检索结果-南通市图书馆

Impact of cancer diagnosis on life expectancy by area-level socioeconomic groups in New South Wales, Australia: a population-based study

引用

Cancer Biology & Medicine 2024年第8期21卷 692-702页

作者： Md Mijanur Rahman Michael David David Goldsbury Karen Canfell kou kou Paramita Dasgupta Peter Baade Xue Qin Yu The Daffodil Centre The University of SydneyA Joint Venture with Cancer Council NSWSydneyNSW 1340Australia School of Medicine and Dentistry Griffith UniversityGold CoastQLD 4222Australia Cancer Council Queensland BrisbaneQLD 4006Australia

Objective: Improvement in cancer survival over recent decades has not been accompanied by a narrowing of socioeconomic disparities. This study aimed to quantify the loss of life expectancy(LOLE) resulting from a cancer diagnosis and examine disparities in LOLE based on area-level socioeconomic status(SES).Methods: Data were collected for all people between 50 and 89 years of age who were diagnosed with cancer, registered in the NSW Cancer Registry between 2001 and 2019, and underwent mortality follow-up evaluations until December 2020. Flexible parametric survival models were fitted to estimate the LOLE by gender and area-level SES for 12 common ***: Of 422,680 people with cancer, 24% and 18% lived in the most and least disadvantaged areas, respectively. Patients from the most disadvantaged areas had a significantly greater average LOLE than patients from the least disadvantaged areas for cancers with high survival rates, including prostate [2.9 years(95% CI: 2.5±3.2 years) vs. 1.6 years(95% CI: 1.3±1.9 years)] and breast cancer [1.6 years(95% CI: 1.4±1.8 years) vs. 1.2 years(95% CI: 1.0±1.4 years)]. The highest average LOLE occurred in males residing in the most disadvantaged areas with pancreatic [16.5 years(95% CI: 16.1±16.8 years) vs. 16.2 years(95% CI: 15.7±16.7 years)] and liver cancer [15.5 years(95% CI: 15.0±16.0 years) vs. 14.7 years(95% CI: 14.0±15.5 years)]. Females residing in the least disadvantaged areas with thyroid cancer [0.9 years(95% CI: 0.4±1.4 years) vs. 0.6 years(95% CI: 0.2±1.0 years)] or melanoma [0.9 years(95% CI: 0.8±1.1 years) vs. 0.7 years(95% CI: 0.5±0.8 years)] had the lowest average ***: Patients from the most disadvantaged areas had the highest LOLE with SES-based differences greatest for patients diagnosed with cancer at an early stage or cancers with higher survival rates, suggesting the need to prioritise early detection and reduce treatment-related barriers and survivorship challenges to improve life expec

关键词： Cancer diagnosis life expectancy loss of life expectancy area-level socioeconomic status flexible parametric model

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Targeted therapeutic effects of oral magnetically driven pectin nanoparticles containing chlorogenic acid on colon cancer

引用

Particuology 2024年第1期84卷 53-59页

作者： Huatai Zhu Limei Zhang Fujia kou Jingyang Zhao Jiandu Lei Jing He Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry UniversityBeijing100083China Institute of Biopharmaceutical and Health Engineering Tsinghua Shenzhen International Graduate SchoolTsinghua UniversityShenzhen518055China

Oral colonic nano-drug delivery system has attracted growing attention in treating colon cancer for their excellent ***,the unique and complex structure of the gastrointestinal tract is still an obstacle to the safe delivery of drugs targeting sites in colon ***,we designed magnetically driven dual-targeted oral colonic nanoparticles loaded with chlorogenic acid using pectin and oleic acid-modified iron oxide(Fe3O4@OA).Specific degradation of pectin by pectinase produced by colonic flora and magnetic fields applied to the colon confers specific targeting of nanoparticles to the *** order to overcome the challenge of preparing magnetically driven nanoparticles with small and homogeneous particle sizes by a single conventional method,we developed the combined ultrasound-emulsification *** average particle size of the prepared nanoparticles was 81.04±1.02 nm,which showed good drug release in the simulated colonic *** vitro anticancer studies,the drug-loaded nanoparticles possess an obvious toxicity and apoptosis-inducing ability against cancer ***,the hemolysis results demonstrated the safety of the nanoplatform(PET/CGA/Fe_(3)O_(4)@OA).This work holds broad prospects as a new treatment modality for colon cancer.

