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Research 2021年第1期2021卷 112-124页

作者： Guanzhao Wu Yangxue Liu Zhen Yang Liulei ma Yao Tang Xianliang Zhao Hossein Rouh Qixuan Zheng Peng Zhou Jia-Yin Wang Farhan Siddique Sai Zhang Shengzhou Jin Daniel Unruh Adelia JAAquino Hans Lischka kristin m.hutchins Guigen Li Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTexas 79409-1061USA Institute of Chemistry and Biomedical Sciences School of Chemistry and Chemical EngineeringNanjing UniversityNanjing 210093China School of Pharmaceutical Sciences and Technology Tianjin UniversityTianjin 300072China Department of mechanical Engineering Texas Tech UniversityLubbockTX 79409USA

Conjugated polymers and oligomers have great potentials in various fields,especially in materials and biological sciences because of their intriguing electronic and optoelectronic *** recent years,the through-space conjugation system has emerged as a new assembled pattern of multidimensional ***,a novel series of structurally condensed multicolumn/multilayer 3D polymers and oligomers have been designed and synthesized through one-pot Suzuki polycondensation(SPC).The intramolecularly stacked arrangement of polymers can be supported by either X-ray structural analysis or computational *** all cases,polymers were obtained with modest to good yields,as determined by GPC and 1 ***-TOF analysis has proven the speculation of the step-growth process of this *** computational study of ab initio and DFT calculations based on trimer and pentamer models gives details of the structures and the electronic *** results of optical and AIE research confirmed by calculation indicates that the present work would facilitate the research and applications in materials.

关键词： properties transition materials

Analytical evaluation of steady-state solute distribution in through- diffusion and membrane behavior test under non-perfectly flushing boundary conditions

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Journal of Rock mechanics and Geotechnical Engineering 2024年第1期16卷 258-267页

作者： Guannian Chen Yuchao Li kristin mSample-Lord Shan Tong School of Civil&Environmental Engineering and Geography Science Ningbo UniversityNingbo315211China mOE Key Laboratory of Soft Soils and Geoenvironmental Engineering College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou310058China Ningbo ZCONE High-tech Company Limited Ningbo315000China Department of Civil and Environmental Engineering Villanova UniversityVillanovaPAUSA

The through-diffusion and membrane behavior testing procedure using a closed-system apparatus has been widely used for concurrent measurement of diffusion and membrane efficiency coefficients of low-permeability clay-based barrier ***,the common assumption of perfectly flushing conditions at the specimen boundaries could induce errors in analyses of the diffusion coefficients and membrane *** this study,an innovative pseudo three-dimensional(3D)analytical method was proposed to evaluate solute distribution along the boundary surfaces of the soil-porous disks system,considering the non-perfectly flushing *** results were consistent with numerical models under two scenarios considering different inflow/outflow *** proposed model has been demonstrated to be an accurate and reliable method to estimate solute distributions along the *** calculated membrane efficiency coefficient and diffusion coefficient based on the proposed analytical method are more accurate,resulting in up to 50%less relative error than the traditional approach that adopts the arithmetic mean value of the influent and effluent *** retar-dation factor of the clay specimen also can be calculated with a revised cumulative mass ***,the simulated transient solute transport matched with experimental data from a multi-stage through-diffusion and membrane behavior test,validating the accuracy of the proposed method.

关键词： Diffusion testing membrane behavior Coupled transport Clay barrier Transport modeling

Solvation Effects on the Dielectric Constant of 1 m LiPF6 in Ethylene Carbonate:Ethyl methyl Carbonate 3:7

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Energy & Environmental materials 2024年第1期7卷 253-256页

作者： Julian Self Nathan T.Hahn kristin A.Persson Department of Chemical Engineering Polytechnique MontrealMontrealQC H3T 1J4Canada Department of materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA material Physical and Chemical Sciences CenterSandia National LaboratoriesAlbuquerqueNM 87185USA

