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Analytical evaluation of steady-state solute distribution in through- diffusion and membrane behavior test under non-perfectly flushing boundary conditions

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Journal of Rock mechanics and Geotechnical Engineering 2024年第1期16卷 258-267页

作者： Guannian Chen Yuchao Li kristin mSample-Lord Shan Tong School of Civil&Environmental Engineering and Geography Science Ningbo UniversityNingbo315211China mOE Key Laboratory of Soft Soils and Geoenvironmental Engineering College of Civil Engineering and ArchitectureZhejiang UniversityHangzhou310058China Ningbo ZCONE High-tech Company Limited Ningbo315000China Department of Civil and Environmental Engineering Villanova UniversityVillanovaPAUSA

The through-diffusion and membrane behavior testing procedure using a closed-system apparatus has been widely used for concurrent measurement of diffusion and membrane efficiency coefficients of low-permeability clay-based barrier ***,the common assumption of perfectly flushing conditions at the specimen boundaries could induce errors in analyses of the diffusion coefficients and membrane *** this study,an innovative pseudo three-dimensional(3D)analytical method was proposed to evaluate solute distribution along the boundary surfaces of the soil-porous disks system,considering the non-perfectly flushing *** results were consistent with numerical models under two scenarios considering different inflow/outflow *** proposed model has been demonstrated to be an accurate and reliable method to estimate solute distributions along the *** calculated membrane efficiency coefficient and diffusion coefficient based on the proposed analytical method are more accurate,resulting in up to 50%less relative error than the traditional approach that adopts the arithmetic mean value of the influent and effluent *** retar-dation factor of the clay specimen also can be calculated with a revised cumulative mass ***,the simulated transient solute transport matched with experimental data from a multi-stage through-diffusion and membrane behavior test,validating the accuracy of the proposed method.

关键词： Diffusion testing membrane behavior Coupled transport Clay barrier Transport modeling

Solvation Effects on the Dielectric Constant of 1 m LiPF6 in Ethylene Carbonate:Ethyl methyl Carbonate 3:7

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Energy & Environmental materials 2024年第1期7卷 253-256页

作者： Julian Self Nathan T.Hahn kristin A.Persson Department of Chemical Engineering Polytechnique MontrealMontrealQC H3T 1J4Canada Department of materials Science and Engineering University of CaliforniaBerkeleyCA 94720USA Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA material Physical and Chemical Sciences CenterSandia National LaboratoriesAlbuquerqueNM 87185USA

We report the dielectric constant of 1 m LiPF_(6)in EC:EmC 3∶7 w/w(ethylene carbonate/ethyl methyl carbonate)in addition to neat EC:EmC 3∶7 w/*** three Debye relaxations,the static permittivity value,or dielectric constant,is extrapolated to 18.5,which is compared to 18.7 for the neat solvent *** EC solvent is found to strongly coordinate with the Li^(+)cations of the salt,which results in a loss of dielectric contribution to the ***,the small amplitude and large uncertainty in relaxation frequency for EmC cloud definitive identification of the Li^(+)solvation ***,the loss of the free EC permittivity contribution due to Li^(+)solvation is almost completely balanced by the positive contribution of the associated LiPF_(6)salt,demonstrating that a significant quantity of dipolar ion pairs exists in 1 m LiPF_(6)in EC:EmC 3∶7.

关键词： batteries dielectric relaxation spectroscopy electrolytes

Design and synthesis of synthetic promoters for consistency of gene expression across growth phases and scale in ***

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Synthetic and Systems Biotechnology 2024年第2期9卷 330-339页

作者： kristin V.Presnell Omar melhem Sarah m.Coleman Nicholas J.morse Hal S.Alper mcKetta Department of Chemical Engineering The University of Texas at Austin200E Dean Keeton St.Stop C0400AustinTX78712USA Institute for Cellular and molecular Biology The University of Texas at Austin2500 Speedway AvenueAustinTX78712USA

metabolic engineering and synthetic biology endeavors benefit from promoters that perform consistently(or robustly)with respect to cellular growth phase(exponential and stationary)and fermentation scale(microtiter plates,tubes,flasks,and bioreactors).However,nearly all endogenous promoters(especially in Saccharomyces cerevisiae)do not perform in this *** this work,a hybrid promoter engineering strategy is leveraged to create novel synthetic promoters with robustness across these *** a multi-dimensional RNA-seq dataset,promoters with specific phase dependencies were *** enriched with functional transcription factors were identified using mEmE *** motif-containing fragments could impart activity dependence in the opposing ***,we obtain two new promoters with high and consistent expression across both phases by increasing the exponential phase activity of the starting stationary-phase scaffold by 38 and 23-fold ***,we show that these promoters function consistently across various laboratory growth scales over time in a microtiter plate and in ***,this work presents and validates a new strategy for engineering promoters in *** with high levels of expression that are robust to cellular growth phase and the scale of the culture.

