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World Journal of Orthopedics 2024年第5期15卷 483-485页

作者： konstantinos tsikopoulos konstantinos Sidiropoulos Department of Orthopaedics Portsmouth Hospitals NHS University TrustPortsmouth University HospitalsPortsmouth PO63LYUnited Kingdom Emergency Department Papageorgiou General Hospital of ThessalonikiThessaloniki 54635Greece Medical School University of PatrasPatras 26504Greece

The practice of implementing an antibiotic holiday before the second stage of hip or knee arthroplasty is currently controversial due to limited evidence for this approach,as per the International Consensus Meeting 2018 on Musculoskeletal Infection.A greater understanding of this issue could augment the quality of Alrayes and Sukeik’s mini-review(2023)on diagnosing,managing,and treating periprosthetic knee ***,a significant lack of literature exists concerning the optimal duration for the antibiotic holiday,calling for more research before establishing any clinical guidelines.

关键词： Septic knee prosthesis revision Two stages Antibiotic holiday

Glucosamine and chondroitin for the treatment of osteoarthritis

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World Journal of Orthopedics 2017年第1期8卷 1-11页

作者： Haris S Vasiliadis konstantinos tsikopoulos Orthopaedie Sonnenhof 1~(st) Orthopaedic Department 424 Army General Training Hospital

The prevalence of primary or idiopathic osteoarthritis(OA) of knee and hip joints has substantially increased in general population during the last decades. Analgesics and non-steroidal anti-inflammatory drugs are currently extensively used as non-surgical treatmentoptions. However, they act as symptomatic treatments, not offering a cure of OA and they are accused for an increased risk of adverse events. Glucosamine(GL) and chondroitin(CH) are nutritional supplements that have recently gained widespread use as treatment options for OA. They potentially or theoretically act as chondroprotectors or/and as "disease-modifying OA drugs" offering not only symptomatic relief but also alteration of the natural history of OA. However, although many studies have showed a significant treatment effect, accompanied with remarkable safety, there is still controversy regarding their relative effectiveness compared with placebo or other treatments. The scope of this review is to present and critically evaluate the current evidence-based information regarding the administration of GL and CH for the treatment of knee or hip OA. Our focus is to investigate the clinical efficacy and safety after the use of these supplements. An effect of GL and CH on both clinical and radiological findings has been shown. However, only a few high-quality level I trials exist in the literature, especially on the assessment of radiological progression of OA. The effect sizes are generally small and probably not clinically relevant. Even the validity of these results is limited by the high risk of bias introduced in the studies. Both GL and CH seem to be safe with no serious adverse events reported. There is currently no convincing information for the efficacy of GL and CH on OA.

关键词： Glucosamine Chondroitin Osteoarthritis Knee Cartilage

Viral infections in orthopedics: A systematic review and classification proposal

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World Journal of Orthopedics 2022年第11期13卷 1015-1028页

作者： konstantinos Sidiropoulos Savvas Ilias Christofilos konstantinos tsikopoulos Dimitrios Kitridis Lorenzo Drago Gabriele Meroni Carlo Luca Romanò Venu Kavarthapu General Hospital of Serres Serres 62100Greece Department of Genetics Evolution and EnvironmentUniversity College LondonLondon WC1E 6BTUnited Kingdom Department of Orthopaedics 404 Army General HospitalLarissa 41222Greece the First Department of Orthopaedics Aristotle University of ThessalonikiThessaloniki 54124Greece Department of Biomedical Sciences for Health and Microbiome University of MilanMilan 20133Italy Department of Biomedical Surgicaland Dental SciencesOne Health UnitUniversity of MilanMilan 20133Italy Gruppo di Studio SIOT Infezioni-Clinica San Gaudenzio-Novara-Gruppo Policlinico di Monza University of MilanMilan 20100Italy Trauma and OrthopaedicsKings College Hospital LondonDenmark HillLondon SE59RSUnited Kingdom

BACKGROUND Although the impact of microbial infections on orthopedic clinical outcomes is well recognized,the influence of viral infections on the musculoskeletal system might have been *** To systematically review the available evidence on risk factors and musculoskeletal manifestations following viral infections and to propose a pertinent classification *** We searched MEDLINE,Cochrane Central Register of Controlled Trials(CENTRAL),the Reference Citation Analysis(RCA),and Scopus for completed studies published before January 30,2021,to evaluate risk factors and bone and joint manifestations of viral infection in animal models and patient *** assessment was performed using SYRCLE's risk of bias tool for animal studies,Moga score for case series,Wylde score for registry studies,and Newcastle-Ottawa Scale for case-control *** Six human and four animal studies were eligible for inclusion in the qualitative *** C virus was implicated in several peri-and post-operative complications in patients without cirrhosis after major orthopedic *** virus may affect the integrity of lumbar discs,whereas Ross River and Chikungunya viruses provoke viral arthritis and bone *** Evidence of moderate strength suggested that viruses can cause moderate to severe arthritis and *** factors such as pre-existing rheumatologic disease contributed to higher disease severity and duration of ***,based on our literature search,the proposed clinical and pathogenetic classification scheme is as follows:(1)Viral infections of bone or joint;(2)Active bone and joint inflammatory diseases secondary to viral infections in other organs or tissues;and(3)Viral infection as a risk factor for post-surgical bacterial infection.