We report the dielectric constant of 1 m LiPF_(6)in EC:EmC 3∶7 w/w(ethylene carbonate/ethyl methyl carbonate)in addition to neat EC:EmC 3∶7 w/*** three Debye relaxations,the static permittivity value,or dielectric constant,is extrapolated to 18.5,which is compared to 18.7 for the neat solvent *** EC solvent is found to strongly coordinate with the Li^(+)cations of the salt,which results in a loss of dielectric contribution to the ***,the small amplitude and large uncertainty in relaxation frequency for EmC cloud definitive identification of the Li^(+)solvation ***,the loss of the free EC permittivity contribution due to Li^(+)solvation is almost completely balanced by the positive contribution of the associated LiPF_(6)salt,demonstrating that a significant quantity of dipolar ion pairs exists in 1 m LiPF_(6)in EC:EmC 3∶7.

关键词： batteries dielectric relaxation spectroscopy electrolytes

Design and synthesis of synthetic promoters for consistency of gene expression across growth phases and scale in ***

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Synthetic and Systems Biotechnology 2024年第2期9卷 330-339页

作者： kristin V.Presnell Omar melhem Sarah m.Coleman Nicholas J.morse Hal S.Alper mcKetta Department of Chemical Engineering The University of Texas at Austin200E Dean Keeton St.Stop C0400AustinTX78712USA Institute for Cellular and molecular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX78712USA

metabolic engineering and synthetic biology endeavors benefit from promoters that perform consistently(or robustly)with respect to cellular growth phase(exponential and stationary)and fermentation scale(microtiter plates,tubes,flasks,and bioreactors).However,nearly all endogenous promoters(especially in Saccharomyces cerevisiae)do not perform in this *** this work,a hybrid promoter engineering strategy is leveraged to create novel synthetic promoters with robustness across these *** a multi-dimensional RNA-seq dataset,promoters with specific phase dependencies were *** enriched with functional transcription factors were identified using mEmE *** motif-containing fragments could impart activity dependence in the opposing ***,we obtain two new promoters with high and consistent expression across both phases by increasing the exponential phase activity of the starting stationary-phase scaffold by 38 and 23-fold ***,we show that these promoters function consistently across various laboratory growth scales over time in a microtiter plate and in ***,this work presents and validates a new strategy for engineering promoters in *** with high levels of expression that are robust to cellular growth phase and the scale of the culture.

关键词： endogenous synthetic stationary

Glyphosate Exposure Associated with Human Neurodegenerative Disorders: A Scoping Review

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Journal of Behavioral and Brain Science 2024年第7期14卷 187-209页

作者： Hannah hutchins David m. Compton Kris Dougherty Behavioral Neuroscience Program Palm Beach Atlantic University West Palm Beach Florida USA Department of Biology Palm Beach Atlantic University West Palm Beach Florida USA

Chemically engineered agricultural products such as pesticides, insecticides, and herbicides, although used considerably for both industrialized and personal agricultural use, have recently been associated with a number of serious human health disorders. This rapid literature review aims to accumulate and analyze research from the last ten years, focusing specifically on the effects of exposure to glyphosate-based herbicide products such as Roundup as associated with the formation of various neurological disorders. Specifically, this review focuses on laboratory research using animal models or human cell cultures as well as human population-based epidemiological studies. It associates exposure to glyphosate or glyphosate-based products with the formation or exacerbation of neurological disorders such as Parkinson’s disease, Alzheimer’s disease, seizures, and autism spectrum disorder. In addition, it examines the correlation between the gut-brain axis, exposure to glyphosate, and neurodegeneration.

