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Neutrophil peptide 1 accelerates the clearance of degenerative axons during Wallerian degeneration by activating macrophages after peripheral nerve crush injury

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Neural Regeneration Research 2024年第8期19卷 1822-1827页

作者： Yuhui kou Yusong Yuan Qicheng Li Wenyong Xie Hailin Xu Na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina National Center for Trauma Medicine BeijingChina Key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina Department of Central Laboratory and Institute of Clinical Molecular Biology Peking University People’s HospitalBeijingChina

Macrophages play an important role in peripheral nerve regeneration,but the specific mechanism of regeneration is still *** preliminary findings indicated that neutrophil peptide 1 is an innate immune peptide closely involved in peripheral nerve ***,the mechanism by which neutrophil peptide 1 enhances nerve regeneration remains *** study was designed to investigate the relationship between neutrophil peptide 1 and macrophages in vivo and in vitro in peripheral nerve crush *** functions of RAW 264.7 cells we re elucidated by Cell Counting Kit-8 assay,flow cytometry,migration assays,phagocytosis assays,immunohistochemistry and enzyme-linked immunosorbent *** debris phagocytosis was observed using the CUBIC(Clear,Unobstructed Brain/Body Imaging Cocktails and Computational analysis)optical clearing technique during Wallerian *** inflammatory factor expression in different polarization states was detected using a protein *** results showed that neutrophil peptide 1 promoted the prolife ration,migration and phagocytosis of macrophages,and CD206 expression on the surfa ce of macrophages,indicating M2 *** axonal debris clearance rate during Wallerian degeneration was enhanced after neutrophil peptide 1 *** peptide 1 also downregulated inflammatory factors interleukin-1α,-6,-12,and tumor necrosis factor-αin invo and in ***,the results suggest that neutrophil peptide 1 activates macrophages and accelerates Wallerian degeneration,which may be one mechanism by which neutrophil peptide 1 enhances peripheral nerve regeneration.

关键词： axonal debris inflammatory factors macrophages neutrophil peptide 1 peripheral nerve injury peripheral nerve regeneration RAW 264.7 cells sciatic nerve Wallerian degeneration

Fusion of Ground-Based and Spaceborne Radar Precipitation Based on Spatial Domain Regularization

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Journal of Meteorological Research 2024年第2期38卷 285-302页

作者： Anfan HUANG Leilei kou Yanzhi LIANG Ying MAO Haiyang GAO Zhigang CHU School of Atmospheric Physics Nanjing University of Information Science&TechnologyNanjing 210044 Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science&TechnologyNanjing 210044

High-quality and accurate precipitation estimations can be obtained by integrating precipitation information measures using ground-based and spaceborne radars in the same target *** the true precipitation state is a typical inverse problem for a given set of noisy radar precipitation *** regularization method can appropriately constrain the inverse problem to obtain a unique and stable *** different types of precipitation with different prior distributions,the L_(1) and L_(2) norms were more effective in constraining stratiform and convective precipitation,*** a combination of L_(1) and L_(2) norms,the Huber norm is more suitable for mixed precipitation *** study uses different regularization norms to combine precipitation data from the C-band dual-polarization ground radar(CDP)and dual-frequency precipitation radar(DPR)on the Global Precipitation Measurement(GPM)mission core *** to single-source radar data,the fused figures contain more information and present a comprehensive precipitation structure encompassing the reflectivity and precipitation *** 27 precipitation cases,the fusion results utilizing the Huber norm achieved a structural similarity index measure(SSIM)and a peak signal-to-noise ratio(PSNR)of 0.8378 and 30.9322,respectively,compared with the CDP *** fusion results showed that the Huber norm effectively amalgamate the features of convective and stratiform precipitation,with a reduction in the mean absolute error(MAE;16.1%and 22.6%,respectively)and root-mean-square error(RMSE;11.7%and 13.6%,respectively)compared to the 1-norm and ***,in contrast to the fusion results of scale recursive estimation(SRE),the Huber norm exhibits superior capability in capturing the localized precipitation intensity and reconstructing the detailed features of precipitation.

