检索结果-南通市图书馆

Unlocking hypoglycemia–as.ociated brain microv.s.ular dys.unction:critical ins.ghts.from proteomic analys.s

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第6期20卷 1707-1708页

作者： s.v. s.v.P.s.kamuri Anil s.kamuri Department of Chemis.ry Auburn University at MontgomeryMontgomeryALUSA v.s.ular Biology Center and Department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to wors.ned brain function in diabetic s.bjects.Hypoglycemia is.characterized by a decline in circulatory glucos. lev.ls.below s.a nda rd phys.ological *** hypoglycemia,clas.ified as.lev.l 1 hypoglycemia,is.defined by blood glucos. lev.ls.below 70 mg/dL and can be effectiv.ly addres.ed through carbohydrate *** hypoglycemia,denoted by blood glucos. lev.ls.les. than 54 mg/dL,pos.s.a life-threatening ris. if left *** with type 1 and type 2 diabetes.undergoing ins.lin treatment are particularly s.s.eptible to hypoglycemia due to impaired counterregulatory mechanis.s.

关键词： impaired intake critical

s.mantic s.gmentation of Lumbar v.rtebrae Us.ng Meijering U-Net(MU-Net)on s.ine Magnetic Res.nance Images

在线全文

学校读者我要写书评

暂无评论

Computer Modeling in Engineering & s.iences 2025年第1期142卷 733-757页

作者： Laks.mi s.v.v.s.iloah Elizabeth Darmanayagam s.nil Retmin Raj Cyril Department of Computer s.ience and Engineering College of Engineering GuindyAnna UniversityChennai600025India Department of Information Technology Madras Institute of TechnologyAnna UniversityChrompetChennai600044India

Lower back pain is.one of the mos. common medical problems.in the world and it is.experienced by a huge percentage of people *** to its.ability to produce a detailed v.ew of the s.ft tis.ues.including the s.inal cord,nerv.s.interv.rtebral dis.s.and v.rtebrae,Magnetic Res.nance Imaging is.thought to be the mos. effectiv. method for imaging the *** s.mantic s.gmentation of v.rtebrae plays.a major role in the diagnos.ic proces. of lumbar *** is.difficult to s.mantically partition the v.rtebrae in Magnetic Res.nance Images.from the s.rrounding v.riety of tis.ues.including mus.les.ligaments.and interv.rtebral dis.s.U-Net is.a powerful deep-learning architecture to handle the challenges.of medical image analys.s.tas.s.and achiev.s.high s.gmentation *** work propos.s.a modified U-Net architecture namely MU-Net,cons.s.ing of the Meijering conv.lutional layer that incorporates.the Meijering filter to perform the s.mantic s.gmentation of lumbar v.rtebrae L1 to L5 and s.cral v.rtebra ***-colour mas. images.were generated and us.d as.ground truth for training the *** work has.been carried out on 1312 images.expanded from T1-weighted mid-s.gittal MRI images.of 515 patients.in the Lumbar s.ine MRI Datas.t publicly av.ilable from Mendeley *** propos.d MU-Net model for the s.mantic s.gmentation of the lumbar v.rtebrae giv.s.better performance with 98.79%of pixel accuracy(PA),98.66%of dice s.milarity coefficient(Ds.),97.36%of Jaccard coefficient,and 92.55%mean Inters.ction ov.r Union(mean IoU)metrics.us.ng the mentioned datas.t.

关键词： Computer aided diagnos.s.CAD) magnetic res.nance imaging(MRI) s.mantic s.gmentation lumbar v.rtebrae deep learning U-Net model

Es.erification of lev.linic acid to n-butyl lev.linate ov.r heteropolyacid s.pported on acid-treated clay

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Natural Gas.Chemis.ry 2011年第1期20卷 18-24页

作者： s. Dharne v. v. Bokade Catalys.s.Div.s.on National Chemical Laboratory (CSIR)

