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Emergency department targeted screening for hepatitis C does not improve linkage to care

World Journal of Gastroenterology 2020年第32期26卷 4878-4888页

作者： Inbal Houri Noya Horowitz Helena Katchman Yael Weksler Ofer Miller Liat deutsch Oren Shibolet Department of Gastroenterology and Hepatology Tel-Aviv Medical CenterTel-Aviv 6423906Israel Sackler Faculty of Medicine Tel-Aviv UniversityTel-Aviv 6997801Israel

BACKGROUND Hepatitis C virus(HCV)infection is a leading cause of chronic liver disease *** treatments for HCV revolutionized management and prompted the world health organization to set the goal of viral elimination by *** developments strengthen the need for HCV screening in order to identify asymptomatic carriers prior to development of chronic liver disease and its *** screening strategies have been attempted,most targeting high-risk *** studies focusing on patients arriving at emergency departments showed a higher prevalence of HCV compared to the general *** To identify previously undiagnosed HCV carriers among high risk emergency room attendees and link them to care for anti-viral *** In this single center prospective study,persons visiting the emergency department in an urban hospital were screened by a risk factor-specific *** risk factors screened for were exposure to blood products or organ transplantation before 1992;origins from countries with high prevalence of HCV;intravenous drug use;human immunodeficiency virus carriers;men who have sex with men;those born to HCV-infected mothers;prior prison time;and chronic kidney *** with at least one risk factor were tested for HCV by serum for HCV antibodies,a novel oral test from saliva(OraQuick®)or *** Five hundred and forty-one participants had at least one risk factor and were tested for *** four percent of all study participants had only one risk *** five percent of participants underwent OraQuick®testing,34%were tested for serum anti-HCV antibodies,and 25%had both tests.3.1%of patients(17/541)had a positive result,compared to local population incidence of 1.96%.Of these,82%were people who inject drugs(current or former),and 64%served time in *** patient had a negative HCV-RNA,and two patients died from non-HCV related *** review of past medical records,12 patients w

关键词： Screening Emergency departments Israel Saliva Hepatitis C Liver

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Ion stopping in dense plasmas: A basic physics approach

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Matter and Radiation at Extremes 2016年第6期1卷 277-307页

作者： Claude deutsch Gilles Maynard Laboratoire de Physique des Gaz et Plasmas CNRSUniv-Paris SudUniversite Paris-Saclay91405 OrsayFrance

We survey quite extensively the present research status of ion-stopping in dense plasmas of potential importance for initial confinement fusion(ICF)drivenby intense and heavy ion beams,and alsofor warm dense matter(WDM).First,we putemphasis on every possible mechanism involved in the shaping of the ion projectile effective charge,while losing energy in a target plasma with classical ions and partially degenerate ***,we switch to ion stopping by target bound electrons,taking detailed account of mean excitation *** electron stopping has already been given a lot of attention in former works[*** et al.,Recent *** 1(2000)1-23;Open Plasma Phys.J.3(2010)88-115].Then,we extend the usual standard stopping model(SSM)framework to nonlinear stopping including a treatment of the Z 3 Barkas effect and a confronting comparison of Bloch and Bohr Coulomb ***,we document low velocity ion slowing down(LVISD)in single ion plasmas as well as in binary ionic mixtures(BIM),in connection with specific ICF fuels.

关键词： Ion projectile effective charge Mean excited energies Nonlinear stopping Binary ionic mixture

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VLAN近况细说——Cabletron公司亚太区培训总监Gene deutsch先生

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微电脑世界 1997年第9期 21-22页

作者： Gene deutsch Cabletron系统公司

随着网络的不断增长,各公司已开始限制通信流的方法,VLAN(虚拟局域网络)正逐渐成为企业连网的关键部分。当这些新的大型网络在各城市和各洲之间跨接宽域路时,一般在服务器、路由器和其他网络节点间结送的、定期的管理通信流可能会产生... 详细信息

随着网络的不断增长,各公司已开始限制通信流的方法,VLAN(虚拟局域网络)正逐渐成为企业连网的关键部分。当这些新的大型网络在各城市和各洲之间跨接宽域路时,一般在服务器、路由器和其他网络节点间结送的、定期的管理通信流可能会产生一些消耗钱财和吸收带宽的通信流,它们对网络的生产力会产生影响。VLAN则可限制这种通信流及带宽需求。VLAN的好处在被人们接受,目前提供VLAN技术的厂商包括CISCO、3COM、Cabletron、Bay、Networks、Newbridge和DEC等厂商。来自评测机构的结果表明,Cabletron在VLAN技术方面似乎处于领先的地位,它的解决方案与其他厂商的不同在哪里呢?借Cabletron总公司高层技术专家来京之际,记者请他简述了VLAN技术的新进展和Ca+bletron的技术优势。

关键词： VLAN Cabletron Gene deutsch 端口镜像路由器

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Adaptive Design of Fluorescence Imaging Systems for Custom Resolution, Fields of View, and Geometries