关键词： Pectin Chlorogenic acid Ultrasound-emulsion Magnetically driven Colon cancer Colon targeted

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Factors Influencing Fracture Propagation in Collaborative Fracturing ofMultiple HorizontalWells

引用

Energy Engineering 2024年第2期121卷 425-437页

作者： Diguang Gong Junbin Chen Cheng Cheng Yuanyuan kou Shanxi Key Laboratory of Well Stability and Fluid&RockMechanics inOil andGas Reservoirs Xi’an Shiyou UniversityXi’an710065China The Second Oil Production Plant Petro China Changqing Oilfield CompanyQingyang745100China

Horizontal well-stimulation is the key to unconventional resource exploration and *** development mode of the well plant helps increase the stimulated reservoir ***,fracture interference between wells reduces the fracturing ***,a 2D hydro-mechanical coupling model describing hydraulic fracture(HF)propagation is established with the extended finite element method,and the effects of several factors on HF propagation during multiple wells fracturing are *** results show that with an increase in elastic modulus,horizontal principal stress difference and injection fluid displacement,the total fracture area and the reservoir stimulation efficiency are both improved in all three fracturing *** a comparison of the three technologies,the method of improved zipper fracturing is proposed,which avoids mutual interference between HFs,and the reservoir stimulation effect is improved *** study provides guidance for optimizing the fracturing technology of multiple horizontal wells.

关键词： Multi-well fracturing inter-fracture interference hydraulic fracturing hydro-mechanical coupling extended finite element horizontal well

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Facile synthesis of a tumor microenvironment-responsive nanomaterial with metallic polyphenol-encapsulated for enhanced synergistic therapy

引用

Journal of Rare Earths 2024年第10期42卷 1895-1902页

作者： Kaige Yu Nuo kou Shouqiang Zhang Tianqi Cao Hanqing Wu Jing Zhou Department of Chemistry Capital Normal University College of Teacher Education Capital Normal University

The tumor microenvironment（TME） differs from normal tissue cells in its physiological and biochemical *** construction of TME-responsive nanoplatforms requires a tedious preparation process and complex multicomponent *** this work,Er@EGCG-Cu,a TME-responsive nanoplatform,was simply and rapidly synthesized by combining rare earth-doped nanomaterials（NaLuF4:Yb,Er） with EGCG-Cu which is based on the ability of metal ions to coordinate with polyphenols to form a metal-phenolic network（MPN） *** MPN structure is then destroyed under an acidic TME,releasing the chemotherapy（CT） drug EGCG,which can cause apoptosis,CuxSyis generated by combining Cu2+with H2S overexpressed in human colorectal cancer cells and can be used for photothermal therapy（PTT）.Cell experiments show that laser irradiation improves the CT/PTT synergistic effect of Er@*** study has significance for the construction of TME-responsive nanomedicines with simple and rapid preparation for synergistic therapy.

关键词： Metal-polyphenol networks Nanomaterials Rare earths Synergistic therapy Tumor microenvironment

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Enhancing Dense Small Object Detection in UAV Images Based on Hybrid Transformer

引用

Computers, Materials & Continua 2024年第3期78卷 3993-4013页

作者： Changfeng Feng Chunping Wang Dongdong Zhang Renke kou Qiang Fu Shijiazhuang Campus People Liberation Army Engineering UniversityShijiazhuang050003China School of Information and Intelligent Engineering Sanya UniversitySanya572000China

