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Cap snatch prevention:a novel approach to tackle influenza viruses

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2435-2436页

作者： konstantin m.j.sparrer Frank Kirchhoff Institute of molecular Virology Ulm University Medical CenterUlmGermany

A recent study published in Science1 by Tsukamoto and colleagues shows that a derivative of tubercidin,a natural product from Streptomyces,selectively inhibits influenza A and B viruses(IAV and IBV,respectively).The compound targets the host RNA methyltransferase mTr1,and thus prevents viral“cap snatching”(Fig.1).These results may help to develop novel drugs that target viral host dependency factors and are thus less likely to induce viral resistance.

关键词： prevention influenza likely

Unexpected little helpers: microbiota stimulate systemic antiviral defenses

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Signal Transduction and Targeted Therapy 2022年第11期7卷 4001-4002页

作者： Susanne Klute Helene Hoenigsperger konstantin m.j.sparrer Institute of molecular Virology Ulm University Medical CenterUlm89081Germany

In a recent study published in Immunity by Erttmann et al.,an unexpected beneficial role of gut microbiota in protecting mice against invading viruses by promoting low levels of systemic innate immune activation via t... 详细信息

关键词： al. interferon ed.

Strong attenuation of SARS-CoV-2 Omicron BA.1 and increased replication of the BA.5 subvariant in human cardiomyocytes

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Signal Transduction and Targeted Therapy 2023年第1期8卷 10-12页

作者： Rayhane Nchioua Federica Diofano Sabrina Noettger Pascal von maltitz Steffen Stenger Fabian Zech jan münch konstantin m.j.sparrer Steffen just Frank Kirchhoff Institute of molecular Virology Ulm University Medical CenterUlmGermany molecular Cardiology Department of Internal Medicine IIUlm UniversityUlmGermany Institute of medical microbiology and Hygiene Ulm University Medical CenterUlmGermany

Dear Editor,Since its first description in South Africa in November 2021,the SARS-CoV-2 Omicron variant rapidly outcompeted the previously dominating Delta *** is the fifth variant of concern(VOC).It contains an unusually high number of mutations compared to previous VOCs,especially in the viral Spike protein,and shows high transmissibility and efficient escape of neutralizing antibodies.

关键词： Strong neutral Omi

SARS-CoV-2 inhibition and specific targeting of infected cells by VSV particles carrying the ACE2 receptor

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Signal Transduction and Targeted Therapy 2023年第6期8卷 2463-2466页

作者： Fabian Zech Stefanie Weber Hanna Dietenberger Linyun Zhang Sabrina Noettger meta Volcic Tim Bergner Clarissa Read konstantin m.j.sparrer Thomas F.E.Barth Frank Kirchhoff Institute of molecular Virology Ulm University Medical CenterUlmGermany Institute of Pathology Ulm UniversityUlmGermany Central Facility for Electron microscopy Ulm UniversityUlmGermany

Dear Editor Effective vaccines and some antiviral agents against SARS-CoV-2,the causative agent of coronavirus disease 2019(COVID-19),have been ***,additional therapeutics are needed since emerging SARS-CoV-2 variants evade immunity induced by vaccination or previous infection and are resistant to therapeutic antibodies and fusion inhibitors.^(1)In addition,many patients experience prolonged post-acute sequelae of SARS-CoV-2.

关键词： ACE2 immunity acute

Synthetic polymers:A review of applications in drilling fluids

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Petroleum Science 2024年第1期21卷 475-518页

作者： Shadfar Davoodi mohammed Al-Shargabi David A.Wood Valeriy S.Rukavishnikov konstantin m.minaev School of Earth Sciences&Engineering Tomsk Polytechnic UniversityLenin AvenueTomskRussia DWA Energy Limited LincolnUnited Kingdom