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Biomedical Engineering Frontiers 2023年第1期4卷 260-273页

作者： Roujia Wang Riley J.deutsch Enakshi D.Sunassee Brian T.Crouch Nirmala Ramanujam Department of Biomedical Engineering Duke UniversityDurhamNCUSA Department of Pharmacology and Cancer Biology Duke University Medical CenterDurhamNCUSA

Objective and Impact Statement:We developed a generalized computational approach to design uniform,high-intensity excitation light for low-cost,quantitative fluorescence imaging of in vitro,ex vivo,and in vivo samples with a single ***:Fluorescence imaging is a ubiquitous tool for biomedical *** extensively modify existing systems for tissue imaging,increasing the time and effort needed for translational research and thick tissue *** modifications are applicationspecific,requiring new designs to scale across sample ***:We implemented a computational model to simulate light propagation from multiple *** a global optimization algorithm and a custom cost function,we determined the spatial positioning of optical fibers to generate 2 illumination *** results were implemented to image core needle biopsies,preclinical mammary tumors,or tumor-derived *** were stained with molecular probes and imaged with uniform and nonuniform ***:Simulation results were faithfully translated to benchtop *** demonstrated that uniform illumination increased the reliability of intraimage analysis compared to nonuniform illumination and was concordant with traditional histological *** computational approach was used to optimize the illumination geometry for the purposes of imaging 3 different fluorophores through a mammary window chamber *** specifically designed for intravital tumor imaging generated higher image contrast compared to the case in which illumination originally optimized for biopsy images was ***:We demonstrate the significance of using a computationally designed illumination for in vitro,ex vivo,and in vivo fluorescence *** illumination increased the reliability of intraimage analysis and enhanced the local contrast of biological *** approach is generalizable across light sources,biological appl

关键词： illumination Fluorescence image

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基于储层静态地质参数的一种随机建模结果排序方法

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石油学报 2010年第3期31卷 445-448页

作者：李少华张昌民 Clayton V. deutsch 长江大学地球科学学院湖北荆州434023 阿尔伯塔大学计算地质统计学中心

储层随机建模可以产生大量实现,而油藏数值模拟由于计算量大,通常只能对非常有限的实现进行模拟计算。随机选择实现常常会导致过于悲观或过于乐观的模拟结果,并且无法合理评价地质模型所包含的不确定性。利用与数模响应密切相关的静态... 详细信息

储层随机建模可以产生大量实现,而油藏数值模拟由于计算量大,通常只能对非常有限的实现进行模拟计算。随机选择实现常常会导致过于悲观或过于乐观的模拟结果,并且无法合理评价地质模型所包含的不确定性。利用与数模响应密切相关的静态地质指标,如连通原油体积对实现进行排序,然后选择典型的实现进行数模,较好地解决这一问题。但是,该指标没有考虑含油网格与生产井之间的距离及渗透率大小,而这两个参数对于流体流动有着重要的控制作用。在连通原油体积的基础上提出了一种新的排序指标。该指标在计算连通原油体积的公式上增加了网格与生产井之间的距离和渗透率两个影响因子。通过实例对这两种指标进行了对比研究,新指标更好地反映了不同实现的差别。

关键词：油藏数值模拟随机建模连通原油体积流体流动静态地质参数排序指标

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Impact of the microenvironment on the pathogenesis of mucosaassociated lymphoid tissue lymphomas

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 153-162页

作者： Barbara Uhl Katharina T Prochazka Karoline Fechter Katrin Pansy Hildegard T Greinix Peter Neumeister Alexander JA deutsch Division of Hematology Medical University of GrazGraz 8036Austria

Approximately 8%of all non-Hodgkin lymphomas are extranodal marginal zone B cell lymphomas of mucosa-associated lymphoid tissue(MALT),also known as MALT *** arise at a wide range of different extranodal sites,with most cases affecting the stomach,the lung,the ocular adnexa and the *** small intestine is involved in a lower percentage of *** growth in the early stages is associated with long-lasting chronic inflammation provoked by bacterial infections(e.g.,Helicobacter pylori or Chlamydia psittaci infections)or autoimmune conditions(e.g.,Sjögren’s syndrome or Hashimoto thyroiditis).While these inflammatory processes trigger lymphoma cell proliferation and/or survival,they also shape the ***,activated immune cells are actively recruited to the lymphoma,resulting in either direct lymphoma cell stimulation via surface receptor interactions and/or indirect lymphoma cell stimulation via secretion of soluble factors like *** addition,chronic inflammatory conditions cause the acquisition of genetic alterations resulting in autonomous lymphoma cell ***,novel agents targeting the microenvironment have been developed and clinically tested in MALT lymphomas as well as other lymphoid *** this review,we aim to describe the composition of the microenvironment of MALT lymphoma,the interaction of activated immune cells with lymphoma cells and novel therapeutic approaches in MALT lymphomas using immunomodulatory and/or microenvironmenttargeting agents.

