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春小麦的产量与源/库关系

国外农学（麦类作物） 1991年第3期 34-36页

作者： E.i.koshkin 张怀渝

在开花期完全摘除穗一侧的小穗(处理穗),以测试新老春小麦品种对源库调控的不同反应,并提出了穗的生产潜力(处理穗的两倍产量)和其余一半穗的潜在蛋白质含量的概念。在系统选择中,现代品种的潜在产量和实际产量的改进是由于提高了茎叶... 详细信息

在开花期完全摘除穗一侧的小穗(处理穗),以测试新老春小麦品种对源库调控的不同反应,并提出了穗的生产潜力(处理穗的两倍产量)和其余一半穗的潜在蛋白质含量的概念。在系统选择中,现代品种的潜在产量和实际产量的改进是由于提高了茎叶重和叶面积持续期(L_(ado)),特别是在不利的灌浆环境条件下,叶面积持续期与实际籽粒产量的比率就会提高。已经确定,在新品种中,潜在的和实际的蛋白质含量有一致降低的倾向,而每株蛋白质总量则有增加的趋势。在老品种中,根对植株总呼吸作用的贡献较大。尽管产量不断改良,但维持呼吸作用与总呼吸作用的比率,以及在整个生育期中以产量为基础的呼吸损失却保持不变。在老品种中,以籽粒氮为基础的真呼吸碳损失(总呼吸减维持呼吸)较少,在其他品种之间没有一致的差异。

关键词：小麦产量源/库关系春小麦

Measurement of AhR Li.ands i. the Ti.sues of Colon Cancer Pati.nts wi.h XRE Luci.erase Reporter

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Journal of Oncology Research 2019年第1期1卷 3-9页

作者： Bystri.kova Margari.a koshkin Sergei.Tolkunova Elena i.sti.ute of Cytology of the Russi.n Academy of Sci.nce St-Petersburg 194064Russia

The Aryl hydrocarbon receptor(AhR)li.ands exhi.i.i.g modulati.g acti.i.y represents a new class of anti.ancer agents that can be di.ected towards several *** have exami.ed AhR expressi.n i. human colon cancer and adjacent non-tumor *** expressi.n level was about 2-7 ti.es hi.her i. tumor ti.sue samples than i. the adjacent non-tumor samples(i. 82%of all the samples).We were unable to fi.d any i.crease of ABCG2 expressi.n on the level of the transcri.ti.n,whi.e the expressi.n of MDR2 was i.creased i. half of the tumors compared to the levels of expressi.n i. normal adjacent *** have used Fi.Z as a potent hi.h affi.i.y li.and of the AhR to cali.rate the reporter cell li.e HEK293TAhR-luc as a potent hi.h affi.i.y li.and of the *** concentrati.n of xenobi.ti. response element(XRE)li.ands i. hi.her,than i. the blood of healthy people i. 86%of the *** proposed test system wi.l allow the use of the AhR li.and level as an addi.i.nal di.gnosti. marker i. the treatment of colon cancer.

关键词： Aryl hydrocarbon receptor Colon cancer HЕК293Т-AhR-luc Polycycli. aromati. hydrocarbon XRE luci.erase reporter bi.assay

Mechani.ms of tyrosi.e ki.ase i.hi.i.or resi.tance i. renal cell carci.oma

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Cancer Drug Resi.tance 2023年第4期6卷 858-873页

作者： Patri.k L.Sweeney Yash Suri.Arnab Basu Vadi. S.koshkin Arpi.a Desai Demi.g Department of Medi.i.e Tulane University School of MedicineNew OrleansLA 70112USA Uni.ersi.y of Ari.ona College of Medi.i.e TucsonAZ 85724USA Di.i.i.n of Hematology and Oncology Department of MedicineUniversity of Alabama at Birmingham Heersink School of MedicineBirminghamAL35233USA Di.i.i.n of Hematology and Oncology Department of MedicineUniversity of California at San Francisco School of MedicineSanFranciscoCA94143USA

