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2012年环境污染与大众健康学术会议

作者： Michèle Bouchard john j.Spinelli Igor Burstyn kristan j.aronson Université de Montréal Montreal Canada BC Cancer Agency Vancouver Canada University of British Columbia Vancouver Canada Drexel University Philadelphia USA Queen's University Kingston Canada

Background:Air pollution from motor vehicle traffic is a major source of polycyclic aromatic hydrocarbon （PAH） exposure in urban areas. Certain PAHs have been classified as probable human carcinogens by the International Agency of Research on Cancer. Some research indicates that people with low socio- economic status （SES） and other vulnerabilities may be exposed to heavier air pollution and thus PAHs. However, these findings have been inconsistent. Methods:A cross-sectional study was conducted in 2011, using as the study population base a random sample of household telephone numbers within defined areas based on distance of residences to major roads and highways on the island of Montreal. 200 volunteers （107 females and 93 males） ages 20-53, without renal disease or history of cancer, were recruited throuch telephone screening. 116 participants lived within 500 feet of highways or major roads;36 participants lived between 500 and 750 feet from highways or major roads;and 48 participants lived greater than 750 feet away from highways or major roads. Each participant completed a self-administered questionnaire assessing demo-graphics that included ethnicity and socio-economic indicators. ArcMap software and DMTI electronic street files were used to create zones of distance to highways and major roads. Residential traffic density was calculated based on routinely-collected traffic volume data from municipalities on the island of Montreal and from Transport Quebec. Results:Persons in full-time employment tended to live closer to heavy traffic （OR:2.71, 95% CI:1.26-5.85 for full-time work vs. unemployed）. No association was detected between ethnicity or education and level of traffic exposure. Conclusion:We observed gradients in exposure to traffic only for the aspect of SES related to employment, in the direction that full-time employment is associated with higher traffic exposure.

关键词： Environmental inequity ethnicity socio-economic status geographic information system (GIS)

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Practice patterns and outcomes of equivocal bone scans for patients with castration-resistant prostate cancer: Results from SEARCH

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Asian journal of Urology 2019年第3期6卷 242-248页

作者： Brian T.Hanyok Mary M.Everist Lauren E.Howard Amanda M.De Hoedt William j.aronson Matthew R.Cooperberg Christopher j.Kane Christopher L.Amling Martha K.Terris Stephen j.Freedland Urology Section Department of SurgeryVeterans Affairs Medical CenterDurhamNCUSA New York Medical College ValhallaNYUSA Department of Biostatistics and Bioinformatics Duke University School of MedicineDurhamNCUSA Urology Section Department of SurgeryVeterans Affairs Medical CenterGreater Los AngelesLos AngelesCAUSA Department of Urology University of California at Los Angeles Medical CenterLos AngelesCAUSA Departments ofUrology and Epidemiology&Biostatistics University of CaliforniaSan FranciscoCAUSA Urology Section Department of SurgeryVeterans Affairs Medical CenterSan FranciscoCAUSA Division of Urology Department of SurgeryUniversity of California at San Diego Medical CenterSan DiegoCAUSA Division of Urology Department of SurgeryOregon Health&Science UniversityPortlandORUSA Urology Section Division of SurgeryVeterans Affairs Medical CenterAugustaGAUSA Division of Urologic Surgery Department of SurgeryMedical College of GeorgiaAugustaGAUSA Division of Urology Department of SurgerySamuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Center for Integrated Research in Cancer and Lifestyle Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA

Objective:To review follow-up imaging after equivocal bone scans in men with castration resistant prostate cancer(CRPC)and examine the characteristics of equivocal bone scans that are associated with positive follow-up ***:We identified 639 men from five Veterans Affairs Hospitals with a technetium-99m bone scan after CRPC diagnosis,of whom 99(15%)had equivocal *** with equivocal scans were segregated into“high-risk”and“low-risk”subcategories based upon wording in the bone scan *** follow-up imaging(bone scans,computed tomography[CT],magnetic resonance imaging[MRI],and X-rays)in the 3 months after the equivocal scan were *** were compared between patients with a positive *** follow-up imaging after an equivocal bone ***:Of 99 men with an equivocal bone scan,43(43%)received at least one follow-up imaging test,including 32/82(39%)with low-risk scans and 11/17(65%)with high-risk scans(p=0.052).Of follow-up tests,67%were negative,14%were equivocal,and 19%were *** those who underwent follow-up imaging,3/32(9%)low-risk men had metastases vs.5/11(45%)high-risk men(p=0.015).Conclusion:While 19%of all men who received follow-up imaging had positive follow-up imaging,only 9%of those with a low-risk equivocal bone scan had metastases versus 45%of those with *** preliminary findings,if confirmed in larger studies,suggest follow-up imaging tests for low-risk equivocal scans can be delayed while high-risk equivocal scans should receive follow-up imaging.

