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HDPairFinder:A data processing platform for hydrogen/deuterium isotopic labeling-based nontargeted analysis of trace-level amino-containing chemicals in environmental water

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Journal of Environmental Sciences 2024年第2期136卷 583-593页

作者： Tingting Zhao kristin Carroll Caley B.Craven Nicholas J.P.Wawryk Shipei Xing Jian Guo Xing-Fang Li Tao Huan Department of Chemistry Faculty of ScienceUniversity of British ColumbiaVancouver Campus2036 Main MallVancouverBritish ColumbiaV6T 1Z1Canada Division of Analytical and Environmental Toxicology Department of Laboratory Medicine and PathologyFaculty of Medicine and DentistryUniversity of AlbertaEdmontonAlberta T6G 2G3Canada

The combination of hydrogen/deuterium(H/D)formaldehyde-based isotopic methyl labeling with solid-phase extraction and high-performance liquid chromatography–high resolution mass spectrometry(HPLC-HRMS)is a powerful analytical solution for nontargeted analysis of trace-level amino-containing chemicals in water *** the huge amount of chemical information generated in HPLC-HRMS analysis,identifying all possible H/Dlabeled amino chemicals presents a significant challenge in data *** address this,we designed a streamlined data processing pipeline that can automatically extract H/D-labeled amino chemicals from the raw HPLC-HRMS data with high accuracy and ***,we developed a cross-correlation algorithm to correct the retention time shift resulting from deuterium isotopic effects,which enables reliable pairing of H-and D-labeled ***,we implemented several bioinformatic solutions to remove false chemical features generated by in-source fragmentation,salt adduction,and natural13C ***,we used a data mining strategy to construct the AMINES library that consists of over 38,000 structure-disjointed primary and secondary amines to facilitate putative compound ***,we integrated these modules into a freely available R program,*** rationale of each module was justified and its performance tested using experimental H/D-labeled chemical standards and authentic water *** further demonstrated the application of HDPairFinder to effectively extract N-containing contaminants,thus enabling the monitoring of changes of primary and secondary N-compounds in authentic water *** is a reliable bioinformatic tool for rapid processing of H/D isotopic methyl labeling-based nontargeted analysis of water samples,and will facilitate a better understanding of N-containing chemical compounds in water.

关键词： Isotope labeling Nontargeted analysis Reactive N-compounds HPLC-HRMS Source water

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Robotics in genital gender-affirming surgery

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Plastic and Aesthetic Research 2023年第1期10卷 74-82页

作者： Brielle Weinstein Henry Govekar Edward Cherullo kristin M.Jacobs Loren Schechter Department of Surgery Division of Plastic and Reconstructive SurgeryRush University Medical CenterChicagoIL 60612USA Department of Surgery Division of Colorectal SurgeryRush University Medical CenterChicagoIL 60612USA Department of Urology Rush University Medical CenterChicagoIL 60612USA Department of Surgery Division of Plastic and Reconstructive SurgeryDepartment of Obstetrics and GynecologyRush University Medical CenterChicagoIL 60612USA

Gender-affirming genital surgery includes a constellation of pelvic procedures that can help feminize or masculinize the *** advances in robotic surgery can aid surgical access to and visualization of the pelvis,thereby facilitating certain *** this scoping review,we will discuss the developing role of the robot in genital affirming genital ***,techniques,and outcomes using the robot in both feminizing and masculinizing genital procedures will be reviewed.

关键词： Robotic surgery gender affirming surgery vaginoplasty peritoneal vaginoplasty intestinal vaginoplasty metoidioplasty colpectomy vaginectomy phalloplasty

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Rufous-and-white wrens Thryophilus rufalbus do not exhibit a dear enemy effects towards conspecific or heterospecific competitors

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Current Zoology 2015年第1期61卷 23-33页

作者： Matthew M. BATTISTON David R. WILSON Brendan A. GRAHAM kristin A. KOVACH Daniel J. MENNILL Department of Biological Sciences University of Windsor Windsor Ontario Canada N9B 3P4