关键词： endogenous synthetic stationary

metabolic syndrome and the urinary microbiome of patients undergoing percutaneous nephrolithotomy

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Asian Journal of Urology 2024年第2期11卷 316-323页

作者： Ryan A.Dornbier Chirag P.Doshi Shalin C.Desai Petar Bajic michelle Van Kuiken mark Khemmani Ahmer V.Farooq Larissa Bresler Thomas m.T.Turk Alan J.Wolfe kristin G.Baldea Loyola University medical Center Department of UrologyMaywoodILUSA Loyola University Chicago Department of Microbiology and ImmunologyMaywoodILUSA

Objective:To identify possible stone-promoting microbes,we compared the profiles of microbes grown from stones of patients with and without metabolic syndrome(metS).The association between metS and urinary stone disease is well established,but the exact pathophysiologic relationship remains *** evidence suggests urinary tract dysbiosis may lead to increased nephrolithiasis ***:At the time of percutaneous nephrolithotomy,bladder urine and stone fragments were collected from patients with and without *** sample types were subjected to expanded quantitative urine culture(EQUC)and 16 S ribosomal RNA gene ***:Fifty-seven patients included 12 controls(21.1%)and 45 metS patients(78.9%).Both cohorts were similar with respect to demographics and non-metS *** controls had uric acid stone *** EQUC,bacteria were detected more frequently in metS stones(42.2%)compared to controls(8.3%)(p=0.041).Bacteria also were more abundant in stones of metS patients compared to *** validate our EQUC results,we performed 16 S ribosomal RNA gene *** 12/16(75.0%)sequence-positive stones,EQUC reliably isolated at least one species of the sequenced *** were detected in both“infectious”and“non-infectious”stone ***:Bacteria are more common and more abundant in metS stones than control *** findings support a role for bacteria in urinary stone disease for patients with metS regardless of stone composition.

关键词： Nephrolithiasis Urolithiasis metabolic syndrome Urinary microbiome Percutaneous nephrolithotomy

Elucidating regulatory processes of intense physical activity by multi-omics analysis

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military medical Research 2024年第4期11卷 479-499页

作者： Ernesto S.Nakayasu marina A.Gritsenko Young-mo Kim Jennifer E.Kyle Kelly G.Stratton Carrie D.Nicora Nathalie munoz Kathleen m.Navarro Daniel Claborne Yuqian Gao Karl K.Weitz Vanessa L.Paurus Kent J.Bloodsworth Kelsey A.Allen Lisa m.Bramer Fernando montes Kathleen A.Clark Grant Tietje Justin Teeguarden kristin E.Burnum-Johnson Biological Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Environmental and molecular Sciences Division Pacific Northwest National LaboratoryRichlandWA 99352USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthWestern States DivisionDenverCO 80204USA Computational Analytics Division Pacific Northwest National LaboratoryRichlandWA 99352USA National Security Directorate Pacific Northwest National LaboratoryRichlandWA 99352USA Los Angeles County Fire Department Los AngelesCA 90063USA Centers for Disease Control and Prevention National Institute for Occupational Safety and HealthRespiratory Health DivisionMorgantownWV 26505USA Environmental and molecular Toxicology Oregon State UniversityCorvallisOR 97331USA

Background:Physiological and biochemical processes across tissues of the body are regulated in response to the high demands of intense physical activity in several occupations,such as firefighting,law enforcement,military,and sports.A better understanding of such processes can ultimately help improve human performance and prevent illnesses in the work ***:To study regulatory processes in intense physical activity simulating real-life conditions,we performed a multi-omics analysis of 3 biofluids(blood plasma,urine,and saliva)collected from 11 wildland firefighters before and after a 45 min,intense exercise *** profiles ***-exercise were compared by Student’s t-test followed by pathway analysis and comparison between the different omics ***:Our multi-omics analysis identified and quantified 3835 proteins,730 lipids and 182 metabolites combining the 3 different types of *** blood plasma analysis revealed signatures of tissue damage and acute repair response accompanied by enhanced carbon metabolism to meet energy *** urine analysis showed a strong,concomitant regulation of 6 out of 8 identified proteins from the renin-angiotensin system supporting increased excretion of catabolites,reabsorption of nutrients and maintenance of fluid *** saliva,we observed a decrease in 3 pro-inflammatory cytokines and an increase in 8 antimicrobial peptides.A systematic literature review identified 6 papers that support an altered susceptibility to respiratory ***:This study shows simultaneous regulatory signatures in biofluids indicative of homeostatic maintenance during intense physical activity with possible effects on increased infection susceptibility,suggesting that caution against respiratory diseases could benefit workers on highly physical demanding jobs.

关键词： multi-omics analysis Intense exercise Human performance Biofluids metabolism Immunity

你真的像你想象的那样擅长某件事吗？（英文）

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英语画刊(高中版) 2024年第6期 3-5页

作者： Robin kramer

自信就等于能力吗？不完全是。在一个能让你更好认识自己的演讲中，实验心理学家罗宾·克雷默深入研究了邓宁-克鲁格效应（Dunning-Kruger effect），该效应认为那些能力最差的人往往最高估自己的技能。I don’t mean to brag, but ther...

