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Castor oil as booster for colon capsule endoscopy preparation reduction: A prospective pilot study and patient questionnaire

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2021年第4期12卷 79-89页

作者： kota takashima Yoriaki Komeda Toshiharu Sakurai Sho Masaki Tomoyuki Nagai Shigenaga Matsui Satoru Hagiwara Mamoru Takenaka Naoshi Nishida Hiroshi Kashida Konosuke Nakaji Tomohiro Watanabe Masatoshi Kudo Department of Gastroenterology and Hepatology Kindai University Faculty of MedicineOsaka 589-8511Japan Division of Gastroenterology Department of Internal MedicineEndoscopy CenterAishinkai Nakae HospitalWakayama-Shi 640-8461Japan

BACKGROUND Preparation for colon capsule endoscopy(CCE)requires a large liquid laxative volume for capsule excretion,which compromises the procedure's *** To assess the safety and utility of castor oil-boosted bowel *** This prospective cohort study including 20 patients(age range,16-80 years;six men and 14 women)suspected of having colorectal disease was conducted at Kindai University Hospital from September 2017 to August *** patients underwent CCE because of the following inclusion criteria:previous incomplete colonoscopy in other facility(n=20),history of abdominal surgery(n=7),or organ abnormalities such as multiple diverticulum(n=4)and adhesion after surgery(n=6).The exclusion criteria were as follows:Dysphagia,history of allergic reactions to the drugs used in this study(magnesium citrate,polyethylene glycol,metoclopramide,and castor oil),possibility of pregnancy,possibility of bowel obstruction or stenosis based on symptoms,or scheduled magnetic resonance imaging within 2 wk after *** primary outcome was the capsule excretion rate within the battery life,as evaluated by the total large bowel observation rate,large bowel transit time,and bowel creasing level using a fivegrade scale in different colorectal *** secondary outcomes were complications,colorectal lesion detection rates,and patients’*** The castor oil-based regimen was implemented in 17 *** patients cancelled CCE because they could tolerate castor oil,but not liquid *** capsule excretion rate within the battery life was 88%(15/17).The mean large bowel transit time was 236 *** 70%of patients had satisfactory colon cleansing *** detected colon polyps(14/17,82%)and colonic diverticulum(4/12,33%).The sensitivity,specificity,and diagnostic accuracy rates for detecting colorectal polyps(size≥6 mm)were 76.9%,75.0%,and 76.4%,*** sensitivity,specificity,and diagnostic accuracy rates for dete

关键词： Bowel preparation regimen Castor oil Colon capsule endoscopy Colonoscopy Colorectal diseases Prospective study

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