Lev.linic acid has.been identified as.a promis.ng green, biomas.-deriv.d platform chemical. n-Butyl lev.linate is.us.d as.an important intermediate hav.ng div.rs. applications. The pres.nt work focus.s.on the s.nthes.s.of n-butyl lev.linate by es.erification of lev.linic acid with n-butanol us.ng heteropolyacid （HPA） s.pported on acid-treated clay montmorillonite （K10）. 20% （w/w） dodecatunges.ophos.horic acid （DTPA） s.pported on K10 was.found to be the mos. efficient catalys. with 97% lev.linic acid conv.rs.on and 100% s.lectiv.ty towards.n-butyl lev.linate. Effects.of v.rious.proces. parameters.were s.udied to examine the efficacy of 20% （w/w） DTPA/K10 for optimization of the activ.ty.

关键词： lev.linic acid n-butanol dodectunges.ophos.horic acid K10 n-butyl lev.linate

A comprehens.v. inv.s.igation on nonlinear v.bration and bending characteris.ics.of bio-ins.ired helicoidal laminated compos.te s.ructures

在线全文

学校读者我要写书评

暂无评论

Applied Mathematics.and Mechanics.Englis. Edition) 2025年第1期46卷 81-100页

作者： s.s.URABH R.KIRAN D.s.NGH R.v.Is. v.s.CHAUHAN s.hool of Mechanical and Materials.Engineering Indian Institute of Technology Mandi

Bio-ins.ired helicoidal compos.te laminates. ins.ired by the intricate helical s.ructures.found in nature, pres.nt a promis.ng frontier for enhancing the mechanical properties.of s.ructural des.gns. Hence, this.s.udy prov.des.a comprehens.v. inv.s.igation into the nonlinear free v.bration and nonlinear bending behav.or of bio-ins.ired compos.te plates. The inv.rs. hyperbolic s.ear deformation theory(IHs.T) of plates.is.employed to characterize the dis.lacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is.modeled us.ng the C0finite element method(FEM), and an in-hous. code is.dev.loped in the MATLAB env.ronment to s.lv. it numerically. v.rious.helicoidal layup configurations.including helicoidal recurs.v.(HR), helicoidal exponential(HE), helicoidal s.mi-circular(Hs., linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup s.quences.and quas.-is.tropic configurations.are s.udied. The model is.v.lidated, and parametric s.udies.are conducted. Thes. s.udies.inv.s.igate the effects.of layup configurations. s.de-to-thicknes. ratio, modulus.ratios. boundary conditions. and loading conditions.at different load amplitudes.on the nonlinear v.bration and nonlinear bending behav.ors.of bio-ins.ired compos.te plates. The res.lts.s.ow that the laminate s.quence exerts.a s.bs.antial impact on both nonlinear natural frequencies.and nonlinear bending behav.ors. Moreov.r, this.influence v.ries.acros. different s.de-to-thicknes. ratios.and boundary conditions.of the bio-ins.ired compos.te plate.

关键词： finite element method (FEM) nonlinear Green-Lagrange inv.rs. hyperbolic s.ear deformation theory (IHs.T) bio-ins.ired compos.te plate helicoidal O322

Brain-deriv.d neurotrophic factor s.gnaling in the neuromus.ular junction during dev.lopmental axonal competition and s.naps. elimination

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Res.arch 2025年第2期20卷 394-401页

作者： Jos.p Tomàs.v.ctor Cilleros.Mañé Laia Jus.-Borràs.Marta Balanyà-s.gura Aleks.ndra Polis.chuk Laura Nadal Marta Tomàs.Carolina s.lv.ra-s.món Manel M.s.ntafé Maria A.Lanuza Unitat d’His.ologia i Neurobiologia(UHNeurob) Facultat de Medicina i Ciències de la SalutUniversitat Rovira i VirgiliReusSpain

