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Internal Microanatomy and Zoological Affinity of the Early Cambrian Olivooides

Acta Geologica Sinica(English Edition) 2016年第1期90卷 38-65页

作者： Han Jian LI Guoxiang kubota shin OU Qiang TOshinO Sho WANG Xing YANG Xiaoguang UESUGI Kentaro MASATO Hoshino SASAKI Osamu KANO Harumasa SATO Tomohiko KOMIYA Tsuyoshi Early Life Institute and Department of Geology and State Key Laboratory of Continental Dynamics Northwest University229 Taibai RoadXi'an 710069China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and PalaeontologyChinese Academy of SciencesNanjing 210008China Seto Marine Biological Laboratory Field Science Education and Research CenterKyoto UniversityShirahamaNishimuroWakayama 649-2211Japan Early Life Evolution Laboratory School of Earth Sciences and ResourcesChina.University of GeosciencesBeijing 100083China Graduate School of Fisheries Sciences Kitasato University1-15-1 KitasatoSagamiharaKanagawa 252-0373Japan Japan Synchrotron Radiation Research Institute(JASRI)1-1-1 Kouto Sayo-choSayo-gunHyogoJapan Tohoku University Museum Tohoku University6-3 AobaAramakiAoba-kuSendaiJapan Department of Earth Science and Astronomy Graduate School of Arts and SciencesThe University of TokyoTokyo 153-8902Japan

The early Cambrian pentamerous microfossil Olivooides/Punctatus in South China, which is characterized by a diagnostic stellate tubular apex, has been well-known for its almost complete development sequence that can be confidently traced from embryos and hatched juveniles, to conical adults. However, its zoological affinity remains highly controversial. Here we describe the internal microanatomic structures of the soft-body inside the peridermal theca of Olivooides multisulcatus Qian, 1977, including interradial pairs of tentacles, adradial and perradial frenula, perradial oral marginal lappets and twins of perradial gastric saccule-like humps as well as a circular velarium with striated coronal muscles. Particularly, one specimen shows bifurcated velarial canals along the bell aperture. Both the components of the soft-body and the external theca （or cyst） are arranged in perfect pentaradial symmetry. These characteristics are more compatible with those of living cubomedusans and co-occurring Cambrian athecate embryonic cubozoans. Concerning the presence of peridermal theca, Olivooides most likely represents an extinct thecate stem-group cubomedusae but devoid of both perradial eyes and specialized pedalia. The well-grown soft body inside the peridermal tube displays a set of mixed features of both polyp and medusa.

关键词： Embryos periderm cnidarians cubozoan early Cambrian Kuanchuanpu Formation

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寒武纪水母化石研究现状与展望

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自然杂志 2014年第1期36卷 24-33页

作者：韩健李国祥久保田信王星欧强西北大学地质学系早期生命研究所及大陆动力学国家重点实验室中国科学院南京地质与古生物研究所日本京都大学临海实验室中国地质大学(北京)早期生命演化实验室

简述了水母的早期化石记录,并根据华南寒武系发现的立方水母干群化石,讨论了祖先型水母的辐射对称、躯体构型、生活史、生活习性,以及外骨骼的形成特征,推测水母类在寒武纪大爆发初期先于两侧对称动物基本完成其高级分类单元的宏演化。... 详细信息

简述了水母的早期化石记录,并根据华南寒武系发现的立方水母干群化石,讨论了祖先型水母的辐射对称、躯体构型、生活史、生活习性,以及外骨骼的形成特征,推测水母类在寒武纪大爆发初期先于两侧对称动物基本完成其高级分类单元的宏演化。寒武纪的水母在生活习性上可以分为底栖固着型和游泳型两种。

关键词：寒武纪宽川铺生物群澄江生物群刺细胞动物两侧对称动物外骨骼

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The advantages of radical distribution control and independent dual frequency on etch/ash

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半导体技术 2004年第8期29卷 41-46页

作者： Tanaka Hideaki kubota Kazuhiro shin Okamoto Tokyo Electron Ltd. Tokyo Electron Ltd.Tokyo Electron Ltd.

The transition to 65 nm beyond and 300 mm wafers posed many challenges on etch depth and critical dimension (CD) uniformity within wafer. In this paper, we introduce a radical distribution con- trol (RDC) system for an excellent uniformity control. Etch depth and CD uniformity within wafer are well controlled by adding RDC function to SCCMTM. For increasing productivity, an all-in-one process, that is, etch/ash at the same chamber continuously is proposed here. By utilizing the advantage of inde- pendent dual frequency, a bias-controlled two-step ash “hybrid ash” is combined in the all-in-one process. Hybrid ash uses bias control and low pres- sure to minimize liner loss and the damage of low-k materials, which is targeting 65nm and beyond.