Transformer-based models have facilitated significant advances in object ***,their extensive computational consumption and suboptimal detection of dense small objects curtail their applicability in unmanned aerial vehicle(UAV)*** these limitations,we propose a hybrid transformer-based detector,H-DETR,and enhance it for dense small objects,leading to an accurate and efficient ***,we introduce a hybrid transformer encoder,which integrates a convolutional neural network-based cross-scale fusion module with the original encoder to handle multi-scale feature sequences more ***,we propose two novel strategies to enhance detection performance without incurring additional inference *** filter is designed to cope with the dense clustering inherent in drone-captured images by counteracting similar queries with a training-aware non-maximum *** denoising learning is a novel enhancement method inspired by adversarial learning,which improves the detection of numerous small targets by counteracting the effects of artificial spatial and semantic *** experiments on the VisDrone and UAVDT datasets substantiate the effectiveness of our approach,achieving a significant improvement in accuracy with a reduction in computational *** method achieves 31.9%and 21.1%AP on the VisDrone and UAVDT datasets,respectively,and has a faster inference speed,making it a competitive model in UAV image object detection.

关键词： UAV images transformer dense small object detection

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Landslide Displacement Prediction Based on Time Series and PSO-BP Model in Three Georges Reservoir, China

引用

Journal of Earth Science 2024年第3期35卷 1079-1082页

作者： Dexiang Gao kou Li Yuncheng Cai Tao Wen School of Geosciences Yangtze UniversityWuhan 430100China School of Science Yunnan Agricultural UniversityKunming 650201China

0 INTRODUCTION Landslides are one of the most frequent geological disasters in the world(Wen et al.,2020;Froude and Petley,2018),which have occurred frequently and widely distributed in China for a long *** landslides are essentially a complex multidimensional nonlinear dynamic system affected by its own geological conditions and external factors(Ma et al.,2021;Wang et al.,2019),including geotechnical characteristics,hydrogeology,geomorphologic conditions,climate,and weathering(Ma et al.,2020).The interaction of these factors makes the change of landslide displacement random,fuzzy and variable(Park and Michalowski,2017),and also brings great difficulties to the landslide displacement prediction(Ma et al.,2018).

关键词： landslide Landslide weathering

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Electricity resonance-induced phase transition of water confined in nanochannels

引用

Communications in Theoretical Physics 2024年第5期76卷 159-165页

作者： Yunqiu Ma Zhigao Zhao Shaoqian Hao Jianlong kou Jiang-Xing Chen Institute of Condensed Matter Physics Zhejiang Institute of Photoelectronics&Zhejiang Institute for Advanced Light SourceZhejiang Normal UniversityJinhua 321004China Department of Physics Inner Mongolia UniversityHohhot 010021China Department of Physics Hangzhou Normal UniversityHangzhou 311121China

The phase transition of water molecules in nanochannels under varying external electric fields is studied by molecular dynamics *** is found that the phase transition of water molecules in nanochannels occurs by changing the frequency of the varying electric *** molecules maintain the ice phase when the frequency of the varying electric field is less than 16 THz or greater than 30 THz,and they completely melt when the frequency of the varying electric field is 24 *** phenomenon is attributed to the breaking of hydrogen bonds when the frequency of the varying electric field is close to their inherent resonant ***,the study demonstrates that the critical frequency varies with the confinement *** new mechanism of regulating the phase transition of water molecules in nanochannels revealed in this study provides a perspective for further understanding of the phase transition of water molecules in nanochannels,and has great application potential in preventing icing and deicing.

关键词： electricity resonance phase transition water molecules molecular dynamics simulations

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Flexible assistance strategy of lower limb rehabilitation exoskeleton based on admittance model

引用

Science China(Technological Sciences) 2024年第3期67卷 823-834页

作者： kou JianGe WANG YiXuan CHEN ZhenLei SHI Yan GUO Qing XU Meng School of Automation Science and Electrical Engineering Beihang UniversityBeijing 100191China School of Aeronautics and Astronautics University of Electronic Science and Technology of ChinaChengdu 611731China Department of Musculoskeletal Tumor Senior Department of Orthopedicsthe Fourth Medical Centerof PLA GeneralHospitalBeijing 100853China

Exercise training based on exoskeleton is an effective rehabilitation method for stroke patients. However, some rehabilitation exoskeletons still have poor wearable performance and obvious human-robot impedance during training, which easily cause secondary injuries to the patients. In this study, a variable admittance control strategy is proposed to improve the operator's wearable comfort, which can adapt to different operators by regulating admittance parameters. The admittance controller has two feedback loops: the position inner-loop and the admittance outer-loop. Meanwhile, the exoskeleton Lagrange model is constructed with unknown friction disturbance. By using Lyapunov technique and backstepping with state observer, the joint position error of exoskeleton is convergence into a zero neighborhood. The effectiveness of the proposed admittance controller is verified by both simulation and experiment. The tracking error of hip and knee joint is less than 4 degrees while the human-robot interaction torque is constrained in a tolerable range of the operator.