With the growth of deep drilling and the complexity of the well profile,the requirements for a more complete and efficient exploitation of productive formations increase,which increases the risk of various ***,reagents based on modified natural polymers(which are naturally occurring compounds)and synthetic polymers(SPs)which are polymeric compounds created industrially,are widely used to prevent emerging complications in the drilling ***,compared to modified natural polymers,SPs form a family of high-molecular-weight compounds that are fully synthesized by undergoing chemical polymerization *** provide substantial flexibility in their ***,their size and chemical composition can be adjusted to provide properties for nearly all the functional objectives of drilling *** can be classified based on chemical ingredients,type of reaction,and their responses to ***,some of SPs,due to their structural characteristics,have a high cost,a poor temperature and salt resistance in drilling fluids,and degradation begins when the temperature reaches 130℃.These drawbacks prevent SP use in some medium and deep ***,this review addresses the historical development,the characteristics,manufacturing methods,classification,and the applications of SPs in drilling *** contributions of SPs as additives to drilling fluids to enhance rheology,filtrate generation,carrying of cuttings,fluid lubricity,and clay/shale stability are explained in *** mechanisms,impacts,and advances achieved when SPs are added to drilling fluids are also *** typical challenges encountered by SPs when deployed in drilling fluids and their advantages and drawbacks are also *** issues also impact the applications of SPs in drilling ***,the cost of the most relevant SPs,and the monomers used in their synthesis,are *** impacts of SPs when deployed in drilling fluids,and t

关键词： Synthetic versus natural polymers Nanopolymers Drilling fluid additives Lubricity Clay swelling Hole cleaning

Actuality and underlying mechanisms of systemic immuneinflammation index and geriatric nutritional risk index prognostic value in hepatocellular carcinoma

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World journal of Gastrointestinal Surgery 2024年第2期16卷 260-265页

作者： konstantin Y Tchilikidi Department of Surgery with Postgraduate Education Altai State Medical UniversityBarnaul 656031Russia

This editorial contains comments on the article“Correlation between preoperative systemic immune inflammation index,nutritional risk index,and prognosis of radical resection of liver cancer”in a recent issue of the World journal of Gastrointestinal *** pointed out the actuality and importance of the article and focused primarily on the underlying mechanisms making the systemic immuneinflammation index(SII)and geriatric nutritional risk index(GNRI)prediction features *** are few publications on both SII and GNRI together in hepatocellular carcinoma(HCC)and patient prognosis after radical *** release cytokines,chemokines,and enzymes,degrade extracellular matrix,reduce cell adhesion,and create conditions for tumor cell *** promote the adhesion of tumor cells to endothelial cells,through physical *** results in the migration of tumor ***-angiogenic factors from platelets enhance tumor angiogenesis to meet tumor cell supply *** can form a protective film on the surface of tumor *** allows avoiding blood flow damage as well as immune system *** also induces the epithelial-mesenchymal transformation of tumor cells that is critical for *** SII is also associated with macro-and microvascular invasion and increased numbers of circulating tumor cells.A high GNRI was associated with significantly better progression-free and overall *** patients are a very special population that requires increased *** and GNRI have significant survival prediction value in both palliative treatment and radical surgery *** underlying mechanisms of their possible predictive properties lie in the field of essential cancer *** features provide tumor nutrition,growth,and distribution throughout the body,such as vascular *** the other hand,they are tied to the possibility of patients to resist tumor progression and development of complications in bot

关键词： Systemic immune-inflammation index Geriatric nutritional risk index Radical surgery Transarterial chemoembolization Hepatocellular carcinoma Prognosis

Ex vivo liver resection and auto-transplantation and special systemic therapy in perihilar cholangiocarcinoma treatment

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World journal of Gastrointestinal Surgery 2024年第3期16卷 635-640页

作者： konstantin Y Tchilikidi Department of Surgery with Postgraduate Education Altai State Medical UniversityBarnaul 656031Russia

This editorial contains comments on the article“Systematic sequential therapy for ex vivo liver resection and autotransplantation:A case report and review of li-terature”in the recent issue of World journal of Gastrointestinal *** points out the actuality and importance of the article and focuses primarily on the role and place of ex vivo liver resection and autotransplantation(ELRAT)and systemic therapy,underlying molecular mechanisms for targeted therapy in perihilar cho-langiocarcinoma(pCCA)*** is a tough malignancy with a high proportion of advanced disease at the time of *** only curative option is radical *** excision and reconstruction become extremely com-plicated and not always could be performed even in localized *** the other hand,ELRAT takes its place among surgical options for carefully selected pCCA *** advanced disease,systemic therapy becomes a viable option to prolong *** editorial describes current possibilities in chemotherapy and reveals underlying mechanisms and projections in targeted therapy with ki-nase inhibitors and immunotherapy in both palliative and adjuvant ***-broblast grow factor and fibroblast grow factor receptor,human epidermal grow-th factor receptor 2,isocitrate dehydrogenase,and protein kinase cAmP activated catalytic subunit alpha(PRKACA)and beta(PRKACB)pathways have been ac-tively investigated in CCA in last *** agents were introduced and approved by the Food and Drug *** all demonstrated mean-ingful activity in CCA patients with no global change in *** is why every successfully treated patient counts,especially those with advanced *** conclusion,pCCA is still hard to treat due to late diagnosis and extremely complicated surgical *** also brings some hope,but it could be performed in very carefully selected *** disease requires systemic anticancer treatment,which is supposed to be indivi