关键词：蚀刻分布控制独立双频 RDC SCCM

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Recent advances in endoscopic ultrasonography-guided biliary interventions

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World Journal of Gastroenterology 2015年第32期21卷 9494-9502页

作者： Kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani shin Haba Shuhei Kawahata Yoko Abe Yoshimasa kubota Kimitoshi Kubo Hiroyuki Isayama Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Graduate School of Medicine Department of Gastroenterology Graduate School of Medicine The University of Tokyo

Interventional endoscopic ultrasonography(EUS) based on EUS-guided fine-needle aspiration has rapidly spread as a minimally invasive procedure. Especially in patients with failed endoscopic retrograde cholangiopancreatography, EUS-guided biliary intervention is reported to be useful as salvage therapy. EUS-guided biliary interventions are carried out using three techniques: EUS-guided bilioenteric anastomosis, EUS-guided rendezvous procedure, and EUS-guided antegrade treatment. Although interventional EUS is not yet a standardized procedure, there have been recent advances in this field that address various biliary diseases. Here, we summarize the indications, techniques, clinical results of previous studies, and future perspectives.

关键词： Endosonography-guided biliary intervention Choledo

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Classification of archaic rice grains excavated at the Mojiaoshan site within the Liangzhu site complex reveals an Indica and Japonica chloroplast complex

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Food Production, Processing and Nutrition 2020年第1期2卷 148-159页

作者： Katsunori Tanaka Chunfang Zhao Ningyuan Wang shinji kubota Masaaki Kanehara Nobuhiko Kamijo Ryuji Ishikawa Hiroyuki Tasaki Minako Kanehara Bin Liu Minghui Chen shin-ichi Nakamura Tetsuro Udatsu Cailin Wang Faculty of Agriculture and Life Science Hirosaki University3 BunkyoHirosakiAomori 036-8561Japan Institute of Food Crops Jiangsu Academy of Agricultural SciencesXiaolingweiNanjing 210014Jiangsu ProvinceChina Zhejiang Provincial Institute of Cultural Relics and Archaeology Gongshuqu Jiashanxincun26Hangzhou 310014Zhejiang ProvinceChina Center for Cultural Resource Studies Kanazawa University Kanazawa UniversityKakumaKanazawaIshikawa 920-1192Japan Department of Teacher Training and School Education Nara University of EducationTakahataNaraNara 630-8528Japan Archaeological Research Center Ehime University10-13 Dogo-hi-mataMatsuyamaEhime 790-8577Japan Agricultural Museum Faculty of AgricultureMiyazaki University1-1 Gakuen-Kibana-dai-NishiMiyazakiMiyazaki 889-2192Japan

To understand rice types that were utilized during postdomestication and in the modern age and the potential of genetic research in aged rice materials,archaeogenetic analysis was conducted for two populations of archaic rice grains from the Mojiaoshan site during the Liangzhu Period in China(2940 to 2840 BC).Sequencing after the PCR amplification of three regions of the chloroplast genome and one region of the nuclear genome showed recovery rates that were comparable to those in previous studies except for one chloroplast genome region,suggesting that the materials used in this work were appropriate for recovering genetic information related to domestication traits by using advanced *** after sequencing in these regions proved the existence of Japonica and Indica chloroplasts in archaic grains from the west trench,which were subsequently classified into eight plastid groups(type I–VIII),and indicated that these rice grains derived from different maternal lineages were stored together in storage houses at the Mojiaohsan *** these plastid groups,type V exhibited the same sequences as two modern Indica accessions that are utilized in basic studies and rice *** was inferred that part of the chloroplast genome of archaic rice has been preserved in modern genetic resources in these two modern Indica accessions,and the results indicated that rice related to their maternal ancestor was present at the Mojiaoshan site during the Liangzhu Period in *** usefulness of archaeogenetic analysis can be demonstrated by our research data as well as previous studies,providing encouragement for the possibility that archaeogenetic analysis can be applied to older rice materials that were utilized in the rice-domesticated period.

