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High rate of clinically relevant improvement following anatomical total shoulder arthroplasty for glenohumeral osteoarthritis

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World Journal of Orthopedics 2024年第2期15卷 156-162页

作者： Marc Randall kristensen Nyring Bo Sanderhoff Olsen Alexander Amundsen Jeppe Vejlgaard Rasmussen Section for Shoulder and Elbow Surgery Department of Orthopaedic SurgeryHerlev and Gentofte University HospitalHellerup 2900Denmark

BACKGROUND The minimal clinically important difference(MCID)is defined as the smallest meaningful change in a health domain that a patient would identify as ***,an improvement that exceeds the MCID can be used to define a successful treatment for the individual *** To quantify the rate of clinical improvement following anatomical total shoulder arthroplasty for glenohumeral *** Patients were treated with the Global Unite total shoulder platform arthroplasty between March 2017 and February 2019 at Herlev and Gentofte Hospital,*** patients were evaluated preoperatively and 3 months,6 months,12 months,and 24 months postoperatively using the Western Ontario Osteoarthritis of the Shoulder index(WOOS),Oxford Shoulder Score(OSS)and Constant-Murley Score(CMS).The rate of clinically relevant improvement was defined as the proportion of patients who had an improvement 24 months postoperatively that exceeded the *** on previous literature,MCID for WOOS,OSS,and CMS were defined as 12.3,4.3,and 12.8 *** Forty-nine patients with a Global Unite total shoulder platform arthroplasty were included for the final *** age at the time of surgery was 66 years(range 49.0-79.0,SD:8.3)and 65%were *** patient was revised within the two years *** mean improvement from the preoperative assessment to the two-year follow-up was 46.1 points[95%confidence interval(95%CI):39.7-53.3,P<0.005]for WOOS,18.2 points(95%CI:15.5-21.0,P<0.005)for OSS and 37.8 points(95%CI:31.5-44.0,P<0.005)for *** years postoperatively,41 patients(87%)had an improvement in WOOS that exceeded the MCID,45 patients(94%)had an improvement in OSS that exceeded the MCID,and 42 patients(88%)had an improvement in CMS that exceeded the *** Based on three shoulder-specific outcome measures we find that approximately 90%of patients has a clinically relevant *** is a clear message when informing patients about the

关键词： Minimal clinically important difference Patient reported outcome measures Glenohumeral osteoarthritis Anatomical total shoulder arthroplasty Clinically relevant improvement

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Rethinking neurodegenerative diseases:neurometabolic concept linking lipid oxidation to diseases in the central nervous system

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Neural Regeneration Research 2024年第7期19卷 1437-1445页

作者： Steinunn Sara Helgudóttir Anne Skøttrup Mørkholt Jacek Lichota Preben Bruun-Nyzell Mads Christian Andersen Nanna Marie Juhl kristensen Amanda Krøger Johansen Mikela Reinholdt Zinn Hulda Maria Jensdóttir John Dirk Vestergaard Nieland 2N Pharma ApS NOVI Science ParkAalborgDenmark Molecular Pharmacology Group Department of Health Science and TechnologyAalborg UniversityAalborgDenmark

Currently,there is a lack of effective medicines capable of halting or reve rsing the progression of neurodegenerative disorde rs,including amyotrophic lateral sclerosis,Parkinson s disease,multiple sclerosis,or Alzheimer s *** the unmet medical need,it is necessary to reevaluate the existing para digms of how to to rget these *** considering neurodegenerative diseases from a systemic neurometabolic perspective,it becomes possible to explain the shared pathological *** innovative approach presented in this paper draws upon exte nsive research conducted by the authors and researchers *** this review,we highlight the importance of metabolic mitochondrial dysfunction in the context of neurodegenerative *** provide an overview of the risk factors associated with developing neurodegenerative disorders,including genetic,epigenetic,and environmental fa ***,we examine pathological mechanisms implicated in these diseases such as oxidative stress,accumulation of misfolded proteins,inflammation,demyelination,death of neurons,insulin resistance,dysbiosis,and neurotransmitter ***,we outline a proposal for the restoration of mitochondrial metabolism,a crucial aspect that may hold the key to facilitating curative therapeutic interventions for neurodegenerative disorders in forthcoming advancements.