Many territorial animals exhibit reduced aggression towards neighbours. Known as ＂the dear enemy effect＂, this phenomenon has been documented among conspecific animals across a wide range of animal taxa. In theory, the dear enemy ef- fect can also exist between individuals of different species, particularly when those species compete for shared resources. To date, a heterospecific dear enemy effects has only been documented in ants. In this study, we test for both a conspecific and heterospe- cific dear enemy effect in neotropical rufous-and-white wrens Thryophilus rufalbus. This species competes for resources with banded wrens Thryophilus pleurostictus, a closely related sympatric congener. We used acoustic playback to simulate ruf- ous-and-white wren and banded wren neighbours and non-neighbours at the edges of rufous-and-white wren territories. Ruf- ous-and-white wrens responded more strongly to signals from their own species, demonstrating that resident males discriminate between conspecific and heterospecific rivals. They did not, however, exhibit a conspecific dear enemy effect. Further, they did not exhibit a heterospecific dear enemy effect. This could be due to neighbours and non-neighbours posing similar levels of threat in this system, to the possibility that playback from the edges of the subjects＇ large territories did not simulate a threatening signal, or to other factors. Our study provides the first test of a heterospecific dear enemy effect in vertebrates, and presents a valuable experimental approach for testing for a heterospecific dear enemy effect in other animals [Current Zoology 61 （1）： 23-33, 2015].

关键词： Conspecific aggression Dear enemy effect Heterospecific aggression Intra-specific interactions Inter-specific interactions Resource competition

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Hepatocellular Ballooning is Due to Highly Pronounced Glycogenosis Potentially Associated with Steatosis and Metabolic Reprogramming

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Journal of Clinical and Translational Hepatology 2024年第1期12卷 52-61页

作者： Silvia Ribback kristin Peters Mohd Yasser Jessica Prey Paula Wilhelmi Qin Su Frank Dombrowski Peter Bannasch Institut für Pathologie Universitaetsmedizin GreifswaldGreifswaldGermany Cell Marque Millipore-SigmaRocklinCAUSA German Cancer Research Center(DKFZ) HeidelbergGermany

Background and Aims:Hepatocellular ballooning is a common finding in chronic liver disease,mainly characterized by rarefied cytoplasm that often contains Mallory-Denk bodies(MDB).Ballooning has mostly been attributed to degeneration but its striking resemblance to glycogenotic/steatotic changes characterizing preneoplastic hepatocellular lesions in animal models and chronic human liver diseases prompts the question whether ballooned hepatocytes(BH)are damaged cells on the path to death or rather viable cells,possibly involved in neoplastic ***:Using specimens from 96 cirrhotic human livers,BH characteristics were assessed for their glycogen/lipid stores,enzyme activities,and proto-oncogenic signaling cascades by enzyme-and immunohistochemical approaches with serial paraffin and cryostat ***:BH were present in 43.8%of cirrhotic *** pronounced excess glycogen storage of(glycogenosis)and/or lipids(steatosis)were characteristic,ground glass features and MDB were often *** glucose-6-phosphatase,increased glucose-6-phosphate dehydrogenase activity and altered immunoreactivity of enzymes involved in glycolysis,lipid metabolism,and cholesterol biosynthesis were ***,components of the insulin signaling cascade were upregulated along with insulin dependent glucose transporter glucose transporter 4 and the v-akt murine thymoma viral oncogene homolog/mammalian target of rapamycin signaling pathway associated with de novo ***:BH are hallmarked by particularly pronounced glycogenosis with facultative steatosis,many of their features being reminiscent of metabolic aberrations documented in preneoplastic hepatocellular lesions in experimental animals and chronic human liver ***,BH are not damaged entities facing death but rather viable cells featuring metabolic reprogramming,indicative of a preneoplastic nature.

关键词： Chronic liver disease Carbohydrate metabolism Insulin signaling Preneoplasia Metabolic reprogramming

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Assessment of Methods for Determining Bioavailability of Trace Elements in Soils: A Review

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Pedosphere 2017年第3期27卷 389-406页

作者： Jurate KUMPIENE Laura GIAGNONI Bernd MARSCHNER Sébastien DENYS Michel MENCH kristin ADRIAENSEN Jaco VANGRONSVELD Markus PUSCHENREITER Giancarlo RENELLA Waste Science & Technology Lule University of Technology Department of Agrifood Production and Environmental Sciences University of Florence Ruhr-Universitt Bochum Joint Research Unit (UMR) Biodiversity Genes & Communities (BIOGECO) French National Institute for Agricultural Research (INRA) Agence Nationale de Sécurité Sanitaire (Anses) i-CLEANTECH Vlaanderen Hasselt University Centre for Environmental Sciences University of Natural Resources and Life Sciences Vienna

Trace element-contaminated soils(TECSs) are one of the consequences of the past industrial development worldwide. Excessive exposure to trace elements(TEs) represents a permanent threat to ecosystems and humans worldwide owing to the capacity of metal(loid)s to cross the cell membranes of living organisms and of human epithelia, and their interference with cell *** of TE bioavailability in soils is complicated due to the polyphasic and reactive nature of soil constituents. To unravel critical factors controlling soil TE bioavailability and to quantify the ecological toxicity of TECSs, TEs are pivotal for evaluating excessive exposure or deficiencies and controlling the ecological risks. While current knowledge on TE bioavailability and related cumulative consequences is growing, the lack of an integrated use of this concept still hinders its utilization for a more holistic view of ecosystem vulnerability and risks for human health. Bioavailability is not generally included in models for decision making in the appraisal of TECS remediation options. In this review we describe the methods for determining the TE bioavailability and technological developments, gaps in current knowledge, and research needed to better understand how TE bioavailability can be controlled by sustainable TECS management altering key chemical properties, which would allow policy decisions for environmental protection and risk management.