关键词： Castration-resistant prostate cancer Equivocal test result Bone scan Radiology report Follow-up imaging Neoplasm metastasis

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为规范处方行为开个处方——一些医学生并不具备熟练开处方的能力

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英国医学杂志中文版 2007年第1期10卷 5-6页

作者： jeffrey K aronson Graeme Henderson David j Webb Michael D Rawlins 肖月（译） British Pharmacological Society London EC1V 2SC Chairman of the committee of heads and professors of clinical pharmacology Wolfson Unit of Clinical Pharmacology University of NewcastleNewcastle upon Tyne NE2 4HH 不详

每年的这个时候，新分配来的医生上岗了，老的担心又出现了——他们受过良好的培训了吗？特别令人担忧的是：他们在临床药物治疗和开处方方面是否受过合格的培训？我们认为培训未必合格。

关键词：处方行为医学生能力药物治疗新分配培训

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蒙大拿州钾膨润土的形成模式

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国外火山地质 1988年第1期 15-21页

作者： S.P.Altaner j.Hower j.L.aronson G.Whitney 姜耀辉

蒙大拿州位移带上白垩统玛丽亚斯河组(Marias River Formation)中已有三十四个钾膨润土矿业经详细研究。厚2.5m的一钾膨润土矿层在矿物和化学成分上具分带性,矿层的上、下接触带比中间层含有更多的伊利石和富钾。矿层中伊利石/蒙脱石的K... 详细信息

蒙大拿州位移带上白垩统玛丽亚斯河组(Marias River Formation)中已有三十四个钾膨润土矿业经详细研究。厚2.5m的一钾膨润土矿层在矿物和化学成分上具分带性,矿层的上、下接触带比中间层含有更多的伊利石和富钾。矿层中伊利石/蒙脱石的K/Ar年龄值也具分带性,上、下接触带比中部年龄要老。提出一个由富钾页岩所包裹的钾膨润土形成的模式,认为钾膨润土是在一次热事件期间(T=100～200℃)由蒙脱石膨润土转变而成的,钾则是从页岩中的矿物(可能是云母和钾长石)分解而来,并通过扩散迁移到膨润土中的。

关键词：页岩膨润土矿接触带全岩碎屑岩伊利石水白云母粘土矿物厚矿层斑脱岩粘土蒙大拿州

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食管闭锁矫治术后的食管炎和巴雷特食管

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世界核心医学期刊文摘（儿科学分册） 2006年第1期2卷 37-38页

作者： Deurloo j.A. Ekkelkamp S. Taminiau j.A.j.M. D.C. aronson 郭战宏 Pediatric Su rgical Center of Amsterdam (Emma Childrens Hospital AMC and VUmc) Meibergdreefg 1105 AZ Amsterdam Netherlands

Background: Gastroesophageal reflux is a frequent problem after esophageal atr esia (EA) repair. Our aim was to determine the prevalence of esophagitis and Bar rett esophagus more than 10 years after repair of EA. Methods: Ninety-two patie nts treated between 1973 and 1985 were included in this prospective study. A que stionnaire was completed by 86 patients; esophagogastroscopy was performed in 49 patients. Results: Only 36 patients had no complaints at all. Thirty-one patie nts complained of difficulties swallowing solid food; 23 complained of heartburn . Esophagogastroscopy revealed grade 3 esophagitis in 2 patients and a macroscop ic image of Barrett esophagus in 2. Histology showed esophagitis in 30 patients, gastric metaplasia in 3, and no intestinal metaplasia (Barrett esophagus). Conc lusions: For epidemiologic reasons, that is, the short interval of follow-up (1 0 years) and the low compliance of the study group, larger numbers are needed to decide if routine long-term endoscopic screening after repair of EA is necessa ry. For now, it cannot yet be recommended. The prevalence of symptoms of gastroe sophageal reflux disease in this study group is higher than that in the general population, but we found no severe complications of gastroesophageal reflux in t he pediatric age group.

关键词：巴雷特食管食管闭锁食管炎矫治术胃食管反流无肠食管胃镜检查胃上皮化生组织学检查固体食

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The Effect of Aprotinin on Outcome after Coronary-Artery Bypass Grafting

The Effect of Aprotinin on Outcome after Coronary-Artery Byp...