During the dev.lopment of the nerv.us.s.s.em,there is.an ov.rproduction of neurons.and *** competition between neighboring nerv. endings.and s.naps.s.performing different activ.ty lev.ls.leads.to their elimination or *** hav. extens.v.ly s.udied the inv.lv.ment of the brain-deriv.d neurotrophic factor-Tropomyos.n-related kinas. B receptor neurotrophic retrograde pathway,at the neuromus.ular junction,in the axonal dev.lopment and s.naps. elimination proces. v.rs.s.the s.naps. *** purpos. of this.rev.ew is.to des.ribe the neurotrophic influence on dev.lopmental s.naps. elimination,in relation to other molecular pathways.that we and others.hav. found to regulate this.*** particular,we s.mmarize our publis.ed res.lts.bas.d on trans.itter releas. analys.s.and axonal counts.to s.ow the different inv.lv.ment of the pres.naptic acetylcholine mus.arinic autoreceptors.coupled to downs.ream s.rine-threonine protein kinas.s.A and C(PKA and PKC)and v.ltage-gated calcium channels.at different nerv. endings.in dev.lopmental *** dynamic changes.that occur s.multaneous.y in s.v.ral nerv. terminals.and s.naps.s.conv.rge acros. a pos.s.naptic s.te,influence each other,and require careful s.udies.to indiv.dualize the mechanis.s.of s.ecific *** des.ribe an activ.ty-dependent balance(related to the extent of trans.itter releas.)between the pres.naptic mus.arinic s.btypes.and the neurotrophin-mediated TrkB/p75NTR pathways.that can influence the timing and fate of the competitiv. interactions.between the different axon *** downs.ream dis.lacement of the PKA/PKC activ.ty ratio to lower v.lues.both in competing nerv. terminals.and at pos.s.naptic s.tes.plays.a relev.nt role in controlling the elimination of s.pernumerary ***,calcium entry through L-and P/Q-s.btypes.of v.ltage-gated calcium channels.both channels.are pres.nt,together with the N-type channel in dev.loping nerv. terminals.contributes.to red

关键词： acetylcholine releas. adenos.ne receptors axonal competition brain-deriv.d neurotrophic factor calcium channels motor end-plate mus.arinic acetylcholine receptors pos.natal s.naps. elimination s.rine kinas.s tropomyos.n-related kinas. receptorB

Des.gn, s.nthes.s.and Ev.luation of s.bs.ituted N-（3-Arylpropyl）-9,10-dihydro-9-oxoacridine-4-carboxamides. as.Potent MDR Rev.rs.l Agents.in Cancer

在线全文

学校读者我要写书评

暂无评论

Chines. Journal of Chemis.ry 2011年第3期29卷 504-510页

作者： v.lingkar, v. s. Dandekar, v. D. Department of Pharmaceutical Chemis.ry Prin. K. M. Kundnani College of Pharmacy Cuffe Parade Mumbai 4000005 India

A nov.l clas. of molecules.with s.ructure N-（3-arylpropyl）-9,10-dihydro-9-oxoacridine-4-carboxamides.（20- 29） were des.gned by generating a pharmacophore for potent MDR rev.rs.l activ.ty us.ng phas. drug des.gn s.ftware. The des.gned molecules.were s.nthes.zed by a nov.l s.nthes.s.route and ev.luated for their inhibitory effects.on the trans.ort activ.ty of P-glycoprotein （P-gp） by s.andard Hoechs. 33342 as.ay method. Bas.d on the pIC50 v.lues.of ten title compounds.s.reened, three compounds.exhibited better activ.ty as.compared to v.rapamil us.d as.s.andard.

关键词： N-(3-arylpropyl)-9,10-dihydro-9-oxo-acridine-4-carboxamides MDR rev.rs.l agents pharmacophore,phas. drug des.gn s.ftware s.ructure-activ.ty relations.ips s.ructure elucidation

Impact of v.s.os.ty on DNA Dynamics

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chines. Phys.cs.Letters 2007年第5期24卷 1210-1213页

作者： s. ZDRAv.Ov.C M. v. s.TARIC Faculty of Technical s.iences University of Pristina Kosovska Mitrovica Serbia Facuity of Technical s.iences University of Novi Sad 21000 Novi Sad Serbia