关键词： bioaccessibility bioavailability biosensors chemical extractions contaminated soils 'metalloids metals

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Giant cavernous hemangioma of the liver with satellite nodules:Aspects on tumour/tissue interface:A case report

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World Journal of Hepatology 2023年第5期15卷 707-714页

作者： Anne kristin Fischer Karl Tobias Erich Beckurts Reinhard Büttner Uta Drebber Institute of Pathology University of CologneKöln 50937North Rhine WestphaliaGermany Visceral Surgery Severinsklösterchen Hospital CologneCologne 50678North Rhine WestphaliaGermany Institute of Pathology University Hospital of CologneCologne 50937North Rhine WestphaliaGermany

BACKGROUND Giant hepatic cavernous hemangioma with multiple satellite nodules is a rare subtype of hepatic cavernous hemangioma,the most common vascular liver *** report on a tumor with unusual histologic features:(1)Finger-like infiltration pattern;(2)lack of encapsulation;(3)blurred tumor/liver interface;and(4)massive satellitosis-referring to the article“Hepatic cavernous hemangioma:underrecognized associated histologic features”.CASE SUMMARY A 60-year-old man presented with increasing uncharacteristic abdominal discomfort and mildly elevated blood parameters of acute *** revealed an unclear,giant liver tumor of the left liver lobe.A massive vascular tumor with extensive satellitosis broadly infiltrating the adjacent liver parenchyma was resected via hemihepatectomy of segmentsⅡ/Ⅲ.Histopathological diagnosis was giant hepatic cavernous hemangioma with multiple satellite nodules,featuring unusual characteristics hardly portrayed in the ***,this particular morphology can explain the difficult pre-and perioperative diagnosis of a vascular liver tumor that is usually readily identifiable by modern imaging *** This case emphasizes the exact histological workup of tumor and tumor-induced parenchyma changes in radiologically unclassifiable liver tumors.

关键词： diagnosis hemangioma elevated

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In the River

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小学生时代（大嘴英语） 2020年第5期 22-24页

作者： kristin Martin Alyssa Sinnen(图) 不详

芦苇丛旁的水里漂着两颗“种子”,黑黑的、圆圆的,我好奇地蹲下来仔细看,哈哈,原来是小乌龟的鼻孔!小乌龟慢慢地伸出脖子,像极了外太空来的不速之客,圆圆的龟壳几乎与水融为一体,那双小小的眼睛提溜提溜打量着我。它还会跟你捉迷藏,你... 详细信息

芦苇丛旁的水里漂着两颗“种子”,黑黑的、圆圆的,我好奇地蹲下来仔细看,哈哈,原来是小乌龟的鼻孔!小乌龟慢慢地伸出脖子,像极了外太空来的不速之客,圆圆的龟壳几乎与水融为一体,那双小小的眼睛提溜提溜打量着我。它还会跟你捉迷藏,你可千万别眨眼,一不留神,它就不见了……

关键词：外太空捉迷藏蹲下来乌龟不速之客好奇

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小型田鼠:研究单配制进化与调控的模型(英文)

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兽类学报 2005年第2期25卷 182-199页

作者： Bruce S Cushing kristin M Kramer The Brain Body Center Department of PsychiatryCollege of MedicineUniversity of Illinoisat ChicagoChicagoIL60612USAThe Brain Body CenterDepartment of PsychiatryCollege of MedicineUniversity of Illinoisat ChicagoChicagoIL60612USA

哺乳动物的单配制通常被认为是社会性单配制,它不是单纯地由性行为来决定,而是由诸多因素,包括长期的pairbond、夫妻双方共同抚育后代、免近亲交配以及雌雄两性相似等来决定的。在这篇综述中,我们论述了如何以啮齿类田鼠属(Microtus)为... 详细信息