自信就等于能力吗？不完全是。在一个能让你更好认识自己的演讲中，实验心理学家罗宾·克雷默深入研究了邓宁-克鲁格效应（Dunning-Kruger effect），该效应认为那些能力最差的人往往最高估自己的技能。I don’t mean to brag, but there are lots of things that I’m pretty average at. From playing table tennis, cooking risotto, finding countries on a map, just to name a few. Now, in our everyday lives, we’re not typically assessed on our skills and abilities, so we’re forced to rely on our own judgments.

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Color change in a marine isopod is adaptive in reducing predation

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Current Zoology 2015年第4期61卷 739-748页

作者： kristin m. HULTGREN Hannah mITTELSTAEDT Department of Biology Seattle University 901 12^th ave. Seattle WA 98122

Although background matching is a common form of camouflage across a wide diversity of animals, there has been surprisingly little experimental work testing the fitness consequences of this camouflage strategy, especially in marine ecosystems. In this study, we tested whether color camouflage enhances survival of the intertidal marine isopod Pentidotea （Idotea） wosnesenskii, quantified patterns of camouflage in different algal habitats, and examined how algal diet affected color change and growth using laboratory assays. In the field, isopods collected from two differently colored algal habitats （the brown alga Fucus distichus and the red alga Odonthaliafloccosa） matched the color of their respective algal habitats, and also differed significantly in body size： smaller red isopods were found on red algae, while larger brown isopods were found on brown algae. Predation ex- periments demonstrated these color differences had fitness benefits： brown isopods that matched their brown algae habitats sur- vived at higher rates than red unmatched isopods. Surprisingly, despite the propensity of isopods to match their algal habitats, algal diet had no effect on color change in color change experiments. Instead, isopods in all treatments turned browner, matching the color of the algal habitat that many isopods are found on as adults. In summary, our data supported our hypothesis that back- ground matching serves an adaptive function in reducing predation, with important evolutionary implications for explaining the wide variation in color change mechanisms in idoteid isopods [Current Zoology 61 （4）： 739-748, 2015].

关键词： Isopod Pentidotea wosnesenskii. Camouflage Crypsis Background matching Color change

Online Induction of Probabilistic Real-Time Automata

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Journal of Computer Science & Technology 2014年第3期29卷 345-360页

作者： Jana Schmidt Stefan kramer Technische Universitt mnchen Institut fr Informatik/I12Boltzmannstr. 385748 Garching b. MnchenGermany Johannes Gutenberg-Universitt mainz Institute for Computer ScienceStaudingerweg 955128 MainzGermany

The probabilistic real-time automaton （PRTA） is a representation of dynamic processes arising in the sciences and industry. Currently, the induction of automata is divided into two steps： the creation of the prefix tree acceptor （PTA） and the merge procedure based on clustering of the states. These two steps can be very time intensive when a PRTA is to be induced for massive or even unbounded datasets. The latter one can be efficiently processed, as there exist scalable online clustering algorithms. However, the creation of the PTA still can be very time consuming. To overcome this problem, we propose a genuine online PRTA induction approach that incorporates new instances by first collapsing them and then using a maximum frequent pattern based clustering. The approach is tested against a predefined synthetic automaton and real world datasets, for which the approach is scalable and stable. moreover, we present a broad evaluation on a real world disease group dataset that shows the applicability of such a model to the analysis of medical processes.

关键词： probabilistic real-time automata online induction maximum frequent pattern based clustering

An improved symmetry-based approach to reciprocal space path selection in band structure calculations

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npj Computational materials 2020年第1期6卷 731-736页

作者： Jason m.munro Katherine Latimer matthew K.Horton Shyam Dwaraknath kristin A.Persson Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA 94720USA Department of Physics University of CaliforniaBerkeleyCA 94720USA Department of materials Science University of CaliforniaBerkeleyCA 94720USA

Band structures for electrons,phonons,and other quasiparticles are often an important aspect of describing the physical properties of periodic *** commonly,energy bands are computed along a one-dimensional path of high-symmetry points and line segments in reciprocal space(the“k-path”),which are assumed to pass through important features of the dispersion ***,existing methods for choosing this path rely on tabulated lists of high-symmetry points and line segments in the first Brillouin zone,determined using different symmetry criteria and unit cell *** we present a new“on-the-fly”symmetry-based approach to obtaining paths in reciprocal space that attempts to address the previous limitations of these *** a unit cell of a magnetic or nonmagnetic periodic solid,the site symmetry groups of points and line segments in the irreducible Brillouin zone are obtained from the total space *** elements in these groups are used alongside general and maximally inclusive high-symmetry criteria to choose segments for the final k-path.A smooth path connecting each segment is obtained using graph *** new framework not only allows for increased flexibility and user convenience but also identifies notable overlooked features in certain electronic band *** addition,a more intelligent and efficient method for analyzing magnetic materials is also enabled through proper accommodation of magnetic symmetry.

关键词： symmetry reciprocal approach