关键词： Viral infection Musculoskeletal system Bone and joint manifestations Chikungunya Zika Hepatitis C virus Herpesviridae Ross River virus Cross-reactivity Classification

In vitro laboratory infection research in orthopaedics:Why,when,and how

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World Journal of Orthopedics 2023年第8期14卷 598-603页

作者： konstantinos tsikopoulos Lorenzo Drago Gabriele Meroni Dimitrios Kitridis Byron Chalidis Fotios Papageorgiou Paraskevi Papaioannidou 1^(st)Department of Pharmacology School of MedicineFaculty of Health SciencesAristotle University of ThessalonikiThessaloniki 54124Greece Department of Biomedical Sciences for Health School of MedicineUniversity of MilanMilan 20133Italy Department of Biomedical Surgical and Dental SciencesUniversity of MilanMilan 20133Italy 1^(st)Department of Orthopaedic School of MedicineFaculty of Health SciencesAristotle University of ThessalonikiThessaloniki 57010Greece Department of Orthopaedic Surgery 404 General Army HospitalLarisa 41222Greece 1^(st)Department of Pharmacology Aristotle University of ThessalonikiThessaloniki 54124Greece

The musculoskeletal system involves multiple tissues which are constantly exposed to being exposed to various biological and mechanical *** such,isolating and studying a particular system from a complex human clinical environment is not always a realistic *** top of that,recruitment limitations,in addition to the nature of orthopaedic interventions and their associated cost,sometimes preclude consideration of human trials to answer a clinical ***,in this mini review,we sought to rationalize the rapid evolution of biomedical research at a basic scientific level and explain why the perception of orthopaedic conditions has fundamentally changed over the last *** more detail,we highlight that the number of orthopaedic in vitro publications has soared since *** but not least,we elaborated on the minimum requirements for conducting a scientifically sound infection-related laboratory experiment to offer valuable information to clinical *** also explained the rationale behind implementing molecular biology techniques,ex vivo experiments,and artificial intelligence in this type of laboratory research.

关键词： Biofilm In vitro Laboratory research Methodology

Network meta-analyses: Methodological prerequisites and clinical usefulness

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World Journal of Methodology 2022年第3期12卷 92-98页

作者： Savvas Ilias Christofilos konstantinos tsikopoulos Alexios tsikopoulos Dimitrios Kitridis konstantinos Sidiropoulos Panagiotis Nikolaos Stoikos Venu Kavarthapu Department of Genetics Evolutionand EnvironmentUniversity College LondonLondon WC1E 6BTUnited Kingdom Department of Pharmacology School of MedicineFaculty of Health Sciences Aristotle University of ThessalonikiThessaloniki 54124Greece Department of Otolaryngology-Head and Neck Surgery AHEPA University General HospitalAristotle University of ThessalonikiThessaloniki 57010Greece Department of Orthopaedics Aristotle University of ThessalonikiSchool of MedicineGeorge Papanikolaou Hospital ThessalonikiThessaloniki 57010Greece Department of Orthopedics General Hospital of SerresSerres 62100Greece Department of Medicine University of ThessalyLarissa 41500Greece Department of Trauma and Orthopaedics King’s College Hospital NHS Foundation TrustLondon SE59RSUnited Kingdom

It is an undeniable fact that systematic reviews play a crucial role in informing clinical practice;however,conventional head-to-head meta-analyses do have *** particular,studies can only be compared in a pair-wise fashion,and conclusions can only be drawn in the light of direct *** contrast,network meta-analyses can not only compare multiple interventions but also utilize indirect evidence which increases their *** top of that,they can also rank competing *** this mini-review,we have aimed to elaborate on the principles and techniques governing network meta-analyses to achieve a methodologically sound synthesis,thus enabling safe conclusions to be drawn in clinical *** have emphasized the prerequisites of a well-conducted Network Meta-Analysis(NMA),the value of selecting appropriate outcomes according to guidelines for transparent reporting,and the clarity achieved via sophisticated graphical *** is more,we have addressed the importance of incorporating the level of evidence into the results and interpreting the findings according to validated appraisal systems(i.e.,the Grade of Recommendations,Assessment,Development,and Evaluation system-GRADE).Lastly,we have addressed the possibility of planning future research via ***,we can conclude that NMAs could be of great value to clinical practice.

关键词： Network meta-analysis Quality of evidence Evidence-based medicine Systematic reviews

Rationalising animal research synthesis in orthopaedic literature

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World Journal of Methodology 2021年第3期11卷 75-80页

作者： konstantinos tsikopoulos konstantinos Sidiropoulos Dimitrios Kitridis Lorenzo Drago Rakesh Ebnezar David Lavalette Orthopaedic Department Harrogate and District Foundation TrustHarrogate HG27SXNorth YorkshireUnited Kingdom Orthopaedic Department General Hospital of SerresSerres 62120Greece First Orthopedic Department of Aristotle University G.Papanikolaou General HospitalThessaloniki 55210Greece Laboratory of Clinical Microbiology Department of Biochemical Sciences for HealthUniversity of MilanMilan 20164Italy

Systematic reviews in orthopaedic literature are frequently criticised for offering inconsistent *** top of that,high-quality randomized human evidence on crucial orthopaedic topics is more often than not *** this situation,pooling animal literature could offer an excellent insight into unanswered critical clinical questions,thus potentially improving *** this paper,we sought to present the rationale and basic principles governing meta-analysis of animal *** specifically,we elaborated on the available evidence-based methods to achieve a scientifically sound animal data *** addition,we discussed result interpretation,strength of recommendations and clinical implications based on the results of these meta-analytic modalities.

关键词： Meta-analysis Animal research Evidence synthesis in vivo Orthopaedics