关键词： human-robot interaction exoskeleton backstepping admittance control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Currentless Multiple Switch Open-Circuit Faults Diagnosis for Modular Multilevel Converters with Nearest Level Modulation in HVDC Systems

引用

CSEE Journal of Power and Energy Systems 2024年第4期10卷 1642-1653页

作者： Zhi Geng Minxiao Han Changjiang Xia Longze kou School of Electrical and Electronic Engineering North China Electric Power University(NCEPU)Beijing 102206China State Key Laboratory of Advanced Power Transmission Technology Global Energy Interconnection Research InstituteBeijing 102209China

Due to the large number of submodules(SMs),and modular multilevel converters(MMCs)in high-voltage applications,they are usually regulated by the nearest level modulation(NLM).Moreover,the large number of SMs causes a challenge for the fault diagnosis strategy(FDS).This paper proposes a currentless FDS for MMC with *** FDS,the voltage sensor is relocated to measure the output voltage of the *** acquire the capacitor voltage and avoid increasing extra sensors,a capacitor voltage calculation method is *** on the measurement of output voltages,the faults can be detected and the number of different-type switch open-circuit faults can be confirmed from the numerous SMs in an arm,which narrows the scope of fault ***,the faulty SMs and faulty switches in these SMs are further located without arm current according to the sorting of capacitor voltages in the voltage balancing *** FDS is independent of the arm current,which can reduce the communication cost in the hierarchical control system of ***,the proposed FDS not only simplifies the identification of switch open-circuit faults by confirming the scope of faults,but also detects and locates multiple different-type faults in an *** effectiveness of the proposed strategy is verified by the simulation results.

关键词： Fault diagnosis high voltage direct current(HVDC) modular multilevel converter(MMC) nearest level modulation(NLM) switch open-circuit fault

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical techniques to prevent delayed gastric emptying after pancreaticoduodenectomy

引用

Hepatobiliary & Pancreatic Diseases International 2024年第5期23卷 449-457页

作者： Peng Duan Lu Sun Kai kou Xin-Rui Li Ping Zhang Department of Hepatobiliary and Pancreatic Surgery General Surgery Centerthe First Hospital of Jilin UniversityChangchun 130021China Department of Dental Implantology Hospital of StomatologyJilin UniversityChangchun 130021China

Background: Delayed gastric emptying(DGE) is one of the most common complications after pancreaticoduodenectomy(PD). DGE represents impaired gastric motility without significant mechanical obstruction and is associated with an increased length of hospital stay, increased healthcare costs, and a high readmission rate. We reviewed published studies on various technical modifications to reduce the incidence of DGE. Data sources: Studies were identified by searching Pub Med for relevant articles published up to December 2022. The following search terms were used: “pancreaticoduodenectomy”, “pancreaticojejunostomy”, “pancreaticogastrostomy”, “gastric emptying”, “gastroparesis” and “postoperative complications”. The search was limited to English publications. Additional articles were identified by a manual search of references from key articles. Results: In recent years, various surgical procedures and techniques have been explored to reduce the incidence of DGE. Pyloric resection, Billroth II reconstruction, Braun's enteroenterostomy, and antecolic reconstruction may be associated with a decreased incidence of DGE, but more high-powered studies are needed in the future. Neither laparoscopic nor robotic surgery has demonstrated superiority in preventing DGE, and the use of staplers is controversial regarding whether they can reduce the incidence of DGE. Conclusions: Despite many innovations in surgical techniques, there is no surgical procedure that is superior to others to reduce DGE. Further larger prospective randomized studies are needed.

关键词： Pancreaticoduodenectomy Delayed gastric emptying Postoperative complications Surgical techniques

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：