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Quantitative tracking of trans-synaptic nose-to-brain transport of nanoparticles and its modulation by odor,aging,and Parkinson’s disease

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nano Research 2023年第5期16卷 7119-7133页

作者： Alexander V.Romashchenko Dmitrii V.Petrovskii Sergey Yu.Trotsky ksenia n.morozova nina B.Illarionova Maria V.Zhukova Elena V.Kiseleva Marina B.Sharapova Daniil S.Zuev Konstantin E.Kuper Sergey Yu.Taskaev Anna I.Kasatova Dmitrii A.Kasatov Olga I.Solovieva Ivan A.Razumov Ludmila A.Gerlinskaya Mikhail P.Moshkin Yuri M.Moshkin The Federal Research Center Institute of Cytology and Genetics SB RASAcademician Lavrentiev Avenue10Novosibirsk 630090Russia International tomography center Institutskaya st.3ANovosibirsk 630090Russia G.K.Boreskov Institute of Catalysis SB RASAcademician Lavrentiev Avenue5Novosibirsk 630090Russia The Federal Research Center Budker Institute of nuclear Physics SB RASAcademician Lavrentiev Avenue11Novosibirsk 630090Russia Institute of Computational Technologies Academician M.A.Lavrentiev avenue6Novosibirsk 630090Russia Institute of Gene Biology Russian Academy of SciencesMoscow 117334Russia Institute of Molecular and Cellular Biology SB RASAcad.Lavrentiev Ave8/2Novosibirsk 630090Russia Federal Research Centre of Biological Systems and Agrotechnologies RASst.January 929Orenburg 460000Russia

nanoparticles(nPs)can be transported via the nose-to-brain(n_(2)B)***,quantitative data on their spatiotemporal dynamics and regulation of the n_(2)B transport are largely *** surveyed metal oxide/hydroxide nPs as magnetic resonance imaging(MRI)contrasts for quantitative n_(2)B *** containing divalent transition metals were the only ones capable of n_(2)B *** T1-weighted(T1W)MRI,we showed that Mn_(3)O_(4)-nPs were readily engulfed by olfactory receptor neurons(ORns)without disrupting olfactory sensing,we mapped their n_(2)B *** neurons,the Mn_(3)O_(4)-nPs were localized to the cytosol,mitochondria,vesicles,moved at mixed fast and slow axonal transport velocities intraand extra-vesicularly through *** nPs’axonal transport is dependent on neuronal activity and microtubule *** Mn_(3)O_(4)-nPs were trans-synaptically transmitted through at least four synapses across the olfactory ***-synaptic transmission of the nPs was dependent on n-type Ca^(2+)channels and nMDA receptors but blocked by GABAB receptor activation.A five-parameter Weibull signal increase/decrease model fitted to the T1W MRI data allowed for estimating kinetic parameters of Mn_(3)O_(4)-nP accumulation/*** and relative accumulation rates,but not elimination,correlated negatively with the number of synapses from ORns,indicating a coupling of the nPs’n_(2)B transport with spontaneous neuronal ***,olfactory stimuli(2,5-dimethylpyrazine and acetophenone)significantly modulated and rerouted the Mn_(3)O_(4)-nP n_(2)B transport odor ***,the nPs’trans-synaptic transmission was impaired by aging and the onset of Parkinson’s *** data suggest new approaches to diagnostics,functional neuroimaging,controlling n_(2)B drug delivery.

关键词： Mn_(3)O_(4)nanoparticles magnetic resonance imaging(MRI) nose-to-brain transport trans-synaptic transmission olfactory stimulation

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Potential of the Arkhangelsk seismic network for European Arctic monitoring

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Earthquake Science 2024年第5期37卷 434-444页

作者： Galina Antonovskaya Yana Konechnaya Ekaterina morozova Yana Mikhailova Eugenia Shakhova n.Laverov Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences Arkhangelsk 163002Russia Geophysical Survey of the Russian Academy of Sciences ObninskKaluga region 249034Russia

The Arkhangelsk Seismic network(ASn)of the *** Federal Center for Integrated Arctic Research of the Ural Branch of the Russian Academy of Sciences,founded in 2003,includes 10 permanent seismic stations located on the coasts of the White,Barents,and Kara Seas and on the Arctic archipelagos of novaya Zemlya,Franz Josef Land,and Severnaya *** network is registered with the International Federation of Digital Seismograph networks and the International Seismological *** used not only ASn data to process earthquakes but also the waveforms of various international seismic *** 13,000 seismic events were registered using ASn data for 2012-2022,and for 5,500 of them,we determined the parameters of the earthquake epicenters from the European *** spatial distribution of epicenters shows that the ASn monitors not only the main seismically active zones but also weak seismicity on the shelf of the Barents and Kara *** representative magnitude of ASn was ML,rep=*** level of microseismic noise has seasonal variations that affect the registration capabilities of each station included in the ASn and the overall sensitivity of the network as a *** summer,the sensitivity of the ASn decreased owing to the increasing microseismic and ambient noises,whereas in winter,the sensitivity of the ASn increased significantly because of the decrease.