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中成药上市后药物流行病学评价培训会议

作者： Andrew D.Shaw Mark Stafford-Smith William D.White Barbara Phillips-Bute Madhav Swaminathan Carmelo Milano Ian j.Welsby Solomon aronson joseph P.Mathew Eric D.Peterson Mark F.Newman the Departments of Anesthesiology Duke University Medical Center DurhamNC M.B. the Departments of Anesthesiology Duke University Medical Center DurhamNCM.D. the Departments of Anesthesiology Duke University Medical Center DurhamNC M.P.H. the Departments of Anesthesiology Duke University Medical Center DurhamNC Ph.D. the Departments of Anesthesiology Duke University Medical Center DurhamNC M.D. the Departments of Surgery Duke University Medical Center DurhamNC M.D. the Departments of the Duke Clinical Research Institute Duke University Medical Center DurhamNC M.D. M.P.H

BACKGROUND Aprotinin has recently been associated with adverse outcomes in patients undergoing cardiac *** reviewed our experience with this agent in patients undergoing cardiac surgery at Duke University Medical Center. METHODS We retrieved data on 10,275 consecutive patients undergoing surgical coronary revascularization at Duke between january 1,1996,and December 31,*** fit data to a logistic-regression model predicting each patient’s likelihood of receiving aprotinin on the basis of preoperative characteristics and to models predicting long-term survival(up to 10 years) and decline in renal function,as measured by increases in serum creatinine levels. RESULTS A total of 1343 patients(13.2%) received aprotinin,6776 patients(66.8%) received aminocaproic acid,and 2029 patients(20.0%) received no antifibrinolytic therapy. All patients underwent coronary-artery bypass grafting,and 1181 patients(11.5%) underwent combined coronary-artery bypass grafting and valve *** the risk-adjusted model,survival was worse among patients treated with aprotinin,with a main-effects hazard ratio for death of 1.32(95%confidence interval[CI],1.12 to 1.55) for the comparison with patients receiving no antifibrinolytic therapy(P=0.003) and 1.27(95%CI,1.10 to 1.46) for the comparison with patients receiving aminocaproic acid(P=0.004).As compared with the use of aminocaproic acid or no antifibrinolytic agent,aprotinin use was also associated with a larger risk-adjusted increase in the serum creatinine level(Pjusted incidence of dialysis(P=0.56). CONCLUSIONS Patients who received aprotinin had a higher mortality rate and larger increases in serum creatinine levels than those who received aminocaproic acid or no antifibrinolytic agent.

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ECLIPSE研究：氯维地平与硝酸甘油、硝普钠、尼卡地平治疗心外手术患者急性高血压的对比研究

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麻醉与镇痛 2009年第5期5卷 34-46页

作者： Solomon aronson Cornelius M. Dyke Kevin A. Stierer jerrold H. Levy Albert T. Cheung Philip D. Lumb Dean j. Kereiakes Mark F. Newman 谢珺田(译) 宋文阁(校) Department of Anesthesiology Duke University Medical Center Durham North Carolina Gaston Memorial Hospital Gastonia North Carolina The Heart Institute at St. joseph Medical Center Towson Maryland Department of Anesthesiology Emory University School of Medicine Atlanta Georgia Department of Anesthesiology and Critical Care University of Pennsylvania Philadelphia Pennsylvania Department of Anesthesiology Keck School of Medicine University of Southern California Los Angeles California The Christ Hospital Heart and Vascular Center/The Lindner Research Center Cincinnati Ohio 不详

背景心外手术过程中的高血压常难以控制，并进而影响手术疗效。氯维地平是一种新型的2-氢吡啶L型钙通道阻滞剂，可有效降低动脉压，起效迅速，且半衰期极短。氯维地平治疗围手术期高血压的安全性事件评估研究（evaluation of clevidipin... 详细信息

背景心外手术过程中的高血压常难以控制，并进而影响手术疗效。氯维地平是一种新型的2-氢吡啶L型钙通道阻滞剂，可有效降低动脉压，起效迅速，且半衰期极短。氯维地平治疗围手术期高血压的安全性事件评估研究（evaluation of clevidipine in the perioperative treatment of hypertension assessing safety events trial, ECLIPSE）旨在比较氯维地平（CLV）与硝酸甘油（NTG）、硝普钠（SNP）、尼卡地平（NIC）治疗心外手术患者急性高血压的疗效与安全性。方法我们分析了3项前瞻性、随机、开放性平行对照研究的资料，这些研究由61家医疗中心参与完成，比较了氯维地平与硝酸甘油、硝普钠、尼卡地平在心外手术患者的围手术期应用情况。共选择1964例患者，1512例按临床标准需紧急治疗高血压，符合随机化纳入标准。这些患者按1：1比例随机编入3个平行的对比治疗组。主要结局为30天内的死亡事件、心肌梗死、中风和肾功能不全，次要结局为血压控制的充分性与精确度的评估报告。结果氯维地平组与其他治疗组相比，心肌梗死、中风和肾功能不全的发生率均无显著差异。硝普钠治疗组与氯维地平组相比，死亡例数显著增加（P=0．04）。与硝酸甘油（P=0．0006）和硝普钠（P=0．003）相比，氯维地平能更有效地把血压控制在预定范围内。在控制血压于一个预定范围方面氯维地平与尼卡地平等效，但当预定血压控制范围较窄时，氯维地平较尼卡地平超出范围的幅度更小。结论氯维地平用于治疗心外手术患者的急性高血压安全有效。