关键词： brain disease carnitine palmitoyl transferase 1 epigenetics metabolism gut microbiome mitochondrial dysfunction neurodegeneration oxidative stress

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“猪Ⅱ型圆环病毒”专栏六:西班牙和丹麦受感染猪场的猪个体感染断奶后多系统衰竭综合征的风险因素

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国外畜牧学（猪与禽） 2013年第5期33卷 27-28页

作者：陶莉 Grau-Roma L Stockmarr A kristensen cs Enφe C López-Soria S Nofrarías M Bille-Hansen V Hjulsager CK Sibila M Jorsal SE Fraile L Baekbo P Vigre H Segalés J Larsen LE

研究人员对来自西班牙（n=3）和丹麦（n=10）13家感染断奶后多系统衰竭综合征（Postweaning Multisystemic Wasting Syndrome,PMWS）的猪场进行了2项前瞻性纵向研究。

关键词：断奶后多系统衰竭综合征猪Ⅱ型圆环病毒西班牙风险因素感染猪场丹麦个体

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西班牙和丹麦受感染猪场的猪个体感染断奶后多系统衰竭综合征的风险因素

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国外畜牧学·猪与禽 2013年第5期

作者： Grau-Roma L Stockmarr A kristensen cs Enφe C L ó pez-Soria S Nofrar í as M Bille-Hansen V Hjulsager CK Sibila M 陶莉

研究人员对来自西班牙(n=3)和丹麦(n=10)13家感染断奶后多系统衰竭综合征(PostweaningMuhisystemic Wasting Syndrome,PMWS)的猪场进行了2项前瞻性纵向研究.猪的血液样本从第1周开始纵向采集直到爆发PMWS为止.相同日龄的健康或衰竭性猪...

研究人员对来自西班牙(n=3)和丹麦(n=10)13家感染断奶后多系统衰竭综合征(PostweaningMuhisystemic Wasting Syndrome,PMWS)的猪场进行了2项前瞻性纵向研究.猪的血液样本从第1周开始纵向采集直到爆发PMWS为止.相同日龄的健康或衰竭性猪都进行安乐死、尸体解剖和组织病理学描述.通过淋巴病变、原位杂交或免疫组织化学方法检测这些组织中的PCV2,从而确诊PMWS.血清分析在纵向采集的血清样本中进行,以检测针对PCV2、猪繁殖与呼吸综合征病毒(Porcine Reproductive And Respiratory Syndrome Virus,PRRSV)、猪细小病毒(Porcine ParvoVirus,PPV)、猪流感病毒(Swine Influenza Virus,SIV)、细胞内罗森氏菌(Lawsonia intracellularis,law)、猪肺炎支原体(Mycoplasma hyopneumoniae)、猪伪狂犬病病毒(Aujeszky's Disease Virus,ADV)和沙门菌(Salmonella spp.)的抗体.Cox比例风险模型(Cox proportional hazards model)被用来研究血清转换和抗所研究病原体母体免疫的同步效应.

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Fatty acid hydratase for value-added biotransformation:A review

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Chinese Journal of Chemical Engineering 2020年第8期28卷 2051-2063页

作者： Yan Zhang Bekir Engin Eser Peter kristensen Zheng Guo Department of Engineering Faculty of Science and TechnologyAarhus UniversityGustav wieds vej 108000 AarhusDenmark Faculty of Engineering and Science Department of Chemistry and BioscienceAalborg University9220 AalborgDenmark

The synthesis of hydroxy fatty acids(HFAs) from renewable oil feedstock by addition of water onto C_C bonds has attracted great attention in recent years. Given that selective asymmetric hydration of non-activated C_C bonds has been proven difficult to achieve with chemical catalysts, enzymatic catalysis by fatty acid hydratases(FAHs) presents an attractive alternative approach to produce value-added HFAs with high regio-, enantioand stereospecificity, as well as excellent atom economy. Even though FAHs have just been investigated as a potential biocatalyst for a decade, remarkable information about FAHs in different aspects is available;however, a comprehensive review has not been archived. Herein, we summarize the research progresses on biochemical characterization, structural and mechanistic determination, enzyme engineering, as well as biotechnological application of FAHs. The current challenges and opportunities for an efficient utilization of FAHs in organic synthesis and industrial applications are critically discussed.

关键词： Hydroxy fatty acids Fatty acid hydratases Enzyme characterization Catalytic mechanism Enzyme engineering Biotransformation

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Using coloured roots to study root interaction and competition in intercropped legumes and non-legumes

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Journal of Plant Ecology 2010年第3期3卷 191-199页

作者： Giacomo Tosti Kristian Thorup-kristensen Department of Agriculture and Environmental Sciences University of PerugiaBorgo XX Giugno 7406121 PerugiaItaly Department of Agriculture and Ecology Faculty of Life SciencesUniversity of CopenhagenHøjbakkegaards Alle 13DK-2630 TaastrupDenmark