关键词： European Arctic Arkhangelsk Seismic network seismic monitoring seismic network registration capabilities

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Target morphology and cell memory:a model of regenerative pattern formation

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neural Regeneration Research 2015年第12期10卷 1901-1905页

作者： nikolai Bessonov Michael Levin nadya morozova natalia Reinberg Alen Tosenberger Vitaly Volpert Institute of Problems of Mechanical Engineering Russian Academy of Sciences Department of Biology Tufts Center for Regenerative & Developmental BiologyTufts University Laboratoire Epigénétique et Cancer Institut des Hautes Etudes Scientiques Unité de Chronobiologie Théorique Faculté des SciencesUniversité Libre de BruxellesCampus Plaine Institut Camille Jordan UMR 5208 CNRSUniversity Lyon 1

Despite the growing body of work on molecular components required for regenerative repair,we still lack a deep understanding of the ability of some animal species to regenerate their appropriate complex anatomical structure following damage.A key question is how regenerating systems know when to stop growth and remodeling-what mechanisms implement recognition of correct morphology that signals a stop condition？In this work,we review two conceptual models of pattern regeneration that implement a kind of pattern *** the first one,all cells communicate with each other and keep the value of the total signal received from the other *** a part of the pattern is amputated,the signal distribution *** difference fromthe original signal distribution stimulates cell proliferation and leads to pattern regeneration,in effect implementing an error minimization process that uses signaling memory to achieve pattern *** the second model,we consider a more complex pattern organization with different cell *** tissue contains a central（coordinator）cell that controls the tissue and communicates with the other central *** of them keeps memory about the signals received from other central *** values of these signals depend on the mutual cell location,and the memory allows regeneration of the structure when it is *** purpose of these models is to suggest possible mechanisms of pattern regeneration operating on the basis of cell memory which are compatible with diverse molecular implementation mechanisms within specific organisms.

关键词： target morphology pattern regeneration cell memory morphogenesis cell signaling mathematical modeling agent-based model

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Functional oxide structures on a surface of metals and alloys

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广东有色金属学报 2005年第2期15卷 488-489页

作者： Rudnev V. S Yarovaya T. P Boguta D.L Lukiyanchuk I. V Tyrina L. M morozova V.P nedozorov P. M Vasilyeva M. S Kondrikov n. B Laboratory of Plasma Electrolytic Processes Institute of Chemistry of Far-Eastern Branch of the Russian Academy of Sciences Vladivostok 690022. Russia Far Eastcrn State Universary Vladivostok Russia

The investigations of the plasma electrolytic processes in our laboratory are aimed to the development of conditions of formation of oxide layers with determined composition, structure and functional properties on the... 详细信息

关键词：功能氧化物结构参数金属材料合金表面处理

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K65(X80)管线钢断口分离及其对冲击韧性的影响

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焊管 2018年第2期41卷 65-68页

作者：方伟(编译) 邹斌(编译) 李为卫(编译) 吕华(编译) FARBER V M KHOTInOV V A morozova A n 中国石油集团石油管工程技术研究院西安710077 中国石油西部管道分公司乌鲁木齐830013 不详

为了研究K65(X80)钢断口分离对冲击韧性的影响,对不同生产厂家的4种典型K65(X80)高韧性管线钢进行了+20^-90℃夏比冲击试验,并对冲击试样断口分离形貌和尺寸进行了分析。结果表明,均匀韧性断口的高能量区长度Lh与冲击韧性A_(kV)直接相关... 详细信息

为了研究K65(X80)钢断口分离对冲击韧性的影响,对不同生产厂家的4种典型K65(X80)高韧性管线钢进行了+20^-90℃夏比冲击试验,并对冲击试样断口分离形貌和尺寸进行了分析。结果表明,均匀韧性断口的高能量区长度Lh与冲击韧性A_(kV)直接相关,考虑了试验温度下降时断口分离形式和数量的变化,确定了管线钢获得高冲击韧性(-60℃A_(kV)≥250 J/cm^2)的条件。

关键词：断口分离 X80钢冲击韧性断口表面夏比转变曲线

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