly, this coating method is also effective for TiO2 coating with amorphous SiO2 and SnO2 layers. However, the lightening power of amorphous TiO2 layer is higher than those of amorphous SiO2 and SnO2 layers. According to the measurements of photoluminescence lifetime, surface photocurrent density, charge-transfer resistance, and electron spin resonance spectroscopy, it is revealed that the amorphous layer can prevent the migration of photogenerated electrons and holes onto the surface, decreasing the densities of surface electron and hole, and thereby suppress the photocatalytic activity.

关键词： TiO2 pigments Pulsed chemical vapor deposition Ultrathin layer Weatherability Lightening power Photocatalytic suppression mechanism

Localization effect in single crystal of RuAs_(2)

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Chinese Physics B 2024年第4期33卷 195-200页

作者：易哲铠刘琪光双魁徐升岳小宇梁慧李娜周颖吴丹丹孙燕李秋菊程鹏夏天龙孙学峰王义炎 Anhui Key Laboratory of Magnetic Functional Materials and Devices Institute of Physical Science and Information TechnologyAnhui UniversityHefei 230601China Department of Physics and Key Laboratory of Strongly-Coupled Quantum Matter Physics University of Science and Technology of ChinaHefei 230026China Department of Physics and Beijing Key Laboratory of Opto-electronic Functional Materials&Micro-nano Devices Renmin University of ChinaBeijing 100872China School of Optical and Electronic Information Suzhou City UniversitySuzhou 215104China School of Physics and Optoelectronic Engineering Anhui UniversityHefei 230601China Collaborative Innovation Center of Advanced Microstructures Nanjing UniversityNanjing 210093China

We report the magnetotransport and thermal properties of RuAs_(2) single ***_(2) exhibits semiconductor behavior and localization *** crossover from normal state to diffusive transport in the weak localization(WL)state and then to variable range hopping(VRH)transport in the strong localization state has been *** transitions can be reflected in the measurement of resistivity and Seebeck *** magnetoresistance(NMR)emerges with the appearance of localization effect and is gradually suppressed in high magnetic *** temperature dependent phase coherence length extracted from the fittings of NMR also indicates the transition from WL to *** measurement of Hall effect reveals an anomaly of temperature dependent carrier concentration caused by localization *** findings show that RuAs_(2) is a suitable platform to study the localized state.

关键词： weak localization variable range hopping RuAs_(2) single crystal

Speed Optimization Technology of Process Control in Pickling Line and Tandem Cold Mill 25th

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Speed Optimization Technology of Process Control in Pickling...