Aims Root interactions between neighbour plants represent a fundamental aspect of the competitive dynamics in pure stand and mixed cropping *** comprehension of such phenomena places big methodological challenges,and still needs *** objectives of this work were(i)to test if a species with coloured roots can be used to examine the interaction in a legume-non-legume intercropping system;(ii)to verify the importance of initial root growth on the successive root development ofmixture component plants;(iii)to test if the root interaction in the shallowlayers has consequences for deep root growth and(iv)to compare the effect of intraspecific and interspecific competition on root development and biomass *** A detailed study on root growth and interaction was carried out using rhizotron tubes where two legume species were grown in pure stands or were intercropped with red beet,a variety of Beta vulgaris *** clear red *** the rhizotrons,the three species were grown either without competitors,with two plants of the same species to measure intraspecific competition or with one legume and one red beet plant to study interspecific *** use of mixtures where one component has clearly coloured roots,together with several scalar measurements of root depth and proliferation,allowed the measurement of the root system of each species when grown in the *** findings The use of rhizotron tubes coupled with species with coloured roots represented a valuable method to study the belowground interaction in mixed cropping *** initial root growth was a very important feature for the subsequent dominance of a species and it was not related to seed *** root growth was also important because the root interactions in the shallower soil layers were found to influence the root growth in deeper *** root system of the red beet showed much faster and deeper growth than that of the legumes,and made red beet

关键词： red beet root competition root interaction root proliferation rhizotron

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High frame rate multi-resonance imaging refractometry with distributed feedback dye laser sensor

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Light(Science & Applications) 2015年第1期4卷 410-414页

作者： Christoph Vannahme Martin Dufva Anders kristensen Technical University of Denmark Department of Micro-and NanotechnologyDTU NanotechDK-2800 Kgs.LyngbyDenmark

High frame rate and highly sensitive imaging of refractive index changes on a surface is very promising for studying the dynamics of dissolution,mixing and biological processes without the need for ***,a highly sensitive distributed feedback(DFB)dye laser sensor for high frame rate imaging refractometry without moving parts is *** dye lasers are low-cost and highly sensitive refractive index *** unique multi-wavelength DFB laser structure presented here comprises several areas with different grating *** two dimensions of space is enabled by analyzinglaser light from all areasin parallelwith an imaging *** this multi-resonance imaging refractometry method,the spatial position in one direction is identified from the horizontal,i.e.,spectral position of the multiple laser lines which is obtained from the spectrometer charged coupled device(CCD)*** orthogonal spatial position is obtained from the vertical spatial position on the spectrometer CCD array as in established spatially resolved ***,the imaging technique is demonstrated by monitoring the motion of small sucrose molecules upon dissolution of solid sucrose in *** omission of moving parts improves the robustness of the imaging system and allows a very high frame rate of up to 12 Hz.

关键词： distributed feedback laser label-free imaging laser sensor refractive index sensor

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Removal of chromophoric dissolved organic matter under combined photochemical and microbial degradation as a response to different irradiation intensities

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Journal of Environmental Sciences 2022年第8期34卷 76-86页

作者： Theis Kragh Kaj Sand-Jensen Emil kristensen Ole Pedersen Mikkel Madsen-Фterbye Department of Biology University of Southern DenmarkSyddanmark 5230Denmark Freshwater Biological Laboratory Department of BiologyUniversity of CopenhagenCopenhagen 2100Denmark

Throughout the freshwater continuum, Dissolved Organic Carbon(DOC) and the colored fraction, Chromophoric Dissolved Organic Material(CDOM), are continuously being added,removed, and transformed, resulting in changes in the chromophoricity and lability of organic matter over time. We examined, experimentally, the effect of increasing irradiationintensities on the combined photochemical and microbial degradation of CDOM and *** was done by using a simulated mixed water column: aged water from a humic lake was exposed to four irradiation-intensities – representing winter, early and late spring, and summer conditions(0.10, 0.16, 0.36, and 0.58 W/m^(2)) – and compared with dark controls over 37days. We found a linear relationship between CDOM degradation and irradiation-intensities up to 0.36 W/m^(2);the degradation rate saturated at higher intensities, both at specific wavelengths and for broader intervals. After 37 days at high irradiation-intensity, CDOM absorption of irradiation at 340 nm had been reduced by 41%;48% of DOC had been removed and DOC degradation continued to increase. Aromaticity(SUVA254) declined significantly over 37 days at the two lowest but not at the two highest UV-intensities;levels in unexposed control water remained constant. Direct observations of the humic lake showed that CDOM absorption of irradiation(340 nm) declined by 27% from winter to summer. A model based on hydrological CDOM input and CDOM degradation calculated from field measurements of UV-radiation and experimental CDOM degradation with UV-exposure from sunlight accurately predicted the annual course as observed in the lake. With no external CDOM input,92% of the CDOM could be degraded in a year. The results support the notion that combined photochemical and microbial CDOM degradation can be remarkably higher in lakes than previously thought and that humic lakes retain their color due to light absorption by ongoing CDOM input.