关键词： Agriculture Archaeology Archaic DNA Diversity Mojiaoshan Rice

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Early effects of oral administration of omeprazole and roxatidine on intragastric pH

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Journal of Zhejiang University-Science B(Biomedicine & Biotechnology) 2012年第1期13卷 29-34页

作者： Hiroshi IIDA shingo KATO Yusuke SEKINO Eiji SAKAI Takashi UCHIYAMA Hiroki ENDO Kunihiro HOSONO Yasunari SAKAMOTO Koji FUJITA Masato YONEDA Tomoko KOIDE Hirokazu TAKAHASHI Chikako TOKORO Ayumu GOTO Yasunobu ABE Noritoshi KOBAYASHI Kensuke kubota Eiji GOTOH shin MAEDA Atsushi NAKAJIMA Masahiko INAMORI Gastroenterology Division Yokohama City University School of Medicine Department of Medical Education Yokohama City University School of Medicine Office of Postgraduate Medical Education Yokohama City University Hospital

Objective： The ideal medication for the treatment of acid-related diseases, e.g., peptic ulcers, stress- related gastric bleeding, functional dyspepsia, and gastroesophageal reflux disease, should have a rapid onset of action to promote hemostasis and relieve the symptoms. The aim of our study was to investigate the inhibitory effects on gastric acid secretion of a single oral administration of a proton pump inhibitor, omeprazole 20 mg, and an H2-receptor antagonist, roxatidine 75 mg. Methods： Ten Heficobacterpylori-negative male subjects participated in this randomized, two-way crossover study. Intragastric pH was monitored continuously for 6 h after single oral admini- stration of omeprazole 20 mg and roxatidine 75 mg. Each administration was separated by a 7-d washout period. Results： During the 6-h study period, the average pH after administration of roxatidine was higher than that after administration of omeprazole （median： 4.45 vs. 2.65; P=0.0367）. Also during the 6-h study period, a longer duration of maintenance at pH above 2, 5, and 6 was observed after administration of roxatidine 75 mg than after administration of omeprazole 20 mg （median： 90.6% vs. 55.2%, P=-0.0284; 43.7% vs. 10.6%, P=0.0125; 40.3% vs. 3.3%, P=0.0125; respectively）. Conclusions： In Helicobacter pylori-negative healthy male subjects, oral administration of roxatidine 75 mg increased the intragastric pH more rapidly than that of omeprazole 20 mg.

关键词： Proton pump inhibitor H2-receptor antagonist Intragastric pH Omeprazole Roxatidine

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Is hepatic arterial infusion chemotherapy effective treatment for advanced hepatocellular carcinoma resistant to transarterial chemoembolization?

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World Journal of Gastroenterology 2012年第16期18卷 1933-1939页

作者： Hiroyuki Kirikoshi Masato Yoneda Hironori Mawatari Koji Fujita Kento Imajo shingo Kato Kaori Suzuki Noritoshi Kobayashi Kensuke kubota shin Maeda Atsushi Nakajima Satoru Saito Gastroenterology Division Yokohama City University Graduate School of Medicine3-9 Fuku-uraKanazawakuYokohama 236-0004Japan

AIM:To evaluate the effectiveness of hepatic arterial infusion chemotherapy(HAIC) for advanced hepatocellular carcinoma(HCC) resistant to transarterial chemoembolization(TACE).METHODS:This study was conducted on 42 patients who received HAIC for advanced HCC between 2001and 2010 at our hospital.5-fluorouracil(5-FU) was administered continuously for 24 h from day 1 to day 5 every 2-4 wk via an injection ***-arterial cisplatin or subcutaneous interferon was administered in combination with the *** patients enrolled in this retrospective study were divided into two groups according to whether or not they fulfilled the criteria for resistance to TACE proposed by the Japan Society of Hepatology in 2010(written in Japanese);one group of patients who did not fulfill the criteria for TACE resistance(group A,n = 23),and another group who fulfilled the criteria for TACE resistance(group B,n = 19).We compared the outcomes in terms of the response and survival rates between the two ***:Both the response rate and tumor suppression rate following HAIC were significantly superior in group A than in group B(response rate:48% vs 16%,P = 0.028,tumor suppression rate:87% vs 53%,P = 0.014).Furthermore,both the progression-free survival rate and survival time were significantly superior in group A than in group B(3-,6-,12-,and 24-mo = 83%,70%,29% and 20% vs 63%,42%,16% and 0%,respectively,P = 0.040,and 9.8 mo vs 6.2 mo,P = 0.040).A multivariate analysis(Cox proportional hazards regression model) showed that resistance to TACE was an independent predictor of poor survival(P = 0.007).CONCLUSION:HAIC administrating 5-FU was not effective against advanced HCC resistant to *** tools for treatment,i.e.,molecular-targeting agents may be considered for these cases.