关键词： Mucosa-associated lymphoid tissue lymphoma Tumor microenvironment Microenvironment Helicobacter pylori Activated immune cells

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Poor Sleep Can Be Deadly for Elderly

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当代外语研究 2003年第3期 15-16页

作者： Nancy deutsch 李缀野

选注者言:文章的标题就警告我们,老人的睡眠事关重大。本文澄清了对老人的睡眠的传统误解,比如:older people need less sleep or shouldn’t be concerned ifthey have sleep problems.本文还劝告老人:… people who seem to sleep wel... 详细信息

选注者言:文章的标题就警告我们,老人的睡眠事关重大。本文澄清了对老人的睡眠的传统误解,比如:older people need less sleep or shouldn’t be concerned ifthey have sleep problems.本文还劝告老人:… people who seem to sleep wellshould work on improving their sleep habits.有些小建议对老人也可参考:Don’tdo work in bed,and no nappingduring the day.你若是年轻读者,请把这些内容介绍给你们年迈的父母吧!

关键词： Poor Sleep Can Be Deadly for Elderly Be

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Framing Cuisine with Food Loss and Waste as a Combined Nutrition Public Health Priority and Climate Change Mitigation Action

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Food and Nutrition Sciences 2019年第9期10卷 1122-1131页

作者： Jonathan M. deutsch Thomas O’Donnell Solomon Katz Department of Food and Hospitality Management College of Nursing and Health Professions Drexel University Philadelphia PA USA Cabrini University Radnor PA USA Emeritus Department of Anthropology University of Pennsylvania Philadelphia PA USA

This paper proposes that fortifying honored traditional recipes with natural foods in tandem with preventing food loss and waste adds a new dimension to sustainable food management—nutrient recovery and bioavailability—while reducing the global prevalence of anemia and other diet-induced maladies. Using the complementarity of iron and Vitamin C as an example, this paper demonstrates that we can recover bioavailable nutrients to ensure recovery is efficient. The authors show by example that returning food loss and waste into a healthy food environment can meet the daily and monthly needs of iron-deficiency in substantial portions of the populations with significant need and in all countries. Further, maximizing the availability of key nutrients, like iron, will reduce the stress of animal husbandry on the environment, reduce greenhouse gas emissions;and thereby, reduce agriculture impacts to climate change and global warming. Considering the quality, quantity, and convenience of food recovery, from farm—and beyond fork—to gut, is key for global policy development in nutrition public health and actions that are ready to implement today.

关键词： Food Loss Food Waste Bioavailability Climate Change Iron Anemia Cuisine Food Fortification Behavior Change

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Decreased Door to Balloon Time: Better Outcome for the Patient?

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World Journal of Cardiovascular Diseases 2015年第3期5卷 49-52页

作者： Steven B. deutsch Eric L. Krivitsky University of South Florida Morsani College of Medicine Tampa Florida USA

Recently the American College of Cardiology and the American Heart Association instituted DTB of 90 minutes or less as a class I recommendation. Since 2006 the percentage of patient meeting this metric has substantially increased, although research has demonstrated discrepancies in whether or not this objective is associated with better patient outcome. Here, we reviewed seven studies in effort to investigate the validity of the 90 minute or less door to balloon time. Our findings suggest that patient outcome in the setting of acute myocardial infarction is multifactorial, and while the door to balloon time metric likely has played a role in better patient outcomes it is not the sole factor in improving mortality rates.

关键词： Door to Balloon Time 90 Minute Door to Balloon Time Coronary Intervention Myocardial Infarction

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Simultaneous development of diabetic ketoacidosis and Hashitoxicosis in a patient treated with pegylated interferon-alpha for chronic hepatitis C

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World Journal of Gastroenterology 2007年第8期13卷 1292-1294页

作者： Aspasia S Soultati Spyridon P Dourakis Alexandra Alexopoulou Melanie deutsch Athanasios J Archimandritis 2nd Department of Internal Medicine University of Athens Medical School Hippokration General Hospital 114 Vas Sofias Avenues Athens 11527 Greece

Classical interferon-alpha has been shown to be correlated with the development of a variety of autoimmune disorders. A 38 year-old female patient developed simultaneously diabetic ketoacidosis and hyperthyroidism 5 mo following initiation of treatment with pegylated interferon-α and ribavirin for chronic hepatitis C. High titers of glutamic acid decarboxylase, antinuclear and thyroid (thyroid peroxidase and thyroglobulin) antibodies were detected. Antiviral treatment was withdrawn and the patient was treated with insulin for insulin-dependent diabetes mellitus and propranolol for hyperthyroidism. Twelve months after cessation of pegylated interferon-α therapy the patient was euthyroid without any medication but remained insulin-dependent.

关键词： Autoimmune thyroiditis Insulin dependent diabetes mellitus Pegylated interferon-alpha Chronic hepatitis C

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