关键词： dual-frequency precipitation radar(DPR) dual-polarization radar data fusion regularization Huber norm

基于高职制图课程项目化教学设计——以焊接专业为例

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襄阳职业技术学院学报 2020年第2期19卷 29-32页

作者：寇艳军辽宁机电职业技术学院辽宁丹东118009

高职焊接专业制图课程,普遍以传统教学方式为主,学生参与度不高,只能被动接受,学习效果相对较差。同时所学内容通常为机械类公共知识,缺少焊接专业知识部分,无法有效对接焊接专业岗位生产,不能满足岗位人才发展需要。为了提高焊接专业... 详细信息

高职焊接专业制图课程,普遍以传统教学方式为主,学生参与度不高,只能被动接受,学习效果相对较差。同时所学内容通常为机械类公共知识,缺少焊接专业知识部分,无法有效对接焊接专业岗位生产,不能满足岗位人才发展需要。为了提高焊接专业学生的学习效果和岗位竞争力,通过引入企业典型生产案例,采用项目化教学改革,以便能够更好地培养焊接专业技能型人才。

关键词：焊接专业制图传统教学项目化教学

Incubation temperature induced developmental plasticity of cold responsive physiological phenotypes in Japanese Quails

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Avian Research 2024年第3期15卷 385-394页

作者： Yingxin kou Rongmiao Zhang Xiaoqian Li Na Zhu Yihang Huang Shuping Zhang College of Life and Environmental Sciences Minzu University of ChinaBeijing100081China

Embryonic development is a critical period for phenotype *** variation during embryonic development can induce changes in postnatal phenotypes of *** thyroxine secretion and aerobic metabolic activity of small birds are important phenotypes closely related to their winter *** the context of climate change,it is necessary to determine whether temperature variation during incubation in birds leads to developmental plasticity of these cold responsive *** incubated Japanese Quail(Coturnix japonica)eggs at 36.8℃,37.8℃,and 38.8℃,and raised the chicks to 35-day old at 22℃with same raising conditions,then all the quails were exposed to gradually temperature dropping environment(from 15℃to 0℃).After cold treatment,serum T3 level,resting metabolic rate,skeletal muscle and liver metabolomes of the birds were *** serum T3 levels were significantly lower in the 38.8℃group and significantly higher in the 36.8℃group compared to the 37.8℃*** metabolic rate in the 38.8℃group was significantly lower compared to the 37.8℃*** with the 37.8℃group,metabolites involved in the tricarboxylic acid cycle in the liver were significantly lower in the 38.8℃group,and metabolites related to lipid oxidation metabolism and fatty acid biosynthesis were significantly lower in the skeletal muscles in the 38.8℃group but significantly higher in the 36.8℃*** results indicate that incubation temperature variation can lead to developmental plasticity in cold responsive physiological *** incubation temperature may impair the capacity of birds coping with cold challenge.

关键词： Cold response Developmental plasticity Incubation temperature Metabolic rate Metabolomes Precocial bird Thyroxin

Morphological Evolution of Self-Assembled Sodium Dodecyl Sulfate/Dodecyltrimethylammonium Bromide@Epoxy-β-Cyclodextrin Supramolecular Aggregates Induced by Temperature

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Journal of Renewable Materials 2024年第4期12卷 629-641页

作者： Qingran Meng Wenwen Xu Zuobing Xiao Qinfei Ke Xingran kou Key Laboratory of Textile Science&Technology Ministry of EducationCollege of TextilesDonghua UniversityShanghai201620China Collaborative Innovation Center of Fragrance Flavor and Cosmetics School of Perfume and Aroma Technology(Shanghai Research Institute of Fragrance&Flavour Industry)Shanghai Institute of TechnologyShanghaiChina