Renal cell carci.oma(RCC),the most prevalent type of ki.ney cancer,i. a si.ni.i.ant cause of cancer morbi.i.y and mortali.y *** tyrosi.e ki.ase i.hi.i.ors(TKls),i. combi.ati.n wi.h i.mune checkpoi.t i.hi.i.ors(i.ls),are among the fi.st-li.e treatment opti.ns for pati.nts wi.h advanced *** therapi.s target the vascular endotheli.l growth factor receptor(VEGFR)tyrosi.e ki.ase pathway and other ki.ases cruci.l to cancer proli.erati.n,survi.al,and *** have yi.lded substanti.l i.provements i. progressi.n-free survi.al(PFS)and overall survi.al(OS)for pati.nts wi.h advanced ***,nearly all pati.nts eventually progress on these drugs as resi.tance *** revi.w provi.es an overvi.w of TKl resi.tance i. RCC and explores di.ferent mechani.ms of resi.tance,i.cludi.g upregulati.n of alternati.e proangi.geni. pathways,epi.heli.l-mesenchymal transi.i.n(EMT),decreased i.tracellular drug concentrati.ns due to efflux pumps and lysosomal sequestrati.n,alterati.ns i. the tumor mi.roenvi.onment i.cludi.g bone marrow-deri.ed cells(BMDCs)and tumor-associ.ted fi.roblasts(TAFs),and geneti. factors such as si.gle nucleoti.e polymorphi.ms(SNPs).A comprehensi.e understandi.g of these mechani.ms opens the door to the development of i.novati.e therapeuti. approaches that can effecti.ely overcome TKl resi.tance,thereby i.provi.g outcomes for pati.nts wi.h advanced RCC.

关键词： Anti.ngi.geni. tyrosi.e ki.ase i.hi.i.ors renal cell carci.oma acqui.ed resi.tance suni.i.i. tumor mi.roenvi.onment i.mune checkpoi.t i.hi.i.ors

i.-transparent MgO-Gd_(2)O_(3) composi.e cerami.s produced by self-propagati.g hi.h-temperature synthesi. and spark plasma si.teri.g

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Journal of Advanced Cerami.s 2021年第2期10卷 237-246页

作者： Dmi.ry A.Permi. Maksi. S.Boldi. Alexander V.Belyaev Stani.lav S.Balabanov Vi.aly A.koshkin Atrem A.Murashov i.or V.Ladenkov Evgeny A.Lantsev Kseni. E.Smetani.a Nadi. M.Khamaletdi.ova G.G.Devyatykh i.sti.ute of chemi.try of hi.h-puri.y substances of the ras nizhny novgorod603137russia Lobachevsky state uni.ersi.y of ni.hny novgorod nizhny novgorod603950russia “Joi.t-stock company”research and producti.n enterpri.e“salut” nizhny novgorod603950russia G.A.Razuvaev i.sti.ute of organometalli. chemi.try of the ras nizhny novgorod603137russia

A glyci.e–ni.rate self-propagati.g hi.h-temperature synthesi.(SHS)was developed to produce composi.e MgO-Gd_(2)O_(3) *** X-ray powder di.fracti.n(XRD)analysi. confi.med the SHS-product consi.ts of cubi. MgO and Gd_(2)O_(3) phases wi.h nanometer crystalli.e si.e and retai.s thi. structure after anneali.g at temperatures up to 1200℃.Near full dense hi.h i.-transparent composi.e cerami.s were fabri.ated by spark plasma si.teri.g(SPS)at 1140℃and 60 *** i.-li.e transmi.tance of 1 mm thi.k MgO-Gd_(2)O_(3) cerami.s exceeded 70%i. the range of 4–5 mm and reached a maxi.um of 77%at a wavelength of 5.3 *** measured mi.rohardness HV0.5 of the MgO-Gd2O3 cerami.s i. 9.5±0.4 GPa,whi.e the fracture toughness(Ki.)amounted to 2.0±0.5МPa·m1/*** characteri.ti.s demonstrate that obtai.ed composi.e MgO-Gd_(2)O_(3) cerami. i. a promi.i.g materi.l for protecti.e i.fra-red(i.)wi.dows.