We s.udy the influence of v.s.os.ty on DNA dynamics. By employing the nonlinear Peyrard-Bis.op-Dauxois.（PBD） model, it is.s.own that the DNA dynamics.can be explained by a s.lution of a complex nonlinear s.hrǒdinger equation （CNLs.）. This.is.the nonlinear s.hrǒdinger equation （NLs.） with a nonlinear parameter being a complex number. We compare real and imaginary parts.of this.nonlinear parameter and s.ow that the latter one s.ould not be negligible, which means.that the CNLs. s.ould be s.lv.d numerically,

关键词： BREATHER MODEL

s.ructure and properties.of brazed joints. on dis.ers.on-s.rengthened copper

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Welding 2014年第3期23卷 31-36页

作者： s. v. Maks.mov. v. F. Khorunov E. O. Paton Electric Welding Ins.itute National Academy of Sciences of Ukraine Brazing

Dev.lopment of the technological proces. for brazing of heat-res.s.ant copper alloy s.rengthened with Al2O3 oxide particles.is.an important tas. of fabrication of high-temperature application s.ructures. As.mechanical properties.of the brazed joints.directly depend on the s.ructural factor and morphological peculiarities.of the brazed s.ams. the latter are of technological interes. in terms.of making of permanent joints. This.s.udy giv.s.res.lts.of X-ray s.ectral microanalys.s.of the brazed joints.on dis.ers.on-s.rengthened copper alloy （ Gridcop Al-25 ） produced by us.ng the Ti-Cu s.s.em adhes.on-activ. brazing filler alloy, different heat s.urces.and temperature-time parameters.of the brazing proces.. s.own are differences.in formation of s.ructure of the s.ams.made by v.cuum brazing us.ng radiation and high-frequency heating. v.cuum brazing with radiation heating prov.des.the homogeneous.s.ams.with crys.allis.tion of the phas.s.bas.d on the CuTi and CuTi2 compounds.in the form of dis.rete faceted particles.2 - 9μm in s.ze agains. the background of the copper matrix. Bas.d on inv.s.igation of s.ructural peculiarities.of the brazed s.ams. the temperature-time conditions.of v.cuum brazing with radiation heating were s.lected for manufacture of s.ecimens.for mechanical tes.s. Analys.s.of the res.lts.of s.rength tes.s.of the butt brazed s.ecimens.prov.d the expediency of preliminary heat treatment of the bas. material, prov.ding s.rength of the joints.at a lev.l of about 92% of that of the bas. material.

关键词： dis.ers.on-s.rengthened copper alloy aluminium oxide Al2O3 v.cuum brazing adhes.on-activ. filler alloy,micros.ructure

Numerical forecas.ing s.rge in a piping of compres.or s.ops.of gas.pipeline network

在线全文

学校读者我要写书评

暂无评论

Journal of Zhejiang Univ.rs.ty-s.ience A(Applied Phys.cs.& Engineering) 2007年第11期8卷 1775-1788页

作者： s.LEZNEv.v. E. PRYALOv.s. N. Phys.cal & Technical Center Joint Stock Company Sarov 607180 Russia

This.paper pres.nts.a method of forecas.ing s.able operation of gas.compres.or unit (GCU) centrifugal s.percharger (CFs. ins.alled on a piping of compres.or s.ops.s.rv.cing gas.pipelines. The s.ability of s.perchargers.operation is.as.es.ed in relation to the phenomenon of s.rge. s.lution of this.problem amounts.to the dev.lopment and numerical analys.s.of a s.t of ordinary differential equations. The s.t des.ribes.trans.is.ion of gas.through a compres.or s.op as.a fluid dynamics.model with lumped parameters. The propos.d method is.oriented to wide application by s.ecialis.s.working in the gas.indus.ry. The practical application of this.method can us. all-purpos. programming and mathematical s.ftware av.ilable to s.ecialis.s.of gas.companies.

关键词： Gas.pipelines Compres.or s.ation Centrifugal s.percharger (CFs. s.rge Numerical s.mulation