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Microsatellite instability and expression of DNA mismatch repair genes in malignant astrocytic tumors from adult and pediatric patients

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中国神经肿瘤杂志 2003年第3期1卷 171-171页

作者： Szybka M Bartkowiak J Zakrzewski K Polis L Liberski P kordek r Department of Pathology Chair of Oncology Medical University of Lodz Poland

Microsatellite instability (MSI) is used as a molecular marker for defective DNA mismatch repair (MMr) *** report here alterations of MSI in 15 malignant astrocytomas (WHO grade Ⅲ) and glioblastomas (GBM; WHO grade Ⅳ) of pediatric patients (2-21 years) and 12 GBM from adults (44-68 years) by comparative analysis of BAT25/BAT26 loci and 10 other microsatellite markers. High-level microsatellite instability (MSI-H) occurred in 4 of the 15 pediatric cases (26.7%) and in 1 of the 12 adult GBM cases (8.3%). Low-level mi-

关键词： in from Microsatellite instability and expression of DNA mismatch repair genes in malignant astrocytic tumors from adult and pediatric patients MSI DNA of

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首发表现为皮肤B细胞淋巴瘤的richter综合征不同于原发性B细胞慢性淋巴细胞白血病

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世界核心医学期刊文摘（皮肤病学分册） 2006年第1期2卷 44-44页

作者： robak E Góra-Tybor J kordek r T. robak 罗素菊 Department of Haematology Medical University of ■odz 93-513 ■odz Poland

richter syndrome (rS) is a transformation to high-grade non-Hodgkin lymphoma in patients with chronic lymphocytic leukaemia (CLL). rS may develop in lymph nodes or rarely extranodally. Skin localization of rS has been described in only a few cases. We present a 77-year-old woman who developed isolated diffuse large B-cell lymphoma (LBCL) in the skin of the nose without any other symptoms of rS. The LBCL in the skin was clonally distinct from the original bone marrow CLL cells. Moreover, LBCL cells were positive for LMP-1 segment of Epstein-Barr virus and overexpressed p53 protein. The patient was successfully treated with CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) and adjuvant local radiotherapy.

关键词： B细胞淋巴瘤 richter 淋巴结外局部放疗长春新碱弥漫性骨髓来源阳性反应

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Hydrogen bonds of interfacial water in human breast cancer tissue compared to lipid and DNA interfaces

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Journal of Biophysical Chemistry 2011年第2期2卷 159-170页

作者： Halina Abramczyk Beata Brozek-Pluska Jakub Surmacki Joanna Jablonska-Gajewicz radzislaw kordek Technical University of Lodz Institute of Applied Radiation Chemistry Laboratory of Laser Molecular Spectroscopy Lodz Poland

The paper presents the results for water confined in a human breast cancerous tissue, a single stranded DNA, a double stranded DNA and in phospholipids (DPPC - D-a-Phosphati dylcholine, dipalmitoyl). The interfacial water in DNA and lipids is represented by a double band in the region of the OH stretching mode of water corresponding to the symmetric and asymmetric vibrational modes, in contrast to water confined in the cancerous breast tissue where only one band at 3311 cm-1 has been recorded. The marked red-shift of the maximum peak position of the OH stretching mode confirms that the vibrational properties of the interfacial water observed in restricted biological environment differ drastically from those in bulk water. The change of vibrational pattern of behavior may be due to the decoupling of the vibrations of the OH bonds in water molecule or change of the vibrational selection rules at biological interfaces. According to our knowledge raman vibrational properties of water confined in the normal and cancerous breast tissue of the same patient have not been reported in literature yet. Here we have also presented the first raman ‘optical biopsy’ images of the non-cancerous and cancerous (infiltrating ductal cancer) human breast tissues.

关键词： H-Bond Lipids Breast Cancer raman Imaging Interfacial Water Vibrational Spectroscopy

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