关键词： MgO-Gd_(2)O_(3) self-propagati.g hi.h-temperature synthesi.(SHS) spark plasma si.teri.g(SPS) opti.al properti.s i.fra-red(i.)cerami.s

Stromal and Tumor Gli.ma-deri.ed Cells wi.h Si.i.ar Characteri.ti.s Have Di.ferences i. α-Smooth Muscle Acti. Expressi.n and Locali.ati.n

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Journal of Oncology Research 2021年第2期3卷 8-21页

作者： i.Gi. i.Chi.tyakova V.Zeni. S.koshkin A.Musori.a Y.Lahi.a G.Ti.i. V.Pospelov S.Pri.hodko A.Petukhov E.Tolkunova i.sti.ute of Cytology Russian Academy of SciencesSt.Petersburg194064Russia Almazov Nati.nal Medi.al Research Centre St.Petersburg197341Russia Peter the Great Sai.t-Petersburg Polytechni. Uni.ersi.y St.Petersburg195251Russia Sci.nti.i. Technologi.al Uni.ersi.y«Si.i.s» Sochi354340Russia

Gli.mas are soli. brai. tumors composed of tumor cells and recrui.ed heterogeni. stromal *** study of the i.teracti.ns between the peri.ascular ni.he and i.s surroundi.g cells i. of great value i. unraveli.g mechani.ms of drug resi.tance i. mali.nant *** thi. study,we i.olated the stromal di.loi. cell populati.n from oli.odendrogli.ma and a mi.ed populati.n of tumor aneuploi. and stromal di.loi. cells from astrocytoma *** stromal cells expressed neural stem/progeni.or and mesenchymal markers showi.g the same di.cordant phenotype that i. typi.al for gli.ma ***,some of the stromal cells expressed *** the fi.st ti.e,we demonstrated that thi. type of stromal cells had the typi.al myofi.roblasti. phenotype as theα-SMA+cells formedα-SMA fi.ers and exhi.i.ed the speci.i. functi.n to deposi. extracellular matri.(ECM)protei.s at least i. *** analysi. showed di.fuse or focalα-SMA stai.i.g i. the cytoplasm of the astrocytoma-deri.ed,A172,T98G,and U251MG gli.ma *** could suggest thatα-SMA may be one of the mai. molecules,beari.g protecti.e *** mechani.ms and consequences ofα-SMA di.rupti.ns i. gli.mas are di.cussed.

关键词： Oli.odendrogli.ma Astrocytoma Pri.ary cell cultures Tumor mi.roenvi.onment Myofi.roblasts Extracellular matri.

Hi.tori. breedi.g of Soci.ble Lapwi.g(Vanellus gregari.s) i. Xi.ji.ng

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Chi.ese Bi.ds 2010年第1期1卷 70-73页

作者： Johannes KAMP Maxi. A.koshkin Robert D.SHELDON The Royal Soci.ty for the Protecti.n of Bi.ds(RSPB) Conservation Science DepartmentThe LodgeSandyBedfordshire SG19 2DLUK Associ.ti.n for the Conservati.n of Bi.di.ersi.y i. Kazakhstan ul.Beibitshilik18office 20301000 AstanaKazakhstan The Royal Soci.ty for the Protecti.n of Bi.ds(RSPB) Scotland HeadquartersDunedin House25 Ravelston TerraceEdinburgh EH4 3TPUK

The Soci.ble Lapwi.g(Vanellus gregari.s) was recently categori.ed as Cri.i.ally Endangered by the i.CN due to a strong decli.e and overall range *** now the only publi.hed Chi.ese record of the speci.s was a vagrant si.hti.g i. *** revi.wed reports and hi.tori. li.erature from a German orni.hologi.al expedi.i.n i. 1876,whi.h reported the speci.s to be a breedi.g bi.d i. Xi.ji.ng,western Chi.a i. the second half of the 19th *** to local experti.e,the speci.s seems si.ce to have become exti.ct i. Xi.ji.ng,but surveys are suggested to clari.y i.s current status.

关键词： Soci.ble Lapwi.g(Vanellus gregari.s) steppe Xi.ji.ng Ui.hur Autonomous Regi.n Alfred Edmund Brehm