Bio-based cyclodextrins(CDs)are a common research object in supramolecular *** special cavity structure of CDs can form supramolecular self-assemblies such as vesicles and microcrystals through weak interaction with guest *** different forms of supramolecular self-assemblies can be transformed into each other under certain *** regulation of supramolecular self-assembly is not only helpful to understand the self-assembly principle,but also beneficial to its *** the present study,the self-assembly behavior of epoxy-β-cyclodextrin(EP-β-CD)and mixed anionic and cationic surfactant system(sodium dodecyl sulfate/dodecyltrimethylammonium bromide,SDS/DTAB)in aqueous solution was *** and particle size characterization found that the SDS/DTAB@EP-β-CD complex,as the basic building unit,self-assembled into worm-like micelles at lower temperatures and vesicles at higher *** magnetic resonance(NMR)and Fourier transform infrared spectroscopy(FT-IR)analysis revealed that the driving force for the formation of vesicles and worm-like micelles was the hydrogen bonds between EP-β-CD molecules,while water molecules played an important role in promoting vesicle formation between SDS/DTAB@EP-β-CD ***,the mechanism of the morphologic transformation of SDS/DTAB@EP-β-CD supramolecular aggregates induced by temperature was elucidated by exploring the self-assembly process,which may provide an excellent basis for the development of delivery carriers.

关键词： Epoxy-β-cyclodextrin SDS/DTAB self-assembly temperature morphological evolution

High-precision temperature retrieval algorithm and verification for mesospheric airglow spectrum photometer

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Science China Earth Sciences 2024年第5期67卷 1639-1651页

作者： Shuqi NIU Haiyang GAO Zhaoai YAN Ke REN Leilei kou Baichuan JIANG Lingbin BU Key Open Laboratory of Aerosol and Cloud Precipitation of China Meteorological Administration Nanjing 210044China School of Atmospheric Physics Nanjing University of Information Science and TechnologyNanjing 210044China National Space Science Center Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100190China

Photometric technology,characterized by its compact structure and relatively high stability,finds wide application in measuring airglow *** instrumentation is anticipated to assume a pivotal role as the primary equipment for extensive network observations of middle and upper atmospheric temperatures in China,thereby providing crucial support for space environmental monitoring and atmospheric dynamic ***,susceptibility to various factors such as instrument inconsistency,variability in observation conditions,and alterations in the background atmospheric environment across different stations poses a challenge,potentially resulting in data inconsistencies in network *** response to these challenges,we propose a multiple-parameter iterative inversion(MPII)algorithm for temperature retrieval based on a mesospheric airglow spectrum photometer(MASP)developed by our research *** algorithm accurately identifies the center of the image circle,corrects image distortion,and thereby obtains an accurate synthetic spectrum reflective of actual *** encompasses five adjustable parameters:sky background light,atmospheric temperature,filter temperature,optical system focal length,and degree of synthetic spectrum *** to traditional methods,significant enhancements in the accuracy of the inverted temperature are *** validate the effectiveness of the MPII algorithm,we conducted combined active and passive remote sensing synchronous measurements using MASP in conjunction with a sodium fluorescence Doppler lidar developed by the National Space Science *** utilizing the lidar temperature as a reference,atmospheric background radiation is mitigated from the MASP data,and the temperature is inverted using the MPII *** analysis with the traditional method reveals that temperatures calculated by the MPII algorithm exhibit better consistency than those observed by the lidar.

关键词： Temperature inversion Airglow spectrum photometer Rotational spectral lines Sodium fluorescence Doppler lidar Comparative observations

Deep Learning-Based Secure Transmission Strategy with Sensor-Transmission-Computing Linkage for Power Internet of Things

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Computers, Materials & Continua 2024年第3期78卷 3267-3282页

作者： Bin Li Linghui Kong Xiangyi Zhang Bochuo kou Hui Yu Bowen Liu State Grid Beijing Urban District Power Supply Company Beijing100034China