关键词：急性高血压尼卡地平紧急治疗硝酸甘油心外手术硝普钠 hypertension 血压控制范围

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抑肽酶对冠状动脉搭桥术后结局的影响

抑肽酶对冠状动脉搭桥术后结局的影响

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中成药上市后药物流行病学评价培训会议

作者： Andrew D.Shaw Mark Stafford-Smith William D.White Barbara Phillips-Bute Madhav Swaminathan Carmelo Milano Ian j.Welsby Solomon aronson joseph P.Mathew Eric D.Peterson Mark F.Newman

背景:最近有报告称,抑肽酶与心脏手术后病人的不良结局相关。我们回顾了在杜克大学医学中心接受心脏手术的病人中使用抑肽酶的经验。方法:我们检索到10275例连续病人的资料,他们于1996年1月1日至2005年12月3 1日在杜克大学接受冠状动脉...

背景:最近有报告称,抑肽酶与心脏手术后病人的不良结局相关。我们回顾了在杜克大学医学中心接受心脏手术的病人中使用抑肽酶的经验。方法:我们检索到10275例连续病人的资料,他们于1996年1月1日至2005年12月3 1日在杜克大学接受冠状动脉血运重建术。我们将资料输入一个对数-回归模型,它可根据术前特点预测每例病人用抑肽酶的可能性,并输入可预测长期(最长10年)生存率和肾功能减退(检测血清肌酐水平的升高)的模型。结果:总共1343例(13.2%)病人使用抑肽酶,6776例(66.8%)病人使用氨基己酸,2029例(20.0%)病人未接受抗纤溶治疗。全部病人做了冠脉搭桥术,1181例(11.5%)病人同时做了冠状动脉搭桥术和瓣膜手术。危险校正模型显示,抑肽酶组病人的生存状况较差,与不用抗纤溶治疗的病人相比,死亡的主效应风险比为1.32[95%可信区间(CI)为1.12～1.55](P=0.003);与用氨基己酸的病人相比,死亡的主效应风险比为1.27(95%CI为1.10～1.46)(P=0.004)。与用氨基己酸或不用抗纤溶制剂相比,使用抑肽酶还与危险校正后的血清肌酐水平升高较多相关(P<0.001),但不与危险校正后的透析率较高相关(P=0.56)。结论:与用氨基己酸或不用抗纤溶制剂的病人相比,用抑肽酶的病人死亡率较高,血清肌酐水平增高较多。

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在进行子宫内激光凝固疗法治疗双胞胎间输血综合征后诊断的回肠闭锁和血栓栓塞性肝脏钙化:2例报道

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世界核心医学期刊文摘（儿科学分册） 2005年第11期1卷 57-57页

作者： Schnater j.M. Van Zalen-Sprock R.M. Schaap A.H.P. D.C. aronson 李丹 Pediatric Surgical Center of Amsterdam Location Emma Children's Hospital AMC PO Box 22700 1100 DE Amsterdam Netherlands

Ileal atresia is considered to be an acquired anomaly. It is thought to be caused by a mesenteric vascular accident during fetal life which leads to necrosis of downstream tissues. We present a case in which ileal atresia occurred after intrauterine laser coagulation therapy for a twin-to-twin transfusion syndrome. The laser treatment might have been the etiological factor of the atresia. A second case in which thrombo-embolic calcifications were found in the liver is presented as well.

关键词：肠闭锁激光凝固疗法栓塞性肠系膜血管胎儿期钙化点

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应用单期相-舒张中期冠状动脉CTA评估左心腔:推导心腔容积标准值以及与传统的舒张末期和收缩末期双期成像相比较

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国际医学放射学杂志 2016年第6期 712-712页

作者： j.R.Walker S.Abadi A.Solomonica D.Mutlak D.aronson Y.Agmon 郭芳芳 Cardiology Department Rambam Health Care Campus

摘要目的随着心脏CT前瞻性扫描技术应用的增多,缺乏心腔容积标准值阻碍了有意义的心腔容积评估。本研究的目的是为舒张中期(MD)心腔容积确定标准值以及分析其

关键词：容积 MD 标准值心腔舒张末期

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