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Combined effects of Gymnema sylvestre and Pergularia daemia on letrozole-induced polycystic ovarian syndrome in rats

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Asian pacific Journal of Reproduction 2021年第2期10卷 68-74页

作者： Sudhakar Pachiappan kothai ramalingam Arul Balasubramanian Department of Pharmacology Vinayaka Mission’s College of PharmacyVinayaka Mission’s Research Foundation(Deemed to be University)Salem-8Tamil NaduIndia Department of Pharmacy Practice Vinayaka Mission’s College of PharmacyVinayaka Mission’s Research Foundation(Deemed to be University)Salem-8Tamil NaduIndia

Objective:To investigate the combined therapeutic potential of Gymnema(G.)sylvestre and Pergularia(P.)daemia on letrozole-induced polycystic ovarian syndrome(PCOS)in ***:Thirty six healthy female Wistar rats with regular estrus cycles were randomly divided into six groups each of ***Ⅰreceived 1 mL of 0.5%carboxyl methyl cellulose orally and served as the vehicle control group,while groupsⅡtoⅥwere treated with letrozole(1 mg/kg body weight p.o.)for 21 days to induce *** induction of PCOS,groupⅡserved as the PCOS control group,without treatment;groupⅢreceived metformin(20 mg/kg body weight p.o.)as the standard group,and groupsⅣtoⅥreceived ***(100 mg/kg body weight p.o.),***(300 mg/kg body weight p.o.),and the combination of *** and ***,respectively,for 28 *** smears were collected from all rats daily throughout the study to determine the phases of the estrus *** completing the treatment schedule,oral glucose tolerance test,serum lipid profile and reproductive hormonal analysis were carried ***,the rats were sacrificed to collect ovary and uterus for histopathological ***:The PCOS control rats showed a significant irregularity in the estrus cycle,hyperglycemia,and the altered serum lipid profile such as the increased low and very low density lipoprotein,triglyceride,and decreased high density *** addition,the PCOS control rats showed a significant increase in serum luteinizing hormone,testosterone,and estrogen,and decrease in follicle stimulating hormone and *** changes were significantly revoked in all the treatment *** test drugs also significantly reduced the gained ovary weight(P<0.001),and histopathology of the ovary showed almost normal *** the treatment groups,the group of combination treatment of *** and *** showed superior ameliorative results in PCOS ***:Combination of *** and *** pr

关键词： Polycystic ovarian syndrome Metformin Letrozole Gymnema sylvestre Pergularia daemia Reproductive hormone Estrus cycle

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