The automatic collection of power grid situation information, along with real-time multimedia interaction between the front and back ends during the accident handling process, has generated a massive amount of power grid data. While wireless communication offers a convenient channel for grid terminal access and data transmission, it is important to note that the bandwidth of wireless communication is limited. Additionally, the broadcast nature of wireless transmission raises concerns about the potential for unauthorized eavesdropping during data transmission. To address these challenges and achieve reliable, secure, and real-time transmission of power grid data, an intelligent security transmission strategy with sensor-transmission-computing linkage is proposed in this paper. The primary objective of this strategy is to maximize the confidentiality capacity of the system. To tackle this, an optimization problem is formulated, taking into consideration interruption probability and interception probability as constraints. To efficiently solve this optimization problem, a low-complexity algorithm rooted in deep reinforcement learning is designed, which aims to derive a suboptimal solution for the problem at hand. Ultimately, through simulation results, the validity of the proposed strategy in guaranteed communication security, stability, and timeliness is substantiated. The results confirm that the proposed intelligent security transmission strategy significantly contributes to the safeguarding of communication integrity, system stability, and timely data delivery.

关键词： Secure transmission deep learning power Internet of Things sensor-transmission-computing

Dispersed Wind Power Planning Method Considering Network Loss Correction with Cold Weather

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Energy Engineering 2024年第4期121卷 1027-1048页

作者： Hanpeng kou Tianlong Bu Leer Mao Yihong Jiao Chunming Liu Hulunbeier Power Supply Company State Grid Inner Mongolia East Power Co.Ltd.Hulunbeier021100China College of Electrical and Electronic Engineering North China Electric Power UniversityBeijing102206China

In order to play a positive role of decentralised wind power on-grid for voltage stability improvement and loss reduction of distribution network,a multi-objective two-stage decentralised wind power planning method is proposed in the paper,which takes into account the network loss correction for the extreme cold ***,an electro-thermal model is introduced to reflect the effect of temperature on conductor resistance and to correct the results of active network loss calculation;secondly,a two-stage multi-objective two-stage decentralised wind power siting and capacity allocation and reactive voltage optimisation control model is constructed to take account of the network loss correction,and the multi-objective multi-planning model is established in the first stage to consider the whole-life cycle investment cost of WTGs,the system operating cost and the voltage quality of power supply,and the multi-objective planning model is established in the second *** model,and the second stage further develops the reactive voltage control strategy of WTGs on this basis,and obtains the distribution network loss reduction method based on WTG siting and capacity allocation and reactive power control ***,the optimal configuration scheme is solved by the manta ray foraging optimisation(MRFO)algorithm,and the loss of each branch line and bus loss of the distribution network before and after the adoption of this loss reduction method is calculated by taking the IEEE33 distribution system as an example,which verifies the practicability and validity of the proposed method,and provides a reference introduction for decision-making for the distributed energy planning of the distribution network.

关键词： Decentralised wind power network loss correction siting and capacity determination reactive voltage control two-stage model manta ray foraging optimisation algorithm

Research on Fatigue Damage Behavior of Main Beam Sub-Structure of Composite Wind Turbine Blade

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Structural Durability & Health Monitoring 2024年第3期18卷 277-297页

作者： Haixia kou Bowen Yang Xuyao Zhang Xiaobo Yang Haibo Zhao School of Mechanical Engineering Lanzhou Jiaotong UniversityLanzhou730070China School of New Energy and Power Engineering Lanzhou Jiaotong UniversityLanzhou730070China

Given the difficulty in accurately evaluating the fatigue performance of large composite wind turbine blades(referred to as blades),this paper takes the main beam structure of the blade with a rectangular cross-sectionas the simulation object and establishes a composite laminate rectangular beam structure that simultaneouslyincludes the flange,web,and adhesive layer,referred to as the blade main beam sub-structure specimen,throughthe definition of blade *** paper examines the progressive damage evolution law of the compositelaminate rectangular beam utilizing an improved 3D Hashin failure criterion,cohesive zone model,B-K failurecriterion,and computer simulation *** static loading,the layup angle of the anti-shear web hasa close relationship with the static load-carrying capacity of the composite laminate rectangular beam;under fatigueloading,the fatigue damage will first occur in the lower flange adhesive area of the whole composite laminaterectangular beam and ultimately result in the fracture failure of the entire *** results provide a theoreticalreference and foundation for evaluating and predicting the fatigue performance of the blade main beamstructure and even the full-size blade.

关键词： Composite laminate wind turbine blade sub-structure progressive damage analysis user material subroutine cohesive zone model