关键词： Perihilar cholangiocarcinoma Klatskin’tumor Ex vivo liver resection and autotransplantation Chemotherapy Immunotherapy Targeted therapy

The Disintegration of a Floating Ferrofluid Layer into an Ordered Drop System in a Vertical magnetic Field

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Fluid Dynamics & materials Processing 2024年第10期20卷 2205-2218页

作者： Christina Khokhryakova konstantin Kostarev Irina mizeva Laboratory of Dispersed System Dynamics Institute of Continuous Media Mechanics UrB RASPerm614018Russia Laboratory of Hydrodynamical Stability Institute of Continuous Media Mechanics UrB RASPerm614018Russia Laboratory of Turbulence Institute of Continuous Media Mechanics UrB RASPerm614018Russia

magnetic fluids,also known as ferrofluids,are versatile functional materials with a wide range of *** applications span from industrial uses such as vacuum seals,actuators,and acoustic devices to medical uses,including serving as contrast agents for magnetic resonance imaging(mRI),delivering medications to specific locations within the body,and magnetic hyperthermia for cancer *** use of a non-wettable immiscible liquid substrate to support a layer of magnetic fluid opens up new possibilities for studying various fluid flows and related instabilities in multi-phase systems with both a free surface and an *** presence of two deformable boundaries within a ferrofluid layer significantly reduces the critical magnetic field strength required to transform the layer into an organized system of drops or polygonal figures evolving according to the intensity,frequency and direction of the considered magnetic *** paper experimentally investigates this problem by assuming a uniform magnetic field perpendicular to the *** specific subject has not been previously explored *** critical magnetic field intensity required to destabilize the ferrofluid layer is determined based on the layer’s thickness and the fluid’s initial magnetic *** is demonstrated that the critical magnetic field strength needed to disrupt the initially continuous ferrofluid layer increases with the layer’s ***,an increase in the ferrofluid’s magnetic susceptibility results in a decrease in the critical magnetic field *** emerging droplet structures are analyzed in terms of the number of drops,their size,and the periodicity of their *** number of droplets formed depends on the initial thickness of the layer,the presence or absence of a stable rupture in the upper layer,and the rate at which the magnetic field strength is increased to the critical value.A characteristic viscous time is proposed

关键词： Ferrofluid liquid substrate normal field instability ordered droplet structure

Robotic surgery in living liver donors and liver recipients

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Laparoscopic, Endoscopic and Robotic Surgery 2024年第3期7卷 123-127页

作者： konstantin Semash Department of mini-Invasive Surgery National Children’s Medical CenterTashkent 100171Uzbekistan

There have been nearly 60 years since Thomas Starzl’s first liver *** this period,advancements in medical technology have progressively enabled the adoption of new methods for *** these innovations,robotic surgery has emerged in recent decades and is gradually being integrated into transplant *** hepatectomy and liver implantation represent significant advancements in the field of transplant *** precision and minimally invasive nature of robotic surgery offer substantial benefits for both living donors and *** living donors,robotic hepatectomy reduces postoperative pain,minimizes scarring,and accelerates *** liver recipients,robotic liver implantation enhances surgical accuracy,leading to better graft positioning and vascular *** systems provide more precise and maneuverable control of instruments,allowing surgeons to perform complex procedures with greater accuracy and reduced risk to *** review encompasses publications on minimally invasive donor liver surgery,with a specific focus on robotic liver resection in transplantation,and aims to summarize current knowledge and the development status of robotic surgery in liver transplantation,focusing on liver resection in donors and graft implantation in recipients.

关键词： Liver transplantation Robotic surgery Robotic liver resection Robotic hepatectomy Robotic liver implantation