关键词： Herbicide Glyphosate Roundup Neurodegeneration Neurodegenerative Disorder Parkinson’s Disease Alzheimer’s Disease Seizures Autism Spectrum Disorder Gut-Brain Axis

metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy

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Asian Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier Chirag P.Doshi Shalin C.Desai Petar Bajic michelle Van Kuiken mark Khemmani Ahmer V.Farooq Larissa Bresler Thomas m.T.Turk Alan J.Wolfe kristin G.Baldea Loyola University medical Center Department of UrologyMaywoodILUSA Loyola University Chicago Department of Microbiology and ImmunologyMaywoodILUSA

Objective:To identify possible stone-promoting microbes,we compared the profiles of microbes grown from stones of patients with and without metabolic syndrome(metS).The association between metS and urinary stone disease is well established,but the exact pathophysiologic relationship remains *** evidence suggests urinary tract dysbiosis may lead to increased nephrolithiasis ***:At the time of percutaneous nephrolithotomy,bladder urine and stone fragments were collected from patients with and without *** sample types were subjected to expanded quantitative urine culture(EQUC)and 16 S ribosomal RNA gene ***:Fifty-seven patients included 12 controls(21.1%)and 45 metS patients(78.9%).Both cohorts were similar with respect to demographics and non-metS *** controls had uric acid stone *** EQUC,bacteria were detected more frequently in metS stones(42.2%)compared to controls(8.3%)(p=0.041).Bacteria also were more abundant in stones of metS patients compared to *** validate our EQUC results,we performed 16 S ribosomal RNA gene *** 12/16(75.0%)sequence-positive stones,EQUC reliably isolated at least one species of the sequenced *** were detected in both“infectious”and“non-infectious”stone ***:Bacteria are more common and more abundant in metS stones than control *** findings support a role for bacteria in urinary stone disease for patients with metS regardless of stone composition.

关键词： Nephrolithiasis Urolithiasis metabolic syndrome Urinary microbiome Percutaneous nephrolithotomy

Elucidating regulatory processes of intense physical activity by multi-omics analysis

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military medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu marina A.Gritsenko Young-mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie munoz Kathleen m.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa m.Bramer Fernando montes Kathleen A.Clark Grant Tietje Justin Teeguarden kristin E.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： multi-omics analysis Intense exercise Human performance Biofluids metabolism Immunity

Transposable elements at the center of the crossroads between embryogenesis, embryonic stem cells, reprogramming,and long non-coding RNAs

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Science Bulletin 2015年第20期60卷 1722-1733页

作者： Andrew Paul hutchins Duanqing Pei Key Laboratory of Regenerative Biology South China Institute for Stem Cell Biology and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangdong Provincial Key Laboratory of Stem Cell and Regenerative medicine South China Institute for Stem Cell Biology and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou Branch of the Supercomputing Center of Chinese Academy of Sciences South China Institute for Stem Cell Biology and Regenerative Medicine Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences

Transposable elements(TEs) are mobile genomic sequences of DNA capable of autonomous and nonautonomous duplication. TEs have been highly successful,and nearly half of the human genome now consists of various families of TEs. Originally thought to be non-functional,these elements have been co-opted by animal genomes to perform a variety of physiological functions ranging from TE-derived proteins acting directly in normal biological functions, to innovations in transcription factor logic and influence on epigenetic control of gene expression. During embryonic development, when the genome is epigenetically reprogrammed and DNA-demethylated, TEs are released from repression and show embryonic stage-specific expression, and in human and mouse embryos, intact TEderived endogenous viral particles can even be detected. Asimilar process occurs during the reprogramming of somatic cells to pluripotent cells: When the somatic DNA is demethylated, TEs are released from repression. In embryonic stem cells(ESCs), where DNA is hypomethylated, an elaborate system of epigenetic control is employed to suppress TEs, a system that often overlaps with normal epigenetic control of ESC gene expression. Finally, many long non-coding RNAs(lnc RNAs) involved in normal ESC function and those assisting or impairing reprogramming contain multiple TEs in their RNA. These TEs may act as regulatory units to recruit RNA-binding proteins and epigenetic modifiers. This review covers how TEs are interlinked with the epigenetic machinery and lnc RNAs, and how these links influence each other to modulate aspects of ESCs,embryogenesis, and somatic cell reprogramming.