关键词： Biodegradation Brownification Carbon cycling CDOM DOC Humic lake Photobleaching UV-bleaching

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Net absorption and liver metabolism of amino acids and heat production of portaldrained viscera and liver in multiparous sows during transition and lactation

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Journal of Animal Science and Biotechnology 2020年第2期11卷 424-439页

作者： Liang Hu Niels Bastian kristensen Lianqiang Che De Wu Peter Kappel Theil Key Laboratory for Animal Disease-Resistance Nutrition of China Ministry of Education Institute of Animal NutritionSichuan Agricultural UniversityNo.211Huimin RoadWenjiang DistrictChengduSichuan 611130People’s Republic of China Department of Animal Science Faculty of Science and TechnologyAarhus UniversityDK-8830 TjeleDenmark Present address:SEGES Danish Pig Research Centre DK-1609 CopenhagenDenmark

Background:Determination of nutrient requirements in the late gestating and lactating sows is essential to optimize sow *** objectives of the present study were to quantify amino acid(AA)fluxes and heat production across portal-drained viscera(PDV)and liver in multiparous sows during transition and ***:Eight second parity sows were fitted with indwelling catheters in the femoral artery and in the mesenteric,portal and hepatic *** hourly sets of blood samples were taken starting 0.5 h before feeding at−10,−3,+3,and+17 d in milk(DIM).Blood gases,plasma metabolites and apparent total tract digestibility(ATTD)of nutrients were ***:Feed intake,the ATTD of DM,energy,nitrogen,fat and crude fiber changed with DIM(P<0.001).Except for Glu,O2,and urea,all net portal fluxes were positive,and all were affected by DIM(P<0.05)and by sampling time(P<0.01).Compared with pre partum levels,net portal uptake of AA was 3-63%lower at+3 DIM but 40-100%higher at+17 *** portal fluxes of AA peaked at 1.5 to 2.5 h after feeding except for Glu,and they were positively correlated with changes in sow feed intake across *** net portal recovery was low for Met(49%),Thr(54%),and His(54%)and high for the remaining essential AA(63-69%)and none of them differed across *** hepatic uptake(*** oxidation)of Lys,Thr,Ile,Leu and Phe peaked at 0.5 to 2.5 h after feeding,whereas uptake of Trp,Val,and His was constant,while that of Met was close to ***:The net portal recovery was substantially lower for Met,Thr,and His than the remaining essential *** AA oxidation peaks 0.5 to 2.5 h after *** heat production in PDV and liver was approximately two-fold higher at peak lactation compared to other *** study suggests that lysine was the limiting AA in peak lactation but not in early lactation.

关键词： Gestation Heat production Lactation Net hepatic flux Net portal flux Sow

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From preference to landscape sustainability:a bibliometric review of landscape preference research from 1968 to 2019

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Ecosystem Health and Sustainability 2021年第1期7卷 271-288页

作者： Gaoyuan Yang Zhaowu Yu Jinguang Zhang Lone Søderkvist kristensen Department of Geosciences and Natural Resource Management Faculty of ScienceUniversity of CopenhagenCopenhagenDenmark Department of Environmental Science and Engineering Fudan UniversityShanghaiChina College of Landscape Architecture Nanjing Forestry UniversityNanjingChina

Landscape preference(LP)studies highlight one of the most important issues of human-environment relationship,and their related publications have increased rapidly over the last two ***,there is no systematic review with a holistic understanding of this *** we applied a bibliometric approach to examine the evolution of LP research and identify its status and future *** obtained 7,637 LP research publications from Web of Science core collection from 1968 to 2019 and analyzed the characteristics of publication outputs as well as performances in various countries and ***,content keywords analysis was conducted to discover the drivers,focus,motivation,and trends of LP *** found that 1)publications,subject categories,and active journals increased rapidly since the 2000s;2)the USA,England,and Australia are the leading countries in LP research,while China is starting to have some influence;3)LP research is most closely linked to ecological and environmental studies,being developed by objective drivers,i.e.,interactions with landscape change,and subjective motivations;and 4)LP research is advancing the landscape sustainability science,integrating natural and social science together through ecosystem *** comprehensively reviewing the evolution and prospect of LP research,we provide insights for further research in this field.

关键词： Landscape preference scientific literature bibliometric analysis trends and prospects landscape sustainability

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