关键词： Hepatocellular carcinoma Hepatic arterial infusion chemotherapy 5-fluorouracil Transarterial chemoembolization

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Retrospective cohort study Lower incidence of complications in endoscopic nasobiliary drainage for hilar cholangiocarcinoma

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World Journal of Gastrointestinal Endoscopy 2016年第9期8卷 385-390页

作者： Kazumichi Kawakubo Hiroshi Kawakami Masaki Kuwatani shin Haba Taiki Kudo Yoko A Taya Shuhei Kawahata Yoshimasa kubota Kimitoshi Kubo Kazunori Eto Nobuyuki Ehira Hiroaki Yamato Manabu Onodera Naoya Sakamoto Department of Gastroenterology and Hepatology Hokkaido University Graduate School of Medicine Sapporo 0608638Japan

AIM:To identify the most effective endoscopic biliary drainage technique for patients with hilar ***:In total,118 patients with hilar cholangiocarcinoma underwent endoscopic management[endoscopic nasobiliary drainage(ENBD)or endoscopic biliary stenting]as a temporary drainage in our institution between 2009 and *** retrospectively evaluated all complications from initial endoscopic drainage to surgery or palliative *** risk factors for biliary reintervention,post-endoscopic retrograde cholangiopancreatography(post-ERCP)pancreatitis,and percutaneous transhepatic biliary drainage(PTBD)were also analyzed using patient-and procedure-related *** risk factors for bilateral drainage were examined in a subgroup analysis of patients who underwent initial unilateral ***:In total,137 complications were observed in92(78%)*** reintervention was required in 83(70%)*** was significantly associated with a low risk of biliary reintervention[odds ratio(OR)=0.26,95%CI:0.08-0.76,P=0.012].Post-ERCP pancreatitis was observed in 19(16%)*** absence of endoscopic sphincterotomy was significantly associated with post-ERCP pancreatitis(OR=3.46,95%CI:1.19-10.87,P=0.023).PTBD was required in 16(14%)patients,and Bismuth type III or IV cholangiocarcinoma was a significant risk factor(OR=7.88,95%CI:1.33-155.0,P=0.010).Of 102 patients with initial unilateral drainage,49(48%)required bilateral *** sphincterotomy(OR=3.24,95%CI:1.27-8.78,P=0.004)and Bismuth II,III,or IV cholangiocarcinoma(OR=34.69,95%CI:4.88-736.7,P<0.001)were significant risk factors for bilateral ***:The endoscopic management of hilar cholangiocarcinoma is *** should be selected as a temporary drainage method because of its low risk of complications.

关键词： Hilar cholangiocarcinoma Endoscopic nasobiliary drainage Endoscopic biliary stenting Endoscopic sphincterotomy Complications

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Clinical Outcomes of Patients Who Perform High-Load Activities after Total Hip Arthroplasty in Snowy Agricultural Areas

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Surgical Science 2018年第8期9卷 248-255页

作者： Tetsuya Kawano Hiroaki Kijima Toshiaki Aizawa shin Yamada Natsuo Konishi Hitoshi kubota Hiroshi Tazawa Takayuki Tani Norio Suzuki Keiji Kamo Yoshihiko Okudera Ken Sasaki Masashi Fujii Yosuke Iwamoto Itsuki Nagahata Takanori Miura Naohisa Miyakoshi Yoichi Shimada Department of Orthopedic Surgery Kita-Akita Municipal Hospital Akita Japan Akita Hip Research Group Akita Japan Department of Orthopedic Surgery Akita University Graduate School of Medicine Akita Japan

Background: In snowy agricultural areas, weeding and snow shoveling are essential activities, and sports activities are common recreational activities. Clarifying the relationships between the degrees of these activities after total hip arthroplasty (THA) and the clinical outcomes may enable us to predict the results of THA for high-load activity patients. Methods: The subjects were 227 post-THA patients who were followed up between 2012 and 2014. Patient-reported outcomes were investigated by the Japanese Orthopaedic Association Hip Disease Evaluation Questionnaire (JHEQ) and a questionnaire on postoperative activity. In addition, the Japanese Orthopaedic Association Hip Score (JOA score) was used to quantify hip function. Results: Patients who resumed activities had significantly higher JOA and JHEQ scores than patients who had given up their activities. However, 25.8% of patients had not resumed weeding with a squatting posture. Furthermore, 20% had not resumed sports activities. The most common reason for giving up these activities was fear of implant failure. Conclusions: If the patients were informed that there is no problem restarting their activities after THA, the patients could resume activities and their clinical outcomes may be improved.

关键词： Total Hip Arthroplasty Postoperative Activities Weeding Snow Shoveling

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