关键词： Transposable elements Endogenousretroviruses Embryonic stem cells lncRNA Reprogramming Pluripotency

Color change in a marine isopod is adaptive in reducing predation

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Current Zoology 2015年第4期61卷 739-748页

作者： kristin m. HULTGREN Hannah mITTELSTAEDT Department of Biology Seattle University 901 12^th ave. Seattle WA 98122

Although background matching is a common form of camouflage across a wide diversity of animals, there has been surprisingly little experimental work testing the fitness consequences of this camouflage strategy, especially in marine ecosystems. In this study, we tested whether color camouflage enhances survival of the intertidal marine isopod Pentidotea （Idotea） wosnesenskii, quantified patterns of camouflage in different algal habitats, and examined how algal diet affected color change and growth using laboratory assays. In the field, isopods collected from two differently colored algal habitats （the brown alga Fucus distichus and the red alga Odonthaliafloccosa） matched the color of their respective algal habitats, and also differed significantly in body size： smaller red isopods were found on red algae, while larger brown isopods were found on brown algae. Predation ex- periments demonstrated these color differences had fitness benefits： brown isopods that matched their brown algae habitats sur- vived at higher rates than red unmatched isopods. Surprisingly, despite the propensity of isopods to match their algal habitats, algal diet had no effect on color change in color change experiments. Instead, isopods in all treatments turned browner, matching the color of the algal habitat that many isopods are found on as adults. In summary, our data supported our hypothesis that back- ground matching serves an adaptive function in reducing predation, with important evolutionary implications for explaining the wide variation in color change mechanisms in idoteid isopods [Current Zoology 61 （4）： 739-748, 2015].

关键词： Isopod Pentidotea wosnesenskii. Camouflage Crypsis Background matching Color change

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P波地震图上的地面反射波与S—P转换波

世界地震译丛 1994年第3期25卷 1-13页

作者： A.Douglas L.Richardson m.hutchins 赵国敏刘宏兵万志超辽宁省地震局

辐射脉冲约1s或更短持续时间的震源理论研究表明:对于假定为实际地壳结构的双力偶震源,短周期P波地震图最突出的震相应当是P,pP和sP波。已注意到显示P波与地面反射的某些地震图,并可以充分模拟。然而,由浅地震观测到的这种地震图数目很... 详细信息

辐射脉冲约1s或更短持续时间的震源理论研究表明:对于假定为实际地壳结构的双力偶震源,短周期P波地震图最突出的震相应当是P,pP和sP波。已注意到显示P波与地面反射的某些地震图,并可以充分模拟。然而,由浅地震观测到的这种地震图数目很小。通常,观测到的地震图要么很简单,即它们显示出突出的初至,而很少有其他信息,要么地震图很复杂,即显示振幅大于或等于初至振幅的30s以上的震相。简单或复杂地震图上缺乏清晰的地面反射是很难解释的。当然,没有这种反射可能是震源上方地壳中横向变化引起的P波和S波的散射与焦散结果。不了解地震带的非常详细的地壳结构,这种假定很难得到检验。本文对简单与复杂sP地震图提出了另一种解释,即许多地震起因于陡倾断层面上单侧破裂随时间向深处传播。对于这种震源,pP和sP的拐角频率将小于P和S向下方辐射的拐角频率。这样的结果就是在sP记录段上,pP和sP的振幅较之P波减小了。如果这种现象确实发生,则在靠近辐射图形的相反节点处离开震源的P波路径上,可以观测到简单地震图。辐射图形中,近节点处离开震源的P波路径上,由于向下行进的S波,入射到地幔波速的较小间i断面上的S—P转换波具有较之P波(以及pP和sP)更大的振幅,并产生复杂的地震图。本文以实例表明所观测到的复杂与简单的地震图可以用单侧破裂模型解释。

关键词：地震图地震波反射波 S-P转换波