哺乳动物的单配制通常被认为是社会性单配制,它不是单纯地由性行为来决定,而是由诸多因素,包括长期的pairbond、夫妻双方共同抚育后代、免近亲交配以及雌雄两性相似等来决定的。在这篇综述中,我们论述了如何以啮齿类田鼠属(Microtus)为模型,通过比较研究来帮助我们理解社会性单配制的进化以及其神经调控机制。对田鼠属的研究不仅证实了单配制起源于艰苦的生存条件的假说,而且还证实了雌性性选择可能有利于维持单配制。不仅如此,哺乳动物单配制的进化还需要雄性的prosocial行为的不断强化。例如,亲近行为可以促进pairbond的形成并强化雄性对后代的哺育行为,而这种强化则来源于神经多肽催产素(OT)和加压素(AVP)与类固醇类激素的相互作用。催产素和加压素调控pairbond和双亲哺育行为的表达,而单配制和多配制田鼠的催产素和加压素受体在脑内的分布有显著的不同。比较研究揭示了小型田鼠单配制的调控机制,而种内差异和行为上的可塑性则有助于我们进一步理解这种机制。比如,在某些条件下,多配制的草原田鼠(Microtuspennsylvanicu)的雄性个体具有哺育后代的行为。尽管草原田鼠的加压素V1a受体在脑内的分布与其他多配制的田鼠相似,但是如果脑室注射加压素,仍可以诱发其哺育后代的行为。

关键词：单配制进化模型哺乳动物调控机制比较研究草原田鼠攻击行为加压素雌激素受体催产素 pair bond 近亲交配生存条件相互作用神经多肽种内差异脑室注射橙腹田鼠受体表达终纹床核敏感程度社会性性行为

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Stem cell application for osteoarthritis in the knee joint: A minireview

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World Journal of Stem Cells 2014年第5期6卷 629-636页

作者： kristin Uth Dimitar Trifonov University of Oxford Old Road Campus Research Building Old Road Campus Oxford OX3 7DQ United Kingdom BioDiscovery Dundee Science Press Scotland DD6 8NR United Kingdom

Knee osteoarthritis is a chronic, indolent disease that will affect an ever increasing number of patients, especially the elderly and the obese. It is characterized by degeneration of the cartilage substance inside the knee which leads to pain, stiffness and tenderness. By some estimations in 2030, only in the United States, this medical condition will burden 67 million people. While conventional treatments like physiotherapy or drugs offer temporary relief of clinical symptoms, restoration of normal cartilage function has been difficult to achieve. Moreover, in severe cases of knee osteoarthritis total knee replacement may be required. Total knee replacements come together with high effort and costs and are not always successful. The aim of this review is to outline the latest advances in stem cell therapy for knee osteoarthritis as well as highlight some of the advantages of stem cell therapy over traditional approaches aimed at restoration of cartilage function in the knee. In addition to the latest advances in the field, challenges associated with stem cell therapy regarding knee cartilage regeneration and chondrogenesis in vitro and in vivo are also outlined and analyzed. Furthermore, based on their critical assessment of the present academic literature the authors of this review share their vision about the future of stem cell applications in the treatment of knee osteoarthritis.

关键词： Multipotent adult mesenchymal stem cells Osteoarthritis Knee joint Clinical trial

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Laparoscopic complete mesocolic excisions for colonic cancer in the last decade:Five-year survival in a single centre

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World Journal of Gastrointestinal Surgery 2017年第11期9卷 215-223页

作者： Kristian Eeg Storli kristin Bentung Lygre Knut B?rge Iversen Maria Decap Geir Egil Eide Department of Surgery Haraldsplass Deaconess Hospital Department of Clinical Medicine University of Bergen Centre for Clinical Research Haukeland University Hospital Department of Global Public Health and Primary Care University of Bergen

AIM To analyse clinical and long-term oncologic results after laparoscopic complete mesocolic excision(CME) for colonic cancer over a 10-year *** Consecutive patients who received laparoscopic CME at our hospital from 2007 to 2017 were prospectively registered and retrospectively analysed. In total, 341 patients were included with tumour-nodal-metastasis(TNM) stages 0-Ⅲ.RESULTS The mean age of the patients was 71.9 years. The median length of stay was 5 d. The mean lymph node harvest was 17.8. The mortality rate was 1.2%. Fifteen patients were reoperated on for anastomotic leaks. The local recurrence rate was 2.3%. Five-year TTR and cancer-specific survival CSS were 83.1% and 90.3%. The location of the tumour was not a significant variable for survival in unadjusted and adjusted survival analysis. TNM stage and anastomotic leaks were significant variables with respect to *** Laparoscopic CME results in acceptable complication rates and long-term oncologic results. It is important to avoid anastomotic leaks because of their negative effect on survival.

关键词： Complete mesocolic excision Central vascular ligature Colonic cancer Laparoscopic surgery Time to recurrence Cancer specific survival

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